著者

Jeong-Woo Lee Ji-Sun Kang Soo-Ji Park Se-Won Yoon Seong-Kwan Jeong Myoung Heo

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.25, no.11, pp.1451-1454, 2013 (Released:2013-12-11)

参考文献数

18

被引用文献数

1 7

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[Purpose] This study examined the effect of the distance between the two electrodes on delayed onset muscle soreness during microcurrent therapy. [Methods] In this study 24 healthy women who hadn’t exercised regularly for six months were selected and randomly divided into two groups. Delayed onset muscle soreness (DOMS) was induced and experimental Group 1 were given microcurrent treatment with the electrodes attached at a close distance evaluated. Experimental Group 2 received the same treatment with the electrodes attached at a greater distance apart. Visual analogue scale pain and the RIII reflex were evaluated after inducing DOMS and after one day, two days, three days and four days of microcurrent treatment. [Results] The visual analogue scale and amplitude of RIII amplitude only showed significant differences with the length of time of the treatment. [Conclusion] This study found that difference of interelectrode distance has no influence on VAS pain and the RIII reflex of DOMS. Although there were no significant differences in RIII amplitude, we suspect that it may be influenced by current parameters such as frequency and intensity.

著者

藤沼祥成 横野光 PascualMartinez-gomez 相澤彰子

雑誌

研究報告自然言語処理(NL)

巻号頁・発行日

vol.2014-NL-216, no.3, pp.1-8, 2014-05-15

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あるイベントの盛り上がりに対して,それに関するツイートにも変化が現れその変化に着目することで盛り上がりを検出することが可能であると考えられる.本研究ではこの盛り上がり時間帯中のツイートに用いられている表現の特性を解析することを試みる.はじめに各時間帯のツイート集合とツイートより構築した言語モデルの関係をクロスエントロピーで算出した.実験結果より複数のハッシュタグ間における一部の盛り上がり時間帯のツイートはツイートより構築した n-gram 言語モデルに従うことを示す.また,盛り上がっている時間帯とそうでない時間帯において,クロスエントロピーにおいて統計的に有意差があることを示した (p<0.02).また,n-gram 言語モデルでは捉えられない素性も検討するため,Support Vector Machine (SVM) と Random Forest により各ツイートを盛り上がり時間帯の二値分類を行い,盛り上がり時間帯の特徴として漢字数が少ないことが明らかになった.

著者

Masashi Goto Takashi Kawamura Takuro Shimbo Osamu Takahashi Masahiko Ando Koichi Miyaki Takahiko Nohara Hidetsuna Watanabe Isamu Suzuki Mitsuru Aono for the Great Cold Investigators-II

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.46, no.15, pp.1179-1186, 2007 (Released:2007-08-02)

参考文献数

17

被引用文献数

5 10

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Objective: To investigate whether loxoprofen, one of the nonsteroidal anti-inflammatory drugs, prolongs the recovery process of naturally acquired upper respiratory tract infections (URTIs) in the clinical setting. Methods: A double-blind, randomized, placebo-controlled trial was conducted in 23 outpatient facilities in Japan. Patients aged 18 through 65 years suffering from URTIs were randomly assigned to receive loxoprofen or its placebo. The primary outcome was duration of illness in days. Results: A total of 174 patients were available for the analyses. Duration of illness was 8.94 ± 3.20 days in the loxoprofen group compared to 8.39 ± 3.39 days in the placebo group (P=.19). The number of days with limited daily activities was fewer in the loxoprofen group than in the placebo group (2.12 ± 2.05 days vs. 2.68 ± 2.54 days, P=.17). Although severe symptoms were less frequent on days 1, 2, and 3 in the loxoprofen group (27%, 33%, and 29%, respectively) than in the placebo group (32%, 39%, and 37%, respectively), symptoms were more frequent on days 6 through 12 in the loxoprofen group (difference, 5-13%). Adverse events were more common in the loxoprofen group (9.5% vs. 1.1%, P=.051). Conclusion: Loxoprofen did not significantly modify the recovery process of URTIs except for a slight tendency to delay.

著者

Je-myung Shim

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.26, no.2, pp.183-185, 2014 (Released:2014-02-28)

参考文献数

14

被引用文献数

2 4

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[Purpose] The purpose of this study was to examine the degree of changes in gait and feet after wet heat and dry heat exposure for 20 minutes. [Subjects] The participants of this study were 17 young adult males. The subjects were divided into a wet heat group of 9 subjects and dry heat group of 8 subjects. [Methods] Dry heat was applied for 20 min. To facilitate temperature adjustment of an electrical hot pack, to which a temperature controller was attached to the hot compress, the outer cover of the electrical pad was wrapped in a cotton towel and then rolled around the femur and the leg. As a hot compress, a constant-temperature water tank with double-boiling functionality was used for the hot pack unit. Its surface was covered with a towel twice or three times, as needed. We measured gait and feet. [Results] Left and right step time and the step width significantly increased in the wet heat group. Left foot flat to heel off significantly increased in the dry heat group. Right heel contact to foot flat significantly increased in the wet heat group. Left rearfoot pressure significantly increased in the dry heat group. [Conclusion] Wet heat affects physical functions like gait more than dry heat. However, there is no great difference between wet heat and dry heat with respect to the distribution of foot pressure.

著者

Takashi TAMAMOTO Koichi OHNO Yuko GOTO-KOSHINO Hajime TSUJIMOTO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0108, (Released:2014-05-15)

被引用文献数

1 9

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The serum amyloid A (SAA) concentration is higher in mammary tumors with metastases in both humans and animals. In the present study, the direct effects of recombinant feline SAA (rfSAA) protein on invasiveness of feline mammary carcinoma cells were evaluated. As an indicator of invasiveness, matrix metalloproteinase-9 (MMP-9) expression was investigated in 4 feline mammary carcinoma cell lines of different origins. In 3 of 4 cell lines, MMP-9 expression was significantly increased by rfSAA stimulation. The invasive capacities of feline mammary carcinoma cells were also stimulated by rfSAA. The findings of this study have identified a novel role for SAA in mammary tumorigenesis and suggest that therapeutic strategies targeting SAA may provide new alternatives in treating tumor invasion and metastasis.

著者

Carlos R. Galvão-Sobrinho

出版者

University of California Press

巻号頁・発行日

2013

著者

浜野 喬士 マティアス ルッツ=バッハマン ハマノ タカシ Hamano Takashi Matthias Lutz-Bachmann

出版者

大阪大学大学院文学研究科哲学講座

雑誌

メタフュシカ (ISSN:13426508)

巻号頁・発行日

vol.39, pp.97-109, 2008-12-25

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翻訳者 : 浜野, 喬士

著者

Todoroki Shin-ichi

出版者

Kyoto University

巻号頁・発行日

pp.1-308, 1993-03-23

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学位授与大学:京都大学;学位の種類:博士(工学);学位記番号:工博第1285号;学位授与日付:1993-03-23

著者

Masashi TAKAHASHI Yuko GOTO-KOSHINO Kenjiro FUKUSHIMA Hideyuki KANEMOTO Ko NAKASHIMA Yasuhito FUJINO Koichi OHNO Yasuyuki ENDO Hajime TSUJIMOTO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0345, (Released:2014-02-10)

被引用文献数

10

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Nimustine (ACNU) is an alkylating agent of the nitrosourea and can be an antineoplastic agent in dogs. But, there has been no report on its dose-limiting toxicity (DLT) in dogs. This study was a phase I dose-escalation clinical trial to determine the maximum tolerated dose (MTD) and DLT of ACNU in tumor-bearing dogs. The starting dosage was 25 mg/m2, and subsequent dosages were administered in increments of 5 mg/m2 in cohort of 3 dogs. Eight dogs were included and the MTD was determined to be 25 mg/m2, DLT was neutropenia and the optimal interval was considered to be 21 days. The data herein provides a basis for the subsequent phase II trial of ACNU in dogs.

著者

In-gyu Yoo Won-gyu Yoo

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.24, no.8, pp.659-661, 2012 (Released:2012-11-07)

参考文献数

14

被引用文献数

2 10

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[Purpose] The purpose of this study was to show the effects of the wearing of tight jeans on lumbar and hip movements during trunk flexion. [Subjects] Twelve male subjects were recruited. [Methods] The lumbar flexion angle and hip flexion angle were measured using a dual inclinometer during trunk flexion, with and without tight jeans. [Results] The lumbar flexion angle significantly increased when wearing tight jeans compared to not wearing and wearing of general jeans. The hip flexion angle significantly decreased when wearing tight jeans compared to not wearing and wearing of general jeans. [Conclusion] We suggest that tight jeans might limit normal lumbar and hip movements. So, abnormal lumbar and hip movements induced by tight jeans may be a cause of low back musculoskeletal disorders.

著者

Hirotaka TOMIYASU Yuko GOTO-KOSHINO Yasuhito FUJINO Koichi OHNO Hajime TSUJIMOTO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0337, (Released:2013-10-25)

被引用文献数

4 5

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Treatments for canine lymphoma often fail because tumor cells acquire multidrug resistance (MDR). MDR can develop through several mechanisms, among which the overexpression of drug transporters in tumor cells is a well-studied mechanism. ATP-binding cassette sub-family G member 2 (ABCG2) belongs to the ABC-transporters, that are representative drug efflux pumps associated with MDR in human tumor cells. However, the regulation of ABCG2 gene expression in canine tumors is not well understood. The purpose of the present study was to reveal the regulatory mechanism of ABCG2 gene expression in 4 canine lymphoid tumor cell lines, GL-1, CLBL-1, UL-1 and Ema. Treatment with phorbol 12-myristate 13-acetate (PMA), the protein kinase C (PKC) activator, stimulated MAPK/ERK pathway in GL-1, UL-1 and Ema cells and JNK pathway in UL-1 and Ema cells. When GL-1 and UL-1 cells were treated with PMA and the MAPK/ERK kinase inhibitor U0126, ABCG2 gene expression levels were elevated above those in untreated cells. Similarly, ABCG2 gene expression increased above control levels in UL-1 and Ema cells treated with PMA and the JNK inhibitor SP600125. However, ABCG2 gene expression was unaffected by U0126 exposure in CLBL-1 cells, in which activation of MAPK/ERK pathway was observed in non-treated cells. These results suggested that MAPK/ERK and JNK pathways downregulate ABCG2 gene expression, which is upregulated by unidentified but possibly PKC-dependent pathways, in several types of canine lymphoid tumor cells.

著者

JungWon KIM Chulho OAK TaeWon JANG MaanHong JUNG BongKwon CHUN Eun-Kee PARK Ken TAKAHASHI

出版者

独立行政法人 労働安全衛生総合研究所

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

pp.MS1385, (Released:2012-12-26)

被引用文献数

1 3

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Industrial talc has been widely circulated in the world for a long time. The pure talc has little effects on humans, but inhalation of talc contaminated with asbestos can causes severe asbestos-related diseases such as lung cancer and malignant mesothelioma. Herein, we represent a case of lung cancer after occupational exposure to industrial talc in the rubber manufacturing industry.

著者

Tanaka Akihito Woltjen Knut Miyake Katsuya Hotta Akitsu Ikeya Makoto Yamamoto Takuya Nishino Tokiko Shoji Emi Sehara-Fujisawa Atsuko Manabe Yasuko Fujii Nobuharu Hanaoka Kazunori Era Takumi Yamashita Satoshi Isobe Ken-ichi Kimura En Sakurai Hidetoshi

出版者

Public Library of Science

雑誌

PLoS ONE (ISSN:19326203)

巻号頁・発行日

vol.8, no.4, 2013-04-23

被引用文献数

156

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効率よく、再現性高くヒトiPS細胞から筋肉細胞を作製 -筋肉疾患の創薬プラットフォームの開発に向けて-. 京都大学プレスリリース. 2013-04-24.

著者

Chang-Hyun LEE Jae Hoon CHO Seung-Jae HYUN Sang Hoon YOON Ki-Jeong KIM Hyun-Jib KIM

出版者

社団法人 日本脳神経外科学会

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

vol.52, no.2, pp.106-108, 2012 (Released:2012-02-24)

参考文献数

12

被引用文献数

2 13

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A 76-year-old woman presented with an extremely rare case of symptomatic gas-containing disc herniation manifesting as left posterolateral thigh pain and ankle dorsiflexion motor weakness. The diagnosis was L3-4 vacuum disc associated with epidural pneumorrhachis. The patient underwent partial hemilaminectomy and cyst incision. After incising the cyst, the thecal sac and root were decompressed sufficiently. Vacuum disc is a common phenomenon in the elderly rarely associated with pneumorrhachis and is usually asymptomatic. Symptomatic epidural gas-containing herniated discs with the vacuum phenomenon are very rare. Gas aspiration should be considered, but excision of the gas-containing herniated disc should be performed in patients with neurological deficits, frequent recurrence, or difficult location to approach.

著者

巽 純子 奥村 寛 岡島 俊三 山本 洋一 タツミ ジュンコ オクムラ ユタカ オカジマ シュンゾウ ヤマモト ヨウイチ Tatsumi-Miyajima Junko Okumura Yutaka Okajima Shunzo Yamamoto Youichi

出版者

日本医学放射線学会

雑誌

日本医学放射線学会雑誌 (ISSN:00480428)

巻号頁・発行日

vol.47, no.3, pp.524-530, 1987-03-25

著者

Ko KOJIMA Yasuhito FUJINO Yuko GOTO-KOSHINO Koichi OHNO Hajime TSUJIMOTO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0168, (Released:2013-01-22)

被引用文献数

4 8 3

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Lymphoid malignancies such as leukemia and many types of lymphoma are common and severe disorders in dogs. Since shortening remission duration caused by resistance to chemotherapy often becomes clinically critical problems, development of novel and effective therapy should be required. The present study investigated the status of NF-κB, and effect of its inhibitor, bortezomib, in six canine neoplastic lymphoid cell lines. NF-κB p65 and p50 were detected in the nuclear fraction of GL-1, CLBL-1 and CL-1, suggesting that NF-κB was constitutively activated in the cells. NF-κB p65 was detected in the cytoplasmic fraction of UL-1 and Ema. After incubation with bortezomib, NF-κB p50 and p65 became undetectable in the nuclear fraction of GL-1, CLBL-1 and CL-1, and CLBL-1, respectively, and p65 was clearly degraded in the cytoplasmic fraction of CLBL-1 and CL-1. Bortezomib inhibited the proliferation of all cell lines except Nody-1 in a concentration-dependent manner. The results indicated that constitutive activation of NF-κB could contribute to the proliferation of canine neoplastic lymphoid cells, and bortezomib would have suppressive effects on the NF-κB activation and the proliferation of neoplastic lymphoid cells in dogs.

著者

Aki FUJIWARA-IGARASHI Yuko GOTO-KOSHINO Hiroyuki MOCHIZUKI Shingo MAEDA Yasuhito FUJINO Koichi OHNO Hajime TSUJIMOTO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0351, (Released:2013-01-24)

被引用文献数

6 11 2

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The p16, p15 and p14 genes are widely known as tumor suppressor genes in human medicine. Although a large number of genetic and epigenetic aberrations in these genes have been reported in human malignancies, canine malignancies have not been well analyzed on the aberrations of these genes. In this study, the full-length complementary DNA (cDNA) of the canine p16 gene was cloned using the 5’ and 3’ rapid amplification of cDNA ends methods. Based on the sequence data, primers specific for p16, p15 and p14 were designed. Using these primers, the expression of p16, p15 and p14 mRNAs could be individually evaluated by reverse transcriptase polymerase chain reaction. Genomic aberrations were also examined using genomic polymerase chain reaction. Two of the six canine lymphoid tumor cell lines did not express detectable levels of p16, p15 and p14 mRNAs, and wide-ranging deletions in the p15-p14-p16 genomic locus were suspected. Wide-ranging deletions were also speculated in 2 of 14 dogs with T-cell lymphoid tumors. On the other hand, similar failure of amplification suggesting wide-ranging deletions were not observed in any of the 14 dogs with B-cell lymphoma. Deletion of the p15-p14-p16 genomic locus could be one of the molecular aberrations in canine lymphoid tumor cells.

著者

Hye-Sook CHANG Hiroaki KAMISHINA Keijiro MIZUKAMI Yasuyuki MOMOI Masaaki KATAYAMA Mohammad Mahbubur RAHMAN Mohammad Mejbah UDDIN Akira YABUKI Moeko KOHYAMA Osamu YAMATO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0451, (Released:2013-01-18)

被引用文献数

9 26

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Canine degenerative myelopathy is an adult-onset, progressive neurodegenerative disease that occurs in multiple dog breeds, particularly Pembroke Welsh Corgis. Recently, a degenerative myelopathy-associated mutation of the canine SOD1 gene was identified as c.118G>A (p.E40K). In the present study, genotyping assays using conventional and real-time PCR methods were developed, and a preliminary genotyping survey was performed on 122 randomly selected Pembroke Welsh Corgis without any degenerative myelopathy-related clinical signs to determine the current allele frequency in Japan. Both of the assays provided clear-cut genotyping. The survey demonstrated the frequencies of the G/G wild-type, G/A heterozygote and A/A homozygote to be 9.0, 42.6 and 48.4%, respectively, indicating that the prevalence of the mutant A allele (69.7%) in Pembroke Welsh Corgis is extremely high in Japan.

著者

Woo-Jin SHIN Young-Kyung KIM Kwang-Hee LEE Baik-Lin SEONG

出版者

Japan Society for Bioscience, Biotechnology, and Agrochemistry

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

vol.76, no.3, pp.581-584, 2012-03-23 (Released:2012-03-23)

参考文献数

27

被引用文献数

8 1

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Based on the broad-spectrum antiviral effect of green tea catechins, we established an experimental skin contact model for influenza virus transmission and evaluated the use of a green tea solution as a first-hand disinfectant. The infectivity of the virus on the skin cell layer became obsolete when washed with the green tea solution. The skin contact model could be applied to develop non-pharmaceutical intervention measures for reducing human transmission of the influenza virus.

著者

宮越 順二 OHTSU SHUJI TATSUMI-MIYAJIMA JUNKO TAKEBE HIRAKU

出版者

日本放射線影響学会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.35, no.1, pp.26-34, 1994-03

被引用文献数

20 24

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To examine the biological effects of extremely low frequency magnetic field (ELFMF), we have designed and manufactured a new equipment for long-term and high-density exposure of cells to ELFMF. The ELFMF exposure system consists of a generator of magnets with a bult-in CO_2 incubator, an alternating current (AC) power supply, a gas compressor and a thermocontroller for the incubator, and a cooling unit for the magnets. The CO_2 incubator made of acrylic resin is inserted into the inner-space of the silicon steel strip-cores. In this system, the temperature of the incubator is maintained at 37±0.5°C. The maximum magnetic flux density on the exposure area of the incubator is 500 mT (T; tesla) at a current of 556 Arms (rms; root mean square) at 50 Hz. The long-term (up to 120 hr) exposure of 400 mT ELFMF did not affect the growth of both HL6ORG and CCRF-CEM cells originated from human leukemia.