著者

Abd. Rahman As-syakur Keiji Imaoka Kakuji Ogawara Manabu D. Yamanaka Tasuku Tanaka Yuji Kashino I Wayan Nuarsa Takahiro Osawa

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.15, pp.216-221, 2019 (Released:2019-11-08)

参考文献数

28

被引用文献数

7

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We analyzed 3-hourly Tropical Rainfall Measuring Mission multi-satellite analysis (TRMM 3B42) version-7 data for the 17-year period 1998-2014 to investigate seasonal and geographic characteristics of the diurnal rainfall cycle (DRC) over Sumatera, Indonesia. Dividing Sumatera into north, central, and south regions approximately perpendicular to the west coast, we point out for the first time early-afternoon initiation of daily rainfall not only in the Barisan Mountains but also in the east-coastal small islands (ECSIs) such as Bangka and Belitung. Westward and eastward migrations of rainfall areas from the Barisan Mountains are varied with seasons and regions, with the most remarkable being westward during September-October-November (SON) in the central region and the least remarkable occurring during June-July-August (JJA) in the southern region. In the central region, the DRC reaches a distance of ∼700 km off the west coast during SON and of only 200 km during March-April-May (MAM). The other westward migrations from the ECSIs in the central and southern regions (except for JJA) have been confirmed by 5-year hourly Multi-functional Transport Satellite-1R (MTSAT-1R) cloud-top data. The results shown in this paper suggest that the rainfall distribution with respect to coastal distance, varying geographically and seasonally.

著者

Shun-ichi I. Watanabe Hiroyuki Tsujino Akihiko Murata Masayoshi Ishii

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.15, pp.183-188, 2019 (Released:2019-09-05)

参考文献数

31

被引用文献数

1

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We evaluated the impact of sea surface temperature (SST) improvement realized by increasing horizontal resolution of an ocean model on dynamical downscaling (DDS) over Japan, focusing on the effects of the Kuroshio on summer precipitation in Japan. Two sets of SSTs were simulated using a high-resolution North Pacific (NP) model and a low-resolution global (GLB) ocean model. Using these SSTs as the lower boundary conditions for the atmosphere, two DDS experiments were conducted (NP-run and GLB-run). In NP-run, summer precipitation increases over the Kuroshio and reduces over Pacific coastal areas of Japan compared with GLB-run. Due to weaker southerly winds north of the Kuroshio in NP-run, the water vapor flux transported to Japan is smaller than in GLB-run. Both the pressure adjustment and the vertical mixing mechanisms weaken the southerly winds, with the latter being slightly more effective. Increasing the horizontal resolution of the ocean model, so that the Kuroshio is more realistically reproduced, improves the accuracy of simulated precipitation over Japan.

著者

鄭 子真 Cheng Tzu-Chen

出版者

大阪大学大学院国際公共政策研究科

雑誌

国際公共政策研究 (ISSN:13428101)

巻号頁・発行日

vol.14, no.1, pp.191-205, 2009-09

著者

Hyo Jin Kang Young Bin Hong Yong Weon Yi Chi-Heum Cho Antai Wang Insoo Bae

出版者

日本毒性学会

雑誌

The Journal of Toxicological Sciences (ISSN:03881350)

巻号頁・発行日

vol.38, no.3, pp.355-361, 2013-06-01 (Released:2013-05-11)

参考文献数

29

被引用文献数

6 11

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The risk factors for breast cancer, the most common female malignant cancer, include environmental factors such as radiation, tobacco, a high-fat diet, and xenoestrogens as well as hormones. In addition, BRCA1 and BRCA2 are the most well-known genetic factors that increase risk for breast cancer. Coincidence of those environmental and genetic factors might augment the risk of tumorigenesis of breast. To verify this hypothesis, we briefly evaluated the carcinogenic potency of various environmental factors in the absence or presence of BRCA1 as a genetic factor in a normal mammary epithelial cell line, MCF10A. Many environmental factors tested increased cellular ROS level in the absence of other insult. In addition, TCDD, DMBA, 3MC, and BPA enhanced the BaP-induced ROS production. BRCA1 knockdown (BRCA1-KD) cells by siRNA significantly induced cellular accumulation of ROS compared to control cells. In this setting, the addition of paraquat, TCDD, DMBA, 2OHE2 or 4OHE2 significantly augmented ROS generation in BRCA1-KD MCF10A cells. Measurements of BaP-DNA adduct formation as a marker of DNA damage also revealed that BRCA1 deficiency leads increased DNA damage. In addition, TCDD and DMBA significantly increased BaP-DNA adduct formation in the absence of BRCA1. These results imply that elevated level of ROS is correlated with increase of DNA damage in BRCA1 defective cells. Taken together, our study suggests that several environmental factors might increase the risk of tumorigenesis in BRCA1 defective breast epithelial cells.

著者

Hanako Y. Inoue Kenichi Kusunoki Toru Adachi Chusei Fujiwara Naoki Ishitsu Ken-ichiro Arai

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

pp.2019-041, (Released:2019-10-18)

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The characteristics and finescale evolution of misovortices within a snowband were examined using low-level high-resolution single- and dual-Doppler radar analysis. From 02:00 to 06:00 JST on 17 January 2017, many misovortices developed within three snowbands in the Japan Sea coastal region. The vortices developed along the shear line between the offshore north-northwesterly and the coastal northeasterly. As discussed in several previous studies of misovortices along airmass boundaries, horizontal shearing instability was considered to be a possible mechanism responsible for misovortex formation. A detailed investigation was performed on the most distinct snowband and misovortices embedded within it. Dual-Doppler analysis revealed a detailed behavior of vortex during merger, such as the morphological change from quasi-circular to elliptical shape, and the counterclockwise rotation which caused high-amplitude inflection of the shear line in less than 10 minutes. During the decay stage, the vortices weakened along with weakening convergence. The results suggest that evolution of the misovortex appears to have been closely tied to the low-level convergence within the vortex.

著者

Irene SACRISTÁN Michael SIEG Francisca ACUÑA Emilio AGUILAR Sebastián GARCÍA María José LÓPEZ Aitor CEVIDANES Ezequiel HIDALGO-HERMOSO Javier CABELLO Thomas W. VAHLENKAMP Javier MILLÁN Elie POULIN Constanza NAPOLITANO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.19-0208, (Released:2019-10-15)

被引用文献数

14

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Owned, free-roaming domestic cats are abundant in the Chilean countryside, having high probability of contact with wildlife and potentially participating as reservoirs of zoonotic pathogens. In the present study, 131 cats from two remote study areas (Valdivia and Chiloe Island) in southern Chile were analyzed for infection/exposure to eight pathogens. Serum samples from 112 cats were tested for antigens against feline leukemia virus (FeLV antigen-ELISA) and antibodies against feline immunodeficiency virus (FIV-ELISA) and canine distemper virus (CDV-serum neutralization), yielded occurrence of 8.9% 1.7% and 0.8% respectively. The presence of DNA of five vector-borne pathogens, piroplasmids, Ehrlichia spp., Anaplasma spp., Rickettsia spp. and Bartonella spp. was investigated in thirty cats. Overall observed occurrence was 6.6% (2/30) for both Anaplasma platys, and B. henselae, and 3.3% (1/30) for both Bartonella sp. and Theileria equi. Observed occurrence for all vector-borne pathogens in Valdivia area was significantly higher than in Chiloe Island (5/15 vs 0/15; P=0.04). Our results represent the first description of exposure to CDV and DNA detection of T. equi and A. platys in domestic cats in Chile. The results highlight the importance of performing pathogen screening in owned, free-roaming rural cats to evaluate their potential role as reservoirs of infection and vectors for disease transmission to wildlife.

著者

Masatsugu Hori Masayasu Matsumoto Norio Tanahashi Shin-ichi Momomura Shinichiro Uchiyama Shinya Goto Tohru Izumi Yukihiro Koretsune Mariko Kajikawa Masaharu Kato Hitoshi Ueda Kazuya Iwamoto Masahiro Tajiri on behalf of the J-ROCKET AF study investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.76, no.9, pp.2104-2111, 2012 (Released:2012-08-24)

参考文献数

13

被引用文献数

304 511

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Background: The global ROCKET AF study evaluated once-daily rivaroxaban vs. warfarin for stroke and systemic embolism prevention in patients with atrial fibrillation (AF). A separate trial, J-ROCKET AF, compared the safety of a Japan-specific rivaroxaban dose with warfarin administered according to Japanese guidelines in Japanese patients with AF. Methods and Results: J-ROCKET AF was a prospective, randomized, double-blind, phase III trial. Patients (n=1,280) with non-valvular AF at increased risk for stroke were randomized to receive 15mg once-daily rivaroxaban or warfarin dose-adjusted according to Japanese guidelines. The primary objective was to determine non-inferiority of rivaroxaban against warfarin for the principal safety outcome of major and non-major clinically relevant bleeding, in the on-treatment safety population. The primary efficacy endpoint was the composite of stroke and systemic embolism. Non-inferiority of rivaroxaban to warfarin was confirmed; the rate of the principal safety outcome was 18.04% per year in rivaroxaban-treated patients and 16.42% per year in warfarin-treated patients (hazard ratio [HR] 1.11; 95% confidence interval 0.87–1.42; P<0.001 [non-inferiority]). Intracranial hemorrhage rates were 0.8% with rivaroxaban and 1.6% with warfarin. There was a strong trend for a reduction in the rate of stroke/systemic embolism with rivaroxaban vs. warfarin (HR, 0.49; P=0.050). Conclusions: J-ROCKET AF demonstrated the safety of a Japan-specific rivaroxaban dose and supports bridging the global ROCKET AF results into Japanese clinical practice.  (Circ J 2012; 76: 2104–2111)

著者

Atsushi Hozawa Takumi Hirata Hiroshi Yatsuya Yoshitaka Murakami Shinichi Kuriyama Ichiro Tsuji Daisuke Sugiyama Atsushi Satoh Sachiko Tanaka-Mizuno Katsuyuki Miura Hirotsugu Ueshima Tomonori Okamura

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20180124, (Released:2018-11-03)

参考文献数

20

被引用文献数

17

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Background: We sought to investigate the optimal values of BMI for the lowest risk of all-cause death and whether the optimal BMI differs according to smoking status in large-scale pooled analysis of 13 Japanese cohorts.Methods: Data from 179,987 participants of 13 well-qualified cohort studies conducted throughout Japan were used for our analysis. A cohort-stratified Cox proportional hazard model was used. P values for interactions were calculated based on the cross product of BMI and age, sex, or smoking status.Results: In the entire study population, all-cause mortality risk was lowest when the BMI was 22.0–24.9 kg/m2. This was also the case for selected healthy participants (never smoked, baseline total cholesterol level ≥4.1 mmol/L; the first 5 years of follow-up data were excluded). No effect modification of age, sex, or smoking status was observed. Regardless of their BMI, never smokers always had a lower all-cause mortality risk than did current smokers even with an ideal BMI in terms of mortality risk.Conclusion: A BMI of 22–24.9 kg/m2 correlated with the lowest risk of mortality, regardless of whether all participants or selected healthy participants were analyzed. The fact that smoking was more strongly associated with mortality than obesity emphasizes the urgency for effective anti-smoking programs.

著者

Hien Xuan Bui Jia-Yuh Yu Hsiao-Wei Liu Chia-Ying Tu Pin-Ging Chiu Huang-Hsiung Hsu

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.15, pp.119-124, 2019 (Released:2019-05-30)

参考文献数

34

被引用文献数

6

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While most studies have argued a slower increase of 1-3% K−1 of precipitation globally, others note that this is not necessarily the case from a regional perspective. In this study, we examine the convective structure changes over the equatorial Pacific with highly increased precipitation under global warming using simulations from the High Resolution Atmospheric Model (HiRAM). The moisture budget analysis shows that the precipitation increases must result from a significant enhancement of convection, with a minor modulation from the thermodynamic effect. Two different types of enhanced convection are identified. Over the mean ascending region, precipitation increases are associated with an enhancement of deep convection; while over the mean descending region, the precipitation increases are a result of enhanced shallow convection.

著者

Shigeru Hanamata Jumpei Sawada Bunki Toh Seijiro Ono Kazunori Ogawa Togo Fukunaga Ken-Ichi Nonomura Takamitsu Kurusu Kazuyuki Kuchitsu

出版者

Japanese Society for Plant Cell and Molecular Biology

雑誌

Plant Biotechnology (ISSN:13424580)

巻号頁・発行日

vol.36, no.2, pp.99-105, 2019-06-25 (Released:2019-07-03)

参考文献数

35

被引用文献数

10

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We have previously shown that autophagy is required for post meiotic anther development including programmed cell death-mediated degradation of the tapetum and pollen maturation in rice. However, the spatiotemporal dynamics of autophagy in the tapetum remain poorly understood. We here established an in vivo imaging technique to analyze the dynamics of autophagy in rice tapetum cells by expressing green fluorescent protein-tagged AtATG8, a marker for autophagosomes. 3D-imaging analysis revealed that the number of autophagosomes/autophagy-related structures is extremely low at the tetrad stage (stage 8), and autophagy is dramatically induced at the uninucleate stages (stage 9–10) throughout the tapetal cells during anther development. The present monitoring system for autophagy offers a powerful tool to analyze the regulation of autophagy in rice tapetal cells during pollen maturation.

著者

Álvaro Huerta Ojeda Sergio Galdames Maliqueo Guillermo Barahona-Fuentes Jorge Cancino López

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.31, no.7, pp.512-515, 2019 (Released:2019-07-02)

参考文献数

16

被引用文献数

1

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[Purpose] The purpose of this study was to determine the behavior of creatine kinase before and after the execution of a pre-activation protocol with intra-set variable resistance in order to generate post-activation potentiation in female athletes. [Participants and Methods] Six sprint women were part of the study. The study had a quasi-experimental intra-participant design. The experimental condition included a pre-activation with intra-set variable resistance + 1 minute rest + 30-m sprint × 3. The variables were metabolic creatine kinase, total creatine kinase, and 30-m sprints. [Results] Both the experimental condition and the control condition showed an increase in creatine kinase and total creatine kinase 24 hours post-effort. Only the experimental condition showed improvement in 30-m sprints after the pre-activation with intra-set variable resistance. [Conclusion] All those sessions oriented to increasing strength levels with a pre-activation protocol through intra-set variable resistance must consider rests longer than 24 hours between sessions in order not to increase creatine kinase in female athletes significantly.

著者

Ryoko YAMADA Sayaka KUZE-ARATA Yasushi KIYOKAWA Yukari TAKEUCHI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.18-0705, (Released:2019-06-05)

被引用文献数

21

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Undesirable behaviors exhibited by dogs are called canine behavioral problems. Behavioral problems are common among dogs kept in ordinary homes; hence, veterinarians need to have sufficient knowledge of these problems, so as to advise owners. Among dogs kept in ordinary Japanese homes, only a few behaviors have been investigated regarding prevalence and relevant factors. To improve understanding of behavioral problems, a comprehensive survey is crucial. In this study, we distributed an online survey including general information and questions about 25 canine behaviors that can become problematic to owners, to investigate (1) the prevalence of behavioral problem, (2) the most common behavioral problems, and (3) the relevant factors of each behavior. We collected 2,050 valid responses. Among all dogs, 86.0% exhibited at least one behavioral problem. “Barking at noises inside the house”, “Barking at unfamiliar visitors”, and “Pica” were the most frequent behavioral problems. To reveal those factors related to the expression of each behavior, we performed multiple logistic regression analyses, with the presence of behaviors as objective variables and dogs’ general information as explanatory variables. Breed, age, the presence of other dogs in the household, sex, neutering status, source of acquisition, and type of residence were associated with 19, 16, 5, 4, 4, 4, and 1 behaviors, respectively. This study revealed the prevalence of 25 canine behavioral problems in Japan and relevant factors of each behavior. Our findings will be useful for veterinarians in advising owners about preventing behavioral problems.

著者

Keiko Kondo Katsuyuki Miura Sachiko Tanaka-Mizuno Aya Kadota Hisatomi Arima Nagako Okuda Akira Fujiyoshi Naoko Miyagawa Katsushi Yoshita Tomonori Okamura Akira Okayama Hirotsugu Ueshima for the NIPPON DATA80 Research Group

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.83, no.6, pp.1254-1260, 2019-05-24 (Released:2019-05-24)

参考文献数

47

被引用文献数

10

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Background:Many studies show that dietary factors such as vegetables, fruit, and salt are associated with cardiovascular disease (CVD) risk. However, a risk assessment chart for CVD mortality according to combinations of dietary factors has not been established.Methods and Results:Participants were 9,115 men and women aged 30–79 years enrolled in the National Nutritional Survey of Japan in 1980 with a 29-year follow-up. Dietary intake was assessed using a 3-day weighed dietary record at baseline. Cox regression models were used to estimate the hazard ratio (HR) of CVD mortality stratified by vegetables, fruit, fish, and salt consumption. HRs of CVD mortality according to combinations of dietary factors were color coded on an assessment chart. Higher intakes of vegetables, fruit, and fish, and lower salt intake were associated with lower CVD mortality risk. HRs calculated from combinations of dietary factors were displayed using 5 colors corresponding to the magnitude of the HR. People with the lowest intake of vegetables, fruit, and fish, and higher salt intake had a HR of 2.87 compared with those with the highest intake of vegetables, fruit, and fish, and lower salt intake.Conclusions:Vegetables, fruit, fish, and salt intake were independently associated with CVD mortality risk. The assessment chart generated could be used in Japan as an educational tool for CVD prevention.

著者

Seongjae CHOI Ye-In OH Keun-Ho PARK Jeong-Seok LEE Jin-Hyung SHIM Byung-Jae KANG

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.81, no.3, pp.434-439, 2019 (Released:2019-03-20)

参考文献数

39

被引用文献数

15

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Limb-sparing surgery is one of the surgical options for dogs with distal radial osteosarcoma (OSA). This case report highlights the novel application of a three-dimensional (3D)-printed patient-specific polycaprolactone/β-tricalcium phosphate (PCL/β-TCP) scaffold in limb-sparing surgery in a dog with distal radial OSA. The outcomes evaluated included postoperative gait analysis, complications, local recurrence of tumor, metastasis, and survival time. Post-operative gait evaluation showed significant improvement in limb function, including increased weight distribution and decreased asymmetry. The implant remained well in place and increased bone opacity was observed between the host bone and the scaffold. There was no complication due to scaffold or surgery. Significant improvement in limb function and quality of life was noted postoperatively. Local recurrence and pulmonary metastasis were identified at 8 weeks postoperatively. The survival time from diagnosis of OSA to death was 190 days. The PCL/β-TCP scaffold may be an effective alternative to cortical allograft in limb-sparing surgery for bone tumors.

著者

Zhi-Bin Lin

出版者

The Japanese Pharmacological Society

雑誌

Journal of Pharmacological Sciences (ISSN:13478613)

巻号頁・発行日

vol.99, no.2, pp.144-153, 2005 (Released:2005-10-18)

参考文献数

51

被引用文献数

79 120 141

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Ganoderma lucidum (Leyss. ex Fr.) Karst. (Lingzhi or Reishi) has been used for a long time in China to prevent and treat various human diseases. G. lucidum polysaccharides extracted from G. lucidum are one of efficacious ingredient groups of G. lucidum. A number of reports have demonstrated that G. lucidum polysaccharides modulate immune function both in vivo and in vitro. The immuno-modulating effects of G. lucidum polysaccharides were extensive, including promoting the function of antigen-presenting cells, mononuclear phygocyte system, humoral immunity, and cellular immunity. Cellular and molecular mechanisms, possible receptors involved, and triggered signaling cascades have also been studied in vitro. However, whole animal experiments are still needed to further establish the mechanism of the immuno-modulating effects by G. lucidum. Evidence-based clinical trials are also needed.

著者

Jin Komuro Yuji Nagatomo Keitaro Mahara Mitsuaki Isobe Ayumi Goda Yasumori Sujino Atsushi Mizuno Yasuyuki Shiraishi Takashi Kohno Shun Kohsaka Tsutomu Yoshikawa West Tokyo Heart Failure (WET-HF) Registry Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.1, no.4, pp.162-170, 2019-04-10 (Released:2019-04-10)

参考文献数

31

被引用文献数

8

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Background: The concept of Clinical Scenario (CS) classification has been widely utilized to aid in choosing appropriate management strategies for acute decompensated heart failure (ADHF). Methods and Results: The West Tokyo-Heart Failure (WET-HF) Registry is a multicenter, prospective cohort registry enrolling consecutive hospitalized ADHF patients. Based on systolic blood pressure (SBP) at admission, 4,000 patients enrolled between 2006 and 2017 were classified into 3 groups: CS1, SBP ≥140 mmHg; CS2, 100≤SBP<140 mmHg; and CS3, SBP <100 mmHg. The CS1 group had a high rate of fluid retention such as leg edema, and the largest reduction in body weight at discharge. In-hospital diuretics use was the most frequent in CS1. Although the primary endpoint of long-term all-cause death and/or ADHF re-hospitalization was more common in more advanced CS, there was no significant difference between the 3 CS groups in patients with HF with preserved ejection fraction (HFpEF; P=0.10). Although more advanced CS was associated with larger left ventricular (LV) chamber size in HF with reduced EF (HFrEF), it was associated with smaller LV size in HFpEF. Conclusions: The long-term prognostic value of CS classification was limited in HFpEF. Whereas CS was closely associated with degree of LV remodeling in HFrEF, a smaller LV chamber might be associated with a lower cardiovascular functional reserve in HFpEF.

著者

Sang-Kab Park Jae-Hyun Park Yoo-Chan Kwon Ho-Sung Kim Mi-Suk Yoon Hyun-Tae Park

出版者

日本生理人類学会

雑誌

Journal of PHYSIOLOGICAL ANTHROPOLOGY and Applied Human Science (ISSN:13453475)

巻号頁・発行日

vol.22, no.3, pp.129-135, 2003 (Released:2003-06-01)

参考文献数

24

被引用文献数

41 91

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The purpose of this study was to investigate the effect of combined aerobic and resistance training on abdominal fat. Our participants in the study consisted of thirty obese women. They were separated into three groups: a control group (n=10), an aerobic training group (n=10) and a combined training group (n=10). The aerobic training group was composed of 60–70% HRmax (intensity), 60 minutes a day (duration) for 6 days a week (frequency). The combined training group was separated into resistance training (3 days a week, Mon, Wed, Fri) and the aerobic training (3 days a week, Tue, Thu, Sat). The levels for abdominal fat volume were measured by determining the subcutaneous fat volume (SFV), visceral fat volume (VFV), and VFV/SFV by CT (computed tomography). The VO2max was significantly (p<0.05) increased in both groups. The subcutaneous fat and visceral fat levels were decreased in the combined training group more than in the aerobics training group. Also, the lean body mass (LBM) was significantly increased only in the combined training group. In addition, the total cholesterol, triglyceride and LDL-C were significantly (p<.05) decreased and the HDL-C was significantly (p<.05) increased in both groups. In conclusion, our results observed that combined training decreased abdominal subcutaneous fat and visceral fat more than aerobic training only.

著者

Takuma Yoshihara Kazunori Shimada Kosuke Fukao Eiryu Sai Yayoi Sato-Okabayashi Rie Matsumori Tomoyuki Shiozawa Hamad Alshahi Tetsuro Miyazaki Norihiro Tada Hiroyuki Daida

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.79, no.7, pp.1470-1478, 2015-06-25 (Released:2015-06-25)

参考文献数

42

被引用文献数

37 54

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Background:Dietary intake of ω3 polyunsaturated fatty acids (ω3-PUFAs) reduces progression of atherosclerosis and prevents future cardiovascular events. Macrophages are key players in the pathogenesis of aortic aneurysm. The effects of ω3-PUFAs on abdominal aortic aneurysm (AAA) formation and macrophage-mediated inflammation remain unclear.Methods and Results:The AAA model was developed by angiotensin II infusion in apolipoprotein E-deficient mice. Mice were supplemented with eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). The development of AAA lesions and macrophage infiltration in the aorta were analyzed. Gene expression of inflammatory markers in aortic tissues and peritoneal macrophages were measured by using quantitative polymerase chain reaction. AAA formation and macrophage infiltration were significantly suppressed after EPA and DHA administration. EPA administration and DHA administration significantly decreased the expression of tumor necrosis factor-α, monocyte chemoattractant protein-1, transforming growth factor-β, matrix metalloproteinases (MMP)-2, MMP-9, and vascular cell adhesion molecule-1 in the aortas. The expression of arginase 2, which is a marker of pro-inflammatory macrophages, was significantly lower and that of Ym1, which is a marker of anti-inflammatory macrophages, and was significantly higher after EPA and DHA administration. The same trends were observed in peritoneal macrophages after EPA and DHA administration.Conclusions:Dietary intake of EPA and DHA prevented AAA development through the inhibition of aortic and macrophage-mediated inflammation. (Circ J 2015; 79: 1470–1478)

著者

Mun Keong KOK Nanako YAMASHITA-KAWANISHI James. K. CHAMBERS Makoto HARITANI Takahiro USHIGUSA Takeshi HAGA Hiroyuki NAKAYAMA Kazuyuki UCHIDA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.18-0771, (Released:2019-03-21)

被引用文献数

13

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The present paper describes Felis catus papillomavirus (FcaPV) type 5-associated cutaneous mass in a Domestic Shorthair cat. Histological examination revealed multicentric epidermal acanthosis with papillomavirus-associated cytopathic changes, which progressed to a tumor lobule with intact basement membrane. An association between FcaPV-5 and the cutaneous lesions was confirmed by detection of virus antigen and genes using immunohistochemistry, polymerase chain reaction (PCR), sequencing analysis, and in situ hybridization. Based on these findings, the lesions were diagnosed as FcaPV-5-associated viral plaques and Bowenoid in situ carcinoma (BISC). To date, this is the first reported case of FcaPV-5 infection in a cat in Japan, and the second case reported worldwide. For the first time this papillomavirus type is associated with BISC development.

著者

Yukihiro Koretsune Takuma Etoh Yousuke Katsuda Tetsuro Suetsugu Kenshi Kumeda Ichiro Sakuma Kenichi Eshima Mitsuhiro Shibuya Shin-ichi Ando Naoto Yokota Shinya Goto Karen S. Pieper Jagan Allu Ajay K. Kakkar for the GARFIELD-AF Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-18-0655, (Released:2018-12-04)

参考文献数

20

被引用文献数

11

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Background: Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective non-interventional study of stroke prevention in patients with newly diagnosed non-valvular AF (NAVF) that is being conducted in 35 countries. Methods and Results: A total of 52,081 patients with a new diagnosis of NVAF were enrolled prospectively in GARFIELD-AF. Of these, 4859 (9.3%) were recruited in Japan (2010–2016). In cohort 1 (2010–2011), few patients were on non-vitamin K antagonist oral anticoagulants (NOAC) globally. From cohort 2 onwards (2011–2016), however, there was a rapid increase in NOAC use around the globe, especially in Japan. By the last year of enrolment (2015–2016), 67.9% of patients in Japan and 43.1% of patients globally were on NOAC±antiplatelet therapy (AP). In Japan and globally, 17.0% and 12.2% of patients, respectively, did not receive stroke prevention treatment. Few patients in Japan (5.7%) received AP only. Compared with the other countries, the unadjusted rates of all-cause mortality and major bleeding were low, while rates of stroke/systemic embolism were similar after 1 year of follow-up. Conclusions: GARFIELD-AF continues to provide important information on the homogeneity and heterogeneity of baseline characteristics and treatment patterns in patients with newly diagnosed NVAF. This diversity reflects the differences in outcomes in Japan compared with the rest of the world.