著者

清田 隆二

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 補冊 (ISSN:09121870)

巻号頁・発行日

vol.1988, no.Supplement26, pp.32-37, 1988-09-30 (Released:2012-11-27)

参考文献数

19

---

It has been reported that healthy persons with normal hearing and without complain of tinnitus have perceivable tinnitus, when the ambient noise level is low. Such tinnitus was observed in 44 (72.1%) of 61 healthy adults with normal hearing in a sound-proof room. In most (91%) of them, tinnitus resembled pure tone, and was composed of middle or high pitch tone.Since their frequency was conce n trated in some ranges relating to each other as multiples, it is suggested that some resonance mechanism in the body is involved in the generation of this type of tinnitus.

著者

時田 喬 宮田 英雄 牧 達夫 浅井 徳光 橋本 正彦 前田 正徳 棚橋 聰子

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.73, no.6special, pp.1124-1130, 1980-06-25 (Released:2011-11-04)

参考文献数

4

---

We report herein the examinations required for evaluation of the effects of treatment of Meniere's disease. Prior to the discussion, it is indispensable to clarify the design of the treatment. In the treatment, the authors take into consideration the following three subjects: (1) treatment of vertigo, (2) treatment of damage to the inner ear, and (3) treatment of recurrence of attacks of vertigo.(1) For evaluation of effects of treatment of vertigo in attacks and dizziness in the chronic stage of the disease, complaints of vertigo and spontaneous nystagmus as objective evidence of vertigo should be investigated. Furthermore, righting reflex and deviation test should be performed in order to demonstrate the mechanism of improvement of the vertigo. Despite the improvement obtained by inhibitory effects of drugs on the vertigo, the righting function and deviation phenomenon remain unchanged. On the contrary, when the pathological condition of the inner ear is healed there is an improvement of these signs.(2) Effects of the treatment for damage of the inner ear are evaluated by hearing and caloric tests. In cases where the labyrinthine excitability is not reversible, compensatory process of balancing activity of the body should be examined using the standing test, tests for spontaneous nystagmus, deviation and caloric tests and tests for postrotatory nystagmus. Disappearance of spontaneous nystagmus and deviation phenomenon reveal a recovery of static balance of the vestibular system. Disappearance of asymmetry of postrotatory nystagmus indicates a restoration of balance in the kinetic labyrinthine reflexes.(3) Recurrences of attacks of vertigo are treated on the basis of the results of examination of etiologic factors of Meniere's disease in each patient. Effects of this treatment should be evaluated by long-term follow-up of the vertiginous attacks.

著者

時田 喬 宮田 英雄 加藤 加藤 鈴木 省吾 小林 武

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.64, no.1, pp.3-15, 1971 (Released:2011-10-14)

参考文献数

22

著者

清水 啓成 高橋 明洋 小口 直彦 石戸谷 淳一

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.90, no.12, pp.1409-1414, 1997-12-01 (Released:2011-11-04)

参考文献数

23

被引用文献数

1

---

Chronic paranasal sinusitis encompasses a variety of pathologies, and eosinophil infiltration of nasal polyps is characteristic of chronic sinusitis in which allergy is a strong etiologic factor (allergic paranasal sinusitis). Suplatast tosilate is an anti-allergy agent that suppresses production of IgE antibody and inhibits tissue infiltration by eosinophils. In the present study we assessed the efficacy of suplatast tosilate immunohistochemically in surgical specimens of nasal polyps before and after drug therapy to evaluate its efficacy in allergic sinusitis.The subjects were 8 patients with allergic sinusitis associated with nasal polyps. These patients were treated with suplatast tosilate for about three months. Nasal polyps were collected before and after treatment, and 5-μm frozen serial sections were prepared and stained with HE and by immunochemical methods. The number of eosinophils and eosinophil activation were assessed by using EG2 antibody, which recognizes secretory type eosinophilic cationic protein (ECP) alone, as the primary antibody, to investigate eosinophil activation.Infiltration by numerous eosinophils, predominantly in the superficial layer of the lamina propria, was observed in the nasal polyps of allergic rhinitis patients. Significant decreases in the number of eosinophils and the number of EG2-positive cells were observed in the nasal polyps after treatment with suplatast tosilate, and a significant decrease was also observed in the ratio of the number of EG2-positive cells to the number of eosinophils. Thus, suplatast tosilate was shown to have eosinophil tissue infiltration suppressing activity in human nasal polyps, and to also possess inhibitory activity against eosinophil degranulation. Based on these findings, suplatast tosilate suppresses allergic inflammation, which is predominantly manifested by eosinophil infiltration, and was found to be effective in the treatment of allergic paranasal sinusitis.

著者

兵 行義 雑賀 太郎 濵本 真一 原田 保 原 浩貴

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.111, no.4, pp.227-234, 2018 (Released:2018-04-01)

参考文献数

16

被引用文献数

1

---

The number of patients suffering from cedar pollinosis is increasing. It would be no exaggeration to say that it is the unique cause of allergic rhinitis in Japan. Allergen immunotherapy has recently attracted attention as a radical treatment for cedar pollinosis, just as for allergic rhinitis. We examined cedar pollinosis was more marked in the cypress season than in the cedar season. The present study included 27 patients who had received allergen immunotherapy for cedar pollinosis for more than a year. A questionnaire survey was also conducted on drug usage according to the Japanese Allergic Conjunctival Disease QOL Questionnaire (JACQLQ), a modified version of the Japanese Allergic Rhinitis Standard QOL Questionnaire.In 2015, the amount of scattered pollen was 1660.7/cm2, being lower than the average of the past 20 years. In patients who had received immunotherapy against cedar pollinosis regardless of the duration of the therapy, the nasal and eye symptoms, medication score, and face scale were worse in the cypress season. In addition, tests for allergn-specific IgE antibodies before and after the cedar/cypress seasons demonstrated that while the cedar-specific IgE levels did not increase, the cypress-specific IgE levels significantly increased in subjects who had received immunotherapy for shorter periods. Cypress-specific IgG4 levels tended to increase in patients who had received cedar-pollen immunotherpy for longer periods, however, to a lesser degree than the cedar-specific IgG4 levels.Thus, the allergen-speccific antibody titers demonstrated the ineffectiveness of cedar allergen immunotherapy against cypress pollen allergy in 2015, in which year, the average amounts of airborne pollen was lower than the average in the last 20 years, suggesting that cypress extracts should also be developed to treat cypress pollen allergy.

著者

田中 信三

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.99, no.7, pp.513-518, 2006-07-01 (Released:2011-10-07)

参考文献数

19

被引用文献数

2

---

Change and its significance in the treatment of the hypopharyngeal carcinoma (HPC) are discussed, chiefly based on the author's experiences. In the nineteen-seventies and eighties, the prognosis of HPC was poor, and the 5-year over-all survival was only 24% in 173 patients. Locoregional recurrence was the most serious problem. To improve locoregional control, we introduced extended surgery with reconstruction using a free jejunal graft, in which a safety margin of 3cm or more was secured at the primary site while bilateral retropharyngeal and paratracheal dissections were added to bilateral radical neck dissections. This treatment achieved a disease-specific 3-year survival of 64% for patients with advanced (stage III, IV) HPC, which was significantly better than that of patients treated by previous methods. Furthermore, postoperative radiotherapy was introduced for advanced HPC treatment, in which a 50Gy dose was basically used to irradiate the bilateral neck and a 10Gy dose was locally added when a retropharyngeal lymphnode metastasis was histopathologically identified or the number of lymphnode metastasis was three or more. In the recent five years, the disease-specific 3-year survival reached 81% in 39 advanced HPC patients. During this period, we endeavored to conserve in laryngeal functions for patients with early (stage I, II) HPC by performing a radiotherapy or partial pharyngectomy. In 14 early HPC patients, there was no recurrence and the larynx was well conserved in eleven. We also developed a new method of reconstruction after partial laryngopharyngectomy, in which aspiration was well prevented by reconsfructing the supraglottis and hypopharynx using hyoid bone attached to sternohyoid muscle and free forearm flap. Progress in surgical reconstruction techniques and radiotherapy changed the treatment of HPC, providing a better prognosis for advanced HPC patients and a better life quality for early HPC patients.

著者

朝日 淳仁 浅野目 充 原渕 保明

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.100, no.10, pp.813-816, 2007-10-01 (Released:2011-10-07)

参考文献数

23

被引用文献数

3 3

---

Pyogenic granuloma is a benign rapidly growing hemorrhagic lesion that involves the skin and mucosa. As pyogenic granulomas often occur on the oral mucosa during pregnancy, they are called pregnancy tumors. The author encountered a case of pyogenic granuloma involving the right nasal septum.A 29-year-old woman, 6 weeks after delivery of a baby, presented with spontaneous right-sided epistaxis that had started in the 32th week of pregnancy. Physical examination demonstrated a dark-red mass that bleed easily at the front of the right side nasal septum.Since the mass did not show any decrease in size, excision of the lesion under local anesthesia was performed about 8 weeks postpartum. Histologic examination demonstrated pyogenic granuloma. There has not been any recurrence for 7 months postoperatively.

著者

佐藤 文彦 竹之内 智 鈴木 由一 矢野原 邦生 日向 誠 田中 康夫

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.74, no.1, pp.109-116, 1981 (Released:2011-11-04)

参考文献数

7

被引用文献数

4

---

A series of 120 unselected radiographs of the larynx without organic laryngeal disorders was analysed from the standpoint of laryngeal calcification or ossification. The special patterns of laryngeal ossification were described in the lateral X-ray using low kilovoltage technique of the larynx.1) Normal “figure 8” configuration of the ossified thyroid cartilage angle was characterized in men (37/45, 82%) but rare in women (10/75, 13%).2) A horn-like shadow of the ossified arytenoid cartilage was characteristic in women (43/75, 57%) as compared with men (7/45, 16%).3) A crescent-shaped shadow of the ossified top of the cricoid cartilage was observed in 42% of the total cases.These special configurations of the laryngeal ossification were also discussed from the viewpoint of laryngeal functional surgery.

著者

関谷 透

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.82, no.12, pp.1822-1823, 1989-12-01 (Released:2011-11-04)

著者

久保 伸夫 川村 繁樹 福武 知重 山下 敏夫

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.89, no.5, pp.533-536, 1996-05-01 (Released:2011-11-04)

参考文献数

9

被引用文献数

1 1

著者

柴田 敏之 坂下 哲史

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.98, no.6, pp.438-439, 2005-06-01 (Released:2011-10-07)

被引用文献数

1 1

著者

稲木 勝英 設楽 哲也 岡本 牧人 徳増 厚二 藤野 明人 石井 豊太 鎌田 利彦

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.82, no.4, pp.537-541, 1989-04-01 (Released:2011-11-04)

参考文献数

12

被引用文献数

2 2

---

Aortitis syndrome is known to be an autoimmune disease, which has many symptoms of occulusive thromboaortopathy. It has recently been reported that the patients with systemic autoimmune diseases may have sensorineural hearing loss and that steroid therapy should be effective not only for the original disorder but also for the associated hearing disturbance.Eleven patients (3 males and 8 females) with aortitis syndrome and sensorineural hearing loss have been treated in Kitasato University Hospital during the 16 years since the opening of the hospital.The onset of hearing impairment was at 32 to 48 years of age, 10 years older than the mean age of onset of the aortitis syndrome reported in the literatures.Various types of hearing impairment were noted : slight hearing loss, total deafness of sudden onset and fluctuating type. Tinnitus was associated with hearing loss in many cases.Several patients also had vertigo and dysequilibrium, and in some of them the diagnosis was peripheral vestibular hearing loss, although in the cases of aortitis syndrome with hearing loss reported in the literature neither vertigo nor dizziness was mentioned.The usual treatment for acute stage sudden deafness was not effective in most of our patients. However, one female patient treated with long-term steroid therapy for systemic arteritis showed marked improvement of both her hearing and her general condition.We cannot conclude that the origin of sensorineural hearing loss is arteritis in the inner ear in all cases of aortitis syndrome with hearing loss. However, our cases of aortitis syndrome with steroid-dependant hearing loss indicate that the possibility remains of hearing loss due to arteritis of the labyrinthine artery in aortitis syndrome.

著者

山本 佳史 北原 糺 久保 武

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.99, no.5, pp.397-401, 2006-05-01 (Released:2011-10-07)

参考文献数

18

---

Cervical lymph node swelling and high fever are common in patients presenting to the Department of Otolaryngology. Kikuchi's disease is an idiopathic necrotizing histiocyte lymphadenitis with the main clinical feature being adenopathy, generally in a cervical location. The disease is relatively rare and often misdiagnosed as lymphoma or lupus and inappropriately treated, potentially causing numerous medical consultations without relief of symptoms. The case described is that of a 28-year-old female with persistent cervical lymphadenitis and fever who presented to our department without an appropriate diagnosis at previous hospitals. All symptoms were quite resistant to antibiotics or NSAIDs. Laboratory results showed WBC decrease and AST/ALT increase, although common viral infectious diseases were denied. Finally, left cervical lymph node biopsy was performed under local anesthesia and the patient was diagnosed as having histiocytic necrotizing lymphadenitis or Kikuchi's disease. Since Kikuchi's disease is sometimes recurrent and coupled with collagen disease, long-term follow-up should be required.

著者

田中 明子 土師 知行 新正 由起子 前田 秀明 竹林 慎治 八木 伸也

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.93, no.11, pp.939-943, 2000-11-01 (Released:2011-11-04)

参考文献数

15

被引用文献数

1

---

We report 2 adult cases of inspiratory dyspnea caused by an epiglottal prolapse.The first case was a 61-year-old man who was suffering from inspiratory dyspnea, especially while sleeping. A laryngofiberscopic examination revealed that the epiglottis was contacting the posterior pharyngeal wall during inspiration, causing airway obstruction. A partial epiglottectomy with a Holmium: YAG laser improved respiratory dystress during sleep.The second case was a 60-year-old man who also suffered from dyspnea while sleeping. The laryngofiberscopic findings were the same as in the first case, and a partial epiglottectomy was also effectve for the dyspnea during sleep. A pathological examination revealed degeneration of the epiglottic cartilageThe Holmiun: YAG laser was useful in resecting the epiglottic cartilage in both cases.

著者

桂 周良

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 補冊 (ISSN:09121870)

巻号頁・発行日

vol.1988, no.Supplement24, pp.10-19, 1988-09-05 (Released:2012-11-27)

参考文献数

15

---

Subglottal pressure signals during phonation were evaluated by linear prediction analysis in fifteen normal adults.The first subglottal resonance frequencies, exhibited individual variation, ranging from 420 Hz to 720 Hz. The change in fundamental frequency affected resonance spectra, also suggesting individual variation of subglottal resonance. Moreover, spectrum differences among vowels indicated coupling between the supraglottal and subglottal systems during the closed phase.

著者

進 武幹 梅崎 俊郎

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.88, no.5, pp.553-559, 1995-05-01 (Released:2011-11-04)

参考文献数

14

被引用文献数

2 3

---

In general, esophagography with a VTR system, electromyography and measurement of the pressure of the digestive tract are used for evaluation of the swallowing function. In previous reports a time lag in movement of the bolus was pointed out in many patients with dysphagia. However, a standardized time reference for this lag was not clarified in most cases.A new concept evaluating dysphagia is introduced in this study to clarify the pathophysiology of swallowing disorders. The movement of the bolus is referred to as a phase, and the time progress of the patterned output from the medullary swallowing center is referred to as a stage. It can, therefore, be considered that dysphagia occurs when the time lag between the phase and stage exceeds the physiologically permissible limits.The standard point of the phase and stage were determined separately from an analysis of the esophagogram with a VTR system in normal volunteers, and the time lag between the two points was measured in patients with dysphagia. We devised a new instrument to evaluate the swallowing function, which can record simultaneously the pressure of the oral cavity and pharynx and the air flow rate. These methods were useful for detecting the delay of the initiation of pharyngeal swallowing which is observed in patients with dysphagia caused by lesions of the corticobulbar tract.

著者

富田 まり子

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.80, no.10, pp.1577-1591, 1987-10-01 (Released:2011-11-04)

参考文献数

34

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The intrinsic laryngeal muscles contract in a slightly different fashion with each movement during respiration, deglutition and phonation. The present study evaluates the oxygen metabolism of each intrinsic laryngeal muscle, with two different experimental procedures:(1) Immunohistochemical distribution of myoglobin in the intrinsic laryngeal muscles, and (2) tissue oxygen pressure in the intrinsic laryngeal muscles during electrical stimulation of the laryngeal nerves.1. In the first series of experiments, the ratio of myoglobin-rich fibers accounted for 67.6% of the cricothyroid muscles, 47.4% of the posterior cricoarytenoid muscles, 33.9% of the lateral cricoarytenoid muscles, 31.6% of the thyroarytenoid muscles and 31.5% of the interarytenoid muscles.2. No definite pattern was observed in the arrangement of myoglobin-rich fibers in any of the intrinsic laryngeal muscles.3. In the posterior cricoarytenoid muscle, myoglobin-rich fibers were thicker than myoglobin-poor fibers. On the contrary, myoglobin-poor fibers were thicker in the thyroarytenoid, lateral cricoarytenoid and interarytenoid muscles. However, in the cricothyroid muscles there was no relationship between the amount of myoglobin and the diameter of the muscle fibers.4. In the second series of experiments, during stimulation of the laryngeal nerves in the cricothyroid and thyroarytenoid muscles, intramuscular tissue oxygen pressures decreased with the onset of muscle contraction. The tissue oxygen pressure dropped further at 30Hz than at 10Hz and showed an even greater decrease at 60Hz than at 30Hz.5. Tissue oxygen pressure decreased more in thyroarytenoid than in cricothyroid muscle.6. The results of the present studies indicate that for laryngeal function oxygen supply is more necessary in slow muscles, such as the cricothyroid and posterior cricoarytenoid muscles than in fast muscles, such as the thyroarytenoid, lateral cricoarytenoid and interarytenoid muscles.

著者

礒部 美也子 川野 通夫 田野 口二三子 本庄 巖 森 一功 倉田 響介

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.87, no.7, pp.933-940, 1994-07-01 (Released:2011-11-04)

参考文献数

7

---

In 289 patients with cleft lip and palate, cleft palate, submucous cleft palate and congenital velopharyngeal insufficiency, various aspects of pharyngeal stops were studied: incidence, place of articulation, factors which influence the occurrence, and elicited consonants (except/k/).Observing those videofluoroscopy of the patients, we selected ones whose back of the tongue (and epiglottis) touched the posterior pharyngeal wall while they pronounced [ka]. The incidence of pharyngeal stops for [ka] was approximately 9%.Pharyngeal stops were divided into three types according to the site of articulation: oropharynx, oro-and laryngopharynx and epiglottis. The oro-and laryngopharynx type, in which the epiglottis as well as the back of the tongue made contact with the posterior pharyngeal wall, was most common. Among the factors which influence the occurrence of pharyngeal stops were the following vowels. When low vowels followed/k/, such as [ka, ko], pharyngeal stops were most frequent. They were somewhat less frequent during the production of [ku], and rare during that of [ki, ke]. It was observed that the site of articulation of [ka, ku, ko] was different from that of [ki, ke] in a single patient. Moreover, the occurence of pharyngeal stops was influenced by the number of syllables: that is, they appeared less frequently in words or sentences than in single syllables. Pharyngeal stops were also observed during the production of/p/and/t/.Pharyngeal stops are considered to be variable abnormal articulations.

著者

八木 繁雄

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.24, no.2, pp.155-164_1, 1930-05-20 (Released:2011-10-14)

参考文献数

27

---

Labyrinth inflammation owing to the experimental injuries in the round or the oval window of the rabbit, displays the pathological changes as following: viz.—1) The intenestity of the pathological changes in the labyrinth is observed to be in the following order: I. cochlea, 2. sacculus, 3. utriculus, 4. semicircular canal.2) Inflammation in the scala tympani caused by the injury in the round window shows that the charges of the lower windings are greater than those of upper windings, and in the scala vestibuli the changes of the upper windings are greater than the lower ones.3) Inflammation caused by the injury in the oval window, shows the changes of the reverse order in intensity to the 2) case.

著者

馬塲 完仁 坂田 英治 大都 京子

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.79, no.11, pp.1761-1769, 1986-11-01 (Released:2011-11-04)

参考文献数

7

---

We reported fistula symptoms in three patients with congenital syphilis, one with sudden deafness and two with cochleovestibular disorders of unknown origin. Fistula symptoms in all six cases were atypical, so we emphasize that nystagmus is not the only symptom. Whether nystagmus or deviation is present depends upon the intensity of the stimulus and the degree of labyrinthine impairment. We observed pendular eye movements, when the external auditory canals were repeatedly compressed and decompressed with the patients' own fingers. Because of the various patterns on electronystagmography, it was suspected that the histopathology in these six patients was different.