著者

Maria D. Perez-Carceles Maria D. Medina Domingo Perez-Flores Jose A. Noguera Juan E. Pereniguez Manuel Madrigal Aurelio Luna

出版者

(公社)日本産業衛生学会

雑誌

Journal of Occupational Health (ISSN:13419145)

巻号頁・発行日

pp.13-0119-OA, (Released:2014-01-16)

被引用文献数

1 8

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Objectives: Despite the great impact the migration has had in economic, social and health-related fields, and the repercussions of alcohol consumption on them, few data exist concerning the extent of alcohol consumption in migrant workers. The aims of this study were to identify workers with a hazardous drinking problem by means of a self-reported questionnaire (Alcohol Use Disorders Identification Test-AUDIT) and a biomarker (carbohydrate-deficient transferrin-CDT) and to ascertain associated risk factors. Methods: A cross-sectional survey was conducted using a random sample of 385 migrant workers, undergoing a routine health examination as part of occupational health services. Results: The results showed that 13.8% (n=53) of the workers were screened as positive with the AUDIT (≥ 8) and/or CDT (> 2.6) and identified as hazardous drinkers and that 53.8% (n=207) were teetotallers. Being a man (OR: 2.0), working in the construction industry (OR: 2.8) or agriculture (OR: 2.2), being resident in Spain for more than 7 years (OR: 2.3) and sharing a house with friends were the factors most closely associated with hazardous drinking. Conclusions: Prevention-orientated programs, adjusted to the characteristics of each country and the origin of the migrants themselves, should be instituted to modify the drinking habits of migrant workers considered at risk.

著者

Koyanagi-Aoi Michiyo Ohnuki Mari Takahashi Kazutoshi Okita Keisuke Noma Hisashi Sawamura Yuka Teramoto Ito Narita Megumi Sato Yoshiko Ichisaka Tomoko Amano Naoki Watanabe Akira Morizane Asuka Yamada Yasuhiro Sato Tosiya Takahashi Jun Yamanaka Shinya

出版者

National Academy of Sciences

雑誌

Proceedings of the National Academy of Sciences of the United States of America (ISSN:00278424)

巻号頁・発行日

2013-11-20

被引用文献数

190

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大規模解析により品質の悪い多能性幹細胞の見分け方を開発. 京都大学プレスリリース. 2013-11-19.

著者

秋山 豊和 寺西 裕一 岡村 真吾 坂根 栄作 長谷川 剛 馬場 健一 中野 博隆 下條 真司 長岡 亨 アキヤマ トヨカズ テラニシ ユウイチ オカムラ シンゴ サカネ エイサク ハセガワ ゴウ ババ ケンイチ ナカノ ヒロタカ シモジョウ シンジ ナガオカ トオル Akiyama Toyokazu Teranishi Yuuichi Okamura Shingo Sakane Eisaku Hasegawa Go Baba Ken-ichi Nakano Hirotaka Shimojo Shinji Nagaoka Toru

出版者

情報処理学会

雑誌

情報処理学会論文誌 (ISSN:03875806)

巻号頁・発行日

vol.49, no.3, pp.1249-1264, 2008-03-15

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大阪大学では,高いセキュリティレベルと標準的なインタフェースを兼ね備えた認証技術として注目されている公開鍵基盤(PKI: Public Key Infrastructure)に基づく全学IT 認証基盤を導入した.本学で導入した全学IT 認証基盤システムでは,署名・暗号化,学内認証,グリッドシステム認証,という異なるポリシに対応する複数のCA を導入・共存させている.これら複数のCA 向けの証明書発行を自動化することにより,安全性と利便性を両立した証明書発行サービスを実現している.また,PKI に対応したシングルサインオン(SSO)機能を導入し,学内ユーザが各システム間で統一的なインタフェースにより認証を行えるようにした.アプリケーションWeb サーバに認証機能を組み込むエージェント型のSSO 機能の導入により,1 度アプリケーションをSSO 対応させてしまえば,アプリケーションを変更することなくシームレスにパスワード認証からPKI 認証へ移行・共存することが可能となった.さらに,ユーザID 体系として,公開用に変更を許容するユーザID と,システム間連携用に1 人に1 つ決まる不変のユーザID とを設け,それらの対応付けを内部的に行うことにより,安全性・柔軟性ある運用を可能とした.本稿では,本認証基盤の設計と実装について述べるとともに,システムの導入により得られた技術的ノウハウや今後の展開についても述べる. # In Osaka University, a campus-wide IT authentication infrastructure based on Public Key Infrastructure (PKI), which is regarded as a technology providing high security and standard interface to many applications, has been adopted. In this authentication infrastructure, multiple CAs for the different purposes such as signing and encryption, intra-campus authentication and grid system authentication coexist. To realize security and convenience, we developed an online certificate issuance service for those multiple CAs. We also introduced PKI enabled Single Sign-On (SSO) system to provide unified authentication interface. Since the SSO system supports ‘SSO agent’, which provides SSO functionality for web applications by installing a web server module, it is possible to migrate from password authentication to PKI authentication without modifying applications. Furthermore, we established secure and flexible identity management by separating changeable, public user ID and static, internal system ID. Internal system ID is used for managing and federating user profiles among the systems. The mapping between those two IDs is done by the SSO system. In this paper, we describe design and implementation of our authentication infrastructure, know-how of system establishment and future works.

著者

Panita Pathipvanich Naho Tsuchiya Archawin Rojanawiwat Wolf-Peter Schmidt Wattana Auwanit Pathom Sawanpanyalert Koya Ariyoshi

出版者

国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

vol.66, no.5, pp.375-378, 2013 (Released:2013-09-19)

参考文献数

14

被引用文献数

3 5

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We conducted a hospital-based descriptive study to describe the changing pattern of patient numbers, characteristics, and mortality rates among human immunodeficiency virus (HIV)-infected patients in northern Thailand over 15 years. The survival status on October 31, 2010 of all HIV-infected adults who attended an HIV center in a government hospital between 1995 and 2010 was ascertained. In total, 3,706 patients were registered, 2,118 (57.2%) of which were male. The survival status of 3,439 patients (92.9%) was available. In addition, 1,543 deaths were identified out of 12,858 person-year-observations (PYO) resulting in a mortality rate of 12.4 deaths/100 PYO (95% confidence interval [CI], 11.3–13.0). An initial decline in mortality rates was observed prior to 1999, probably because of an increase in the proportion of less symptomatic patients. After the introduction of the national highly active antiretroviral therapy (HAART) program, a profound decline in mortality rates was observed, reaching 2.0 deaths/100 PYO (95% CI, 1.4–2.9) in 2010. Simultaneously, the number of patients on follow-up increased by nearly fourfold. Although HAART has drastically improved the survival of HIV-infected patients, the number of patients receiving therapy at this HIV clinic has substantially increased. While referral of HIV patients to general physicians' care should be urged, we cannot overemphasize the importance of preventing new HIV infections.

著者

Masaki Ishihara Yuka Takagi Gefei Li Masato Noguchi Shin-ichiro Shoda

出版者

(社)日本化学会

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

pp.130646, (Released:2013-08-02)

被引用文献数

10

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A convenient protection-free synthetic route toward alkyl glycosides has been developed. The alcoholysis of one-step preparable glycosyl donors, 4,6-dibenzyloxy-1,3,5-triazin-2-yl (DBT) glycosides, under hydrogenolytic conditions gave the corresponding glycosides in good yields without adding any acid promoters. The method could be successfully applied to the glycosylation of an acid-labile oligosaccharide.

著者

稲谷 昌之 後藤 浩之 盛川 仁 小倉 祐美子 徳江 聡 Xin-rui ZHANG 岩崎 政浩 荒木 正之 澤田 純男 ZERVA Aspasia

出版者

公益社団法人 土木学会

雑誌

土木学会論文集A1(構造・地震工学) (ISSN:21854653)

巻号頁・発行日

vol.69, no.4, pp.I_758-I_766, 2013 (Released:2013-06-19)

参考文献数

7

被引用文献数

1

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2011年東北地方太平洋沖地震では内陸部の宮城県大崎市古川地区において地震動による構造物被害が多く発生した.古川地区の中でも一部地域に被害が集中していることから,その原因の一つとして地盤震動特性の違いが考えられる.そこで,本研究では古川地区に展開されている超高密度地震観測のデータを利用して地盤震動特性の違いを検討した,古川地区内の地盤が各点毎に構造の異なる一次元水平成層構造であると仮定して地盤モデルを推定したところ,被害が集中した地域において表層地盤が厚くなる傾向が見られた.ただし,推定した地盤モデルを用いて時刻歴観測波形の再現を試みたところ,一部の観測点には再現出来ない特徴的なフェーズが認められた.このことは,表層の地盤構造を一次元水平成層構造でモデル化するという従来の枠組みでは,古川地区の地震動を説明する上で本質的に不十分であることを示唆している.

著者

Miyako Yuasa-Kawase Daisaku Masuda Taiji Yamashita Ryota Kawase Hajime Nakaoka Miwako Inagaki Kazuhiro Nakatani Kazumi Tsubakio-Yamamoto Tohru Ohama Akifumi Matsuyama Makoto Nishida Masato Ishigami Toshiharu Kawamoto Issei Komuro Shizuya Yamashita

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.19, no.3, pp.263-275, 2012 (Released:2012-03-26)

参考文献数

48

被引用文献数

9 32

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Aim: The clustering of dyslipidemia, impaired glucose tolerance and hypertension increases the morbidity and mortality from cardiovascular events. A class B scavenger receptor, CD36, is a receptor for oxidized LDL and a transporter of long-chain fatty acids. Because of the impaired uptake of oxidized LDL in CD36-deficient macrophages and from the results of CD36 knockout mice, CD36 deficiency (CD36-D) was supposed to be associated with reduced risks for coronary artery disease (CAD); however, CD36-D patients are often accompanied by a clustering of coronary risk factors. The current study aimed to investigate the morbidity and severity of cardiovascular diseases in CD36-D patients.Methods: By screening for CD36 antigen on platelets and monocytes using FACS or the absent myocardial accumulation of 123I-BMIPP by scintigraphy, 40 patients with type I CD36-D were collected, the morbidity of CAD and their features of atherosclerotic cardiovascular diseases were observed. Screening for CD36-D in both CAD patients (n =319) and healthy subjects (n =1,239) were underwent.Results: The morbidity of CAD was significantly higher in CD36-D patients than in the general population; 50% of patients (20 out of 40) had CAD identified by BMIPP scintigraphy and 37.5% (3 out of 8) by FACS screening, respectively. Three representative CD36-D cases demonstrated severe CAD and atherosclerosis. The frequency of CD36-D was three times higher in CAD patients than in healthy subjects (0.9% vs 0.3%, p <0.0001).Conclusion: The morbidity of CAD is significantly higher in CD36-D patients suffering from severe atherosclerosis, implying that the status of CD36-D might be atherogenic.

著者

Hikichi Takafusa Matoba Ryo Ikeda Takashi Watanabe Akira Yamamoto Takuya Yoshitake Satoko Tamura-Nakano Miwa Kimura Takayuki Kamon Masayoshi Shimura Mari Kawakami Koichi Okuda Akihiko Okochi Hitoshi Inoue Takafumi Suzuki Atsushi Masui Shinji

出版者

National Academy of Sciences

雑誌

Proceedings of the National Academy of Sciences of the United States of America (ISSN:10916490)

巻号頁・発行日

2013-04-02

被引用文献数

31

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初期化を阻害する転写因子が分化を促進する. 京都大学プレスリリース. 2013-04-02.

著者

Toyotaka SATO Shin-ichi YOKOTA Torahiko OKUBO Kanako ISHIHARA Hiroshi UENO Yasukazu MURAMATSU Nobuhiro FUJII Yutaka TAMURA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0186, (Released:2012-11-14)

被引用文献数

8 30

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Fluoroquinolone resistance is mainly caused by mutations in quinolone resistance-determining regions of DNA gyrase and topoisomerase IV in Escherichia coli. The AcrAB-TolC efflux pump contributes to resistance against fluoroquinolone and other antimicrobials. In this study, we investigated a high-level mechanism of fluoroquinolone resistance in E. coli that was isolated from human clinical samples and canine fecal samples. E. coli strains with high levels of fluoroquinolone resistance have been found to be frequently resistant to cephalosporins. Strains with high-level fluoroquinolone resistance exhibited lower intracellular enrofloxacin (ENR) concentrations, higher expression of AcrA, and a greater reduction in the fluoroquinolone minimum inhibitory concentration for treatment with an efflux pump inhibitor. The frequency of strains with enhanced ENR resistance selection and the survival rate of E. coli in the presence of ENR in vitro were correlated well with AcrA protein expression levels in the parental strains. These results suggest that AcrAB-TolC efflux pump over-expression is related to high-level fluoroquinolone resistance and the selection of strains with enhanced fluoroquinolone resistance.

著者

杉田 繁治 尹 載秀 劉 仁善 全 京秀 高 恵星 (全 恵星) 朝倉 敏夫 嶋 陸奥彦 KOH Chun He-sung CHUN Kyung-soo YOON Jae-soo YU In-sun

出版者

国立民族学博物館

雑誌

国際学術研究

巻号頁・発行日

1995

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本研究の目的は、一つに18世紀における中国、日本、韓国、ヴェトナムの四ケ国の刑律および刑事判例を使い、それぞれの国の家族・親族の構造を折出し比較すること、二つに18世紀の東アジアにおける刑律および刑事判例のデータベースを作成することにある。ことに第一の目的において、刑律および刑事判例を使うことによって、これまでなされてきた上層階級ばかりでなく、すべての社会階層における東アジアの家族・親族の比較を考えている。これら四ケ国は、7世紀に中国の『唐律』を受容し、それぞれの国の要求および状況に即しこれを修正し、17・18世紀にはそれぞれの国における刑律が確立し、刑事判例がだされている。これらの刑律と刑事判例の中から、本研究の目的に合致し、最も信頼すべき、かつ比較に供する史料を慎重に選択し、四ケ国において共通する漢字による原本をコンピュータに入力し分析することが、本研究の一義的な作業となる。これにそって今年度は、昨年度に続き、第3次、第4次、第5次の三回のワークショップで以下の研究作業を進めた。1.各国の刑律および刑事判例のうち、コンピュータに入力する史料を特定し、入力作業を行う。そのサンプルとして、韓国の『増補文献備考:刑考』とヴェトナムの『黎朝刑律』に加えて、韓国の『続大典』『秋官録』『審理録』、中国の『刑案匯覧』『清律』、日本の『御仕置例類集』を選択する。そして、それらの史料を基とした用語解の作成と、参考とすべき各国の刑律・刑事判例の書誌解題の作成する。なお、史料の選択の過程で、ヴェトナムの法が『唐律』に、韓国の法が『明律』に基づいていることから、これらの法を考慮すべきであることを確認する。2.コンピュータに入力する時のコード化の開発とその分析方法を検討する。3.韓国とヴェトナムの史料の具体的入力と編集を行う。中国、日本の史料についても順次入力と編集の作業を進めていく。4.四ケ国それぞれにおける親族研究の回顧と展望をする。5.四ケ国それぞれにおける刑法の展開についての研究の回顧と展望をする。また、以下の点について討議を行った。1.本研究に使用する史料が総合的な法規の実行記録であるため現代西洋の概念との対照が困難であり、法と文化に関する概念の再検討が必要であることを確認する。2.四ケ国における親族の概念の違いが明らかになる。これに関して、さらに社会学、歴史学など各国の専門家との討議が必要であることを確認する。3.コンピュータに入力するための刑律・刑事判例の構文解釈をどのように行うかを各国の法学研究者に諮問し、批判と教示をあおぐ。4.入力・出力の一貫性のため四ケ国の漢字使用の対照表を作成する。四ケ国における漢字のコンピュータ入力の互換性について、今後さらに検討していく。本研究は学際的な研究であり、その構成員も幅広い学問分野から構成されているが、研究を効率的に推進するために、研究作業の分担とともに、研究成果の発表と最終報告の執筆についても試案ではあるが、すでに調整してある。なお、本研究は平成9年度からも2年間の予定で継続していく計画であるが、そこでは本研究で入力されたデータを出力し、これを分析するとともに、さらに入力のコード化を比較文化研究に使用できるよう再検討し、より汎用性と精度の高いデータベースの作成を行い、このデータベースに基づいて、各研究者がそれぞれの学問分野においてテーマを定めて研究を展開していく予定である。

著者

Ichimura Atsuhiko Hirasawa Akira Poulain-Godefroy Odile Bonnefond Amélie Hara Takafumi Yengo Loïc Kimura Ikuo Leloire Audrey Liu Ning Iida Keiko Choquet Hélène Besnard Philippe Lecoeur Cécile Vivequin Sidonie Ayukawa Kumiko Takeuchi Masato Ozawa Kentaro Tauber Maithé Maffeis Claudio Morandi Anita Buzzetti Raffaella Elliott Paul Pouta Anneli Jarvelin Marjo-Riitta Körner Antje Kiess Wieland Pigeyre Marie Caiazzo Roberto Van Hul Wim Van Gaal Luc Horber Fritz Balkau Beverley Lévy-Marchal Claire Rouskas Konstantinos Kouvatsi Anastasia Hebebrand Johannes Hinney Anke Scherag Andre Pattou François Meyre David Koshimizu Taka-Aki Wolowczuk Isabelle Tsujimoto Gozoh Froguel Philippe

出版者

Nature Publishing Group

雑誌

Nature (ISSN:14764687)

巻号頁・発行日

2012-02-19

被引用文献数

540

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脂肪センサーGPR120が食事性肥満の原因遺伝子であることの発見. 京都大学プレスリリース. 2012-02-20.

著者

Kim Young-il Hirai Shizuka Goto Tsuyoshi Ohyane Chie Takahashi Haruya Tsugane Taneaki Konishi Chiaki Fujii Takashi Inai Shuji Iijima Yoko Aoki Koh Shibata Daisuke Takahashi Nobuyuki Kawada Teruo

出版者

Public Library of Science

雑誌

PLoS ONE (ISSN:19326203)

巻号頁・発行日

vol.7, no.2, pp.e31317, 2012-02-09

被引用文献数

57

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トマトから脂肪肝、血中中性脂肪改善に有効な健康成分を発見:効果を肥満マウスで確認. 京都大学プレスリリース. 2012-02-10.

著者

Castets-Renard Céline

出版者

Graduate School of Law and Politics, Osaka University

雑誌

Osaka University Law Review (ISSN:04721381)

巻号頁・発行日

vol.57, pp.65-86, 2010-02

著者

Thi Tra Bui Minji Han Ngoc Minh Luu Thi Phuong Thao Tran Min Kyung Lim Jin-Kyoung Oh

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20230158, (Released:2023-08-26)

参考文献数

1

著者

Yu-Tai Liu Yung Liao Ming-Chun Hsueh Hsin-Yen Yen Jong-Hwan Park Jae Hyeok Chang

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.33, no.11, pp.574-581, 2023-11-05 (Released:2023-11-05)

参考文献数

35

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Background: The impact of meeting leisure-time physical activity (LTPA) recommendations and household physical activity (HPA) on all-cause mortality in the Taiwanese population is unclear. We aimed to investigate the relationship between sufficient LTPA and all-cause mortality in middle-aged and older Taiwanese adults and the role of HPA in those with insufficient LTPA.Methods: This nationwide prospective cohort study included 4,960 participants aged ≥50 years from the Taiwan Longitudinal Study in Aging (TLSA) survey. Physical activity patterns were assessed in 2003 and then followed up until 2015 for mortality through the National Death Registration Record. Cox proportional hazards regression was conducted to evaluate hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality.Results: Of the 4,960 participants, 1,712 died of all-cause mortality. Compared to those who had insufficient LTPA, participants who engaged in sufficient LTPA showed a significantly lower risk of all-cause mortality (HR = 0.84, 95% CI, 0.73–0.97). For those with insufficient LTPA, HPA also had a significantly reduced risk of all-cause mortality (HR = 0.85, 95% CI, 0.75–0.96) among general population. Similar associations were observed in subsequent sensitivity analyses. The subgroup analysis showed that the relationship between HPA and reduced mortality risk was only found in the women with insufficient LTPA group.Conclusion: This study confirmed that sufficient LTPA is associated with a lower risk of all-cause mortality. If sufficient LTPA cannot be performed, additional HPA is related to lower mortality.

著者

Sunghyun S HONG Sungryong KIM Myung-Kyo SEO Mi-Na HAN Jeongho KIM Sang-Myeong LEE Ki-Jeong NA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.23-0312, (Released:2024-01-01)

被引用文献数

1

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Parrot bornavirus (PaBV) has been reported to cause indigestion and other wasting symptoms such as weight loss and lethargy. The pathogenesis of PaBV has yet to be fully elucidated. This study reports PaBV infections in South Korea and suggests a trend in the genetic information gathered from clinical cases. A total of 487 birds with or without clinical symptoms were tested for bornavirus. Twelve of 361 asymptomatic birds tested positive for bornavirus, while 15 of 126 birds with various symptoms tested positive. A segment of approximately 1,540 bps including the N, X, P and M proteins were obtained from 23 of the positive strains and analyzed with other strains found on GenBank that had clinical information. PaBV was type 2 and 4 in South Korea, and certain amino acid sequences showed a difference between symptom presenting animals and asymptomatic animals in the X protein and P protein. When considering that some asymptomatic cases may have been latent infections at the time of examination, it is plausible these trends may grow stronger with time. Majority of PaBV was type 4 in South Korea. If these trends are confirmed, diagnosis of potentially pathogenic PaBVs in a clinical manner will be possible during the early stages of infection.

著者

Kohei Tsuji Takuya Kobayakawa Takahiro Ishii Nobuyo Higashi-Kuwata Chika Azuma Kouki Shinohara Yutaro Miura Kenichi Yamamoto Soshi Nishimura Shin-ichiro Hattori Haydar Bulut Hiroaki Mitsuya Hirokazu Tamamura

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.71, no.12, pp.879-886, 2023-12-01 (Released:2023-12-01)

参考文献数

53

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In the development of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) drugs, its main protease (Mpro), which is an essential enzyme for viral replication, is a promising target. To date, the Mpro inhibitors, nirmatrelvir and ensitrelvir, have been clinically developed by Pfizer Inc. and Shionogi & Co., Ltd., respectively, as orally administrable drugs to treat coronavirus disease of 2019 (COVID-19). We have also developed several potent inhibitors of SARS-CoV-2 Mpro that include compounds 4, 5, TKB245 (6), and TKB248 (7), which possesses a 4-fluorobenzothiazole ketone moiety as a reactive warhead. In compounds 5 and TKB248 (7) we have also found that replacement of the P1-P2 amide of compounds 4 and TKB245 (6) with the corresponding thioamide improved their pharmacokinetics (PK) profile in mice. Here, we report the design, synthesis and evaluation of SARS-CoV-2 Mpro inhibitors with replacement of a digestible amide bond by surrogates (9–11, 33, and 34) and introduction of fluorine atoms in a metabolically reactive methyl group on the indole moiety (8). As the results, these compounds showed comparable or less potency compared to the corresponding parent compounds, YH-53/5h (2) and 4. These results should provide useful information for further development of Mpro inhibitors.

著者

Shang-Ju Wu Li-Wei Lo Fa-Po Chung Yenn-Jiang Lin Shih-Lin Chang Yu-Feng Hu Yu-Cheng Hsieh Cheng-Hung Li Ta-Chuan Tuan Tze-Fan Chao Jo-Nan Liao Chin-Yu Lin Ting-Yung Chang Ling Kuo Chih-Min Liu Shin-Huei Liu Cheng-I Wu Chi-Jen Weng Ming-Jen Kuo Guan-Yi Li Yu-Shan Huang Jose Antonio Bautista Yoon-Kee Siow Nguyen Dinh Son Ngoc Shih-Ann Chen

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0364, (Released:2023-10-20)

参考文献数

25

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Background: Circumferential pulmonary vein isolation (CPVI) has supplanted segmental PVI (SPVI) as standard procedure for atrial fibrillation (AF). However, there is limited evidence examining the efficacy of these strategies in redo ablations. In this study, we investigated the difference in recurrence rates between SPVI and CPVI in redo ablations for PV reconnection.Methods and Results: This study retrospectively enrolled 543 patients who had undergone AF ablation between 2015 and 2017. Among them, 167 patients (30.8%, including 128 male patients and 100 patients with paroxysmal AF) underwent redo ablation for recurrent AF. Excluding 26 patients without PV reconnection, 141 patients [90 patients of SPVI (Group 1) and 51 patients of CPVI (Group 2)] were included. The AF-free survival rates were 53.3% and 56.9% in Group 1 and Group 2, respectively (P=0.700). The atrial flutter (AFL)-free survival rates were 90% and 100% in Group 1 and Group 2, respectively (P=0.036). The ablation time was similar between groups, and there no major complications were observed.Conclusions: For redo AF ablation procedures, SPVI and CPVI showed similar outcomes, except for a higher AFL recurrence rate for SPVI after long-term follow-up (>2 years). This may be due to a higher probability of residual PV gaps causing reentrant AFL.

著者

Makiko Kinoshita Kouji Higashi Hiroyuki Takaoka Takayuki Sakai Daichi Murayama Hideki Uchikawa Tomonori Kanaeda Yusei Nishikawa Shuhei Aoki Satomi Yashima Katsuya Suzuki Kazuki Yoshida Haruka Sasaki Noriko Suzuki-Eguchi Michiko Daimon Yoshio Kobayashi

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0485, (Released:2023-11-07)

参考文献数

1

著者

Ji Woong Roh SungA Bae Thomas W. Johnson Seok-Jae Heo Yongcheol Kim Deok-Kyu Cho Jung-Sun Kim Byeong-Keuk Kim Donghoon Choi Myeong-Ki Hong Yangsoo Jang Myung Ho Jeong on behalf of the KAMIR-NIH Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0189, (Released:2023-05-30)

参考文献数

21

被引用文献数

3

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Background: In the setting of acute myocardial infarction (AMI), there are no data regarding the benefits of intravascular ultrasound (IVUS) for chronic kidney disease (CKD) patients.Methods and Results: This study used data from the Korea Acute Myocardial Infarction Registry, a large, multicenter prospective cohort. We evaluated 1,759 patients with AMI and CKD, defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2, and patients were classified into 2 groups: with and without IVUS. The primary outcome was target lesion failure (TLF) at 3 years. The hazard ratio (HR) of TLF according to eGFR was also analyzed. A total of 1,759 patients with AMI and CKD who underwent IVUS-guided PCI (19.2%) had a significantly lower risk of TLF at 3 years (8.9% vs. 15.3%; HR 0.55; 95% confidence interval [CI]: 0.38 to 0.81; P=0.002) than those who underwent angiography-guided PCI, regardless of their eGFR and the presence of end-stage renal disease (ESRD). The results were consistent after confounder adjustment and inversed probability weighting.Conclusions: In patients with CKD and AMI who underwent PCI with 2nd-generation DES implantation, the use of IVUS guidance was associated with a significant reduction in 3-year TLF and showed consistently favorable outcomes regardless of eGFR and ESRD.