1 0 0 0 バンコマイシンの初期投与法の検討
- 著者
- 前田 頼伸 小西 敏夫 西園寺 真二 船越 幸代 中村 護 仁井 雅子 正木 史子 突合 皐月
- 出版者
- 日本医療薬学会
- 雑誌
- 病院薬学 (ISSN:03899098)
- 巻号頁・発行日
- vol.25, no.5, pp.517-524, 1999-10-10
- 参考文献数
- 12
- 被引用文献数
- 11
To elucidate the current status of the dosage regimen of vancomycin, we reviewed its therapeutic drug monitoring (TDM) data obtained from 99 patients undergoing vancomycin treatment at the Chugoku Rousai Hospital. The plasma concentrations of vancomycin at one dosage under 750 mg deviated from its therapeutic ranges (the level at one hour after the end of infusion : 25-40 μg/mL, trough level :≦10μg/mL). Therefore, the dosing interval at a uniform dosage of 1000 mg was calculated from a vancomycin nomogram reported by Moellering et al., and the utility of the dosing interval at the uniform dosage of 1000 mg combined with a creatinine clearance nomogram reported by Nielsen et al. was examined. As a result, the plasma levels of 66 percent of the subjects were controlled within the accepted therapeutic ranges in the early stage. Accordingly, the nomogram of vancomycin prepared as an indication in the early stage in our hospital was thus concluded to be clinically acceptable.
1 0 0 0 インスリン注入器の第一印象と手技体験後印象の比較調査
- 著者
- 中野 玲子 武藤 達也 虎石 顕一 朝倉 俊成
- 出版者
- 日本医療薬学会
- 雑誌
- 医療薬学 (ISSN:1346342X)
- 巻号頁・発行日
- vol.34, no.7, pp.705-710, 2008-07-10
To clarify the factors in preference for insulin injectors, 69 subjects (aged 20-49 years) were asked to select 1 of 4 different injectors and then to complete a questionnaire regarding 9 selection factors regarded as important, among them "ease of gripping" and "portability" , before and after instruction on operating the injectors. "Portability" was considered the most important factor for selecting injectors on first impression, i.e. before instruction, and the percentage of subjects choosing "simplicity of operation" increased after instruction. About half of the subjects selected a different injector before and after instruction, so there appeared to be a relationship between injector selection and the evaluation factors. From the results, we made a table which we thought would be helpful in selecting insulin injectors based on factors regarded as important when using them in practice.
- 著者
- 保坂 恵玲 高柳 理早 鈴木 あやな 折井 孝男 清野 敏一 清水 秀行 山村 喜一 中村 幸一 小滝 一 澤田 康文 伊賀 立二
- 出版者
- 日本医療薬学会
- 雑誌
- 病院薬学 (ISSN:03899098)
- 巻号頁・発行日
- vol.23, no.4, pp.342-347, 1997-08-10
- 被引用文献数
- 8
We conducted a survey to evaluate a system adopted by the Pharmacy Department of Tokyo University Hospital to address the problem of drug compliance under this system, patients are provided with a "Drug History Handbook", or drug notebook. This survey attempted to determine the extent to which a "Drug History Handbook" helped patients understand the drug they were taking, and the extent to which it was utilized during visits to other institutions. Based on the results of the survey we evaluated the efficacy of "Drug History Handbook" as a means to enable patients themselves to perform comprehensive drug information management. Out of 288 patients respondmg to the survey 149 (52%) had a "Drug History Hand-book"149out of 286 respondents or 40% had been diagnosed at other institutions. The respondents who said they had shown their "Drug History Handbook" to phamacists or physicians at other pharmacies, hospitals, or medical institutions were numbered 7 1 out of 149 (48%), including duplicate responses. At community pharmacies conducted at the same time, responses were obtained from 48 pharmacies. Of the 48 responding pharmacies, 21 (44%) said that patients had presented either "Drug History Handbook"or "prescription cards" From these results, it is clear that the patients thus realized the importance of keeping a complete record of the drugs they had taken, and that presenting information about drug history can be a very valuable aid in both prescribing and preparing appropriate medications. From thus survey, it was found that the use of a "Drug History Handbook" can help prevent the dispersal of information about purchase of over the counter drugs as well as prescription drugs. As a means of patient education, it can also be extremely effective for avoiding the duplicated administration of medications and drug-drug interactions.
1 0 0 0 アロプリノール含嗽水の安定性並びに臨床使用効果
- 著者
- 谷名 寧子 室井 政子 丁 元鎮 大谷 トミ子 吉上 裕子 中村 順 真崎 規江 坂上 吉一
- 出版者
- 日本医療薬学会
- 雑誌
- 病院薬学 (ISSN:03899098)
- 巻号頁・発行日
- vol.18, no.5, pp.510-515, 1992-10-20
- 被引用文献数
- 6 1
The chemical stability and the microbial numbers of non-sterilized and sterilized 0.1% allopurinol gargle (allopurinol gargle) were studied. Furthermore, studied the efficacy for some patients who were afflicted with oral mucositis. Allopurinol gargle (0.1%) was chemically stable under the storage in the room temperature or in the refrigerator at least for 15 days. Bacterial numbers in the non-sterilized samples increased at regular interval, while the sterilized sample wasn't detected the bacterial colonies for 15 days. On the therapeutical efficacy of allopurinol gargle for 8 patients, all 8 cases were judged effective. However, we think that more modification to the allopurinol gargle preparation and more clinical data would be needed.
- 著者
- 粟屋 敏雄 大滝 康一 石原 昌司 小野 尚志 千葉 薫 板垣 祐一 山田 武宏 須野 学 早勢 伸正 田崎 嘉一 松原 和夫
- 出版者
- 日本医療薬学会
- 雑誌
- 医療薬学 (ISSN:1346342X)
- 巻号頁・発行日
- vol.31, no.6, pp.425-434, 2005-06-10
- 参考文献数
- 11
- 被引用文献数
- 1 5
出版社版新規システム導入後のオーダシステム内の記録から,処方が試みられた併用禁忌の組み合わせなどを解析した.相互作用チェックは,その処方の投与期間内に重複しているすべての薬品を自処方内および他処方内の薬歴データファイルから抽出し,チェック対象薬剤が重複した場合,チェックメッセージを表示した.システム運用開始以降,13ヵ月間における処方せんおよび注射指示せんの枚数はそれぞれ290956枚,299017枚の計589973枚であった.調査期間内にチェックのかかった回数は299件であった.警告としたものを除く173件中,96件は処方が中止された.時間外の併用禁忌の処方の危険率は時間内に比べ実に4倍近くにも上った.オーダ別にみると,実に80%近くの併用禁忌の組み合わせは注射薬が関与するものであった.最もチェックのかかった頻度が高かった薬剤の組み合わせはトランサミン注とトロンビン細粒の組み合わせであった
- 著者
- 狭間 研至
- 出版者
- 日本医療薬学会
- 雑誌
- 日本医療薬学会年会講演要旨集
- 巻号頁・発行日
- vol.16, 2006-09-01
- 著者
- 橋本 聖子
- 出版者
- 日本医療薬学会
- 雑誌
- 日本医療薬学会年会講演要旨集
- 巻号頁・発行日
- vol.18, 2008-09-01
- 著者
- 荻窪 哲也 日高 宗明 奥村 学 藤田 健一 山崎 啓之 浅生 将英 岩切 智美 佐々木 裕美 児玉 裕文 有森 和彦
- 出版者
- 日本医療薬学会
- 雑誌
- 医療薬学 (ISSN:1346342X)
- 巻号頁・発行日
- vol.32, no.5, pp.392-399, 2006-05-10
- 被引用文献数
- 2 2
In view of the lack of information on the extent to which tea beverages inhibit the activity of human cytochrome P 450 3A (CYP 3A), we investigated their effect on the midazolam 1' -hydroxylation activity of CYP 3A contained in human liver microsomes. "Grapefruit (white)" was used as a positive control, and "Valencia Orange", as a negative control. All the tea beverages tested significantly inhibited the midazolam 1' -hydroxylation activity of CYP 3A in a concentration-dependent manner and inhibition was particularly marked for Katekin 600^[○!R] and Banso-reicha^[○!R] (5.0%, v/v). The potency of the inhibitory effects was similar to that of grapefruit. The inhibitory effects on the activity of CYP 3A were enhanced by preincubation of tea samples (2.5%, v/v) with microsomal fractions for 5 to 30min in a preincubation period-dependent manner. These results suggest that Katekin 600^[○!R] and Banso-reicha^[○!R] contain mechanism-based inhibiting agents. Further, the inhibitory effects on CYP 3A of green tea beverages seemed to be enhanced by catechins with the enhancement depending on the catechin concentration indicated on the label. In conclusion, we found that there were ingredients that inhibited CYP 3A activity in all of the tea beverages, and they were probably catechins.
- 著者
- 木村 康浩 大浜 修 土井 穂波 柴田 ゆうか 木平 健治
- 出版者
- 日本医療薬学会
- 雑誌
- 医療薬学 (ISSN:1346342X)
- 巻号頁・発行日
- vol.34, no.6, pp.573-577, 2008-06-10
- 被引用文献数
- 4
Very little information is available on the quality of generic products and it has recently been reported that anaphylaxy shock occurred when a generic formulation of an injectable cefazolin sodium product was used in a patient before surgery. This suggests that the generic product contained impurities that caused such an adverse reaction. It is therefore important to determine the constituents of generic products and compare them with those of the original products. We analyzed the original cefazolin sodium product and 4 generics of it by means of high performance liquid chromatography in order to determine differences in quality between them. Three impurities were found in the original product and 4 in the generic products, respectively. However, the impurity content of all of the generic products was significantly higher than that of the original product and on analyzing synthetic samples of impurities which could possibly be contained in the cefazolin sodium products, the chromatographic peaks of three of them overlapped with the peaks observed in the chromatograms of the original and generic products. These results suggest that there can be great differences in quality between the original and generic products, and that the impurities might be cefazolin-related substances. We must therefore select generics based on an appraisal of the quality information available for them in order to minimize unexpected adverse reactions and achieve more cost effective and safe therapy.