著者

Sung-Jin Hong Byeong-Keuk Kim

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0750, (Released:2023-11-07)

参考文献数

60

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Dual antiplatelet therapy (DAPT), consisting of aspirin and a P2Y12inhibitor, has been the principal antiplatelet therapy after drug-eluting stent (DES) implantation in patients with acute coronary syndrome (ACS) and chronic coronary disease. Particularly in patients with ACS, which presents a higher ischemic risk than chronic coronary artery disease, DAPT for up to 12 months is the recommended standard treatment. However, to decrease bleeding events related to the potency of P2Y12inhibitors and a prolonged duration of DAPT, recent studies have suggested P2Y12inhibitor monotherapy after short-term DAPT (1–3 months), which decreased the bleeding risk without an increased ischemic risk. In this article, we discuss the evidence related to the efficacy of a P2Y12inhibitor as single-antiplatelet therapy after short-term DAPT compared with standard DAPT, with a focus on patients with ACS treated with DES.

著者

Daisuke NISHIO-HAMANE Takeshi YAJIMA Issei IKARI Yoshiya OHKI Hirofumi HORI Yoshihiro OHARA

出版者

Japan Association of Mineralogical Sciences

雑誌

Journal of Mineralogical and Petrological Sciences (ISSN:13456296)

巻号頁・発行日

vol.118, no.1, pp.230605, 2023 (Released:2023-10-12)

参考文献数

26

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Kiryuite and gunmaite were found as new minerals from Tsukubara, Kiryu City, Gunma Prefecture, Japan. Kiryuite is a Mn-rich analogue of viitaniemiite with an ideal formula of NaMnAl(PO4)F3 that mainly occurs as a white powder in cracks in triplite aggregate and occasionally forms porous plate-like aggregates up to 5 mm in size, while the grains are several micrometers in size. In most cases, the aggregates are also accompanied by small amounts of other minerals such as goyazite, gorceixite, and fluorite. Kiryuite shows white streaks with a vitreous luster, and its Mohs hardness is estimated to be 5 by analogy with viitaniemiite. The calculated density is 3.32 g·cm−3 based on the empirical formula and unit cell volume refined from powder X-ray diffraction (XRD) data. The empirical formula for kiryuite calculated on the basis of O = 4 and F + OH = 3 is Na0.97(Mn0.56Ca0.38Fe0.04Mg0.02)Σ1.00Al0.98P1.02O4(F2.29OH0.71)Σ3. Kiryuite is monoclinic (P21/m) with a = 5.425(4) Å, b = 7.128(4) Å, c = 6.817(6) Å, β = 109.41(7)°, and V = 248.7(3) Å3 (Z = 2). The parameters [d in Å (I/I0) hkl] for the six strongest lines associated with kiryuite in the powder XRD pattern are 3.123 (57) 002, 2.923 (53) 012 and 120, 2.877 (100) 121, 2.560 (27) 200, 2.263 (43) 103, and 2.155 (76) 221. Gunmaite is a new alunite-related mineral with a new structure type that has an ideal formula of (Na2Sr)Sr2Al10(PO4)4F14(OH)12. Gunmaite mainly occurs as a core in hexagonal tablet crystals that coexist with gorceixite and goyazite-like minerals. Gunmaite is colorless and transparent with a greasy to resinous luster and is non-fluorescent. As a bulk crystal including gunmaite, the Mohs hardness is 5, cleavage is perfect on {001} planes, and the tenacity is brittle. The calculated density based on the empirical formula is 3.38 g·cm−3 using the empirical formula and single-crystal XRD data. The empirical formula for gunmaite calculated on the basis of O = 16 and F + OH = 26 is (Na1.72Sr0.70Mg0.56Ca0.01)Σ2.99(Sr1.32Ba0.68)Σ2(Al9.82Mg0.18)Σ10P3.99O16F16.21(OH)9.79. Gunmaite is trigonal (R3m) with a = 6.9972(2) Å, c = 50.270(2) Å, and V = 2131.51(13) Å3 (Z = 3). The structure consists of two PO4, AlO2(OH)4, AlF6, AlOF3(OH)2, SrO6(OH)6, and NaF8 polyhedra. Kiryuite and gunmaite are products of the final stage of hydrothermal activity in association with greisenization.

著者

Akiko Fujimoto Katsuhiro Mizuno Yasuyuki Iwata Hiroyuki Yajima Daisuke Nishida Hirofumi Komaki Akihiko Ishiyama Madoka Mori-yoshimura Hisateru Tachimori Yoko Kobayashi

出版者

The Japanese Association of Rehabilitation Medicine

雑誌

Progress in Rehabilitation Medicine (ISSN:24321354)

巻号頁・発行日

vol.8, pp.20230038, 2023 (Released:2023-10-28)

参考文献数

50

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Objectives: This study investigated the outcomes of the early introduction of a standing program for patients with Duchenne muscular dystrophy (DMD).Methods: This was a retrospective observational study of 41 outpatients with DMD aged 15–20 years. We introduced the standing program using knee–ankle–foot orthoses (KAFO) to slow the progression of scoliosis when ankle dorsiflexion became less than 0° in the ambulatory period.Results: Thirty-two patients with DMD were offered the standing program with KAFO; 12 continued the program until the age of 15 years (complete group) and 20 discontinued the program before the age of 15 years (incomplete group). The non-standing program group included 9 patients. The standing program with KAFO was significantly associated with the Cobb angle at the age of 15 years after adjustment for the duration of corticosteroid use and DMD mutation type (P=0.0004). At the age of 15 years, significant correlations were found between the ankle dorsiflexion range of motion (ROM) and non-ambulatory period (P=0.0010), non-ambulatory period and Cobb angle (P<0.0001), Cobb angle and percent predicted forced vital capacity (P=0.0004), and ankle dorsiflexion ROM and Cobb angle (P=0.0066). In the complete group, the age at ambulation loss (log-rank P=0.0015), scoliosis progression (log-rank P=0.0032), and pulmonary dysfunction (log-rank P=0.0006) were significantly higher than in the non-standing program group.Conclusions: The early introduction of a standing program for DMD patients may prolong the ambulation period and slow the progression of scoliosis and pulmonary dysfunction.

著者

Daisuke NISHIO-HAMANE Takeshi YAJIMA Norimasa SHIMOBAYASHI Masayuki OHNISHI Takefumi NIWA

出版者

Japan Association of Mineralogical Sciences

雑誌

Journal of Mineralogical and Petrological Sciences (ISSN:13456296)

巻号頁・発行日

pp.230711, (Released:2023-10-25)

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Asagiite, a newly-discovered mineral having the ideal formula NiCu4(SO4)2(OH)6·6H2O, is a member of the ktenasite group, representing a Ni analogue. It occurs as a secondary mineral on smithsonite aggregates that overlie fractures in a serpentinite found in the Nakauri mine within Aichi Prefecture, Japan. Asagiite exhibits a unique pale blue-green coloration and so is named after the traditional Japanese color “asagi-iro.” Asagiite occurs as thin plate-like crystals with perfect cleavage along {001} planes. The crystal size of this mineral is typically 0.1 to 0.2 mm, although in rare cases crystals may range up to 0.5 mm in length. These crystals are vitreous, transparent and non-fluorescent and have also been shown to be brittle with a Mohs hardness of 2½. The measured and calculated densities of asagiite are 2.90(3) and 2.92 g·cm-3, respectively. This mineral is optically biaxial (-) with α = 1.577(2), β = 1.620(2) and γ = 1.631(2) together with a 2Vcalc value of 52.4°. Electron microprobe analyses determined an empirical formula (based on 2S) of (Cu3.44Ni0.76Zn0.59Co0.18Fe0.01)Σ4.98S2O7.95(OH)6.05·6H2O. Based on single crystal X-ray diffraction data, the structure is monoclinic with space group P21/c and unit cell parameters a = 5.6095(8), b = 6.1259(7), c = 23.758(3) Å, β = 95.288(4)°, V = 812.92(17) Å3 and Z = 2. Single-crystal structural determination also gives an R1 value of 0.0303. The seven most intense peaks in the powder X-ray diffraction pattern [d in Å (I/I0) hkl] were found to be 11.830 (100) 002, 5.912 (64) 004, 4.845 (55) 013, 3.920 (45) 006, 2.953 (33) 008, 2.668 (57) 202 and 2.571 (36) 123, with unit cell parameters of a = 5.614(5), b = 6.108(8), c = 23.758(18) Å, β = 95.62(7)° and V = 810.8(14) Å3.

著者

Chihiro Kodama Akira Kuwano-Yoshida Shingo Watanabe Takeshi Doi Hiroki Kashimura Tomoe Nasuno

出版者

Japan Agency for Marine-Earth Science and Technology

雑誌

JAMSTEC Report of Research and Development (ISSN:18801153)

巻号頁・発行日

vol.28, pp.5-34, 2019-04-01 (Released:2019-04-03)

参考文献数

133

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The JAMSTEC Model Intercomparison Project (JMIP) provides a first opportunity to systematically compare multiple global models developed and/or used in JAMSTEC with the aim of moving toward better weather and climate predictions. Here, we evaluate climate simulations obtained from atmospheric models (AFES and MIROC5), atmospheric model with slab ocean (NICAM.12), and fully coupled model (SINTEX-F1 and SINTEX-F2). In these simulations, the sea surface temperature is fixed (for AFES and MIROC5) or nudged (NICAM.12, SINTEX-F1, and SINTEX-F2) to the observed historical one. We focus on the climatology and variability of precipitation and its associated phenomena, including the basic state, the energy budget of the atmosphere, extratropical cyclones, teleconnection, and the Asian monsoon. We further discuss the possible causes of similarities and differences among the five JMIP models. Though some or most of the dynamical and physical packages in the JMIP models have been developed independently, common model biases are found among them. The AFES and MIROC5, and the SINTEX-F1 and SINTEX-F2, show strong similarities. In many respects, NICAM.12 shows unique characteristics, such as the distributions of precipitation, shortwave radiation, and explosive extratropical cyclones and the onset of the Asian summer monsoon. To some extent, the similarities and differences among the JMIP models overlap with those among the Coupled Model Intercomparison Project Phase-5 (CMIP5) models, suggesting that JMIP can be used as a simple and in-depth version of CMIP to investigate the mechanisms of model bias. We suggest that this JMIP framework could be expanded to an intercomparison of weekly-to-seasonal scale weather forecasting; here, more fruitful discussion is expected through intensive collaboration among modeling and observation groups.

著者

Motoyasu Otani Kosuke Kitayama Hiroki Ishikuro Jun-ichiro Hattan Takashi Maoka Hisashi Harada Yuko Shiotani Akane Eguchi Eiji Nitasaka Norihiko Misawa

出版者

Japanese Society for Plant Biotechnology

雑誌

Plant Biotechnology (ISSN:13424580)

巻号頁・発行日

vol.38, no.2, pp.219-226, 2021-06-25 (Released:2021-06-25)

参考文献数

42

被引用文献数

2

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Ipomoea obscura, small white morning glory, is an ornamental plant belonging to the family Convolvulaceae, and cultivated worldwide. I. obscura generates white petals including a pale-yellow colored star-shaped center (flower vein). Its fully opened flowers were known to accumulate trace amounts of carotenoids such as β-carotene. In the present study, the embryogenic calli of I. obscura, were successfully produced through its immature embryo culture, and co-cultured with Agrobacterium tumefaciens carrying the β-carotene 4,4′-ketolase (crtW) and β-carotene 3,3′-hydroxylase (crtZ) genes for astaxanthin biosynthesis in addition to the isopentenyl diphosphate isomerase (idi) and hygromycin resistance genes. Transgenic plants, in which these four genes were introduced, were regenerated from the infected calli. They generated bronze (reddish green) leaves and novel petals that exhibited a color change from pale-yellow to pale-orange in the star-shaped center part. Especially, the color of their withered leaves changed drastically. HPLC-PDA-MS analysis showed that the expanded leaves of a transgenic line (T0) produced astaxanthin (5.2% of total carotenoids), adonirubin (3.9%), canthaxanthin (3.8%), and 3-hydroxyechinenone (3.6%), which indicated that these ketocarotenoids corresponded to 16.5% of the total carotenoids produced there (530 µg g−1 fresh weight). Furthermore, the altered traits of the transgenic plants were found to be inherited to their progenies by self-crossing.

著者

Mineko Tsukamoto Asahi Hishida Takashi Tamura Mako Nagayoshi Rieko Okada Yoko Kubo Yasufumi Kato Nobuyuki Hamajima Yuichiro Nishida Chisato Shimanoe Rie Ibusuki Kenichi Shibuya Naoyuki Takashima Yasuyuki Nakamura Miho Kusakabe Yohko Nakamura Yuriko N. Koyanagi Isao Oze Takeshi Nishiyama Sadao Suzuki Isao Watanabe Daisuke Matsui Jun Otonari Hiroaki Ikezaki Sakurako Katsuura-Kamano Kokichi Arisawa Kiyonori Kuriki Masahiro Nakatochi Yukihide Momozawa Kenji Takeuchi Kenji Wakai Keitaro Matsuo

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20220341, (Released:2023-07-29)

参考文献数

72

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Background: The present genome-wide association study (GWAS) aimed to reveal the genetic loci associated with folate metabolites as well as to detect related gene-environment interactions in Japanese.Methods: We conducted the GWAS of plasma homocysteine (Hcy), folic acid (FA), and vitamin B12 (VB12) levels in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study participants who joined from 2005 to 2012, and also estimated gene-environment interactions. In the replication phase, we used data from the Yakumo Study conducted in 2009. In the discovery phase, data of 2,263 participants from four independent study sites of the J-MICC Study were analyzed. In the replication phase, data of 573 participants from the Yakumo Study were analyzed.Results: For Hcy, MTHFR locus on chr 1, NOX4 on chr 11, CHMP1A on chr 16, and DPEP1 on chr 16 reached genome-wide significance (P < 5×10-8). MTHFR also associated with FA, and FUT2 on chr 19 associated with VB12. We investigated gene-environment interactions in both studies and found significant interactions between MTHFR C677T and ever drinking, current drinking, and physical activity > 33% on Hcy (β = 0.039, 0.038 and -0.054, P = 0.018, 0.021 and < 0.001, respectively) and the interaction of MTHFR C677T with ever drinking on FA (β = 0.033, P = 0.048).Conclusions: The present GWAS revealed the folate metabolism-associated genetic loci and gene-environment interactions with drinking and physical activity in Japanese, suggesting the possibility of future personalized CVD prevention.

著者

Masumi Kamata Naohisa Wada Nina Yasuda Daniel Varela Jorge I. Mardones Javier Paredes-Mella Satoshi Nagai

出版者

The Plankton Society of Japan, The Japanese Association of Benthology

雑誌

Plankton and Benthos Research (ISSN:18808247)

巻号頁・発行日

vol.18, no.1, pp.55-59, 2023-02-28 (Released:2023-03-02)

参考文献数

35

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Outbreaks of paralytic shellfish poisoning caused by the toxic dinoflagellate Alexandrium catenella (Dinophyceae) are currently a serious global problem both from economic and food hygiene perspectives. In Chile, A. catenella was first recorded in 1972 and is currently the main harmful algae species in the country, in terms of seafood security. As no relevant microsatellite markers for Chilean A. catenella populations were available, we isolated 23 new polymorphic microsatellite loci of A. catenella from Chile, of which 15 are applicable to both Chilean and Japanese populations. We found a strong genetic break between Chilean and Japanese A. catenella populations (FST=0.298, P<0.001), consistent with the morphological differences between them. In contrast to the Japanese population, for which genetic diversity ranged from 0.268 to 0.937, the Chilean population had a lower genetic diversity, ranging between 0.065 and 0.512. This study successfully developed A. catenella microsatellite markers that can be used to investigate its genetic spatial and temporal bloom diversity and assess further genetic connectivity between the population from southern and northern Chilean areas.

著者

黄 琬茜 コウ ワンセン Huang Wan-Chien

出版者

同志社大学社会学会

雑誌

評論・社会科学 = Social science review (ISSN:02862840)

巻号頁・発行日

no.117, pp.179-199, 2016-06

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論文(Article)台湾における国際結婚は年々増加し,それらの新移民の子どもが就学する数もどんどん増えてきている。2012年には,小中学校に就学している「新台湾之子」が20万人を超えた。台湾政府は,台湾が本格的な多文化社会になるために,近年,国際結婚家庭をサポートする政策やプログラムなどを積極的に推進している。そして,2012年には「全国新住民たいまつプログラム(全国新住民火炬計画)」を策定した。これは,新移民の人々と台湾人の関係をより良くするための,学校を中心として行われるプログラムと言える。この「たいまつプログラム」では,新移民の母語・文化を継承するため,小学校でその母語学習のコースを設けた。そして,このコースのために,『新住民母語生活学習教材』を開発し編成した。しかし,授業中,その教材はほとんど採用されていなかったことが報告されている。本研究の主な目的は,その教材の構成やその長所と短所を分析した上で,子どもの言語学習教材として適切であるかどうかを明らかにすることである。また,なぜ,その教材が教師に採用されなかったのかについても考察する。

著者

The Working Group for Renaming Diabetes Insipidus Hiroshi Arima Timothy Cheetham Mirjam Christ-Crain Deborah Cooper Mark Gurnell Juliana B Drummond Miles Levy Ann I McCormack Joseph Verbalis John Newell-Price John A H Wass

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.69, no.11, pp.1281-1284, 2022 (Released:2022-11-28)

参考文献数

10

被引用文献数

1 5

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“What’s in a name? That which we call a rose/By any other name would smell as sweet.” (Juliet, from Romeo and Juliet by William Shakespeare). Shakespeare’s implication is that a name is nothing but a word and it therefore represents a convention with no intrinsic meaning. Whilst this may be relevant to romantic literature, disease names do have real meanings, and consequences, in medicine. Hence, there must be a very good rational for changing the name of a disease that has a centuries-old historical context. A working group of representatives from national and international endocrinology and pediatric endocrine societies now proposes changing the name of “diabetes insipidus” to “Arginine Vasopressin Deficiency (AVP-D)” for central etiologies, and “Arginine Vasopressin Resistance (AVP-R)” for nephrogenic etiologies. This editorial provides both the historical context and the rational for this proposed name change.

著者

Sahar Y. Al-Okbi Shaimaa E Mohammed Enas S.K. Al-Siedy Naglaa A. Ali

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.69, no.7, pp.771-782, 2020 (Released:2020-07-02)

参考文献数

56

被引用文献数

2 4

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The role of fish oil, primrose oil and their mixture in ameliorating the changes in Alzheimer’s like model was evaluated in rats. Primrose oil and primrose/fish oil mixture fatty acids composition was assessed by gas chromatography. The rat experiment consisted of 5 groups; the first fed on balanced diet as control normal (CN); the other four groups treated with intraperitoneal aluminum lactate and consumed dyslipidemic diet; one group served as control Alzheimer’s like disease (CA) while the other three groups (test groups) received daily oral dose from primrose oil, fish oil and primrose/fish oil mixture separately for 5 weeks. Results showed primrose oil and primrose/ fish oil mixture to contain gamma linolenic acid as 9.15 and 4.3% of total fatty acids, respectively. Eicosapentaenoic and docosahexaenoic were present as 10.9 and 6.5 %, respectively in the oil mixture. Dyslipidemia and increased erythrocyte sedimentation rate (ESR), plasma butyrylcholinesterase (BChE), brain malondialdehyde (MDA) and NO with decrease in plasma magnesium, brain catalase, reduced glutathione, body weight gain and brain weight were demonstrated in CA compared to CN. Brain histopathology and immuno-histochemistry showed neuronal degeneration and neurofibrillary tangles with elevated myeloperoxidase and nuclear factor-kappa B in CA compared to CN. The tested oils demonstrated neuro-protection reflected in the variable significant improvement of biochemical parameters, immuno-histochemistry and brain histopathology. Primrose/fish oil mixture was superior in reducing ESR, brain MDA, plasma activity of BChE and brain histopathological changes along with elevating plasma magnesium. Primrose/fish oil mixture and fish oil were more promising in improving plasma high density lipoprotein cholesterol (HDL-C) than primrose. Fish oil was the most efficient in improving plasma total cholesterol (T-C), low density lipoprotein cholesterol and T-C /HDL-C. Primrose/fish oil mixture and primrose oil were superior in elevating brain catalase compared to fish oil. Other parameters were equally improved by the different oil treatments. Primrose oil, fish oil and their mixture reduced the progression of Alzheimer’s disease in rats with superiority to primrose/fish oil mixture.

著者

Takayuki Hishiki Kengo Usui Tadaichi An Rieko Suzuki Jun-ichi Sakuragi Yuki Tanaka Yu Matsuki Jun Kawai Yasushi Kogo Yoshihide Hayashizaki Tomohiko Takasaki

出版者

National Institute of Infectious Diseases

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

vol.75, no.3, pp.277-280, 2022-05-31 (Released:2022-05-24)

参考文献数

21

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, in December 2019. Despite the recent introduction of vaccines against SARS-CoV-2, more effective vaccines and antiviral drugs must be developed. Here, we isolated five SARS-CoV-2 strains from four patients with coronavirus disease (COVID-19) and an asymptomatic individual using pharyngeal swabs, nasopharyngeal swabs, and sputum samples. Cytopathic effects in inoculated Vero cells were observed between days 3 and 7. SARS-CoV-2 infection was confirmed by quantitative reverse-transcription polymerase chain reaction (RT-qPCR) and next-generation sequencing. Phylogenetic analyses of the whole genome sequences showed that the virus isolates from the clinical samples belonged to the Wuhan and European lineages. These findings and the isolated viruses may contribute to the development of diagnostic tools, vaccines, and antiviral drugs for COVID-19.

著者

Claude Obsomer and Sylvie Favre-Briant [translation by Travis Watters]

出版者

Safran

巻号頁・発行日

2015

著者

三浦 周 関口 真理子 大倉 拓也 小竹 秀明 白玉 公一 斉藤 嘉彦 カラスコ-カサド アルベルト 阿部 侑真 辻 宏之

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

電子情報通信学会論文誌 C (ISSN:13452827)

巻号頁・発行日

vol.J106-C, no.9, pp.344-353, 2023-09-01

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5G/Beyond 5Gと衛星通信を含む非地上系通信網(Non-Terrestrial Networks:NTN)の連携に関し,現在の動向や技術課題,情報通信研究機構(NICT)による研究開発の取組みを俯瞰的に記述する.衛星通信を含むNTNプラットホームが低軌道(Low Earth Orbit:LEO)衛星,高高度プラットホーム(High-Altitude Platform Station: HAPS)等の登場や電波・光技術の進展によって従来よりも大容量化,低遅延化,低コスト化が進んでいる.これを背景として,衛星通信/NTN-5G/Beyond 5G連携のためのネットワークアーキテクチャや無線アクセス方式が検討され,The 3rd Generation Partnership Project(3GPP)等での標準化が進んでおり,国内でも議論や提言,構想の提案がなされている.衛星通信/NTN-5G/Beyond 5G連携のキーとなる技術はネットワーク技術と,これを支える電波・光技術である.NICTでは,Beyond5Gにおける海・空・宇宙をつなぐ3次元ネットワークの実現を目指して衛星通信/NTNと5G/Beyond 5Gの連携技術の研究開発の取組みを進めている.ネットワーク技術では,異なる特徴をもつ複数のネットワークを連携させ,ユーザ及び運用事業者の満足度を最大化するため,統合的なネットワーク制御が必要である.そのため5Gネットワークと衛星の連携の研究や,NTNと地上系を相互接続するためのシステム構成の検討,リソース割当アルゴリズムの開発を行っている.電波技術では,高速大容量化を実現するための高周波数帯(Ka/Q/V帯)の利用,高速大容量化のためのマルチビーム化と周波数利用効率を向上するためのデジタル化を活用したリソース割当の柔軟性の向上,移動体地球局の柔軟性向上のための電子走査型平面アンテナ(AESA)の開発を行っている.光技術では,高速大容量通信や小型軽量化を実現できる利点を生かし,GEO衛星やLEO衛星,HAPS,ドローン等様々なプラットホームに搭載可能な光通信機器の開発や,地上衛星間光通信における大気揺らぎを補償する補償光学の研究を行っている.

著者

Masahito Michikura Masatsune Ogura Masahiro Yamamoto Masahiko Sekimoto Chizuru Fuke Mika Hori Koji Arai Shinji Kihara Kiminori Hosoda Koji Yanagi Mariko Harada-Shiba

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.81, no.12, pp.1879-1885, 2017-11-24 (Released:2017-11-24)

参考文献数

20

被引用文献数

34 32

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Background:Difficulty in detecting and measuring Achilles tendon (AT) xanthomas may be responsible for underdiagnosis of familial hypercholesterolemia (FH). We aimed to determine a cutoff value for AT thickness (AT-T) using ultrasonography to diagnose FH, and to investigate the relationship between AT-T and atherosclerosis.Methods and Results:Ultrasonographic AT-T and carotid intima-media thickness (IMT) were evaluated in 130 genetically diagnosed FH patients and 155 non-FH patients. The outline and internal properties of the AT could be clearly determined using ultrasonography, and a good correlation in AT-T was observed between ultrasonography and the conventional method of X-ray radiography (r=0.924, P<0.001). Cutoff values for the diagnosis of FH derived from receiver-operating curves were 5.8 mm (sensitivity 71%, specificity 78%) in men, and 5.5 mm (sensitivity 80%, specificity 81%) in women. Importantly, increased AT-T was positively associated with carotid IMT only in the FH group. Additionally, increased AT-T was associated with the presence of coronary artery disease in a logistic regression analysis adjusted for traditional cardiovascular risk factors.Conclusions:This is the first study to determine a cutoff value for AT-T based on ultrasonography for the diagnosis of FH in Japanese subjects. Clearer detection and easier measurement of AT-T using ultrasonography would encourage clinicians to diagnose FH more actively, and could solve the problem of underdiagnosis of FH.

著者

Ferran CUENCA-MARTÍNEZ Sara CORTÉS-AMADOR Gemma Victoria ESPÍ-LÓPEZ

出版者

Japanese Society of Physical Therapy

雑誌

Physical Therapy Research (ISSN:21898448)

巻号頁・発行日

vol.21, no.1, pp.16-22, 2018-06-20 (Released:2018-06-20)

参考文献数

42

被引用文献数

22 24

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Introduction: Chronic low back pain is a pathological process that compromises the functionality and quality of life worldwide. The objective of the study was to evaluate the effectiveness of classical physiotherapy in the management of non-specific chronic low back pain. Methods: A literature search in English electronic databases was performed from November to December of 2015. Only those studies addressing chronic non-specific low back pain by manual therapy and different types of exercises methods were included, and those, which combined acute or subacute pain with systematic reviews and clinical practice guidelines, were excluded. Studies involving cognitive-behavioral approaches were also excluded. Results: 487 studies were identified, 16 were analyzed and 10 were excluded. Of the 6 studies reviewed, 5 of them achieved a moderate quality and 1 of them was of a low quality. Back School exercises and McKenzie's method were all ineffective. Osteopathic spinal manipulation proved effective when performed on the lower back and the thoracic area but only immediately after it was received, and not in the medium or long term. Massages proved effective in the short term too, as well as the global postural reeducation although ultimately this study can be considered of a low methodological quality. Conclusions: Based on the data obtained, classical physiotherapy proposals show ineffectiveness in the treatment of chronic non-specific low back pain. More multidimensional studies are needed in order to achieve a better treatment of this condition, including the biopsychosocial paradigm.

著者

Fukie Niijima-Yaoita Masahiro Tsuchiya Hiroshi Ohtsu Kazuhiko Yanai Shunji Sugawara Yasuo Endo Takeshi Tadano

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.35, no.1, pp.91-97, 2012-01-01 (Released:2012-01-05)

参考文献数

35

被引用文献数

29 30

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Exercise necessitates a large supply of O2 and nutrients and rapid removal of CO2 and waste products. Histamine is a regulator of the microcirculation (which performs these exchanges), suggesting a possible involvement of histamine in exercise. Histamine is released from either mast cells or non-mast cells. In the latter, histamine is newly formed via the induction of histidine decarboxylase (HDC) in response to an appropriate stimulus, and it is released without being stored. Here, in mice, we examined the role of histamine or HDC induction in exercise. Prolonged walking (PW) (in a cylindrical cage turned electrically) increased HDC mRNA and HDC activity in quadriceps femoris muscles. Mice given a histamine H1-receptor antagonist [fexofenadine (peripherally acting) or pyrilamine (peripherally and centrally acting)] or an irreversible HDC inhibitor (α-fluoromethylhistidine) displayed less PW endurance than control mice. Ranitidine (H2-receptor antagonist) tended to reduce endurance. Other histamine-receptor (H3 and H4) antagonists had no significant effects on endurance. Mice deficient in HDC or histamine H1-receptors displayed markedly less endurance than control mice, and HDC activity in the quadriceps femoris of H1-deficient mice was rapidly elevated by PW. Fexofenadine significantly reduced the muscle levels of nitric oxide (NO) metabolites and glycogen after PW. The results support the ideas that (i) histamine is involved in protecting against exercise-induced fatigue or exhaustion, (ii) histamine exerts its protective effect via H1 receptors and the ensuing production of NO in skeletal muscle, and (iii) histamine is provided, at least in part, by HDC induction in skeletal muscles during prolonged exercise.

著者

Chul-Ho Yun Chun-Sik Bae Taeho Ahn

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.39, no.8, pp.1338-1346, 2016-08-01 (Released:2016-08-01)

参考文献数

42

被引用文献数

17 17

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Nanoparticles (NPs) containing cationic monovalent lipids such as 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) and N-(1-[2,3-dioleyloxy]propyl)-N,N,N-trimethylammonium chloride (DOTMA), have been widely used for the delivery of nucleic acid such as small-interfering RNA and polypeptide to cells as cancer therapies and vaccine development. Several previous reports have suggested that cationic liposomes induce reactive oxygen species (ROS) and ROS-mediated toxicity in cells. Here, we systematically investigated the effects of DOTAP- or DOTMA-containing NPs without any cargo on the human carcinoma cells, HepG2. Treatment with NPs containing DOTAP or DOTMA increased the production of cellular ROS, such as H2O2 and lipid peroxidation, in HepG2 cells and concomitantly decreased cell viability. These effects were dependent on the lipid concentration, surface density of cationic lipids, and particle size of NPs. However, neutral NPs consisting of 1,2-dioleoyl-3-phosphocholine did not elicit the effective ROS generation or cell death regardless of the lipid concentration and particle size. The present study suggests that DOTAP- and DOTMA-NPs are able to induce cancer cell death through production of ROS in the absence of any therapeutic cancer reagents. These results also provide a rational background for the design of delivery systems using cationic lipid-based NP formulations.

著者

Ken-ichi Okumura Ren-Chung Cheng

出版者

Arachnological Society of Japan

雑誌

Acta Arachnologica (ISSN:00015202)

巻号頁・発行日

vol.72, no.1, pp.17-21, 2023-06-20 (Released:2023-07-01)

被引用文献数

1

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A new synonymy of coelotine spider is proposed through a comparison of the morphological characteristics and the results of our molecular analysis. Coelotes hachijoensis Ono 2008, described on the basis of specimens from Hachijo Island, is a junior synonym of Coelotes oshimaensis Shimojana 2000. The original distribution of C. oshimaensis is considered to be on Amami-oshima Island and the Tokara Islands in southwestern Japan, far from Hachijo Island. Various circumstantial evidences suggested that C. oshimaensis on Hachijo Island may have been artificially introduced from Amami-oshima Island.

著者

Hideaki Yamamoto Ayumi Hirano-Iwata Shigeo Sato

出版者

The Japan Society of Applied Physics

雑誌

JSAP Review (ISSN:24370061)

巻号頁・発行日

vol.2023, pp.230420, 2023 (Released:2023-07-06)

参考文献数

18

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The structure and function of complex neuronal networks in the brain can be partially reconstituted in vitro by integrating cell culture and microfluidic device technologies. In this report, we review our recent studies on developing microfluidic devices to reconstitute small neuronal networks bearing a modular structure, which is a canonical structure found in the nervous systems of animals. We also describe the process of recording functional activity from the reconstituted neuronal networks. These fundamental technologies offer novel tools for investigating structure–function relationships in living neuronal networks and exploring the physical basis of biological computing in the brain.