著者

北原 糺 久保 武

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.97, no.12, pp.1029-1039, 2004-12-01 (Released:2011-10-07)

参考文献数

55

---

Transient receptor potential cation channel subfamily V (TRPV) is a non-specific cation ion channel receptor family with six transmembrane domains. At first, TRPV1 was cloned in 1997 as a nociceptive receptor sensitive to capsaicin, an essence of hot chili pepper. So far, it has been revealed to be responsive to various kinds of nociceptive stimuli such as, heat, proton ion, low extracellular osmolarity and so on. That's why we, neuro-otologists, are quite interested in roles of this family in the inner ear. It might be possible that TRPV family in the inner ear is involved in the mechanism of caloric-induced nystagmus, the way of bicarbonate action against vertigo and the pathogenesis of endolymphatic hydrops syndrome including Meniere's disease. Here, we would like to review recent findings about TRPV family together with our data and suggest new insights for breaking through unsolved questions in neuro-otology.

著者

比嘉 輝之 我那覇 章 近藤 俊輔 親川 仁貴 安慶名 信也 平川 仁 鈴木 幹男

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.114, no.12, pp.909-916, 2021

---

<p>Cochlear implant surgery has been introduced successfully and is now one of the commonly performed surgeries. However, the surgical strategy of cochlear implantation in patients with chronic middle ear diseases, such as chronic otitis media and cholesteatoma, has not yet been fully established. In the present report, we describe the surgical technique adopted and prognosis of two patients with severe adhesive otitis media who underwent cochlear implant surgeries. Both underwent one-stage cochlear implantation combined with external auditory canal closure (blind-sac closure). Mastoidectomy with removal of the whole canal wall was performed to remove the otitis lesion thoroughly, and external auditory canal wall closure was performed to prevent recurrence of the lesion. A pneumatized tympanic cavity was observed and canal wall closure was maintained in both cases. Both patients acquired fair hearing ability with the cochlear implants. No severe complications have occurred until now, four years since the cochlear implantation. Although external ear canal closure destroys the natural structure of the external ear, one-stage cochlear implant surgery combined with canal closure is useful for elderly patients with systemic complications who desire shortening of hearing-deprived period.</p>

著者

吉本 裕

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.63, no.7, pp.665-675, 1970-07-01 (Released:2011-10-14)

参考文献数

13

著者

岩塚 和子

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.98, no.6, pp.447-452, 2005-06-01

参考文献数

11

被引用文献数

3 1

---

A 31-year old woman with Churg-Strauss Syndrome (CSS) including eosinophilic otitis media is presented. Other manifestations included an 11-year history of nasal allergy followed by bronchial asthma, sinusitis with nasal polyps, eosinophilic pneumonia accompanied by peripheral eosinophilia (34% of 6, 600/&mu;l leukocytes), and erythema in both legs. Repeated episodes of painless right otitis media occurred without fever during the first stage of CSS characterized by an allergic state. This progressed to bilateral otitis media with gelatinous mucoid fluid accumulations shortly before the second stage of CSS characterized additionally by peripheral eosinophilia and eosinophilic pneumonia. Numerous eosinophils were found in gelatinous fluid within the tympanic cavity.<br>The patient was diagnosed with bilateral eosinophilic otitis media, which was controlled by nebulizer therapy with 2% fosfomycin and 0.2% betamethasone solution directed into the Eustachian tube and tympanic cavity. Hearing loss and vertigo have been avoided. This case strongly suggests that eosinophilic otitis media can be a manifestation of CSS.

著者

間島 雄一 坂倉 康夫 浜口 富美 村井 須美子

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.85, no.8, pp.1333-1340, 1992-08-01 (Released:2011-11-04)

参考文献数

13

被引用文献数

5 8

---

This study was desiged to determine the effectiveness of Tsumura Shin'i-seihai-to (TJ-104), a Kampo medicine, in chronic sinusitis. The subjects of this study were 30 patients aged 19 to 80 years, who received TJ-104 7.5g p. o. per day for four weeks.The general effectiveness of TJ-104 On subjective symptoms and rhinoscopic observations was 69.0%.Nasal mucociliary clearance (ST) was determined by the saccharin method in 28 subjects before (week 0) and four weeks after the start of the administration (week 4). At week 0, ST was within the normal range in 15 patients, and was retarded in 13 patients. At week 4, ST was signiflcantly better than at week 0 in those patients whose ST was retarded before treatment (p<;0.001). No significant difference was observed in either the elasticity (G') or the viscosity (η') of nasal mucus between week 0 and week 4.It was concluded that 1) TJ-104 can improve reduced nasal mucociliary clearance, 2) TJ-104 has no effect on reducing the viscoelasticity of the nasal mucus, and 3) TJ-104 is considered to be a useful drug for the conservative treatment of chronic sinusitis.

著者

岡村 由美子

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床. 補冊 = Practica otologica. Suppl. (ISSN:09121870)

巻号頁・発行日

vol.98, pp.49-51, 1998-05-25

参考文献数

3

被引用文献数

1

---

Sai-rei-to is believed to have steroid-like properties, and is often used to reduce the amount of steroids prescribed to patients. In facial nerve paralysis, steroids are often used to reduce the amount of edema in the area of the damaged nerve. We have noted Sai-rei-to's steroid-like properties, and thus investigated whether recovery from facial nerve paralysis can be expedited when this drug is used in combination with steroid during periods when the dosage of the steroid is being reduced. Moreover, we administered Sai-rei-to to those patients unable to receive steroids due to complications in order to assess whether it can produce effects similar to steroids.<BR>In patients with facial nerve paralysis, we provided a regular intravenous drip and administered the steroids orally, and then used Tsumura Sai-rei-to in combination during those periods of steroid reduction. This regimen increased the rate of improvement from the paralysis. We also gave Saireito to patients suffering from steroid-related complications during the course of their treatment, and observed remarkable improvements thereafter.

著者

幸田 純治 武田 直也 堀 洋二

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 補冊 (ISSN:09121870)

巻号頁・発行日

vol.1993, no.Supplement61, pp.84-90, 1993-04-15 (Released:2012-11-27)

参考文献数

34

被引用文献数

1 1

---

Voice tremor has been associated with neurological disorders such as essential tremor, Parkinson's disease, cerebellar ataxia. Voice tremor most commonly accompanies essen- tial tremor which is a common neurologic disorder that is often an autosomal dominant trait. It may appear in childhood or later life and runs a slowly progressive course.Voice tremor is characterized by rhythmic alternations in pitch and loudness of vowel sounds, and is usually accompanied by tremor in other parts of the body. The frequency ranges from 4 to 8 Hz. Physiological lesions or mechanisms of voice tremor have not been throughly studied. Essential voice tremor can resemble spasmodic dysphonia, therefore differentiation between essential voice tremor and spasmodic dysphonia must be made. Laryngoscopy and laryngeal electromyography are useful for diagnosis.Currently available therapies for voice tremor are not satisfactory, however propranolol is most commonly used.

著者

橋本 喜輝 深澤 啓二郎 藤井 恵美 高安 定 阪上 雅史

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.98, no.2, pp.131-135, 2005-02-01

参考文献数

10

被引用文献数

2 1

---

We reviewed three cases (0.52%) of congenital anosmia without hypogonadism. None of the three cases demonstrated any response to the intravenous olfactory test, or to T & T olfactometry. Each olfactory cleft was normal with endoscopy. Biopsy of mucosa of the olfactory cleft in one of three cases showed that olfactory mucosa could not be detected in the mucosal specimen and that only respiratory mucosa was identified. Hypoplasia or lack of olfactory bulbs and sulci olfactorius was demonstrated on brain MRI in all cases, supporting a diagnosis of congenital anosmia. MRI was useful for the diagnosis of congenital anosmia without hypogonadotropic hypogonadism.

著者

稲村 和俊 川合 正和 青柳 優

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.90, no.4, pp.431-436, 1997-04-01

参考文献数

18

被引用文献数

3 1

---

Surgical treatments for postoperative maxillary cysts include the peroral method (trans-maxillary sinus method) in which the cyst wall is totally removed or conserved, and opened to the nasal cavity by incising from the gingiva, and the endonasal method in which the cyst wall is opened to the nasal cavity by the nasal approach. Recently, the endonasal method is more widely used because CT and endoscopy can be applied. Forty-two patients (56 sides) who underwent surgery for postoperative maxillary cysts in Nanyo City Hospital over the last four years were reviewed. Preoperative CT findings, surgical methods, operative findings and prognosis were analyzed. Forty-one sides were monocystic and 15 sides were multicystic. Forty-two sides were of the medial type, 4 sides were of the lateral type and 10 sides were of the mixed type. Twenty sides (35.7%), which were both monocystic and medial, were operated on by the endonasal method, while the transmaxillay sinus method was used for the remaining sicks. Though one of endonasal patients experienced a relapse of the maxillary cyst, the endonasal method was associated with less suffering and a shorter operative time than the trans-maxillary sinus method. Therefore, the endonasal method is recommended, if the postoperative maxillary cyst is both monocystic and medial.

著者

河田 了 四ノ宮 隆 安田 範夫 久 育男 村上 泰

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.89, no.1, pp.57-61, 1996-01-01 (Released:2011-11-04)

参考文献数

15

---

One hundred two patients with parotid tumor were treated in the ENT Department, Kyoto Pref ectural University of Medicine between 1989 and 1994. Twenty-four of the 102 parotid tumors were Warthin's tumor (adenolymphoma). This incidence of Warthin's tumor was higher than that in any previous reports. This and other recent reports show that the incidence of Warthin's tumor has tended to increase recently, but the reason for this increase is not clear. In general, it is said that Warthin's tumor is found much more frequntly in males than in females, so we reviewed and analyzed 9 clinical cases of Warthin's tumor found in women. The average age of these women was approximately 10 years younger than that of male patients. No substantial differences were seen between male and female cases of Warthin's tumor on CT and Echo findings.

著者

山下 勝 篠原 かおる 辻 智子 岸本 正直 大森 孝一

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.95, no.7, pp.673-677, 2002-07-01 (Released:2011-11-04)

参考文献数

11

被引用文献数

4 3

---

We treated 265 patients (270 ears) with idiopathic sudden deafness by intravenous corticosteroid hormone administration. Complete recovery occurred in 31% of patients, definite improvement in 17%, slight improvement in 19%, and no improvement in 33%. Prognostic factors for better hearing were as follows: younger age, absence of vestibular symptoms, hearing loss configuration without high tone impairment, mild initial hearing loss, and early initial treatment after onset. In the past 10 years, only three reports analyzing more than 200 patients were found in the Japanese literature. All papers reported complete recovery in approximately 30%.

著者

向井 將 向井 千珈子 浅岡 一之

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.84, no.12, pp.1753-1762, 1991-12-01 (Released:2011-11-04)

参考文献数

18

被引用文献数

1 1

---

We have treated 38 adults with ankyloglossia with deviation of the epiglottis and larynx.1) The patients had type III occlusion of Angle's and had irregular teeth in the upper jaw.2) The patients' chief complaints were shoulder stiffness, cold extremities, feeling of obstruction in the throat, insomnia, fatigue, snoring, irritated, dry skin, incorrect articulation and muscle cramps during physical activity, pregnancy and/or sleep.3) Correction of the ankyloglossia and deviation of the epiglottis and larynx resulted in great relief of their chief complaints as well as their respiratory function.4) In addition, patients said that they breathed more easily, could bite well, and that their joints could bend better. They also remarked that they were less angry.However there were no significant changes in their incorrect articulations.

著者

森本 賢治 久々湊 靖 朝倉 光司 形浦 昭克

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.82, no.8, pp.1087-1094, 1989-08-01 (Released:2011-11-04)

参考文献数

31

被引用文献数

2 2

---

The authors present five cases of mucormycosis of maxillary sinuses treated at Ebetsu City Hospital from May 1987 to November 1988, including a very rare case bilateral maxillary sinus involvement.The patients were treated surgically, the prognosis appeared to be good. The pertinent literature is reviewed.

著者

佐久間 仁 大河内 幸男 馬場 陽子 大谷 巌 平山 和美 佐藤 正憲 児玉 南海男

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 補冊 (ISSN:09121870)

巻号頁・発行日

vol.1991, no.Supplement43, pp.70-76, 1991-04-25 (Released:2012-11-27)

参考文献数

25

---

A case of brainstem cavernous angioma associated with hearing loss and dizziness is reported. A 25-year-old female initially complained of hearing loss in the leftear and dizziness. Six months thereafter she suddenly developed additional symptoms, and was diagnosed as having hemorrhage in the brainstem on the basis of CT scan and MRI findings. Otological examination revealed low- and high-frequency hearing loss and abnormal ABR consisting of only wave I in the left ear. Follow-up MRI showed cavernous angioma, which was surgically removed.

著者

角田 保雄 尾股 丈夫 大谷 巌

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 補冊 (ISSN:09121870)

巻号頁・発行日

vol.1995, no.Supplement83, pp.53-67, 1995-08-01 (Released:2012-11-27)

参考文献数

41

被引用文献数

1

---

Correlations were made between audiometric pattern (especially flat and gradual high tone loss)and speech discrimination score (SDS) in 255 ears with sensorineural hearing loss that were tested at the Department of Otolaryngology of Shirakawa Kousei General Hospital during the past 6 years.First, the audiometric pattern was defined on all frequencies (0.125 k-8 kHz). SDS of each audiometric pattern resembled that in all similarly affected ears, but in younger ears (under 75 years old, the average value of pure tone hearing level subtracted from speech reception threshold was under 10 dB), SDS of patients with flat audiogram or abrupt high tone loss (mainly 8 kHz) maintained a good score (over 70%) at 10 dB intervals below 70 dB, then sharply decreased at 70 dB. However, SDS of patients with gradual high tone loss decreased in proportion to hearing loss. This fact supports Schuknecht's classification of hearing loss in presbycusis. Furthermore, this suggests that there is a boundary of good SDS at the 60 dB level, at which SDS was marked by deafness and a flat audiometric pattern caused by atrophy of the stria vascularis.Second, the audiometric pattern was defined by the slope of the audiogram (value of 2 kHz loss subtracted from 0.5 kHz loss, and 4 kHz loss from 0.5 kHz loss). The gradual high tone loss group had a good SDS (over 70%) under 50 dB. In cases involving hearing loss reaching and exceeding 50 dB, SDS declined abruptly. Good SDS almost disappeared and poor SDS (under 50%) increased suddenly. This suggests that not only that the decrease in neurons reached the minimum necessary to maintain a good SDS, but also that the neurons which transfer information under 50 dB exerted great influence on SDS.Differences were analyzed, between each audiometric pattern and between the group before abrupt deccrease in SDS and the group after the abrupt decrease in the flat audiogram or gradual high tone loss group.

著者

小林 泰輔 暁 清文 柳原 尚明 松本 康 町田 敏之 堀内 譲治

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.86, no.3, pp.321-327, 1993-03-01 (Released:2011-11-04)

参考文献数

15

被引用文献数

1 1

---

Case 1: a 59-year-old male with a one-year history of diabetes mellitus complained of right sudden deafness with vertigo. Otoneurological examinations showed sensorineural hearing loss of the right ear and bidirectional horizontal gaze nystagmus. MRI revealed infarction of the right cerebellar hemisphere indicating occlusion of the anterior inferior cerebellar artery (AICA). With conservative treatment his hearing returned to the contralateral ear level. Case 2: a 49-year-old female who complained of right sudden deafness with vertigo and ipsilateral facial palsy. Audiometric studies showed total deafness on the right. Bidirectional horizontal gaze nystagmus, together with V, VII, IX and X cranial nerve palsies were recognized. CT and MRI proved infarction of the right cerebellum and pons. Her hearing improved only partially. Other neurological signs disappeared within eight months. Case 3: a 54-year-old male with a history of hypertension and angina pectoris complained of right sudden deafness with dizziness. Right sensorineural hearing loss and spontaneous nystagmus toward the left were noted. His hearing improved on the next day. Two days later, however, he lost consciousness. CT showed no abnormality, but angiography revealed occlusion of the basilar artery.These three cases showed the importance of differential diagnosis between acute hearing loss due to cerebral infarction and idiopathic sudden deafness. We emphasize the diagnostic importance of risk factors such as hypertension and diabetes mellitus and the sign of vertigo with nystagmus of central origin in cases of cerebral infarction.

著者

宮崎 純二 松下 英友 山田 昇一郎 井之口 昭

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.97, no.8, pp.697-705, 2004-08-01 (Released:2011-10-07)

参考文献数

17

被引用文献数

2 3

---

In order to obtain a sufficient effect when instilling steroid nasal drops in patients with olfactory dysfunction, the medication must reach and be deposited into the olfactory cleft. Some head positions, such as head-down-and-backwards position, are recommended to instill drops. These positions are, however, known to be uncomfortable and can lead to poor patient compliance. Moreover, there is no clear evidence showing that nasal drops can be delivered into the olfactory cleft in these positions.In this study, we reviewed these positions by utilizing a cadaver head and performing a gravitational flow study using colored nasal drops. The results showed that when using these positions, instilled nasal drops did not reach the olfactory cleft except in limited trials. With the above-mentioned negative points in mind, we devised a new head position, on the side, head down, and found it to be both effective and comfortable for delivering nasal drops into the olfactory cleft.

著者

熊沢 忠躬 本田 啓二

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.75, no.9, pp.1755-1766, 1982-09-01 (Released:2011-11-04)

参考文献数

18

---

An honorable presentation entitled “Clinical and Fundamental Studies on the Eustachian Tube” was reported at the annual meeting of Japan Society of Otolaryngology in 1980. In this presentation, the function of the Eustachian tube was discussed fundamentally and clinically, although we found that various clinical problems still remain in our practice on this tube.The following points should be considered;1) Are Eustachian tube problems functional or organic?2) The location of the lesion.3) Patency.4) Reversibility of dysfunction.5) Clearance function of fluid and air through the tube.6) Relationship between this tube and peritubal lesion in the pharyngeal ostium, tympanal ostium, parotid gland and submaxillar joint.7) Choice of therapeutic methods and evaluation of the result.When these problems are solved, the diagnosis of the Eustachian tube function will be made clearly. Tubo-tympanoaerodynamic graphy, tympanometry, cndoscopic and electromyographic findings will be useful for this purpose. Physical and anatomical research should also be performed.

著者

吉本 裕 村主 好弘

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.61, no.12, pp.1903-1912, 1968-12-01 (Released:2011-10-14)

参考文献数

24

著者

野中 聡 海野 徳二

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 補冊 (ISSN:09121870)

巻号頁・発行日

vol.1987, no.Supplement15, pp.160-166, 1987-08-10 (Released:2012-11-27)

参考文献数

17

被引用文献数

1 1

---

We examined the neuronal mechanisms of sneezing in precollicular postmammillary decerebrate cats. Mechanical stimulation (duration; 5 s, frequency; 20 Hz, amplitude; 500μm) of the nasal membrane by means of a spring coil vibrator evoked sneezes. In the same preparation, electrical stimulation (0.2 ms,10 Hz,10-40 μA) of a certain area within the lower brainstem evoked sneezes. The sequences of EMG activation and the accompanying change in the subglottic pressure were almost the same for mechanically and electrically induced sneezes. The sneeze evoking region was located ventromedial to the spinal trigeminal nucleus, and extended rostrocaudally from P4.0 to 12.0 according to Horsley-Clarke coordinates. A microlesion made at a caudal portion of this region diminished the effects of rostral stimulation, but a microlesion made at the rostral portion had no effect on caudal stimulation.These results suggest that the sneeze evoking region is located in the medulla oblongata, with no regional differences from the rostral region to the caudal region. This region appears to control the respiratory, intrinsic laryngeal, epipharyngeal muscles. The integrated activity of these muscles evokes sneezes.