著者

Takashi NAKAMURA Katsuyuki SATO Mitsuo AKIBA Masao OHNISHI

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.55, no.4, pp.191-197, 2006 (Released:2006-03-14)

参考文献数

16

被引用文献数

4 12

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In these experiments, the antioxidative activity of urobilinogen, a major fecal pigment-related compound and reduced metabolite of bilirubin, was shown. Urobilinogen was synthesized from commercial bilirubin by reduction, and the structure was confirmed with mass spectroscopy and NMR analyses. The product was identified as i-urobilinogen. The DPPH radical scavenging activity of urobilinogen was higher than other antioxidants (α-tocopherol, bilirubin and β-carotene). Moreover, the formation of hydroperoxides of linoleic acid with 2, 2’-azobis (2, 4- dimethylvaleronitrile) in methanol was suppressed by the addition of synthesized urobilinogen. On the other hand, in the NMR spectrum measurement, we found the signal decrease of a proton from C10 methylene. It was shown that this proton was exchanged with a deutrium of CD3OD. This methylene can easily release the hydrogen as proton donor. These results suggest that urobilinogen can inhibit the radical chain reaction by trapping free radicals.

著者

Ayami NOJIRI Hideo AKIYOSHI Fumihito OHASHI Atsuki IJIRI Osamu SAWASE Tomiharu MATSUSHITA Mitsuru TAKEMOTO Shunsuke FUJIBAYASHI Takashi NAKAMURA Tsutomu YAMAGUCHI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0548, (Released:2014-10-16)

被引用文献数

4

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A 4-year-old Shih-Tzu, referred for an enlarged left carpus, was diagnosed with a unicameral bone cyst. A customized titanium device was inserted into cystic lesion and fixed by titanium screws. Sufficient strength of the affected bone with the device inserted to maintain limb function was established after resection of contents of cystic lesion. There was no deterioration of the lesion of bone cyst, and acceptable function of the affected limb with no clinical signs of lameness was maintained during 36 months follow-up. The results of this study demonstrated that bone cyst curettage and use of a customized titanium device could provide an effective alternative treatment of huge lesion of unicameral bone cysts with the intent of preventing pathologic fractures.

著者

Ryozo Tanaka Yusuke Okita Takashi Nakamura Kennosuke Kawama

出版者

The Japanese Association of Rehabilitation Medicine

雑誌

Progress in Rehabilitation Medicine (ISSN:24321354)

巻号頁・発行日

vol.7, pp.20220053, 2022 (Released:2022-09-29)

参考文献数

26

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Objectives: The gait characteristics of people with bilateral transtibial amputation are not well understood. This study aimed to clarify changes in trunk lateral bending and the trunk flexion angle during walking in people with bilateral transtibial amputation.Methods: In this cross-sectional study, four participants with bilateral transtibial amputation who could walk without assistance (BTTA group) and ten able-bodied participants (control group) were recruited. The range of motion of trunk lateral bending, the trunk flexion angle, and other gait parameters during comfortable-speed and maximum-speed walking were measured using a three-dimensional motion analysis system and force plates. These parameters were compared between the amputees and the controls.Results: During maximum-speed walking, the BTTA group walked slower with a smaller trunk flexion angle (median, 1.75° vs. 4.79°, P=0.036) and greater double leg support time (0.18 vs. 0.12, P=0.008) when compared with the control group. The other parameters during maximum-speed walking were not significantly different between the two groups. During comfortable-speed walking, none of the parameters were significantly different between the two groups.Conclusions: Compensatory trunk flexion angle decreases markedly during maximum-speed walking in people with bilateral transtibial amputation. People with bilateral transtibial amputation may be changing the trunk flexion angle to walk faster. When evaluating gait compensation for people with bilateral transtibial amputation, trunk flexion angle may be an important index and maximum-speed walking is needed to detect the change in trunk flexion angle.

著者

末松 俊二 石塚 只夫 吉田 正広 中村 孝 福田 正大 三好 甫 SUEMATSU Shunji ISHIZUKA Tadao YOSHIDA Masahiro Takashi Nakamura FUKUDA Masahiro MIYOSHI Hajime

出版者

航空宇宙技術研究所

雑誌

航空宇宙技術研究所資料 = Technical Memorandum of National Aerospace Laboratory (ISSN:04522982)

巻号頁・発行日

vol.369, pp.48, 1978-10

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資料番号: NALTM0369000

著者

Norimasa Taniguchi Takeshi Nakamura Takahisa Sawada Kinya Matsubara Keizo Furukawa Mitsuyoshi Hadase Yoshifumi Nakahara Takashi Nakamura Hiroaki Matsubara

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.74, no.11, pp.2365-2371, 2010 (Released:2010-10-25)

参考文献数

37

被引用文献数

52 63

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Background: Erythropoietin (EPO) enhances re-endothelialization and anti-apoptotic action. Larger clinical studies to examine the effects of high-dose EPO are in progress in patients with acute myocardial infarction (AMI). Methods and Results: The aim of this multi-center pilot study was to investigate the effect of `low-dose EPO' (6,000 IU during percutaneous coronary intervention (PCI), 24 h and 48 h) in 35 patients with a first ST-elevated AMI undergoing PCI who was randomly assigned to EPO or placebo (saline) treatment. Neointimal volume, cardiac function and infarct size were examined in the acute phase and 6 months later (ClinicalTrials.gov identifier: NCT00423020). No significant regression in in-stent neointimal volume was observed, whereas left ventricular (LV) ejection fraction was significantly improved (49.2% to 55.7%, P=0.003) and LV end-systolic volume was decreased in the EPO group (47.7 ml to 39.0 ml, P=0.036). LV end-diastolic volume tended to be reduced from 90.2% to 84.5% (P=0.159), whereas in the control group it was inversely increased (91.7% to 93.7%, P=0.385). Infarction sizes were significantly reduced by 38.5% (P=0.003) but not in the control group (23.7%, P=0.051). Hemoglobin, peak creatine kinase values, and CD34+/CD133+/CD45dim endothelial progenitors showed no significant changes. No adverse events were observed during study periods. Conclusions: This is a first study demonstrating that short-term `low-dose' EPO to PCI-treated AMI patients did not prevent neointimal hyperplasia but rather improved cardiac function and infarct size without any clinical adverse effects. (Circ J 2010; 74: 2365-2371)

著者

Itsuko Miyazawa Aya Kadota Katsuyuki Miura Motozumi Okamoto Takashi Nakamura Tsuyoshi Ikai Hiroshi Maegawa Atsushi Ohnishi

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.65, no.5, pp.527-536, 2018 (Released:2018-05-28)

参考文献数

31

被引用文献数

19

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The prevalence of obesity is increasing globally in patients with diabetes. This study aimed to examine 12-year trends of increasing obesity in Japanese patients with diabetes, and their clinical features. The study used results of the Shiga Diabetes Clinical Survey, which recorded medical performance in diabetic patients in 2000, 2006 and 2012. Data were analyzed from 14,205, 14,407 and 21,449 adult patients in these three years, respectively. Overweight and obesity prevalence and the clinical features of diabetes patients were examined, stratified by body mass index (BMI) and age. The prevalence of overweight (BMI 25–30 kg/m2) and obesity (BMI ≥30 kg/m2) were 27.0% and 5.1% in 2000, 28.9% and 7.3% in 2006 and 30.9% and 10.0% in 2012. Glycemic control, blood pressure and serum lipid profile improved over 12 years in all BMI categories. However, glycemic and triglyceride control were insufficient in obese patients aged <65 years (hemoglobin A1c 7.5 ± 1.4%, triglyceride 197.7 ± 178.4 mg/dL in 2012). The percentage of patients who used antihypertensive and lipid-lowering drugs increased and patients with higher BMI had increased frequency of using these drugs, both in young and old age groups. Higher BMI was significantly and positively associated with albuminuria. In summary, overweight and obesity have increased in Japanese diabetic patients, particularly for younger generations. Findings suggest that obesity may lead to poorer glycemic control, blood pressure and lipid profiles. Overweight and obesity are important modifiable risk factors for diabetes, suggesting that more active weight-control interventions are warranted.

著者

Takashi NAKAMURA

出版者

The Japan Academy

雑誌

Proceedings of the Japan Academy, Series B (ISSN:03862208)

巻号頁・発行日

vol.82, no.9, pp.311-327, 2006 (Released:2006-12-12)

参考文献数

63

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Numerical simulations were performed for the formation process of rotating black holes. It is suggested that Kerr black holes are formed for wide ranges of initial parameters. The nature of gravitational waves from a test particle falling into a Kerr black hole as well as the development of 3D numerical relativity for the coalescing binary neutron stars are discussed. (Communicated by Chushiro HAYASHI, M.J.A.)

著者

Kota MOTOHASHI Takanori SANADA Takashi NAKAMURA Yuta KIMURA Yoshiharu UCHIMOTO Koji AMEZAWA

出版者

The Electrochemical Society of Japan

雑誌

Electrochemistry (ISSN:13443542)

巻号頁・発行日

pp.22-00114, (Released:2022-10-27)

被引用文献数

1

著者

Keisei Kosaki Atsumu Yokota Koichiro Tanahashi Kanae Myoenzono Jiyeon Park Toru Yoshikawa Yasuko Yoshida Takayo Murase Seigo Akari Takashi Nakamura Seiji Maeda

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

pp.21-118, (Released:2022-04-12)

参考文献数

30

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Circulating xanthine oxidoreductase (XOR) activity may contribute to the pathogenesis of obesity-related adverse cardiometabolic profiles. This pilot study aimed to examine the cross-sectional associations between plasma XOR activity and cardiometabolic risk (CMR) markers in overweight and obese men. In 64 overweight and obese Japanese men (aged 31–63 years), plasma XOR activity and several CMR markers, such as homeostasis model assessment of insulin resistance (HOMA-IR), and clustered CMR score were measured in each participant. Clustered CMR score was constructed based on waist circumference, triglyceride, blood pressure, fasting plasma glucose, and high-density lipoprotein cholesterol. Plasma XOR activity in overweight and obese men was positively associated with the body mass index, waist circumference, visceral fat area, body fat mass, hemoglobin A1c, serum 8-hydroxy-2'-deoxyguanosine, HOMA-IR, and clustered CMR score and was inversely associated with handgrip strength and high-density lipoprotein cholesterol. Multiple linear regression analysis further demonstrated that the associations of plasma XOR activity with HOMA-IR and the clustered CMR score remained significant after adjustment for covariates including uric acid. Our data demonstrate that circulating XOR activity was independently associated, albeit modestly, with HOMA-IR and the clustered CMR score. These preliminary findings suggest that circulating XOR activity can potentially be one of the preventive targets and biomarkers of cardiometabolic disorders in over­weight and obese men.

著者

Yuta KIMURA Keita FUNAYAMA Mahunnop FAKKAO Takashi NAKAMURA Naoaki KUWATA Tatsuya KAWADA Junichi KAWAMURA Koji AMEZAWA

出版者

The Electrochemical Society of Japan

雑誌

Electrochemistry (ISSN:13443542)

巻号頁・発行日

pp.21-00033, (Released:2021-03-16)

被引用文献数

6

著者

諏訪 僚太 中村 崇 井口 亮 中村 雅子 守田 昌哉 加藤 亜記 藤田 和彦 井上 麻夕里 酒井 一彦 鈴木 淳 小池 勲夫 白山 義久 野尻 幸宏 Ryota Suwa Takashi Nakamura Akira Iguchi Masako Nakamura Masaya Morita Aki Kato Kazuhiko Fujita Mayuri Inoue Kazuhiko Sakai Atsushi Suzuki Isao Koike Yoshihisa Sirayama Yukihiro Nojiri 京都大学フィールド科学教育研究センター瀬戸臨海実験所 九州大学付属天草臨海実験所 琉球大学熱帯生物圏研究センター瀬底研究施設 琉球大学熱帯生物圏研究センター瀬底研究施設 琉球大学熱帯生物圏研究センター瀬底研究施設 琉球大学大学院理工学研究科 琉球大学大学院理工学研究科 東京大学海洋研究所 琉球大学熱帯生物圏研究センター瀬底研究施設 産業技術総合研究所 琉球大学 京都大学フィールド科学教育研究センター瀬戸臨海実験所 国立環境研究所地球環境研究センター Seto Marine Biological Laboratory Field Science Education and Research Center Kyoto University Amakusa Marine Laboratory Kyusyu University Sesoko Station Tropical Biosphere Research Center University of the Ryukyus Sesoko Station Tropical Biosphere Research Center University of the Ryukyus Sesoko Station Tropical Biosphere Research Center University of the Ryukyus Graduate School of Engineering and Science University of the Ryukyus Graduate School of Engineering and Science University of the Ryukyus Ocean Research Institute The University of Tokyo Sesoko Station Tropical Biosphere Research Center University of the Ryukyus Geological Survey of Japan National Institute of Advanced Industrial Science and Technology(AIST) University of the Ryukyus Seto Marine Biological Laboratory Field Science Education and Research Center Kyoto University Center for Global Environmental Research National Institute for Environmental Studies

出版者

日本海洋学会

雑誌

海の研究 (ISSN:09168362)

巻号頁・発行日

vol.19, no.1, pp.21-40, 2010-01-05

参考文献数

102

被引用文献数

3

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産業革命以降の二酸化炭素(CO_2)排出量の増加は,地球規模での様々な気候変動を引き起こし,夏季の異常高海水温は,サンゴ白化現象を引き起こすことでサンゴ礁生態系に悪影響を及ぼしたことが知られている。加えて,増加した大気中CO_2が海水に溶け込み,酸として働くことで生じる海洋酸性化もまた,サンゴ礁生態系にとって大きな脅威であることが認識されつつある。本総説では,海洋酸性化が起こる仕組みと共に,海洋酸性化がサンゴ礁域の石灰化生物に与える影響についてのこれまでの知見を概説する。特に,サンゴ礁の主要な石灰化生物である造礁サンゴや紅藻サンゴモ,有孔虫に関しては,その石灰化機構を解説すると共に,海洋酸性化が及ぼす影響について調べた様々な研究例を取り上げる。また,これまでの研究から見えてきた海洋酸性化の生物への影響評価実験を行う上で注意すべき事項,そして今後必要となる研究の方向性についても述べたい。The increase of the atmospheric carbon dioxide (CO_2) concentration after the industrial revolution caused global climate change. During the last several decades, coral reef ecosystems have been devastated by the mass-scale coral bleaching events caused by abnormally high seawater temperature in summer. In addition, increased atmospheric CO_2dissolves in the ocean, acts as an acid and finally decreases the pH level of seawater. This phenomenon, known as ocean acidification, is now being considered as a future threat to the calcifying organisms in coral reef ecosystems. In this review, we summarize basic backgrounds of ocean acidification as well as its potential impacts on coral reef calcifiers. Together with the distinctive mechanisms of calcification among specific groups, we review the impacts of ocean acidification on major reef-builders such as scleractinian corals, calcareous red algae and reef-dwelling foraminifera. Finally, we point out some recently-recognized problems in acidified seawater experiments as well as the future direction of this research field.

著者

Masato Furuhashi Kazuma Mori Marenao Tanaka Takuto Maeda Megumi Matsumoto Takayo Murase Takashi Nakamura Masayuki Koyama Norihito Moniwa Hirofumi Ohnishi Shigeyuki Saitoh Kazuaki Shimamoto Tetsuji Miura

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ18-0127, (Released:2018-08-02)

被引用文献数

17

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Hypouricemia is a high-risk factor of exercise-induced acute kidney injury (EIAKI) probably through a lack of an antioxidant effect of uric acid. Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the formation of uric acid from hypoxanthine and xanthine, leading to an increase in superoxide and reactive oxygen species. Activation of XOR has been proposed to promote oxidative stress-related tissue injury. We measured plasma XOR activity by a sensitive and accurate assay using a combination of liquid chromatography and triple quadrupole mass spectrometry in subjects with relatively low levels of uric acid (≤4.0 mg/dL) who were recruited from 627 subjects (male/female: 292/335) in the Tanno-Sobetsu Study, a population-based cohort. The numbers of subjects with uric acid ≤4.0 mg/dL, ≤3.0 mg/dL and ≤2.0 mg/dL were 72 (11.5%, male/female: 5/67), 13 (2.1%, all females) and 2 (0.3%, both females), respectively. Plasma XOR activities in 5 male subjects were below the median value of the 292 male subjects. In 12 (17.9%) of the 67 female subjects with uric acid ≤4.0 mg/dL, plasma XOR activities were above the upper quartile value of the 335 female subjects. Eleven of the 12 female subjects with high plasma XOR activity and a low uric acid level had liver dysfunction and/or insulin resistance. In conclusion, unexpected high plasma XOR activities were found in some female subjects with relatively low levels of uric acid. Measurement of plasma XOR activity may help to identify hypouricemic patients with a high risk for EIAKI.

著者

Mahunnop FAKKAO Kazuki CHIBA Yuta KIMURA Takashi NAKAMURA Toyoki OKUMURA Kiyofumi NITTA Yasuko TERADA Yoshiharu UCHIMOTO Koji AMEZAWA

出版者

公益社団法人 日本セラミックス協会

雑誌

Journal of the Ceramic Society of Japan (ISSN:18820743)

巻号頁・発行日

vol.125, no.4, pp.299-302, 2017-04-01 (Released:2017-04-03)

参考文献数

9

被引用文献数

13

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In this work, we directly observed the reaction distribution formed in a composite cathode of the all-solid-state lithium-ion battery (ASSLIB) LiCoO2/Li2.2C0.8B0.2O3|Li2.2C0.8B0.2O3|PEO|Li during charging by using the two-dimensional X-ray absorption spectroscopy (2D-XAS) at Co K-edge. The two-dimensional mapping of the state of charge in a composite cathode indicated that the reaction distribution was formed during charging process in the in-plane direction due to the disconnection in electron pathway at cracks. It was experimentally confirmed that the 2D-XAS technique was a useful tool for evaluating the reaction distribution in a composite cathode of an ASSLIB and investigating the influence factors for the formation of the reaction distribution.

著者

Takashi Nakamura Yosuke Noma Yu Sakurai Hideyoshi Harashima

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.40, no.2, pp.234-237, 2017-02-01 (Released:2017-02-01)

参考文献数

12

被引用文献数

17

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Intravesical drug delivery by cationic liposomes (Cat-LPs) represents a potent nanotechnology for enhancing therapeutic effects against bladder disorders. However, preventing the aggregation of Cat-LPs in urine poses a significant barrier. We report on an examination of the effect of modifying liposomes with polyethylene glycol (PEG) lipids to prevent Cat-LPs from aggregating in human urine. Although Cat-LPs underwent significant aggregation in human urine, introducing 5 mol% of PEG2k lipid or 2 mol% of PEG5k lipid completely inhibited the aggregation of the Cat-LPs. When 2 mol% of PEG2k lipids were introduced, the lipid structures of 1,2-distearoly-sn-glycero-3-phosphoethanolamine (DSPE) and 1,2-distearoyl-sn-glycerol (DSG) greatly prevented aggregation compared with cholesterol. By contrast, when Cat-LPs, after incubation in urine, were exposed to bladder cancer cells, only introducing cholesteryl-PEG into the Cat-LPs showed a significant enhancement in cellular uptake. These results offer the potential for incorporating cholesteryl-PEG into Cat-LPs for achieving both stability in urine and effective cellular uptake.

著者

Keiichiro MIE Mizuki TOMIHARI Kiyotaka HOSHI Takashi NAKAMURA Tomohiro YAMAGUCHI Kazuro MIYAHARA Terumasa SHIMADA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0626, (Released:2016-01-02)

被引用文献数

1

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The influence of transfusion of lymphokine-activated T killer cells (T-LAK) on inflammatory responses was examined in dogs after laparotomy. Plasma C-reactive protein (CRP) level, cell numbers of peripheral blood lymphocytes (PBLs) and T lymphocyte subsets (CD3+, CD4+ and CD8+) and mRNA expression levels of cytokines including interleukin (IL)-2, IL-12, IL-4, IL-10 and transforming growth factor (TGF)-β in peripheral blood mononuclear cells (PBMCs) were measured in dogs with (T-LAK group) or without (control group) a single T-LAK administration immediately after laparotomy. The plasma CRP level initially increased and then decreased to the normal range at 7 days after laparotomy in the T-LAK group, which was earlier than in the control group. The expression level of IL-10 mRNA showed a marked postoperative increase and was significantly higher than the preoperative level on day 7 (P<0.05), whereas the level in the control group showed no clear change after laparotomy. A significant increase in IL-2 mRNA expression level in the T-LAK group was observed on day 14, which was two weeks earlier than in the control group (P<0.05). These results suggest that T-LAK therapy in dogs after laparotomy leads to earlier resolution of postoperative inflammation by production of an anti-inflammatory cytokine (IL-10) in the early phase of the postoperative period and earlier restoration of cell-mediated immunity related to cytokine production by PBMCs.