- 著者
- Masato Terashita Kazuhiro Iguchi Shigeyuki Usui Kazuyuki Hirano
- 出版者
- 日本医療薬学会
- 雑誌
- 医療薬学 (ISSN:1346342X)
- 巻号頁・発行日
- vol.39, no.3, pp.156-165, 2013-03-10 (Released:2014-03-10)
- 参考文献数
- 8
Anxieties about the quality of generic drugs are one of reasons why these drugs are not generally used in therapies in Japan. To reduce anxieties, we propose a statistical and objective method to evaluate the quality of generic drugs using the coefficient of variances (CVs) calculated from their pharmacokinetic parameters. CVs were estimated from AUC, Cmax, Tmax, t1/2, and MRT, which were provided as publicly-available drug information. The generic drug assessment tool (G-DAT), an original equation derived from the ratio of CVs of corresponding generic to original drugs, and the quality of generic drugs was statistically evaluated. As expected, when evaluated with G-DAT, there was little variance between original and generic drugs using 11 medicines. Antihypertensive dihydropyridines with a lower solubility were shown to have a larger CV. No significant difference in CVs was observed when famotidine and ebastine OD tablets were taken with or without water. G-DAT and the ratio of CVs (CCVs) of generic to original drugs revealed pharmacokinetic equivalences between generic and original drugs. The proposed comparative evaluation showing equivalent pharmacokinetics of generic to original drugs can be used as one solution to reduce anxieties and increase the reliability of generic drugs.
1 0 0 0 ハイパーカードによる医薬品情報解析システムMacDrugの開発
- 著者
- 佐藤 均 佐藤 里美 若園 智弥 堀越 勇
- 出版者
- 日本医療薬学会
- 雑誌
- 病院薬学 (ISSN:03899098)
- 巻号頁・発行日
- vol.21, no.5, pp.418-427, 1995-10-10
- 被引用文献数
- 1 1
Conventional printed databases (or manuals) for drug information have unequivocal problems in adding new information, which are critical for drug safety, and in extracting required information from large amounts of data. Therefore, in this study, we developed a problem-solving system of drug information, named "MacDrug", using HyperTalk on Macintosh personal computers. This system consists of major four functions ; organizing various kinds of drug information, converting data sets from other databases, searching and extracting required information under any condition, and analyzing patient compatibility with drugs. All of these functions worked efficiently with the test data, and were shown to be useful in utilizing as much as possible the drug information. MacDrug can be localized in the public domain since the HyperCard program is bundled in every Macintosh computer with free of charge. Thus, we believe that MacDrug can help clinical pharmacists manage the advanced and complex drug information in an efficient manner.
- 著者
- 佐藤 由美子
- 出版者
- 日本医療薬学会
- 雑誌
- 日本医療薬学会年会講演要旨集
- 巻号頁・発行日
- vol.21, 2011-09-09
- 著者
- 斎藤 寛子 中村 爽子 宮堂 寛美 高崎 保郎 仲野 達之助
- 出版者
- 日本医療薬学会
- 雑誌
- 病院薬学 (ISSN:03899098)
- 巻号頁・発行日
- vol.18, no.3, pp.288-292, 1992-06-20
Symmetrel (Amantadine hydrochloride) has pharmacological actions as both anti-Parkinsonism and antiviral drugs, however, it is used only as an anti-Parkinsonism drug in Japan, In this report, we surveyed the frequency of fever caused by influenza for the patients in hospital from November 1989 to March 1990 and assessed the relationship between the reduction in fever and taking Symmetrel. The fever caused by influenza was significantly reduced by taking Symmetrel. In the period from the end of November 1989 to the end of January 1990, in which the influenza A Hong-Kong was raging throughout Aichi Prefecture, the fever was more significantly reduced by taking Symmetrel than that in total period.
- 著者
- 武隈 洋 岩井 美和子 藤原 俊恵 川岸 亨 熊井 正貴 松浦 麻耶 馬渕 朋美 須田 範行 宮本 剛典 荻野 修 菅原 満 宮崎 勝巳
- 出版者
- 日本医療薬学会
- 雑誌
- 医療薬学 (ISSN:1346342X)
- 巻号頁・発行日
- vol.31, no.7, pp.575-584, 2005-07-10
- 被引用文献数
- 5 6
The results of cancer chemotherapy have been improved remarkably by the development of new drugs and combining drugs in treatment. However, cancer chemotherapy protocols are complicated and the adverse effects are more severe than those of other pharmacotherapies. It was therefore felt important to create a database of protocols for the preparation and dispensing of drugs used in cancer chemotherapy. Using Microsoft Access, we have created a database from 320 protocols we have collected so far from 12 clinical departments and developed operating programs for it. The database has enabled us to search for a protocol using keywords-names of drugs, diseases and clinical departments-and most of the operations can be carried out by the click of a mouse. With our database, pharmacists are able to access protocols quickly and check prescriptions of anticancer drugs even if they are unfamiliar with computers, and we consider it to be a useful tool for this purpose.
- 著者
- 三好 淳子 井門 敬子 松岡 綾 武市 佳己 山口 巧 岡本 千恵 末丸 克矢 荒木 博陽
- 出版者
- 日本医療薬学会
- 雑誌
- 医療薬学 (ISSN:1346342X)
- 巻号頁・発行日
- vol.31, no.3, pp.233-237, 2005-03-10
- 被引用文献数
- 10 14
At the Division of Pharmacy in Ehime University Hospital, we conduct drug counseling training for undergraduate students and graduate students aimed at helping them acquire communication skills as well as clinical knowledge. The program relies largely on case-based learning (CBL) procedures and role-play practice using video tape recordings. In the following, we describe the drug counseling training program and report the results of a student evaluation of the program. The training program consists of the following : 1. Explanation of the procedure of the practical training; 2. Presentation of a mock case file-including a patient profile, diagnosis, clinical history, laboratory data and prescription; 3. Explanation of how to collect drug information; 4. Study of individual cases by students, 5. Role-play in providing drug counseling and recording this on video (with a student in the counseling role and a pharmacist in the patient role) and 6. Discussion and review by students and clinical pharmacists (including the person who played the patient role) after watching the video recording. After the training, we conducted a survey of the participating students by questionnaire regarding their opinions of the training program. Almost all of the students considered the practical training to be useful because it enabled them to evaluate their performance in drug counseling and communication skills objectively. They also felt that the guidance they had received from clinical pharmacists had been useful. Our training program on drug counseling using CBL procedures and video recordings is thus a simple method of training students which enables them to improve both their communication skills and clinical knowledge.
1 0 0 0 治験薬の一元管理
- 著者
- 川上 英治 二神 幸次郎 定金 典明 西原 茂樹 荒木 博陽 川崎 博巳 五味田 裕
- 出版者
- 日本医療薬学会
- 雑誌
- 病院薬学 = Journal of the Nippon Hospital Pharmacists Association (ISSN:03899098)
- 巻号頁・発行日
- vol.25, no.1, pp.69-75, 1999-02-10
- 被引用文献数
- 8
Pharmacists need to have a clear policy for managing investigational drugs under circumstances that are consistent with Good Clinical Practice. We studied the management and support system for the clinical research of investigational drugs based on the management of investigational drugs. We experienced 126 cases of pharmaceutical consultations in 650 prescriptions for investigational drugs from April 1997 to March 1998. Seven cases which might induce a patient to drop out, were included in pharmaceutical consultations. We found it was important to communicate with all investigators regarding giving adequate prior information to having a clearly defined protocol. Our pharmaceutical program for the clinical research of investigational drugs was thus found to be useful in the management of investigational drugs.