著者
Hisanori Tokuda Toshiaki Sueyasu Masanori Kontani Hiroshi Kawashima Hiroshi Shibata Yoshihiko Koga
出版者
Japan Oil Chemists' Society
雑誌
Journal of Oleo Science (ISSN:13458957)
巻号頁・発行日
vol.64, no.6, pp.633-644, 2015 (Released:2015-06-01)
参考文献数
51
被引用文献数
8 10

Several studies have reported that the supplementation of long-chain polyunsaturated fatty acids (LCPUFA), such as docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and arachidonic acid (ARA) improve cognitive function in the elderly. However, the doses used in these studies were higher than general dietary LCPUFA intake levels. This randomized, double-blind, placebo-controlled trial evaluated the effects of low doses of LCPUFA supplementation corresponding to general dietary intake on cognitive function in non-demented elderly Japanese participants. Japanese men aged 55-64 years were enrolled and randomly allocated to the placebo or LCPUFA group. Participants received 4 weeks of supplementation with LCPUFA-containing oil (DHA, 300 mg/day; EPA, 100 mg/day; and ARA, 120 mg/day) or purified olive oil as placebo. Event-related potential P300, reflecting cognitive processes, was measured before and after supplementation. A total of 113 participants completed the supplementation period, and the per-protocol analysis included 69 participants. Changes in P300 latency were significantly different between the placebo group (+13.6 msec) and the LCPUFA group (-1.8 msec) after supplementation. Significant increases in DHA (+0.9%) and ARA (+0.6%) contents in plasma phospholipids were observed in the LCPUFA group; no changes were observed in the placebo group. Dietary DHA, EPA, and ARA intake were in the normal range for Japan participants and remained unchanged during the study. These results suggest that low doses of LCPUFA supplementation have the potential to improve cognitive function in elderly Japanese men.
著者
Soek Sin Teh Augustine Soon Hock Ong Yuen May Choo Siau Hui Mah
出版者
Japan Oil Chemists' Society
雑誌
Journal of Oleo Science (ISSN:13458957)
巻号頁・発行日
vol.67, no.6, pp.697-706, 2018 (Released:2018-06-01)
参考文献数
42
被引用文献数
1

Saturated fats are commonly claimed to raise human blood cholesterols and contribute to cardiovascular disease. Previous literature data were highlighted that although palm oil is 50% saturated, it does not behave like a saturated fat. Human trials were conducted to compare the effects on serum cholesterol levels given by palm olein and monounsaturated oils. It was postulated that saturation/unsaturation of the fatty acids situated at sn-2 positions of triglycerides in the fat molecules determine the induced blood lipid levels but not the overall saturation of oils. The results showed that the lipid parameters (LDL and HDL) effects induced by these oils are similar with no significant differences. This study provides concrete evidence that the unsaturation levels of these oils at sn-2 position of TG are similar (90-100%) which are claimed to be responsible for the lipid parameters. In conclusion, the public negative perception on believing that the overall saturation of oils is detrimental to health should be corrected because in fact the unsaturation at sn-2 positions of the saturated vegetable fat such as palm olein and cocoa butter make them behave like mono-unsaturated oils, unlike saturated animal fats that possess a high content of saturated fatty acids at sn-2 position.
著者
坂田 隆 市川 宏文
出版者
Japan Oil Chemists' Society
雑誌
日本油化学会誌 (ISSN:13418327)
巻号頁・発行日
vol.46, no.10, pp.1205-1212, 1997-10-20 (Released:2009-10-16)
参考文献数
58
被引用文献数
3 1 18

大腸内細菌は酢酸, プロピオン酸, 酪酸のような短鎖脂肪酸をつくる。大腸内での短鎖脂肪酸生産の主要な制御要因は基質の種類と流入速度, 大腸内での内容物の滞留速度である。短鎖脂肪酸は大腸上皮細胞の主要エネルギー源であるとともに, 全身のエネルギー収支に貢献する。また, 短鎖脂肪酸は大腸での水や溶質の吸収, 大腸粘膜の血流, 腸上皮増殖, 腸運動, 膵臓外分泌などの機能に影響する。
著者
Azusa Takahashi Hisae Shimizu Yukako Okazaki Hirohide Sakaguchi Toshio Taira Takashi Suzuki Hideyuki Chiji
出版者
Japan Oil Chemists' Society
雑誌
Journal of Oleo Science (ISSN:13458957)
巻号頁・発行日
vol.64, no.12, pp.1243-1250, 2015 (Released:2015-12-01)
参考文献数
34
被引用文献数
5 14

Aronia fruits (chokeberry: Aronia melanocarpa E.) containing phenolic phytochemicals, such as cyanidin 3-glycosides and chlorogenic acid, have attracted considerable attention because of their potential human health benefits in humans including antioxidant activities and ability to improved vision. In the present study, the effects of anthocyanin-rich phytochemicals from aronia fruits (aronia phytochemicals) on visceral fat accumulation and fasting hyperglycemia were examined in rats fed a high-fat diet (Experiment 1). Total visceral fat mass was significantly lower in rats fed aronia phytochemicals than that in both the control group and bilberry phytochemicals-supplemented rats (p < 0.05). Moreover, perirenal and epididymal adipose tissue mass in rats fed aronia phytochemicals was significantly lower than that in both the control and bilberry phytochemicals group. Additionally, the mesenteric adipose tissue mass in aronia phytochemicals-fed rats was significantly low (p < 0.05). Furthermore, the fasting blood glucose levels significantly decreased in rats fed aronia phytochemicals for 4 weeks compared to that in the control rats (p < 0.05). Therefore, we investigated the effects of phytochemicals on postprandial hyperlipidemia after corn oil loading in rats, pancreatic lipase activity in vitro, and the plasma glycemic response after sucrose loading in order to elucidate the preventive factor of aronia phytochemical on visceral fat accumulation. In the oral corn oil tolerance tests (Experiment 2), aronia phytochemicals significantly inhibited the increases in plasma triglyceride levels, with a half-maximal inhibitory concentration (IC50) of 1.50 mg/mL. However, the inhibitory activity was similar to that of bilberry and tea catechins. In the sucrose tolerance tests (Experiment 3), aronia phytochemicals also significantly inhibited the increases in blood glucose levels that were observed in the control animals (p < 0.05). These results suggest that anthocyanin-rich phytochemicals in aronia fruits suppress visceral fat accumulation and hyperglycemia by inhibiting pancreatic lipase activity and/or intestinal lipid absorption.
著者
Takashi NAKAMURA Katsuyuki SATO Mitsuo AKIBA Masao OHNISHI
出版者
Japan Oil Chemists' Society
雑誌
Journal of Oleo Science (ISSN:13458957)
巻号頁・発行日
vol.55, no.4, pp.191-197, 2006 (Released:2006-03-14)
参考文献数
16
被引用文献数
4 6

In these experiments, the antioxidative activity of urobilinogen, a major fecal pigment-related compound and reduced metabolite of bilirubin, was shown. Urobilinogen was synthesized from commercial bilirubin by reduction, and the structure was confirmed with mass spectroscopy and NMR analyses. The product was identified as i-urobilinogen. The DPPH radical scavenging activity of urobilinogen was higher than other antioxidants (α-tocopherol, bilirubin and β-carotene). Moreover, the formation of hydroperoxides of linoleic acid with 2, 2’-azobis (2, 4- dimethylvaleronitrile) in methanol was suppressed by the addition of synthesized urobilinogen. On the other hand, in the NMR spectrum measurement, we found the signal decrease of a proton from C10 methylene. It was shown that this proton was exchanged with a deutrium of CD3OD. This methylene can easily release the hydrogen as proton donor. These results suggest that urobilinogen can inhibit the radical chain reaction by trapping free radicals.
著者
Hideaki Kabuto Tomoko T. Yamanushi Najma Janjua Fusako Takayama Mitsumasa Mankura
出版者
Japan Oil Chemists' Society
雑誌
Journal of Oleo Science (ISSN:13458957)
巻号頁・発行日
vol.62, no.1, pp.21-28, 2013 (Released:2013-01-29)
参考文献数
30
被引用文献数
12 13

Active oxygen has been implicated in the pathogenesis of Parkinson’s disease (PD); therefore, antioxidants have attracted attention as a potential way to prevent this disease. Squalene, a natural triterpene and an intermediate in the biosynthesis of cholesterol, is known to have active oxygen scavenging activities. Squalane, synthesized by complete hydrogenation of squalene, does not have active oxygen scavenging activities. We examined the effects of oral administration of squalene or squalane on a PD mouse model, which was developed by intracerebroventricular injection of 6-hydroxydopamine (6-OHDA). Squalene administration 7 days before and 7 days after one 6-OHDA injection prevented a reduction in striatal dopamine (DA) levels, while the same administration of squalane enhanced the levels. Neither squalene nor squalane administration for 7 days changed the levels of catalase, glutathione peroxidase, or superoxide dismutase activities in the striatum. Squalane increased thiobarbituric acid reactive substances, a marker of lipid peroxidation, in the striatum. Both squalane and squalene increased the ratio of linoleic acid/linolenic acid in the striatum. These results suggest that the administration of squalene or squalane induces similar changes in the composition of fatty acids and has no effect on the activities of active oxygen scavenging enzymes in the striatum. However, squalane increases oxidative damage in the striatum and exacerbates the toxicity of 6-OHDA, while squalene prevents it. The effects of squalene or squalane treatment in this model suggest their possible uses and risks in the treatment of PD.
著者
奥田 拓道
出版者
Japan Oil Chemists' Society
雑誌
日本油化学会誌 (ISSN:13418327)
巻号頁・発行日
vol.48, no.10, pp.989-996,1195, 1999-10-20 (Released:2009-11-10)
参考文献数
27
被引用文献数
1 1

脂肪細胞には, 脂肪の合成と分解の代謝経路が存在する。脂肪合成には, グルコース経路とリポタンパク経路がある。グルコース経路については, 現在広く信じられているインスリン受容体説の他に, 我々の提唱するNa+/H+チャネル説を紹介した。また, ヒトの脂肪細胞にもATP-citrate lyaseが存在するので, グルコースからの脂肪酸合成も可能なことを示した。リポタンパク経路は, 毛細血管内皮細胞に固定されたリポタンパクリパーゼによって, カイロミクロンやVLDLの脂肪部分が分解され, 生じた脂肪酸が細胞内に取り込まれ, 脂肪に合成される経路である。合成された脂肪は小胞の二重層の内部に蓄積され, その容量を増す。したがって, 生じた油滴の表面は, 小胞膜を形成するリン脂質やタンパク質の単層膜で覆われている。カテコールアミンやACTHによる脂肪分解反応の促進はサイクリックAMP→タンパクキナーゼ→ホルモン感性リパーゼのリン酸化による活性化といういわゆるサイクリックAMP説で説明されている。しかし調べてみると, 脂肪細胞内には, ホルモンを作用させない状態でも大量のリパーゼが存在し, ホルモンによって脂肪分解が促進したり阻害されたりしても, このリパーゼの活性は変動しない。脂肪分解反応は, リパーゼ活性の増減ではなく, リパーゼと油滴との接触の程度によって調節されているのではないかという新しい提言をめぐって議論した。

4 0 0 0 OA 油脂の味

著者
薄木 理一郎 金田 尚志
出版者
Japan Oil Chemists' Society
雑誌
油化学 (ISSN:18842003)
巻号頁・発行日
vol.19, no.8, pp.612-619, 1970-08-20 (Released:2009-10-20)
参考文献数
34
被引用文献数
1 1
著者
Nakamura Takashi Sato Katsuyuki Akiba Mitsuo OHNISHI Masao
出版者
Japan Oil Chemists' Society
雑誌
Journal of Oleo Science (ISSN:13458957)
巻号頁・発行日
vol.55, no.4, pp.191-197, 2006
被引用文献数
6

In these experiments, the antioxidative activity of urobilinogen, a major fecal pigment-related compound and reduced metabolite of bilirubin, was shown. Urobilinogen was synthesized from commercial bilirubin by reduction, and the structure was confirmed with mass spectroscopy and NMR analyses. The product was identified as <i>i</i>-urobilinogen. The DPPH radical scavenging activity of urobilinogen was higher than other antioxidants (α-tocopherol, bilirubin and β-carotene). Moreover, the formation of hydroperoxides of linoleic acid with 2, 2'-azobis (2, 4- dimethylvaleronitrile) in methanol was suppressed by the addition of synthesized urobilinogen. On the other hand, in the NMR spectrum measurement, we found the signal decrease of a proton from C<sub>10</sub> methylene. It was shown that this proton was exchanged with a deutrium of CD<sub>3</sub>OD. This methylene can easily release the hydrogen as proton donor. These results suggest that urobilinogen can inhibit the radical chain reaction by trapping free radicals.<br>
著者
Yuuki Aita Yoshimune Nonomura
出版者
Japan Oil Chemists' Society
雑誌
Journal of Oleo Science (ISSN:13458957)
巻号頁・発行日
pp.ess15250, (Released:2016-05-16)
被引用文献数
1 2

The surface properties and the tactile texture of human hair are important in designing hair-care products. In this study, we evaluated the temporal changes of friction and temperature during the drying process of wet human hair containing water, silicone oil, or oil-in-water (O/W) emulsion. The wet human hair including water or O/W emulsion have a moist feel, which was caused by the temperature reduction of approximately 3-4°C. When human hair is treated with silicone oil, more than 60% of the subjects felt their hair to be slippery and smooth like untreated hair. Treating hair with O/W emulsion after drying made the subject perceive a slippery feeling because the surfactant reduced friction on the hair surface. These results indicated that both friction and thermal properties of the hair surface are important to control the tactile texture of the human hair.
著者
園 良治
出版者
Japan Oil Chemists' Society
雑誌
日本油化学会誌 (ISSN:13418327)
巻号頁・発行日
vol.48, no.10, pp.1161-1168,1202, 1999-10-20 (Released:2009-11-10)
参考文献数
47

大豆レシチンは, 食品工業分野における重要な界面活性剤であり, 大豆から抽出した原油に加水し, 分離したガム質を乾燥することにより得られる。この総説では, 先ず品質の良いレシチンを得るために重要な問題点と, 筆者らで実用化した粗レシチンの直接濾過法による新規な精製法について紹介し, 近年開発され市販されている脱脂レシチン, 分別レシチン, 酵素分解レシチン, 水素添加およびヒドロキシル化等の化学修飾レシチンの製造法と特徴についても紹介した。これらの新規な製造法によって得られる生理機能に優れたレシチンが, 食品分野のみならず医薬・化粧品分野へも発展していくことを期待する。
著者
畑中 顯和
出版者
Japan Oil Chemists' Society
雑誌
油化学 (ISSN:18842003)
巻号頁・発行日
vol.33, no.10, pp.703-714, 1984-10-20 (Released:2009-11-13)
参考文献数
112
著者
山岡 正和 田中 章夫 RAHAYU Wuryaningsih Sri HERNANDEZ Carmelita Lacap JAMILAH
出版者
Japan Oil Chemists' Society
雑誌
油化学 (ISSN:18842003)
巻号頁・発行日
vol.37, no.7, pp.502-507, 1988
被引用文献数
1

アブラヤシの葉,パーム原油,ファイバー及び空果房の糖脂質を同定定量した。糖脂質の同定には,主にTLCのR<SUB><I>f</I></SUB>値と1-ナフトールや過塩素酸による呈色反応を利用した。定量はデンシトメータで行った。アブラヤシの葉の主な糖脂質はアシルステリルグリコシド,モノガラクトシルジグリセリド,ステリルグリコシド(SG),セレブロシド,ジガラクトシルジグリセリド及びスルホキノボシルジグリセリド(SQDG)であった。一方,パーム原油には,SGとSQDGは存在せず,またファイバーと空果房にはSQDGが存在しなかった。<BR>アブラヤシの葉とパーム原油の各糖脂質の脂肪酸組成についても検討した。飽和脂肪酸ではいずれの糖脂質もパルミチン酸が主であった。不飽和脂肪酸ではアブラヤシの葉ではリノレン酸が多いのに比べ,パーム原油ではオレイン酸が多い点に特徴があった。

2 1 1 1 OA 脳神経の脂質

著者
林 浩平
出版者
Japan Oil Chemists' Society
雑誌
油化学 (ISSN:18842003)
巻号頁・発行日
vol.20, no.10, pp.745-754, 1971-10-20 (Released:2009-11-10)
参考文献数
67
著者
Kazuko Iwamoto Hirokazu Kawamoto Fumiaki Takeshita Shinichi Matsumura Ikuto Ayaki Tatsuya Moriyama Nobuhiro Zaima
出版者
Japan Oil Chemists' Society
雑誌
Journal of Oleo Science (ISSN:13458957)
巻号頁・発行日
pp.ess19135, (Released:2019-08-14)

Ginkgo biloba extract (GBE) is widely used as herbal medicine. Preventive effect of GBE against dementia, including Alzheimer’s disease, has been reported. The bioactive compounds in GBE that impart these beneficial effects, flavonoids and terpene lactones, have poor bioavailability. Our previous study found distribution of bioactive compounds of sesame extract in mice brain after mixing it with turmeric oil. Here, we evaluate the distribution of bioactive compounds of GBE by combining it with the mixture of sesame extract and turmeric oil (MST). The content of terpene lactones in mice serum was significantly increased in a dose-dependent manner after administration of GBE. However, the contents of terpene lactones in mice brain were not significantly changed. Concentration of ginkgolide A in mice brain increased significantly when GBE was co-administrated with MST than when GBE was administered alone. These results suggest that MST may be effective in enhancing the bioavailability of ginkgolide A in GBE.
著者
Minako Okukawa Takamasa Watanabe Maki Miura Hiroyuki Konno Shigekazu Yano Yoshimune Nonomura
出版者
Japan Oil Chemists' Society
雑誌
Journal of Oleo Science (ISSN:13458957)
巻号頁・発行日
pp.ess19074, (Released:2019-07-10)

1,2-Alkanediol exhibits antibacterial activity against several bacteria and yeast. However, few studies have reported antimicrobial tests on skin microbiome. Bacterial microbiome on the skin surface include Staphylococcus aureus (S. aureus), which causes rough skin and inflammation in atopic dermatitis and Staphylococcus epidermidis (S. epidermidis), which enhances innate immunity. In this study, the minimal inhibitory concentration (MIC) was evaluated for 1,2-alkanediol comprising 4–12 carbon atoms against S. aureus and S. epidermidis. 1,2-Alkanediol comprising 6–12 carbon atoms exhibited antimicrobial activity against both species of Staphylococcus. The antibacterial activity depended on the alkyl chain length. In addition, the minimum bactericidal concentration (MBC) on agar was evaluated for 1,2-alkanediol comprising 6–12 carbon atoms. 1,2-Octanediol and 1,2-decanediol exhibited significant bactericidal activity.
著者
太田 静行
出版者
Japan Oil Chemists' Society
雑誌
油化学 (ISSN:18842003)
巻号頁・発行日
vol.29, no.7, pp.469-488, 1980-07-20 (Released:2009-11-10)
参考文献数
90
被引用文献数
4 2
著者
中野 稔 桜井 民子
出版者
Japan Oil Chemists' Society
雑誌
油化学 (ISSN:18842003)
巻号頁・発行日
vol.39, no.10, pp.784-790, 1990-10-20 (Released:2009-10-16)
参考文献数
27
被引用文献数
1 1

Free iron could easily be chelated with phosphate moiety in biomembrane surface and reduced enzymatically by certain membrane components or non enzymatically by ascorbate.A model membrane lipid peroxidation induced by iron-adriamycin or iron-glycated peptide was discussed. Most probable active species for their lipid peroxidations could be iron oxygen complexes, such as FeV= O and Fe IV=O type compounds. Heme-compounds, hemoglobin, cytochrome P-450 and hematin could mainly act to decompose lipid hydroperoxides to their corresponding alkoxy radicals and hydroperoxy radicals, by which lipid peroxidation should be promoted.
著者
Aicha O. Cherif Marine De Person Mhamed Ben Messaouda Manef Abderrabba Fathi Moussa
出版者
Japan Oil Chemists' Society
雑誌
Journal of Oleo Science (ISSN:13458957)
巻号頁・発行日
pp.ess19017, (Released:2019-06-10)

In the present work, a high-performance liquid chromatographic method coupled with mass spectrometry (HILIC-HPLC /ESI-MS) was used for the characterization and the quantification of glycerophospholipids (GPLs) classes and their molecular species in three genetically different Tunisian apricot cultivars (bitter, sweet and semi-sweet apricots). The application of the proposed method to the analysis of apricot oil allowed to separate and identify 74 molecular species of GPLs. Phosphatidylcholine (PC) class was found to be the most abundant GLPs in the three seed oils (38.6-62.4%) especially in bitter apricot, followed by phosphatidylinositol (PI) and phosphatidylethanolamine (PE) classes with values of 8.3-38.9% and 1.7-25.4% respectively. Phosphatidic acid (PA), phosphatidylglycerol (PG) and lysophosphatidylcholine (LPC) compounds were minor ones with maximums of 11.3%, 9.8% and 9.2% respectively. The results we obtained for the three Tunisian apricot seed varieties clearly indicate that the phospholipids of Tunisian apricot are of great interest. In fact, the high content of phosphatidylcholine (PC) determines it as a suitable and valuable source for obtaining corresponding phospholipids concentrates.