著者
Kensuke NAKAJIMA Eizi TOYODA Masaki ISHIWATARI Shin-ichi TAKEHIRO Yoshi-Yuki HAYASHI
出版者
(公社)日本気象学会
雑誌
気象集誌. 第2輯 (ISSN:00261165)
巻号頁・発行日
vol.82, no.6, pp.1483-1504, 2004 (Released:2005-03-02)
参考文献数
23
被引用文献数
6 9 7

For the purpose of examining the initial development of the atmospheric response to a warm SST anomaly placed at the equator, an ensemble switch-on experiment is conducted with an aqua-planet GCM. An ensemble average of the size of 128 significantly reduces the transient noises caused by both small scale convective activity and large scale intraseasonal variability.In the first three days after the switch-on of the SST anomaly, a convection center develops above the warm SST area. As a barotropic response to the heating of convection center, a global increase of surface pressure occurs outside the low pressure region around the warm SST area. The response after the emergence of the high pressure anomaly is consistent with Gill (1980); a warm Kelvin wave-like anomaly is emitted to the east of the convection center, while a warm Rossby wave-like anomaly is emitted to the west.The Kelvin wave-like signal propagates at a speed slower than that of free Kelvin wave expected from its vertical wavelength, suggesting that the signal is a “moist” Kelvin wave. Transient decrease of precipitation occurs at the moist Kelvin wave front; a decrease of convection associated with the downward motion at the wave front is consistent with its slow propagation. After several days, precipitation recovers and is even intensified because of the surface frictional convergence associated with the Kelvin wave-like equatorial low pressure anomaly. To the west of the warm SST area, on the other hand, precipitation decreases monotonically. The continuous reduction of precipitation is caused by the equatorial surface frictional divergence associated with the relatively high pressure anomaly at the equator of the Rossby wave structure.Finally, there appears a slow zonally symmetric response within the Hadley cell characterized with surface pressure rise in the tropics and westerly wind anomaly in the troposphere. The change of eddy zonal momentum transport, together with the transport toward the lower level by the Hadley circulation and the geostrophic adjustment to the resulting low level westerly acceleration, seems to be responsible for the response.
著者
Jun-ichi Shiraishi Daichi Ijiri Ayumi Katafuchi Shozo Tomonaga Saki Shimamoto Hanwool Do Shinya Ishihara Akira Ohtsuka
出版者
Japan Poultry Science Association
雑誌
The Journal of Poultry Science (ISSN:13467395)
巻号頁・発行日
vol.60, no.2, pp.2023017, 2023 (Released:2023-07-22)
参考文献数
28
被引用文献数
1

The concentration of Nτ-methylhistidine in plasma provides an index of skeletal muscle protein breakdown. This study aimed to establish a quantitative method for measuring the concentrations of Nτ-methylhistidine and its isomer Nπ-methylhistidine in chicken plasma, using liquid chromatography–tandem mass spectrometry with stable isotope dilution analysis. The acceptable linear ranges of detection were 1.56–50.00 μmol/L for Nτ-methylhistidine and 0.78–25.00 μmol/L for Nπ-methylhistidine. The proposed method detected changes in the plasma levels of Nτ-methylhistidine and Nπ-methylhistidine in response to fasting and re-feeding. These results suggest that the method developed in this study can be used for the simultaneous measurement of Nτ-methylhistidine and Nπ-methylhistidine in chicken plasma.
著者
Kentaro Saito Nopphon Keerativoranan Jun-ichi Takada
出版者
The Institute of Electronics, Information and Communication Engineers
雑誌
IEICE Communications Express (ISSN:21870136)
巻号頁・発行日
vol.12, no.7, pp.379-384, 2023-07-01 (Released:2023-07-01)
参考文献数
3

Recently, the cyber-physical-system (CPS) has attracted great interest in the information and communications technology (ICT) research field for the virtual test of wireless communication systems. Since the performance of wireless communication significantly depends on the radio propagation channel characteristics, the development of accurate radio propagation simulation technology becomes essential for the purpose. This paper proposed the scenario-specific radio propagation simulation method from LiDAR point cloud data. By the continuous environment measurement by LiDAR, the positions of dynamic objects like pedestrians are tracked, as well as the site-specific propagation environment characteristics and their influences are taken into the simulation. For performance evaluation, the radio propagation measurement was conducted in the 28GHz band in an indoor office. The result showed a significant improvement in the RMSE of received power prediction. The proposed method will be utilized for the radio channel emulation in the CPS.
著者
JIRIGALA 大西 健夫 千家 正照 SAMDAN Shiirev-Adiya
出版者
公益社団法人 農業農村工学会
雑誌
農業農村工学会論文集 (ISSN:18822789)
巻号頁・発行日
vol.81, no.1, pp.33-40, 2013-02-25 (Released:2014-02-25)
参考文献数
27

モンゴル国では,ゾドと呼ばれる家畜の大量死につながる寒候季の寒雪害が頻繁に発生し,遊牧に甚大な影響を与えている.ゾド発生の有無は,気象要因と人的要因とが複合して決まるため,両要因を峻別することはゾド被害軽減策のために極めて重要である.本研究では,モンゴル国東部のドルノド県を対象にして気象条件とゾド被害発生との関係を分析した.その結果,冬季多雪条件下で降雪量と斃死率との相関が明瞭になり,夏季少雨および冬季低温の条件が重なると,さらに傾向が顕著となることが明らかになった.他方,夏季少雨,冬季低温,冬季少雪の単独条件下では,気象条件と斃死率との間には明瞭な相関関係が見られなかった.以上より,冬季多雪が要因と言われるツァガン・ゾド(寒雪被害)は気象条件を規定要因とみなすことができ,その他のガン・ゾド(干ばつ被害),ハラ・ゾド(無降雪被害),フィテン・ゾド(寒冷被害)は気象要因のみが決定要因ではないことが示唆された.
著者
Julien Ternacle Romain Gallet Armand Mekontso-Dessap Guy Meyer Bernard Maitre Alexandre Bensaid Priscille Jurzak Pascal Gueret Jean-Luc Dubois Randé Pascal Lim
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-13-0404, (Released:2013-07-13)
参考文献数
22
被引用文献数
16 19

Background: The benefit of load expansion is controversial in acute pulmonary embolism (PE). The aim of this study was to evaluate the benefit of furosemide in cases of normotensive acute PE. Methods and Results: We retrospectively included 70 consecutive normotensive patients (systolic blood pressure ≥90mmHg) admitted for acute PE with right ventricular dilation. Overall, 40 patients were treated during the first 24h by repeated bolus of furosemide (78±42mg, range 40–160mg) and 30 patients received isotonic saline solution (1.6±0.9L). Severity of hemodynamic status was similar in both groups, but patients in the furosemide group were older and had a greater creatinine level. At 24h, only the furosemide group had a decreased shock index (0.82±0.22 vs. 0.63±0.16, P<0.0001) with improved systolic blood pressure (118±18 vs. 133±17mmHg, P<0.0001), and creatinine levels. After treatment, there were fewer patients with simplified pulmonary embolism severity index ≥1 in the diuretic group (45% vs. 55%, P=0.03) than in the fluid expansion group (47% vs. 40%, P<0.0001). Finally, oxygen requirement at 24h decreased only in the diuretic group (75% to 47%, P=0.0004), and in-hospital survival without death and PE-related shock were similar between the 2 groups. Conclusions: In normotensive PE with RV dilatation, diuretics may improve hemodynamics and oxygenation requirement.
著者
Thi Khanh Van MAI KIM Doo-Chul
出版者
The Association of Japanese Geographers
雑誌
Geographical review of Japan series B (ISSN:18834396)
巻号頁・発行日
vol.93, no.1, pp.1-10, 2020-11-30 (Released:2020-12-08)
参考文献数
22
被引用文献数
2 2

Phong Nha-Kẻ Bàng National Park (PNKB NP) is a world heritage site in Vietnam, where ecosystem conservation is accompanied by government policies intended to improve local livelihoods. Currently, two policies have been implemented: the tourism development and payments for forest environmental services (PFES) programs. This study employs both semi-structured and in-depth interviews to analyze the relationships between tourism development, ethnic differences, and the PFES in the PNKB NP area. The results are as follows. The PNKB NP has devoted much time to the tourism development policy, with some success. However, disparities in implementation have meant that central areas, such as Xuan Tien Village, have benefited significantly from tourism revenue, whereas remote areas, such as Rao Con village have not yet had the opportunity to participate in income-generating tourism activities. As a result, the gap between the livelihoods of the two villages has widened, exacerbated by inappropriate distributions of the financial budget (the Phong Nha fee). Moreover, the lack of participation in the policy by local residents has meant the PFES has had little effect on their livelihoods. Thus, although the aforementioned policies were expected to improve local livelihoods, this has not occurred, because the PFES mechanism does not sufficiently consider those living in the area.
著者
Toyonobu Tsuda Takeshi Kato Keisuke Usuda Takashi Kusayama Soichiro Usui Kenji Sakata Kenshi Hayashi Masa-aki Kawashiri Masakazu Yamagishi Masayuki Takamura Takayuki Otsuka Shinya Suzuki Akio Hirata Masato Murakami Mitsuru Takami Masaomi Kimura Hidehira Fukaya Shiro Nakahara Wataru Shimizu Yu-ki Iwasaki Hiroshi Hayashi Tomoo Harada Ikutaro Nakajima Ken Okumura Junjiroh Koyama Michifumi Tokuda Teiichi Yamane Yukihiko Momiyama Kojiro Tanimoto Kyoko Soejima Noriko Nonoguchi Koichiro Ejima Nobuhisa Hagiwara Masahide Harada Kazumasa Sonoda Masaru Inoue Koji Kumagai Hidemori Hayashi Kazuhiro Satomi Yoshinao Yazaki Yuji Watari Masaru Arai Ryuta Watanabe Katsuaki Yokoyama Naoya Matsumoto Koichi Nagashima Yasuo Okumura on behalf of the AF Ablation Frontier Registry and the Hokuriku-Plus AF Registry Investigators
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.87, no.7, pp.939-946, 2023-06-23 (Released:2023-06-23)
参考文献数
36
被引用文献数
5

Background: A recent randomized trial demonstrated that catheter ablation for atrial fibrillation (AF) in patients with heart failure with reduced ejection fraction (EF) is associated with a reduction in death or heart failure. However, the effect of catheter ablation for AF in patients with heart failure with mid-range or preserved EF is unclear.Methods and Results: We screened 899 AF patients (72.4% male, mean age 68.4 years) with heart failure and left ventricular EF ≥40% from 2 Japanese multicenter AF registries: the Atrial Fibrillation registry to Follow the long-teRm Outcomes and use of aNTIcoagulants aftER Ablation (AF Frontier Ablation Registry) as the ablation group (525 patients who underwent ablation) and the Hokuriku-Plus AF Registry as the medical therapy group (374 patients who did not undergo ablation). Propensity score matching was performed in these 2 registries to yield 106 matched patient pairs. The primary endpoint was a composite of cardiovascular death and hospitalization for heart failure. At 24.6 months, the ablation group had a significantly lower incidence of the primary endpoint (hazard ratio 0.32; 95% confidence interval 0.13–0.70; P=0.004) than the medical therapy group.Conclusions: Compared with medical therapy, catheter ablation for AF in patients with heart failure and mid-range or preserved EF was associated with a significantly lower incidence of cardiovascular death or hospitalization for heart failure.
著者
Satoru Takahashi Chieko Saito Ikuko Koyama-Honda Noboru Mizushima
出版者
Japan Society for Cell Biology
雑誌
Cell Structure and Function (ISSN:03867196)
巻号頁・発行日
vol.47, no.2, pp.89-99, 2022 (Released:2022-12-22)
参考文献数
48
被引用文献数
17

In macroautophagy, disk-shaped double-membrane structures called phagophores elongate to form cup-shaped structures, becoming autophagosomes upon closure. These autophagosomes then fuse with lysosomes to become autolysosomes and degrade engulfed material. Autophagosome formation is reported to involve other organelles, including the endoplasmic reticulum (ER) and mitochondria. Organelles are also taken up by autophagosomes as autophagy cargos. However, few studies have performed systematic spatiotemporal analysis of inter-organelle relationships during macroautophagy. Here, we investigated the organelles in contact with phagophores, autophagosomes, and autolysosomes by using three-dimensional correlative light and electron microscopy with array tomography in cells starved 30 min. As previously reported, all phagophores associate with the ER. The surface area of phagophores in contact with the ER decreases gradually as they mature into autophagosomes and autolysosomes. However, the ER still associates with 92% of autophagosomes and 79% of autolysosomes, suggesting that most autophagosomes remain on the ER after closure and even when they fuse with lysosomes. In addition, we found that phagophores form frequently near other autophagic structures, suggesting the presence of potential hot spots for autophagosome formation. We also analyzed the contents of phagophores and autophagosomes and found that the ER is the most frequently engulfed organelle (detected in 65% of total phagophores and autophagosomes). These quantitative three-dimensional ultrastructural data provide insights into autophagosome–organelle relationships during macroautophagy.Key words: 3D-CLEM, autophagosome, electron microscopy, endoplasmic reticulum, lysosome
著者
Kunihiko Komatsu Takashi Sayama Ken-ichiro Yamashita Yoshitake Takada
出版者
Japanese Society of Breeding
雑誌
Breeding Science (ISSN:13447610)
巻号頁・発行日
pp.22098, (Released:2023-06-28)

To avoid crop failure because of climate change, soybean (Glycine max (L.) Merrill) cultivars adaptable to early planting are required in western Japan. Because current Japanese cultivars may not be adaptable, ge‍netic resources with high early-planting adaptability, and their genetic information must be developed. In the present study, summer type (ST) soybeans developed for early planting were used as plant materials. We examined their phenological characteristics and short reproductive period as an indicator of early planting adaptability and performed genetic studies. Biparental quantitative trait loci (QTL) analysis of a representative ST cultivar revealed a principal QTL for the reproductive period duration on chromosome 11. The results of resequencing analysis suggested that circadian clock-related Tof11 (soybean orthologue of PRR3) is a can‍didate QTL. Additionally, all 25 early planting-adaptable germplasms evaluated in this study possessed mutant alleles in Tof11, whereas 15 conventional cultivars only had wild-type alleles. These results suggest that mutant alleles in Tof11 are important genetic factors in the high adaptability to early planting of these soybeans, and thus, these alleles were acquired and accumulated in the ST soybean population.
著者
Yuki Sudo Hiroyuki Terashima Rei Abe-Yoshizumi Seiji Kojima Michio Homma
出版者
The Biophysical Society of Japan
雑誌
BIOPHYSICS (ISSN:13492942)
巻号頁・発行日
vol.5, pp.45-52, 2009 (Released:2009-06-12)
参考文献数
25
被引用文献数
18 22

Flagellar motor proteins, MotA/B and PomA/B, are essential for the motility of Escherichia coli and Vibrio alginolyticus, respectively. Those complexes work as a H+ and a Na+ channel, respectively and play important roles in torque generation as the stators of the flagellar motors. Although Asp32 of MotB and Asp24 of PomB are believed to function as ion binding site(s), the ion flux pathway from the periplasm to the cytoplasm is still unclear. Conserved residues, Ala39 of MotB and Cys31 of PomB, are located on the same sides as Asp32 of MotB and Asp24 of PomB, respectively, in a helical wheel diagram. In this study, a series of mutations were introduced into the Ala39 residue of MotB and the Cys31 residue of PomB. The motility of mutant cells were markedly decreased as the volume of the side chain increased. The loss of function due to the MotB(A39V) and PomB(L28A/C31A) mutations was suppressed by mutations of MotA(M206S) and PomA(L183F), respectively, and the increase in the volume caused by the MotB(A39V) mutation was close to the decrease in the volume caused by the MotA(M206S) mutation. These results demonstrate that Ala39 of MotB and Cys31 of PomB form part of the ion flux pathway and pore with Met206 of MotA and Leu183 of PomA in the MotA/B and PomA/B stator units, respectively.
著者
Kohsyo Yamauchi Noboru Manabe Yoshiki Matsumoto Koh-en Yamauchi
出版者
Japan Poultry Science Association
雑誌
The Journal of Poultry Science (ISSN:13467395)
巻号頁・発行日
vol.51, no.3, pp.327-332, 2014-07-25 (Released:2014-07-25)
参考文献数
19
被引用文献数
7 7

Effects of wood vinegar (WV) on red mites, safety test for chicks, and egg production performance were examined. In the counting of red mite numbers at cage knots using RGB color range of red mites by the image analyzer, the red mite were decreased after spraying (P<0.01). In a WV safety test for 8-day-old chicks, one ml of water, original WV, or WV diluted 500 and 1,000 times were tube-fed twice daily for 6 days. The rate of body weight gain was decreased in original WV group than that in the control (P<0.05), but it was not different in both WV dilution groups compared with that in the water-only group. In spraying one ml WV to the hen’s face twice per day for 8 days, the egg production performances of WV group did not changed so much compared with those of the control and initial day. These results suggest that the WV did not reduced production performance.From these results, WV could exterminate red mites, and did not reduce egg production, suggesting that WV is a useful natural substance to exterminate red mites without harmful effect.
著者
Jazmín Pérez-Pazos Amparo Rosero Enrique Vergara Rocío Gámez
出版者
The Japanese Society for Horticultural Science
雑誌
The Horticulture Journal (ISSN:21890102)
巻号頁・発行日
pp.QH-017, (Released:2023-06-20)

The sweet potato is a highly important crop in terms of food security worldwide, its nutraceutical properties have increased demand, generating new market opportunities. The availability of disease-free planting material ensures success in establishing this crop, achieving higher yield and better quality. This study aimed to improve the production system of high-quality planting material in greenhouse conditions through the evaluation of three mixtures of substrates based on peat, vermicompost, rice husk, and coconut substrate in different proportions; the best treatment was subsequently evaluated in the acclimatization process of in vitro plants. The substrates were characterized physicochemically and their effect on growth parameters in sweet potato seedlings was determined. For the acclimatization process of in vitro plants, the best mixture of substrates and a humid chamber during the first eight days of growth was compared to the conventional technique. A substrate composed of peat, vermicompost, and rice husk (3:1:1) resulted in the best seedling development. The proposed in vitro plant acclimatization strategy produced seedlings with good growth, high survival rates (92%), and a good multiplication rate (3.53) compared to the conventional strategy (peat without a humid chamber). The use of an optimal substrate and the incorporation of a humid chamber during the first days of growth guaranteed adequate ranges of temperature and relative humidity that kept the vapor pressure deficit of the leaves below critical levels (< 1.2 kPa). Increased efficiency in the production of high-quality planting material with carefully controlled phytosanitary conditions can make an important contribution to improving global disease management strategies in sweet potato cultivation.
著者
Yuka Inada Naomi Oyama-Okubo Masumi Yamagishi
出版者
The Japanese Society for Horticultural Science
雑誌
The Horticulture Journal (ISSN:21890102)
巻号頁・発行日
pp.QH-066, (Released:2023-06-10)

Although a strong floral scent is typical of hybrid lilies, Asiatic hybrid lilies (Lilium spp.) have only a weak scent. Therefore, developing new cultivars with pleasant floral scents is an important objective in Asiatic hybrid lily breeding programs. Among the wild species contributing to Asiatic hybrid lily establishment, L. cernuum has a characteristic scent that the nose can perceive. We crossed Asiatic hybrid lily cultivars twice with L. cernuum to introduce floral scent traits into Asiatic hybrid lilies, and scent emission in the F1 plants and their progeny lines was evaluated instrumentally. Flowers of L. cernuum emitted benzenoids/phenylpropanoids (mainly 2-phenylethanol and benzaldehyde), monoterpenes (predominantly linalool and linalool oxides), and a fatty acid (iso-valeric acid). Lilium cernuum gave off unpleasant odors mainly because of iso-valeric acid emission. The F1 flowers also emitted these three chemical classes. Among the lines derived from the crosses between Asiatic hybrid lily cultivars and the F1 plant, lines that emitted all three chemical classes and lines that released one or two of the three chemical classes were segregated, and some lines emitted benzenoids/phenylpropanoids or terpenoids without emitting fatty acids. We successfully selected elite breeding lines that predominantly emitted pleasant scents. Therefore, this study demonstrated the introduction of pleasant scent production capability into Asiatic hybrid lilies using interspecific hybridization with L. cernuum.
著者
You-Chiun WANG Yi-No YAO
出版者
The Institute of Electronics, Information and Communication Engineers
雑誌
IEICE TRANSACTIONS on Information and Systems (ISSN:09168532)
巻号頁・発行日
vol.E106-D, no.6, pp.1155-1164, 2023-06-01

Many countries are facing the aging problem caused by the growth of the elderly population. Nursing home (NH) is a common solution to long-term care for the elderly. This paper develops a simulator to model elder behavior in an NH, which considers public areas where elders interact and imitates their general, group, and special activities. Elders have their preferences to decide activities taken by them. The simulator takes account of the movement of elders and abnormal events. Based on the simulator, two seeking methods are proposed for caregivers to search lost elders efficiently, which helps them fast find out elders who may incur accidents.
著者
Silvano Gallus Alessandra Lugo Chiara Stival Sonia Cerrai Luke Clancy Filippos T. Filippidis Giuseppe Gorini Maria José Lopez Ángel López-Nicolás Sabrina Molinaro Anna Odone Joan B. Soriano Olena Tigova Piet A. van den Brandt Constantine I. Vardavas Esteve Fernandez the TackSHS Project Investigators
出版者
Japan Epidemiological Association
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
vol.33, no.6, pp.276-284, 2023-06-05 (Released:2023-06-05)
参考文献数
44
被引用文献数
3

Background: Limited data on electronic cigarette prevalence, patterns, and settings of use are available from several European countries.Methods: Within the TackSHS project, a face-to-face survey was conducted in 2017–2018 in 12 European countries (Bulgaria, England, France, Germany, Greece, Ireland, Italy, Latvia, Poland, Portugal, Romania and Spain). Overall, 11,876 participants, representative of the population aged ⩾15 years in each country, provided information on electronic cigarette.Results: 2.4% (95% confidence interval [CI], 2.2–2.7%) of the subjects (2.5% among men and 2.4% among women; 0.4% among never, 4.4% among current- and 6.5% among ex-smokers) reported current use of electronic cigarette, ranging from 0.6% in Spain to 7.2% in England. Of the 272 electronic cigarette users, 52.6% were dual users (ie, users of both electronic and conventional cigarettes) and 58.8% used liquids with nicotine. In all, 65.1% reported using electronic cigarette in at least one indoor setting where smoking is forbidden; in particular, at workplaces (34.9%) and bars and restaurants (41.5%). Multivariable logistic regression analysis showed that electronic cigarette use was lower among older individuals (P for trend <0.001) and higher among individuals with high level of education (P for trend = 0.040). Participants from countries with higher tobacco cigarette prices more frequently reported electronic cigarette use (odds ratio 3.62; 95% CI, 1.80–7.30).Conclusion: Considering the whole adult population of these 12 European countries, more than 8.3 million people use electronic cigarettes. The majority of users also smoked conventional cigarettes, used electronic cigarettes with nicotine, and consumed electronic cigarettes in smoke-free indoor areas.
著者
Won-Kyung Lee Hye-Ah Lee Seung-sik Hwang Ho Kim Youn-Hee Lim Yun-Chul Hong Eun-Hee Ha Hyesook Park
出版者
Japan Epidemiological Association
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
vol.25, no.8, pp.544-552, 2015-08-05 (Released:2015-08-05)
参考文献数
38
被引用文献数
17 19

Background: There are few data on the interaction between temperature and snow and rain precipitation, although they could interact in their effects on road traffic injuries.Methods: The integrated database of the Korea Road Traffic Authority was used to calculate the daily frequency of road traffic injuries in Seoul. Weather data included rain and snow precipitation, temperature, pressure, and fog from May 2007 to December 2011. Precipitation of rain and snow were divided into nine and six temperature range categories, respectively. The interactive effects of temperature and rain and snow precipitation on road traffic injuries were analyzed using a generalized additive model with a Poisson distribution.Results: The risk of road traffic injuries during snow increased when the temperature was below freezing. Road traffic injuries increased by 6.6% when it was snowing and above 0°C, whereas they increased by 15% when it was snowing and at or below 0°C. In terms of heavy rain precipitation, moderate temperatures were related to an increased prevalence of injuries. When the temperature was 0–20°C, we found a 12% increase in road traffic injuries, whereas it increased by 8.5% and 6.8% when it was <0°C and >20°C, respectively. The interactive effect was consistent across the traffic accident subtypes.Conclusions: The effect of adverse weather conditions on road traffic injuries differed depending on the temperature. More road traffic injuries were related to rain precipitation when the temperature was moderate and to snow when it was below freezing.
著者
Hayato Tada Mika Hori Kota Matsuki Masatsune Ogura Atsushi Nohara Masa-aki Kawashiri Mariko Harada-Shiba
出版者
Japan Atherosclerosis Society
雑誌
Journal of Atherosclerosis and Thrombosis (ISSN:13403478)
巻号頁・発行日
pp.62869, (Released:2021-07-01)
参考文献数
25
被引用文献数
5 18

Aim: The 2017 Japan Atherosclerosis Society (JAS) familial hypercholesterolemia (FH) criteria adopt a cut-off value of ≥ 9 mm of Achilles tendon thickness (ATT) detected by X-ray as one of the three key items. This threshold was determined based on an old data evaluating the ATT of 36 non-FH individuals that was published in 1977. Although the specificity of these clinical criteria is extremely high due to a strict threshold, there are a significant number of patients with FH whose ATT <9 mm. We aimed to determine a cut-off value of ATT detected by X-ray to differentiate FH and non-FH based on genetic diagnosis. Methods: The individuals (male/female=486/501) with full assessments of genetic analyses for FH-genes (LDLR and PCSK9), serum lipids, and ATT detected by X-ray at the Kanazawa University Hospital and National Cerebral and Cardiovascular Center Research Institute were included in this study. Receiver operating characteristic (ROC) analyses were conducted to determine a better cut-off value of ATT that predicts the pathogenic mutation of FH. Results: The ROC analyses revealed that the best cut-off values of ATT are 7.6 mm for male and 7.0 mm for female, with the sensitivities/specificities of 0.83/0.83 for male and 0.86/0.85 for female, respectively. If the thresholds of ATT of 8.0/7.5 mm and 7.5/7.0 mm were applied to the diagnosis of male/female FH, the sensitivities/specificities predicting the pathogenic mutation of FH by the 2017 JAS FH clinical criteria would be 0.82/0.90 and 0.85/0.88, respectively. Conclusions: These results suggest that the cut-off value of ATT detected by X-ray is obviously lower than 9.0 mm, which was adopted by the 2017 JAS FH clinical criteria.
著者
NOBORU ADACHI HIDEAKI KANZAWA-KIRIYAMA TAKASHI NARA TSUNEO KAKUDA IWAO NISHIDA KEN-ICHI SHINODA
出版者
The Anthropological Society of Nippon
雑誌
Anthropological Science (ISSN:09187960)
巻号頁・発行日
vol.129, no.1, pp.13-22, 2021 (Released:2021-04-27)
参考文献数
42
被引用文献数
1 7

Starting 16000 years ago, the Neolithic lifestyle known as the Jomon culture spread across the Japanese archipelago. Although extensively studied by archaeology and physical anthropology, little is known about the genetic characteristics of the Jomon people. Here, we report the entire mitogenome and partial nuclear genome of skeletal remains from the initial Jomon period that were excavated from the Higashimyo shell midden site at Saga City, Kyushu Island, Japan. This is the first genome analysis of the initial Jomon people of Kyushu Island. These results provide important data for understanding the temporal transition and regional differences of the Jomon people. The mitochondrial DNA and Y-chromosome haplogroups were similar to those found in the previously reported later Jomon people. Moreover, comparison of three nuclear genomes from the initial to final Jomon periods indicated genetic continuity throughout the Jomon period within the Japanese archipelago with no significant evidence of admixture. This indicates that the genetic differentiation found among the Jomon people was promoted by the progression of regionalization throughout the Jomon period. Further accumulation of high-quality Jomon genome data spanning a wide range of regions and ages will clarify both intimate regional and temporal differences of the Jomon people and details of their admixture history with rice farmers, as suggested by Jomon mitochondrial genome data. The results obtained from this study provide important information for further analysis.