著者
Hirofumi Tomita Ken Okumura Hiroshi Inoue Hirotsugu Atarashi Takeshi Yamashita Hideki Origasa Eiki Tsushima on behalf of the J-RHYTHM Registry Investigators
出版者
日本循環器学会
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-15-0095, (Released:2015-05-13)
参考文献数
35
被引用文献数
9 42

Background:Because the current Japanese guideline recommends CHADS2score-based risk stratification in nonvalvular atrial fibrillation (NVAF) patients and does not list female sex as a risk for thromboembolic events, we designed the present study to compare the CHA2DS2-VASc and CHA2DS2-VA scores in the J-RHYTHM Registry.Methods and Results:We prospectively assessed the incidence of thromboembolic events for 2 years in 997 NVAF patients without warfarin treatment (age 68±12 years, 294 females). The predictive value of the CHA2DS2-VASc and CHA2DS2-VA scores for thromboembolic events was evaluated by c-statistic difference and net reclassification improvement (NRI). Thromboembolic events occurred in 7/294 females (1.2%/year) and 23/703 males (1.6%/year) (odds ratio 0.72 for female to male, 95% confidence interval (CI) 0.28–1.62, P=0.44). No sex difference was found in patient groups stratified by CHA2DS2-VASc and CHA2DS2-VA scores. There were significant c-statistic difference (0.029, Z=2.3, P=0.02) and NRI (0.11, 95% CI 0.01–0.20, P=0.02), with the CHA2DS2-VA score being superior to the CHA2DS2-VASc score. In patients with CHA2DS2-VASc scores 0 and 1 (n=374), there were markedly significant c-statistic difference (0.053, Z=6.6, P<0.0001) and NRI (0.11, 95% CI 0.07–0.14, P<0.0001), again supporting superiority of CHA2DS2-VA to CHA2DS2-VASc score.Conclusions:In Japanese NVAF patients, the CHA2DS2-VA score, a risk scoring system excluding female sex from CHA2DS2-VASc, may be more useful in risk stratification for thromboembolic events than CHA2DS2-VASc score, especially in identifying truly low-risk patients.
著者
Tae-Young Moon Jee-Hee Kim Hak-Ju Gwon Bang-Sung Hwan Gyoung-Yong Kim Neal Smith Gun-Soo Han Hyo-Cheol Lee Byung-Jun Cho
出版者
理学療法科学学会
雑誌
Journal of Physical Therapy Science (ISSN:09155287)
巻号頁・発行日
vol.27, no.3, pp.581-583, 2015 (Released:2015-03-31)
参考文献数
14
被引用文献数
11

[Purpose] The purpose of this study was to determine how an exercise program focusing on muscular strength could aid firefighters with chronic lower back pain. [Subjects] The research subjects were randomly assigned to two groups, the experimental group (n=8) and the control (n=8). [Methods] The experimental group performed two types of exercise programs four times per week for 8 weeks under supervision. Tests were performed before and after the 8 weeks of exercise in accordance with the Korea Occupational Safety and Health Agency’s program. [Results] At the end of the 8 weeks of the rehabilitation program, abdominal muscular strength were significantly increased in the experimental group, and this indicates that the exercise therapy was effective for improvement of muscular strength. [Conclusion] We found that exercise therapy is an effective intervention that can reduce the pain of patients with chronic lower back pain. The firefighters with chronic lower back pain who participated in this study exhibited enhanced lower back muscular strength and obtained some additional benefits. They need regular exercise.
著者
Akira Yamazaki Meiji Honda Akira Kuwano-Yoshida
出版者
(公社)日本気象学会
雑誌
SOLA (ISSN:13496476)
巻号頁・発行日
vol.11, pp.59-64, 2015 (Released:2015-05-11)
参考文献数
12
被引用文献数
1 16

The influence of large-scale atmospheric blocking over the northwestern Pacific on heavy snowfall events in the Kanto area and on the Pacific Ocean side of northern Japan (PNJ) within the time scale of ∼10 days was examined through blocking case studies. The past 14 blocking cases over the Pacific, including the blocking during early- to mid-February 2014 that influenced a record-breaking snowfall over the Kanto area, were analyzed using a long-term reanalysis dataset and local meteorological observation station data. Results reveal that blocking over the Pacific causes large precipitation over the Kanto area and the PNJ by shifting cyclone (storm) tracks towards the east coast of Japan from their usual eastward course across the mid-Pacific via the south coast of Japan. Excessive passing of cyclones caused large precipitation in the Kanto area and snowfall in the PNJ. In the blocking cases with heavy snowfall events in the Kanto area, a strong cold-air inflow over Japan also existed in the lower troposphere originating from east Siberia, which initiated synoptic ground cold-air environments in the Kanto area.
著者
Tao Wu Yan Dong Xiaohua Hu Jianhua Li Zhao-Hong Shi
出版者
理学療法科学学会
雑誌
Journal of Physical Therapy Science (ISSN:09155287)
巻号頁・発行日
vol.27, no.3, pp.645-647, 2015 (Released:2015-03-31)
参考文献数
19
被引用文献数
1 4

[Purpose] The aim of this study was to observe the relationships among heart rate, rate of perceived exertion, and oxygen consumption in stroke patients and the effectiveness of improving aerobic capacity during routine rehabilitation therapy. [Subjects and Methods] Thirty-six stroke patients participated in the study. A K4b2 pulmonary function device was used to record heart rate (beats per minute), oxygen consumption (Equation Section (Next)ml·min−1·kg−1), and rate of perceived exertion. Results were recorded after completing the following activities continuously: (1) silent sitting, (2) sit-to-stand transfers, (3) hip extension while standing against a wall, (4) weight loading on the affected leg, (5) upward and downward leg movements on a stall bar, (6) walking up and down a flight of stairs, and (7) a 60-meter walk. Correlation analyses were performed to demonstrate the relationship of oxygen consumption with HR and RPE. [Results] Moderate correlation was found between HR and oxygen consumption, and low correlation was found between rate of perceived exertion and oxygen consumption. The routine rehabilitation therapy could reduce the accumulation of lactate. [Conclusion] HR is a better index than rate of perceived exertion in evaluating exercise intensity in stroke patients. The routine rehabilitation therapy can improve the aerobic capacity of stroke patients.
著者
Jin-seop Kim Duck-won Oh
出版者
理学療法科学学会
雑誌
Journal of Physical Therapy Science (ISSN:09155287)
巻号頁・発行日
vol.27, no.1, pp.31-33, 2015 (Released:2015-01-09)
参考文献数
19
被引用文献数
1 4

[Purpose] The aim of this study was to determine the effects of high-frequency current therapy on the abdominal obesity levels of young women. [Subjects] Twenty-two women with abdominal obesity were randomly allocated to either an experimental group (n1 = 10) or a control group (n2 = 12). [Methods] The experimental group subjects received high-frequency current therapy for the abdominal region 3 times per week for 6 weeks (a total of 18 sessions). Outcome measures were waist circumference, body mass index, and body composition data (abdominal obesity rate, subcutaneous fat mass, and body fat percentage). [Results] Significant main effects of time in the waist circumference, abdominal obesity rate, subcutaneous fat mass, and body fat percentage were found. Significant time-by-group interactions were found for waist circumference, abdominal obesity rate, subcutaneous fat mass, and body fat percentage. [Conclusion] The use of the high-frequency current therapy may be beneficial for reducing the levels of abdominal obesity in young women.
著者
Ma Guangyong Yasunaga Jun-Ichirou Akari Hirofumi Matsuoka Masao
出版者
National Academy of Sciences
雑誌
Proceedings of the National Academy of Sciences of the United States of America (ISSN:00278424)
巻号頁・発行日
vol.112, no.7, pp.2216-2221, 2015-02-02
被引用文献数
24

ヒトT細胞白血病ウイルス1型の感染特異性の解明に成功 -HTLV-1感染症の病態解明に期待-. 京都大学プレスリリース. 2015-02-05.
著者
Juyeon OH Ju-hwan LEE Kyoung-oh CHO Jihye CHOI
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.14-0115, (Released:2015-01-10)
被引用文献数
1 2

This report described radiographic and CT features of atypical diffuse idiopathic skeletal hyperostosis in a 5-year-old, female Shih-tzu showing marked proliferative bone lesions in the appendicular skeleton with minor spinal changes. Continuous or flowing bony bridge formation of vertebrae is used as the gold standard for diagnosing diffuse idiopathic skeletal hyperostosis. However, this criterion seems not to be suitable for appendicular type diffuse idiopathic skeletal hyperostosis, as in the present case. Diffuse idiopathic skeletal hyperostosis is a progressive skeletal disease, and thus, enthesophysis and the multiple bony proliferations at insertion sites of ligaments and tendons to appendicular bones in a lamellar or trabecular pattern were considered diagnostic features of the appendicular type of diffuse idiopathic skeletal hyperostosis.
著者
藤沼祥成 横野光 PascualMartinez-gomez 相澤彰子
雑誌
研究報告音声言語情報処理(SLP)
巻号頁・発行日
vol.2014-SLP-101, no.3, pp.1-8, 2014-05-15

あるイベントの盛り上がりに対して,それに関するツイートにも変化が現れその変化に着目することで盛り上がりを検出することが可能であると考えられる.本研究ではこの盛り上がり時間帯中のツイートに用いられている表現の特性を解析することを試みる.はじめに各時間帯のツイート集合とツイートより構築した言語モデルの関係をクロスエントロピーで算出した.実験結果より複数のハッシュタグ間における一部の盛り上がり時間帯のツイートはツイートより構築した n-gram 言語モデルに従うことを示す.また,盛り上がっている時間帯とそうでない時間帯において,クロスエントロピーにおいて統計的に有意差があることを示した (p<0.02).また,n-gram 言語モデルでは捉えられない素性も検討するため,Support Vector Machine (SVM) と Random Forest により各ツイートを盛り上がり時間帯の二値分類を行い,盛り上がり時間帯の特徴として漢字数が少ないことが明らかになった.
著者
Akemi SUTO Yukinori SUTO Nozomi ONOHARA Yu TOMIZAWA Yukiko YAMAMOTO-SUGAWARA Taro OKAYAMA Kenichi MASUDA
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.14-0406, (Released:2014-10-29)
被引用文献数
5 17

Canine atopic-like dermatitis (ALD) is suspected to be associated with food allergies, particularly those mediated by lymphocytes. In this study, 54 cases were included as ALD dogs, based on the negative IgE test results. In the dogs, the percentage of activated cells helper-T lymphocytes were measured by flow cytometry using cultured peripheral lymphocytes under food allergen stimulation. We observed that 49 of the 54 ALD dogs (90.7%) had positive lymphocyte reactions against one or more food allergens. The most common food allergen was soybean, showing positive results in 21 dogs (49.2%), while the allergen to cause the lowest number of reactions was catfish (only 5 dogs, 10.2%). These results may be useful in considering elimination diets for ALD dogs.
著者
Ya-Pei CHANG Hsuan-Ping HONG Yen-Hua LEE I-Hsuan LIU
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.14-0265, (Released:2014-11-12)
被引用文献数
2 8

Mesenchymal stem cells (MSCs) hold great potential in cell therapy and have attracted increasing interests in a wide range of biomedical sciences. However, the scarcity of MSCs and the prolonged isolation procedure limited the clinical application. To address these two issues, we developed a method to isolate MSCs from bone biopsy tissues of euthanized canine body donors. Compared to the traditional method to isolate MSCs from aspirated bone marrow (BMSCs), the isolation procedure for MSCs from harvested epiphyseal cancellous bone (EMSCs) was less time-consuming. The isolated EMSCs had similar plastic-adherence, tri-lineage differentiation and consistent surface marker profiles compared to BMSCs. We harvested BMSCs and EMSCs from 24 euthanized cases from clinics and 42 euthanized donors from a local shelter. The successful rate for EMSC isolation is significantly higher compared to BMSC isolation, while the other properties of the isolated MSCs including the clonogenicity, proliferative potentials and molecular phenotypes were not discernibly different between the MSCs established by the two methods. In conclusion, we demonstrated a new procedure to harvest MSCs by bone biopsy at the epiphyseal region. This method is less time consuming and more reliable, and the resulting MSCs are comparable to those harvested by bone marrow aspiration. The combination of the two methods can greatly improve the efficiency to harvest MSCs.
著者
Song Qilei Cao Shuai Pritchard Robyn H Ghalei Behnam Al-Muhtaseb Shaheen A Terentjev Eugene M Cheetham Anthony K Sivaniah Easan
出版者
Nature Publishing Group
雑誌
Nature communications (ISSN:20411723)
巻号頁・発行日
vol.5, 2014-09-04
被引用文献数
255

排ガスを膜でキャッチ -空気洗浄技術、実用化に期待-. 京都大学プレスリリース. 2014-09-10.
著者
宮田 Susanne 伊藤 恵子 大伴 潔 白井 英俊 杉浦 正利 平川 眞規子 MACWHINNEY Brian OSHIMA-TAKANE Yuriko SHIRAI Yasuhiro 村木 恭子 西澤 弘行 辰巳 朝子 椿田 ジェシカ
出版者
愛知淑徳大学
雑誌
基盤研究(B)
巻号頁・発行日
2006

1歳から5歳までの日本語を獲得する子どもの縦断発話データに基づき発達指標DSSJ(Developmental Sentence Scoring for Japanese)を開発し、この日本語の発達指標を84人の子どもの横断データ(2歳~5歳)にあてはめ、標準化に向けて調整を行った.DSSJはWWW上のCHILDES国際発話データベースの解析プログラムCLANの一部として一般公開されている.
著者
Dah-Renn FU Daiki KATO Ai WATABE Yoshifumi ENDO Tsuyoshi KADOSAWA
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.14-0245, (Released:2014-08-25)
被引用文献数
2 10

Apoptosis, Ki-67 and survivin expression have been reported as prognostic values in human cancer treated with radiation therapy. The aim of this study was to evaluate the correlation between the outcome of canine nasal carcinomas treated with radiation therapy and these cancer markers. The apoptotic index (AI) was evaluated with TUNEL assays, and an immunohistochemical evaluation was performed on Ki-67 and survivin in 33 biopsy samples taken before treatment. Median survival times were estimated using Kaplan-Meier curves and the log-rank method. The AI ranged from 0 to 0.7%, and the percentage of Ki-67-positive cells defined as the proliferative index (PI) ranged from 0.8 to 77% in all samples. Neither the AI nor the PI had a significant relationship with survival time (P=0.056 and 0.211). Survivin expression was detected in 84.9% of samples of canine nasal carcinoma. Dogs with high survivin expression were associated with poorer response to treatment and had shorter survival times (P=0.017 and 0.031). Advanced-stage tumors were also significantly associated with a high level of survivin (P=0.026). Overexpression of survivin was shown to be an unfavorable prognostic factor in dogs with nasal carcinomas treated with radiation therapy.
著者
Osama HALABI Fatma AL-MESAIFRI Mariam AL-ANSARI Roqaya AL-SHAABI Kazunori MIYATA
出版者
The Institute of Electronics, Information and Communication Engineers
雑誌
IEICE TRANSACTIONS on Information and Systems (ISSN:09168532)
巻号頁・発行日
vol.E97-D, no.8, pp.2048-2052, 2014-08-01

This paper proposes a novel multimodal interactive surgical simulator that incorporates haptic, olfactory, as well as traditional vision feedback. A scent diffuser was developed to produce odors when errors occur. Haptic device was used to provide the sense of touch to the user. The preliminary results show that adding smell as an aid to the simulation enhanced the memory retention that lead to better performance.
著者
Ando Ho Kakuda Ken-ichi Nakayama Munetaka YOKOTO Kei-ichi
出版者
一般社団法人日本土壌肥料学会
雑誌
Soil science and plant nutrition (ISSN:00380768)
巻号頁・発行日
vol.46, no.1, pp.105-115, 2000-03-01
被引用文献数
2

Due to high the labor cost, direct seeding is being gradually applied for crop establishment throughout Asia. Recently, the development of the so-called, "controlled release fertilizers" (CRFs) which requires only "one shot dose" of N, has enabled to reduce the cost of labor for the application of topdressed N. Thus, in order to limit pollution and cost, no-tillage direct-seeded lowland rice cultivation accompanied by the use of CRF is being recommended. To evaluate the effects of CRFs on the growth and yield of no-tillage direct-seeded rice, a field experiment was carried out in the north-eastern region of Japan in 1993 and 1994. Five N treatments were used: (1) ammonium sulfate (AS) band placement application with seeds at the time of seeding (AS1); (2) AS broadcast application after irrigation (AS2); (3) CRF (LP100) co-situs application at the time of seeding (L1); (4) CRF (LPS100) co-situs application at the time of seeding (L2); and (5) minus N (MN). The rate of basal N was 60 kg N ha^<-1>. Topdressed N in the AS1 and AS2 treatments was applied at 25 d before heading at the rate of 20 kg N ha^<-1>. The highest yield was obtained in the L1 treatment in both years. The number of grains per unit area was affected by the amount of N in the plants at heading. The percentage of filled grains in the L2 treatment was the lowest by about 15 to 20% among the treatments. The recovery percentages of basal N on July 20 were about 20 to 30% in the AS1, AS2, and L1 treatments, and only about 14% in the L2 treatment. About 75 to 80% of basal N was absorbed by the plants at harvest in the L1 and L2 treatments. On the other hand, the plants had absorbed only about 25 to 30% of the applied basal N in the AS1 and AS2 treatments at harvest. There was no difference in the N-recovery percentage (based on the amount of released N) between the L1 and L2 treatments. Nitrogen-use efficiency was not significantly different among the treatments. However, higher N-use efficiency was obtained in this experiment than in early studies in the tropics. The agronomic efficiency of CRFs was higher than that of ammonium sulfate.
著者
Reo TAMAI Masaru FURUYA Shingo HATOYA Hideo AKIYOSHI Ryohei YAMAMOTO Yoshiaki KOMORI Shin-ichi YOKOI Kenichiro TANI Yuji HIRANO Masayuki KOMORI Shigeo TAKENAKA
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.14-0043, (Released:2014-08-13)
被引用文献数
3 15

Canine lymphoma is a common cancer that has high rates of complete remission with combination chemotherapy. However, the duration of remission varies based on multiple factors, and there is a need to develop a method for early detection of recurrence. In this study, we compared the metabolites profiles in serum from 21 dogs with lymphoma and 13 healthy dogs using gas chromatography mass spectrometry (GC-MS). The lymphoma group was separated from the control group in an orthogonal projection to latent structure with discriminant analysis (OPLS-DA) plot using ions of m/z 100–600, indicating that the metabolites profiles in lymphoma cases differed from those in healthy dogs. The lymphoma group was also separated from the control group on OPLS-DA plot using 29 metabolites identified in all serum samples. Significant differences were found for 16 of these metabolites with higher levels in the lymphoma group for 15 of the metabolites and lower levels for inositol. An OPLS-DA plot showed separation of the lymphoma and healthy groups using these 16 metabolites only. These results indicate that metabolites profile with GC-MS may be a useful tool for detection of potential biomarker and diagnosis of canine lymphoma.
著者
Byeong-mu Mun Tae-ho Kim Jin-hwan Lee Jin-youg Lim Dong-kwon Seo Dong-jin Lee
出版者
理学療法科学学会
雑誌
Journal of Physical Therapy Science (ISSN:09155287)
巻号頁・発行日
vol.26, no.4, pp.563-566, 2014 (Released:2014-04-23)
参考文献数
21
被引用文献数
7 16

[Purpose] This study sought to identify the gait aspects according to the FES stimulation position in stroke patients during gait training. [Subjects and Methods] To perform gait analysis, ten stroke patients were grouped based on 4 types of gait conditions: gait without FES stimulation (non-FES), gait with FES stimulation on the tibialis anterior (Ta), gait with FES stimulation on the tibialis anterior and quadriceps (TaQ), and gait with FES stimulation on the tibialis anterior and gluteus medius (TaGm). [Results] Based on repeated measures analysis of variance of measurements of gait aspects comprised of gait speed, gait cycle, and step length according to the FES stimulation position, the FES stimulation significantly affected gait aspects. [Conclusion] In conclusion, stimulating the tibialis anterior and quadriceps and stimulating the tibialis anterior and gluteus medius are much more effective than stimulating only the tibialis anterior during gait training in stroke patients using FES.