著者
加藤 裕久 広瀬 瑞夫 山口 昌之 吉沢 催章 福田 宏志 小田 積一 永山 徳郎
出版者
The Japanese Circulation Society
雑誌
JAPANESE CIRCULATION JOURNAL (ISSN:00471828)
巻号頁・発行日
vol.31, no.12, pp.1857-1863, 1968-01-15 (Released:2008-04-14)
参考文献数
9
被引用文献数
1

The mechanism of the anoxic spells in the patient with tetralogy of Fallot is still uncertain, but beta adrenergic stimulation has been shown to accentuate cyanosis and occasionally to precipitate an anoxic spell. The purpose of the present study is to investigate the hemodynamic responses to isoproterenol (adrenergic beta stimulant) and propranolol (adrenergic beta blockade). Materials and Methods: Eleven children ranging in age from 3 to 14 years have been studied at cardiac catheterization (tetralogy of Fallot 7 cases, pulmonary stenosis with intact ventricular septum 2 cases, ventricular septal defect 1 case, patent ductus arteriosus 1 cases). All patients were sedated with hydroxyzine hydrochloride, secobarbital and pethidine HCl. The pressure pulses of pulmonary artery, right ventricle and femoral artery were obtained by the Siemens electro manometer. Determinations of oxygen satura-tions were obtained with the gas analyser (In-strumentation Laboratory) on arterial, pulmo- nary and mixed venous blood. Oxygen consumptions were measured by Fukuda Irika's respirometer. The phonocardiogram and the first derivative of right ventricular pressure pulse (dp/dt) were simultaneously recorded. Isoproterenol (0.1mg/20cc in 5% dextrose in water)was infused intravenously until the heart rate increased by 50 per cent. Then blood samples were obtained and pressure pulses were recorded. Thereafter, while the action of isoproterenol persisted, the infusion of propranolol in a dose of 5γ/kg (2mg/20cc in 5% dextrose in water) was administered, and the parameters were restudied. The angiocardiogram was obtained in one case before and after isoproterenol infusion. Results and Discussion: In tetralogy of Fallot the isoproterenol in-fusion resulted in an increase of right ventricular systolic pressure and a decrease of pulmonary systolic pressure. Pulmonary blood flow was decreased and systemic blood flow and right to left shunt were increased, so arterial oxygen saturation was markedly decreased. In angio-cardiogram the marked narrowing of the right ventricular outflow tract was demonstrated after isoproterenol infusion. In simultaneously recorded phonocardiogram the ejective systolic murmur due to pulmonary stenosis was decreased by isoproterenol infusion. In pulmonary stenosis with intact ventricular septum the pressure gradient of pulmonary artery and right ventricle was markedly increased, but arterial oxygen saturation was unchanged after isoproterenol infusion. Thereafter, while the action of isoproterenol persisted, a infusion of propranolol was administered. In tetralogy of Fallot the propranolol infusion resulted in an increase of arterial oxygen saturation. And the systolic pressure gradient of pulmonary artery and right ventricle was decreased. Pulmonary blood flow was increased and systemic blood flow and right to left shunt were decreased. So the patients were recovered from anoxic state. The mechanism of the anoxic spells in tetralogy of Fallot is still uncertain, but our study suggests that the increase of the contraction in the outflow tract of right ventricle makes the hypoxic condition. Relaxation of the outflow tract of right ventricle is seen after propranolol, and the patient is recovered from anoxic condition. In one case with tetralogy of Fallot in age of 9 months who had frequent cyanotic at-tacks we used propranolol orally 5 mg a day. After propranolol there has been no anoxic spell in this patient. So it may have been some practical usefulness in prevention and treatment of anoxic spells in tetralogy of Fallot.
著者
大友 章司 竹島 久美子 広瀬 幸雄
出版者
人間環境学研究会
雑誌
人間環境学研究 (ISSN:13485253)
巻号頁・発行日
vol.8, no.2, pp.123-132, 2010 (Released:2010-12-29)
参考文献数
19
被引用文献数
2 1

We examined the effects of mood on the information processing and on the multiple functions of advertisement. The first experiment hypothesized that positive mood promoted an automatic processing of information and negative mood promoted a controlled processing of information. Moods were induced by asking about happy (positive mood) or unhappy (negative mood) event. Next, participants were presented with the statement advertisement or image advertisement. The results showed that participants in negative mood elaborated the statement advertisement and changed attitude more than participants in positive mood, whereas positive and negative participants presented with image advertisement indicated little attitude change. The second experiment hypothesized that the persuasive effects of image advertisement were depended on the interaction between mood and image relevance to merchandise. Positive or negative mood participants were presented with relevant image advertisement or irrelevant image advertisement. The results showed participants in positive mood indicated more attitude change in irrelevant image advertisement than participants in negative mood, whereas positive and negative mood participants presented with relevant image advertisement indicated little attitude change. Therefore, our results suggest that mood state does not only affect the information processing but also the persuasive effects of information.
著者
竹村 勇司 菅野 茂 広瀬 昶 澤崎 坦
出版者
公益社団法人 日本畜産学会
雑誌
日本畜産学会報 (ISSN:1346907X)
巻号頁・発行日
vol.55, no.7, pp.508-514, 1984-07-25 (Released:2008-03-10)
参考文献数
14

慢性的な低酸素暴露が,成長期ラットの心肺機能に及ぼす影響を明らかににるために,コントロールチャンバーを用いて実験を行なった.5週令のWistar系雄ラット35匹を7群次分けた.5週令で観察する群をC0,標高2,500m相当の低圧低酸素環境に5週令から暴露し,8および11週令で観察する群をT3,T6,11週令まで暴露したのち海面相当の常圧常酸素環境にもどし,22週令で観察する群をT17とし,それぞれの群に対して海面相当で飼育にる対照群C3,C6,C17,を設けた.温度,湿度,および二酸化炭素濃度はそれぞれ常に25°C,60%,および500~1,500ppmに制御した.各群に対して,形態的,心電図的,血液学的検査を常圧常酸素条件下で実施した.暴露群では対照群と比べて,成長にともなう体重の増加が抑圧され,QT間隔は延長し,心臓重量も大きい傾向にあったが,暴露による副腎重量の増大は,常圧常酸素環境へ戻すことにより回復した.赤血球数,Hb濃度,Hct値,および右心室重量はT3群で大きく増加したが,その後の増加は抑圧された.T6群では,平均電気軸のバラツキが大きくなり,肺重量体重比ならびにMCV,MCHが大きくなった.高地環境下でみられる心肺系の典型的な変化が低酸素暴露のみによって生じたことから,心肺機能にとって酸素分圧の低下が多くの高地環境要因の中で最も重要な作用因子であり,高地環境への適応過程として生理状態の安定に向け段階的な変化が生ずる可能性が示唆された.
著者
山田 敏郎 幡中 憲治 広瀬 勇次
出版者
公益社団法人 日本材料学会
雑誌
材料 (ISSN:05145163)
巻号頁・発行日
vol.22, no.235, pp.335-341, 1973-04-15 (Released:2009-06-03)
参考文献数
12
被引用文献数
2 1

Many studies have been carried out in regard to the grain size dependence of fatigue strength of metals. And it has been made clear that fatigue strength of f. c. c. metals greatly depends on the stacking fault energy γ, and the effect of γ on the crack propagation process is different from that on the crack initiation process. In this work, the grain size dependence of the fatigue strength was mainly examined under the rotating bending fatigue test, and the cyclic work hardening behavior under the push-pull fatigue test. Furthermore, the surface structure due to fatigue deformation was observed by means of optical and electron microscopes. From the viewpoints of both microscopic structure and dynamical behavior of the materials, the grain size dependence of fatigue strength was investigated in copper and α-brass.The results obtained are summarized as follows:(1) The grain size dependence in the crack initiation process in α-brass is very remarkable at 200°C as well as at room temperature. This result suggests that the effect of grain size on fatigue strength must be considered from both viewpoints of the configuration of slip line and ageing effect.(2) The grain size dependence in crack propagation process in α-brass is very small at R.T, but it increases at 200°C.(3) The cyclic work hardening in α-brass is larger in fine grains than in coarse grains. On the other hand, in copper almost opposite result was obtained. From these results the difference in grain size dependence under constant stress fatigue test can be explained.
著者
柳下 幸太郎 広瀬 統一
出版者
一般社団法人 日本アスレティックトレーニング学会
雑誌
日本アスレティックトレーニング学会誌 (ISSN:24326623)
巻号頁・発行日
vol.2, no.1, pp.37-43, 2016-11-12 (Released:2019-05-27)
参考文献数
29
被引用文献数
1

本実験では骨盤傾斜の違いが動作の遅速に与える影響を検証することを目的とした.被験者は健常な男子大学サッカー選手13名.方法は骨盤自然肢位(n.p)と後傾位(p.t)の2つの姿勢をとりダッシュを行った.評価は床反力,筋活動量(%MVC),重心位置を比較した.実験結果は動作開始時間において右脚離地までの時間がp.tのほうが有意に遅い値を示した.重心位置は静止時,体幹移動開始時の局面でp.tの方が後方にあった(p<0.05).床反力は水平方向,鉛直方向共にp.tが有意に小さい値を示した(p<0.05).%MVCではp.tが大腿二頭筋と腹直筋が共に有意に低い値を示した.体幹傾斜角度を時系列にみると,p.tでは開始からの振れ幅が大きかった.よって,後傾位は静止時の重心の後方位置,体幹傾斜変化の増大,ハムストリングスの不十分な筋活動の3要因により,動作時間の遅延につながったと示唆された.
著者
佐藤 稜 沢谷 洋平 柴 隆広 広瀬 環 佐藤 南 石坂 正大 久保 晃
出版者
理学療法科学学会
雑誌
理学療法科学 (ISSN:13411667)
巻号頁・発行日
vol.35, no.5, pp.673-677, 2020 (Released:2020-10-20)
参考文献数
22
被引用文献数
3 3

〔目的〕要支援・軽度要介護高齢者における抑うつとサルコペニアの関係を明らかにすること.〔対象と方法〕通所リハビリテーション利用者,要支援1・要支援2・要介護1の65歳以上の高齢者79名,男性45名,女性34名を対象とした.抑うつの程度におけるサルコペニアの有病率と抑うつの程度における筋力,身体機能,骨格筋量の関係を検討した.〔結果〕男性のみ抑うつの程度とサルコペニアの有病率に有意な関連を認めた.また,男性は抑うつが強くなるに伴い骨格筋量の有意な低下が認められた.女性においては有意差が認められなかった.〔結語〕抑うつとサルコペニア間に,性差が存在し男性要支援・軽度要介護高齢者において抑うつとサルコペニアに関連があることが明らかとなった.
著者
大澤 英昭 広瀬 幸雄 寺本 義也
出版者
科学技術社会論学会
雑誌
科学技術社会論研究 (ISSN:13475843)
巻号頁・発行日
vol.5, pp.93-109, 2008-06-30 (Released:2021-08-01)

The purpose of this case study on the collaboration between citizens and experts, dealing with the future plan of the estuary weir of the Yoshino River is to understand how we can create renewed public knowledge for solving the social problems associated with science and technology as first step of the study. In order to analyze the case, the collaboration patterns were classified based on the condition of information/knowledge-sharing and the relationship between citizens and experts. The condition of information/knowledge-sharing was classified into two types as unshared condition or shared condition, whereas the relationship between citizens and experts was classified into two types as soft relationship (relationship of trust) or hard relationship (conflicting relationship). The process of collaboration was classified into four phases as making issues, forming hypothesis, confirming by experiment, and synthesizing and practicing future scenario. In addition, the utilization of the citizens' and experts' knowledge was analyzed based on a scheme applied Johari's Window. The results were as follows. a) The collaboration pattern between citizens and experts transformed itself as the process of collaboration made progress. b) The citizens' and experts' knowledge learnt in the past experience was utilized in order to make common context required for increasing mutual understanding of the issue. Based on these results, the conceptual model for collaboration between citizens and experts was discussed.

1 0 0 0 耶蘇

著者
エルネスト・ルナン著 広瀬哲士訳
出版者
東京堂
巻号頁・発行日
1935

1 0 0 0 笑の観察

著者
広瀬哲士著
出版者
三省堂
巻号頁・発行日
1930