著者

Lobna MKAOUAR Yoshifumi ENDO He Xi JUN Soo-Jung LEE Tassanee JAROENSONG Manabu MOCHIZUKI Kazuyuki UCHIDA Hiroyuki NAKAYAMA Nobuo SASAKI Takayuki NAKAGAWA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.6, pp.713-718, 2012 (Released:2012-07-04)

参考文献数

29

被引用文献数

2 5 1

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In this study, the nuclear expression of nuclear factor kappa B (NF-κB) in 48 tissues specimens from 25 canine spontaneous mammary gland tumor (MGT) patients was assessed by immunohistochemistry to compare their levels with clinical features, histological types, prognostic outcomes and proliferative activities, including the mitotic index (MI) and cylcinD1 expression. Twelve of eighteen (66.7%) malignant tumor tissues showed greater than 10% nuclear staining, while benign tumor and hyperplastic tissues showed less than 10% nuclear staining. Higher nuclear expression of NF-κB was positively correlated with larger tumor size, lymph node metastasis and higher MI; however, no correlation was observed with distant metastasis and cyclin D1 expression. Higher NF-κB nuclear expression correlated with shorter patient survival. These findings suggest that NF-κB is a useful prognostic factor for canine MGT patients.

著者

Myowa-Yamakoshi Masako Scola Céline Hirata Satoshi

出版者

Nature Publishing Group

雑誌

Nature Communications

巻号頁・発行日

vol.3, pp.693, 2012-02-21

被引用文献数

55

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ヒト特有の学びのスタイルが明らかに. 京都大学プレスリリース. 2012-02-22.

著者

李 志炯 Lee Jee-Hyung

出版者

筑波大学比較・理論文学会

雑誌

文学研究論集 (ISSN:09158944)

巻号頁・発行日

no.20, pp.166(93)-149(110), 2002-03-31

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はじめに 関東大震災を語る際、最も多く用いられることばは〈未曾有〉である。そのことばは当然そのような出来事の希有さを意味するものであるが、その希有さとは、単に地震そのものや「日本史上最大」といわれる被害規模の大きさのみに向けられるものではない。 ...

著者

Lam Quang TRUONG Jung Taek KIM Byung-Il YOON Moon HER Suk Chan JUNG Tae-Wook HAHN

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.73, no.12, pp.1597-1601, 2011 (Released:2012-01-06)

参考文献数

29

被引用文献数

13 15

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Brucella infections in wildlife originate either from contact with infected livestock or from a natural sustainable reservoir in wildlife populations. As South Korea has set a goal of brucellosis eradication by 2013, it is necessary to determine the prevalence of Brucella in wildlife and wild rodents. This information will play an important role in the control of brucellosis. Because of the absence of prominent clinical signs, direct and indirect laboratory tests are essential for diagnosing brucellosis. In this study, tissue and blood samples were taken from wild animals, abandoned dogs, a cat and wild rodents, and they were tested for Brucella or Brucella-specific antibodies by isolation, PCR and serology. Results showed that 18.6% (33/177) of blood samples were positive by PCR, and 5.7% (11/194) were positive by C-ELISA. However, none of these samples yielded culturable bacteria. Of the tissue samples, 9.7% (8/82) were positive by PCR. Brucella was isolated from only one tissue culture from a Chinese water deer carcass. This Brucella species was identified as Brucella abortus biovar 1 by biotyping, 16S rRNA PCR and the Bruce-ladder PCR assay. In this study, we reported the prevalence of Brucella in wildlife, dogs, a cat and rodents by using serological and molecular methods, and we report the first isolation of B. abortus in wild Chinese water deer in South Korea.

著者

国立国会図書館と大学図書館との連絡会 NDL-ILLに係る文献提供サービスの連携に関するワーキンググループ

出版者

国立国会図書館

巻号頁・発行日

2006-06

著者

Fumio Terasaki Hiroshi Okamoto Katsuya Onishi Akira Sato Hiroaki Shimomura Bin Tsukada Kyoko Imanaka-Yoshida Michiaki Hiroe Toshimichi Yoshida Yasushi Kitaura Akira Kitabatake Study Group for Intractable Diseases by a Grant from the Ministry of Health Labor and Welfare of Japan

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.71, no.3, pp.327-330, 2007 (Released:2007-02-25)

参考文献数

29

被引用文献数

60 72

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Background Tenascin-C (TN-C), an extracellular matrix glycoprotein, is specifically expressed at high levels during embryonic development, but not in the adult heart. TN-C reappears at sites of inflammatory tissue remodeling or wound healing under various pathologic conditions, such as acute myocardial infarction, acute myocarditis, and some cases of cardiomyopathy. Therefore, the expression of TN-C might be useful for detecting the clinical characteristics of, and ventricular remodeling in, dilated cardiomyopathy (DCM). Methods and Results Circulating serum TN-C levels in 107 patients with DCM were measured using an ELISA kit. Clinical data were also assessed by Pearson's or Spearman's correlation analysis to estimate correlations between variables. Serum TN-C levels in DCM patients were higher than those in normal controls (p<0.001). TNC levels showed a significantly positive correlation with New York Heart Association functional class (p<0.001), B-type natriuretic peptide level (p<0.001), cardiothoracic ratio on chest X-ray (p<0.01), left ventricular end-diastolic diameter (p<0.05) and left ventricular end-systolic diameter (p<0.01), and a significantly negative correlation with left ventricular ejection fraction (p<0.01). Conclusions The findings suggest that increased serum TN-C levels indicate the severity of heart failure, left ventricular dysfunction and remodeling in patients with DCM. (Circ J 2007; 71: 327 - 330)

著者

Leroi-Gourhan A. 高橋 壯

出版者

名城大学人文研究会

雑誌

名城大学人文紀要 (ISSN:02878224)

巻号頁・発行日

vol.38, no.1, pp.1-22, 2002-09

著者

椎尾 一郎 浜田 玲子 美馬 のゆり Itiro Siio Reiko Hamada Noyuri Mima お茶の水女子大学理学部情報科学科 東京大学情報理工学系研究科 公立はこだて未来大学システム情報科学部 Department of Information Sciences Ochanomizu University Graduate School of Information Science and Technology The University of Tokyo School of Systems Information Science Future University-Hakodate

出版者

Japan Society for Software Science and Technology

雑誌

コンピュータソフトウェア = Computer software (ISSN:02896540)

巻号頁・発行日

vol.23, no.4, pp.36-46, 2006-10-26

参考文献数

9

被引用文献数

10

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キッチンは生産の場であり,調理を媒介とした教育とコミュニケーションの場でもある.このため,家庭環境の中でも,実用的なユビキタスコンピュータアプリケーションの可能性が高い場所と考えられる.そこで筆者らは,コンピュータ,ネットワーク,センサを組み込んだ未来のキッチン,Kitchen of the Futureを開発している.このコンピュータ強化されたキッチンにより,単に調理の効率を向上させるだけではなく,キッチンを学びとコミュニケーションの場として復活させることができると考えている.本論文では,Kitchen of the Futureを利用して実装した,調理の記録とネットワークでの公開と共有,調理過程の再生,遠隔地キッチンを接続しての調理支援,調理教材の効果的な提示を実現するアプリケーションについて報告する.A kitchen is a place of food production, education, and communication. As it is more active place than other parts of a house, there are lot of potential ubiquitous computing applications in a kitchen. We are developing a computer-augmented kitchen environment: the Kitchen of the Future that embeds various computing elements into a standard kitchen unit. In this paper, we will describe overview of the Kitchen of the Future system and its three applications, i.e, web-ready recipe pages generator, video conference system for cooking instruction, and interactive cooking navigation system.

著者

藤田 雄介 (2023) 藤田 雄介 (2021-2022)

出版者

広島大学

雑誌

特別研究員奨励費

巻号頁・発行日

2023-03-08

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自然界にはながれと関係しているにもかかわらず流線型ではない凹凸形状が観察される.トンボ翼と砂丘はその代表例といえる.それぞれは,流れとの関係において翼性能の向上や,形成維持のメカニズムとの関係が示唆されているが,詳細な研究は不十分である.本研究では流れと凹凸形状の関係に的を絞って理解することを考える.数値計算や実験により,トンボ翼や砂丘の凹凸形状をモデル化した模型周りの流れを解析し,流体力学的に考察する.最終的に,両者の研究を統合し,自然界に見られる流線型でない凹凸形状の普遍的機能やその設計原理を明らかする.

著者

Naoki Kameyama Aiko Murata Junji Watanabe Hsin-Ni Ho

出版者

THE VIRTUAL REALITY SOCIETY OF JAPAN

雑誌

日本バーチャルリアリティ学会論文誌 (ISSN:1344011X)

巻号頁・発行日

vol.28, no.4, pp.321-324, 2023 (Released:2023-12-27)

参考文献数

15

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A haptic device has been developed that enables individuals to feel heartbeat through the sense of touch by converting heartbeat sounds into vibrotactile feedback. We conducted two experiments with this device: the first focused on feeling one’s own heartbeat, and the second on feeling another person’s heartbeat. Our findings indicate that feeling one’s own heartbeat can reduce anxiety and make a person calm, while touching another person’s heartbeat can enhance interpersonal closeness.

著者

Ayako Nishizawa-Yokoi Seiichi Toki

出版者

Japanese Society for Plant Biotechnology

雑誌

Plant Biotechnology (ISSN:13424580)

巻号頁・発行日

pp.23.0525a, (Released:2023-08-28)

参考文献数

52

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Transposons are mobile genetic elements that can move to a different position within a genome or between genomes. They have long been used as a tool for genetic engineering, including transgenesis, insertional mutagenesis, and marker excision, in a variety of organisms. The piggyBac transposon derived from the cabbage looper moth is one of the most promising transposon tools ever identified because piggyBac has the advantage that it can transpose without leaving a footprint at the excised site. Applying the piggyBac transposon to precise genome editing in plants, we have demonstrated efficient and precise piggyBac transposon excision from a transgene locus integrated into the rice genome. Furthermore, introduction of only desired point mutations into the target gene can be achieved by a combination of precise gene modification via homologous recombination-mediated gene targeting with subsequent marker excision from target loci using piggyBac transposition in rice. In addition, we have designed a piggyBac-mediated transgenesis system for the temporary expression of sequence-specific nucleases to eliminate the transgene from the host genome without leaving unnecessary sequences after the successful induction of targeted mutagenesis via sequence-specific nucleases for use in vegetatively propagated plants. In this review, we summarize our previous works and the future prospects of genetic engineering with piggyBac transposon.

著者

Masami Nishino Yasuyuki Egami Shodai Kawanami Masaru Abe Mizuki Ohsuga Hiroaki Nohara Kohei Ukita Akito Kawamura Koji Yasumoto Masaki Tsuda Naotaka Okamoto Yasuharu Matsunaga-Lee Masamichi Yano

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0470, (Released:2023-10-05)

参考文献数

31

被引用文献数

1

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Background: Acute decompensated heart failure (ADHF) is the main cause of hospitalization and death of octogenarians, but no data on the 1-year post-discharge mortality rate. We evaluated the clinical status and predictors of 1-year mortality in octogenarians with ADHF.Methods and Results: From the AURORA (Acute Heart Failure Registry in Osaka Rosai Hospital) study, we examined 1,246 hospitalized ADHF patients. We compared the in-hospital mortality rate and the proportion of heart failure (HF) with preserved ejection fraction (HFpEF) between octogenarians and non-octogenarians. After discharge we compared the 1-year mortality rate between these groups, and we also evaluated the predictors of death in both groups. The proportion of HFpEF among the in-hospital deaths of octogenarians was significantly higher than in non-octogenarians (46.2% vs. 15.0%, P=0.031). The 1-year mortality rate after discharge was significantly higher in the octogenarians than non-octogenarians (P=0.014). Multivariable Cox regression analysis revealed that albumin ≤3.0 g/dL and antiplatelet agents were useful predictors of 1-year death after discharge of octogenarians whereas chronic kidney disease was a predictor in the non-octogenarians.Conclusions: The proportion of HFpEF among in-hospital deaths of octogenarians with ADHF was high as compared with non-octogenarians. When octogenarians with ADHF have severe hypoalbuminemia and antiplatelet agents, early nutritional and medical interventions after discharge may be important to improve the 1-year prognosis.

著者

Wataru Fujimoto Manabu Nagao Makoto Nishimori Masakazu Shinohara Makoto Takemoto Koji Kuroda Soichiro Yamashita Junichi Imanishi Masamichi Iwasaki Takafumi Todoroki Masanori Okuda Hidekazu Tanaka Tatsuro Ishida Ryuji Toh Ken-ichi Hirata

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0577, (Released:2023-11-14)

参考文献数

32

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Background: Diabetes increases the risk of heart failure (HF). 3-Hydroxyisobutyric acid (3-HIB) is a muscle-derived metabolite reflecting systemic insulin resistance. In this study, we investigated the prognostic impact of 3-HIB in patients with chronic HF.Methods and Results: The KUNIUMI Registry chronic cohort is a community-based cohort study of chronic HF in Awaji Island, Japan. We analyzed the association between serum 3-HIB concentrations and adverse cardiovascular (CV) events in 784 patients from this cohort. Serum 3-HIB concentrations were significantly higher in patients with than without diabetes (P=0.0229) and were positively correlated with several metabolic parameters. According to Kaplan-Meier analysis, rates of CV death and HF hospitalization at 2 years were significantly higher among HF patients without diabetes in the high 3-HIB group (3-HIB concentrations above the median; i.e., >11.30 μmol/L) than in the low 3-HIB group (log-rank P=0.0151 and P=0.0344, respectively). Multivariable Cox proportional hazard models adjusted for established risk factors for HF revealed high 3-HIB as an independent predictor of CV death (hazard ratio [HR] 1.82; 95% confidence interval [CI] 1.16–2.85; P=0.009) and HF hospitalization (HR 1.72; 95% CI 1.17–2.53, P=0.006) in HF patients without diabetes, whereas no such trend was seen in subjects with diabetes.Conclusions: In a community cohort, circulating 3-HIB concentrations were associated with prognosis in chronic HF patients without diabetes.

著者

Minori Hikawa-Endo Takao Ikeuchi Shuji Kozai Tomoya Nakamura Masanori Yamaji Ryosuke Yamanaka Hisashi Yoshikoshi Hiroki Kawashima

出版者

The Japanese Society for Horticultural Science

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.QH-106, (Released:2023-12-20)

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In general, either high or low branching may contribute to the yield potential of a cultivated crop. In this study, we evaluated the varietal differences in branching characteristics in asparagus crowns and examined the relationship between branching types and harvest characteristics among six varieties tested by careful observation. ‘UC 157’ developed numerous tillers and shoot apical meristems 6 months after sowing; thus, it was considered to be a high-branching type variety. In contrast, ‘All-male Gulliver’ and ‘Ryuryoku’ developed few tillers or shoot apical meristems and, were therefore considered to be low-branching type varieties. The final order of sympodial shoots and composition of sympodial shoots by order were similar between the varieties. ‘UC 157’ had fewer scale leaves attached to the underground shoots than other varieties, which may have been advantageous for developing underground shoots more rapidly. The total spear yield of ‘UC 157’ was high, but the marketable spear yield was similar to that of other varieties owing to the large number of thin spears. Although further studies are needed to determine whether high-branching or low-branching type asparagus varieties are more high-yielding, we determined that high-branching type varieties have lower labor productivity under unimproved growing conditions such as non-sparsely planted growing conditions.

著者

Yusei Nishikawa Hiroyuki Takaoka Masato Kanda Sae Yumita Sadahisa Ogasawara Michiko Daimon Yoshitada Noguchi Shuhei Aoki Katsuya Suzuki Kazuki Yoshida Satomi Yashima Makiko Kinoshita Haruka Sasaki Noriko Suzuki-Eguchi Naoya Kato Yoshio Kobayashi

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0823, (Released:2023-12-20)

参考文献数

1

著者

Seok Young Lee Jun-Hyung Ryu In-Beum Lee

出版者

The Society of Chemical Engineers, Japan

雑誌

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN (ISSN:00219592)

巻号頁・発行日

vol.55, no.1, pp.51-60, 2022-01-20 (Released:2022-01-20)

参考文献数

34

被引用文献数

1

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This study used process simulation to assess the overall economic feasibility of a hydrogen energy system involving a power-to-ammonia process as a transportation energy source. While the relevant individual processes for the overall energy system have already been used in the chemical industry, it is financially important to approach them in a holistic simulation framework. According to the proposed simulation, the ammonia and hydrogen production costs were 288.3 &#36;/t and 5.43–6.13 &#36;/kg, respectively. The results could motivate further studies on accelerating the implementation of renewable energy systems to mitigate climate change.

著者

Takeo Horikoshi Takamitsu Nakamura Toru Yoshizaki Jun Nakamura Manabu Uematsu Tsuyoshi Kobayashi Yukio Saito Jun-ei Obata Takao Sawanobori Hajime Takano Ken Umetani Tetsuya Asakawa Akira Sato

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0733, (Released:2023-12-15)

参考文献数

22

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Background: Non-ST-elevation myocardial infarction (NSTEMI) carries a poor prognosis, and accurately prognostication has significant clinical importance. In this study, we analyzed the predictive value of the CHADS2, CHA2DS2-VASc, and R2-CHADS2scores for major adverse cardiac events (MACE) following percutaneous coronary intervention (PCI) in patients with NSTEMI using data from a prospective multicenter registry.Methods and Results: The registry included 440 consecutive patients with NSTEMI and coronary artery disease who underwent successful PCI. Patients were clinically followed for up to 3 years or until the occurrence of MACE. MACE was defined as a composite of all-cause death and nonfatal MI. During the follow-up period, 55 patients (12.5%) experienced MACE. Risk analysis of MACE occurrence, adjusted for the multivariable model, demonstrated a significant increase in risk with higher CHADS2, CHA2DS2-VASc, and R2-CHADS2scores. Kaplan-Meier analysis showed a higher incidence of MACE in patients with higher CHADS2, CHA2DS2-VASc, and R2-CHADS2scores, both in the short- and long-term periods.Conclusions: Patients with NSTEMI and higher CHADS2, CHA2DS2-VASc, and R2-CHADS2scores displayed a greater incidence of MACE.

著者

Tatsuhito II James K CHAMBERS Ko NAKASHIMA Yuko GOTO-KOSHINO Kazuyuki UCHIDA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.23-0339, (Released:2023-12-08)

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Our previous study indicated that cytotoxicity of intraepithelial lymphocytes is a poor prognostic factor in feline intestinal T-cell lymphoma (FITL), but the effect of cytotoxic lymphocytes on mucosal epithelium is still unknown. Thus, we investigated the association between cytotoxic lymphocytes and mucosal epithelium in 71 cases of feline intestinal T-cell lymphoma (FITL): epithelial injury, basement membrane injury, cleaved-caspase-3 positivity of epithelial cells, and the number and Ki67 positivity of intraepithelial lymphocytes in granzyme B (GRB)+ and GRB- FITLs were evaluated. Epithelial injury score and the number of intraepithelial lymphocytes in granzyme B (GRB)+ FITL were significantly higher than those of GRB- FITL (P<0.05, P<0.05), but no significant differences were found in the basement membrane injury score, the percentage of cleaved-caspase-3+ epithelial cells, and the percentage of Ki67+ intraepithelial lymphocytes. There was a significant correlation between the epithelial injury score and the number of intraepithelial lymphocytes (P<0.05), but no significant correlation was observed between the epithelial injury score and Ki67+ percentage of intraepithelial lymphocytes. Because epithelial cell cleaved-caspase-3 positivity was observed in FITL, regardless of GRB expression in lymphocytes, GRB-mediated apoptosis may not contribute to epithelial injury in FITL. The association between increased number of intraepithelial lymphocytes and epithelial injury suggests that intraepithelial lymphocytes infiltration may contribute to epithelial injury in FITL.

著者

Yuki G. Baba Suguru Ohno Ukuda-Hosokawa Rie Akio Tanikawa

出版者

Arachnological Society of Japan

雑誌

Acta Arachnologica (ISSN:00015202)

巻号頁・発行日

vol.66, no.1, pp.17-18, 2017-08-31 (Released:2017-09-11)

参考文献数

14

被引用文献数

1

著者

Toshiro Kitagawa Takayuki Hidaka Makiko Naka Susumu Nakayama Kanako Yuge Mitsuaki Isobe Yasuki Kihara for the REAL-HF Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.2, no.4, pp.226-234, 2020-04-10 (Released:2020-04-10)

参考文献数

23

被引用文献数

8 7

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Background:We investigated the current medical and social conditions and outcomes of heart failure (HF) patients in Hiroshima Prefecture, a local district in Japan.Methods and Results:From March 2017 to February 2018 we enrolled all adult patients with hospitalized HF in 8 regional core hospitals that provided an interprofessional team approach for HF patients. We collected patients’ clinical characteristics and information regarding living circumstances, cognitive function, quality of life, and interprofessional team approach. For patients discharged home, we followed up the primary endpoint (all-cause death and all-cause unscheduled readmission), conditions of outpatient cardiac rehabilitation, and home nursing-care services over a 1-year period after discharge. Of the registered patients (n=1,218), 39.2% were super-elderly (≥85 years old); more than half of these patients had preserved ejection fraction (≥50%). In the follow-up cohort (n=632), 140 patients (22.2%) were readmitted with HF exacerbation as the primary endpoint, and almost half (n=295, 46.7%) experienced any primary endpoint. The multivariate analysis adjusted for medical and social factors showed that completion of outpatient cardiac rehabilitation (5-month program) remained a strong negative predictor of the primary endpoint (hazard ratio: 0.15; 95% confidence interval: 0.05–0.48; P=0.0013).Conclusions:Our cohort study highlighted the super-aging of current HF patients in Japan. Cardiac rehabilitation through continuous team approach appears to be associated with favorable overall outcomes in this population.