著者

Hisashi Ogawa Yasuhiro Hamatani Kosuke Doi Yuji Tezuka Yoshimori An Mitsuru Ishii Moritake Iguchi Nobutoyo Masunaga Masahiro Esato Yeong-Hwa Chun Hikari Tsuji Hiromichi Wada Koji Hasegawa Mitsuru Abe Gregory YH Lip Masaharu Akao on behalf of the Fushimi AF Registry Investigators

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-0071, (Released:2017-05-25)

参考文献数

33

被引用文献数

14

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Background:Female sex is considered a risk factor for thromboembolism in patients with atrial fibrillation (AF), and is included in the risk stratification scheme, CHA2DS2-VASc score. The purpose of the present study was to investigate the clinical outcomes of female Japanese AF patients.Methods and Results:The Fushimi AF Registry is a community-based prospective survey of the AF patients in Fushimi-ku, Kyoto. Follow-up data were available for 3,878 patients. Female AF patients (n=1,551, 40.0%) were older (77.0 vs. 71.4 years; P<0.001) than male patients (n=2,327, 60.0%). Female patients were more likely to have heart failure (31.1% vs. 23.7%; P<0.001). Previous stroke incidence (19.2% vs. 21.4%; P=0.083) was comparable between male and female patients. During the median follow-up period of 1,102 days, Cox regression analysis demonstrated that female sex was not independently associated with a risk of stroke or systemic embolism (adjusted hazard ratio [HR] 0.74; 95% confidence interval [CI]: 0.54–1.00, P=0.051). However, female sex showed an association with a lower risk of intracranial hemorrhage (adjusted HR 0.54; 95% CI: 0.30–0.95, P=0.032) and all-cause death (adjusted HR 0.56; 95% CI: 0.46–0.68, P<0.001).Conclusions:We demonstrated that female sex is not independently associated with an increased risk of thromboembolism, but is associated with a decreased risk of intracranial hemorrhage and all-cause death in Japanese AF patients enrolled in the Fushimi AF Registry.

著者

Hiroya Gotouda Ikuo Nasu Tetsuro Kono Yukari Ootani Takeshi Kanno Ryo Tamamura Takao Kuwada-Kusunose Kunihiro Suzuki Tomohiko Hirayama Tatsuya Hirayama Toshiro Sakae Hiroyuki Okada

出版者

硬組織再生生物学会

雑誌

Journal of Hard Tissue Biology (ISSN:13417649)

巻号頁・発行日

vol.26, no.1, pp.81-86, 2017 (Released:2017-01-06)

参考文献数

20

被引用文献数

5

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The aim of this study was to show the reaction varieties of human tooth enamel and dentin with a carbonated soft drink, Sprite. After one week exposing into the soft drink, the sliced tooth specimens were examined by macroscopic and microscopic and then carried out the micro X-ray diffraction analysis using a 100 μm diameter X-ray beam. The macroscopic and microscopic results showed the wide varieties from the one showing a very slight increase white-spot areas in the enamel to the another showing almost complete decay of the enamel. The crystallites in the examined enamel and dentin changed drastically as follows; the one enamel sample showed the decrease of crystal amount and some ionic substitutions, and the another dentin sample showed the increase in crystallinity and ionic substitutions. These results clearly showed that the original tooth enamel and dentin had their own crystallographic properties differing from each others. This study provided a crystallographic basic data which will be applied to a tayler-made individual preventive dentistry in near future.

著者

Camilo Barrios-Perez Julian Ramires-Villegas Alexandre Bryan Heinemann

出版者

日本作物学会

雑誌

日本作物学会講演会要旨集 第243回日本作物学会講演会

巻号頁・発行日

pp.119, 2016 (Released:2017-03-27)

著者

Manuel Ruiz-García Pablo Orozco-terWengel Armando Castellanos Leonardo Arias

出版者

日本遺伝学会

雑誌

Genes & Genetic Systems (ISSN:13417568)

巻号頁・発行日

vol.80, no.1, pp.57-69, 2005 (Released:2005-04-12)

参考文献数

55

被引用文献数

10 25

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DNA samples of the spectacled bear (Tremarctos ornatus) from five Andean countries, Venezuela, Colombia, Ecuador, Peru and Bolivia, were analyzed for nine microsatellite loci. Seven of them were polymorphic, which led us to investigate several population-genetic parameters. Private alleles and significant differences in gene frequencies were found among the populations studied, which demonstrated the extent of genetic differentiation among the spectacled bear populations. The levels of gene diversity measured with these microsatellites were rather modest in this species. Hardy-Weinberg disequilibrium was especially found for the overall and the Ecuadorian samples, and might be due to the Wahl-und effect or consanguinity. Significant genetic heterogeneity was mainly observed among the Colombian and the Ecuadorian populations. Markov chain Monte Carlo simulations clearly showed that two different gene pools were present, one present in the Venezuelan-Colombian bears and other in the Ecuadorian ones.

著者

古橋 忠晃 津田 均 小川 豊昭 鈴木 國文 清水 美佐子 北中 淳子 照山 絢子 堀口 佐知子 清水 克修 後岡 亜由子 Figueiredo Cristina Pionné-Dax Nancy Tajan Nicolas Vellut Natacha Singly François de Pierrot Alain Castel Pierre-Henri Furuhashi Tadaaki Tsuda Hitoshi Ogawa Toyoaki Suzuki Kunifumi Shimizu Misako Kitanaka Junko Teruyama Junko Horiguchi Sachiko Shimizu Katsunobu Sedooka Ayuko

出版者

名古屋大学総合保健体育科学センター

雑誌

総合保健体育科学 (ISSN:02895412)

巻号頁・発行日

vol.34, no.1, pp.29-33, 2011-03-31 (Released:2014-06-11)

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In recent years the hikikomori (social withdrawal) phenomenon described in Japan has also come to be seen in Europe, particularly France. Despite the high level of interest in hikikomori in France, it has not been clearly defined and there is no clear overall understanding of the phenomenon. Our Japanese-French research team, supported by a Grant-in-Aid for Scientific Research (B) (overseas surveys), compared hikikomori youths in France and Japan from the perspectives of researchers in various fields. The aim of this study was to investigate the kinds of people to whom the concept of hikikomori is applied in France and Japan. A clinical conference was held in Paris in September 2010 to discuss cases considered to be hikikomori in the two countries. This article is an interim report from research in the first year of a series of international joint studies, and describes the commonalities and differences in the state of hikikomori in Japan and France.

著者

Li-Hua Li Hua-Yi Hsieh Cheng-Chih Hsu

出版者

The Mass Spectrometry Society of Japan

雑誌

Mass Spectrometry (ISSN:2187137X)

巻号頁・発行日

vol.6, no.2, pp.S0060-S0060, 2017-02-22 (Released:2017-02-24)

参考文献数

100

被引用文献数

31

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Ambient ionization allows mass spectrometry analysis directly on the sample surface under atmospheric pressure with almost zero sample pretreatment. Since the development of desorption electrospray ionization (DESI) in 2004, many other ambient ionization techniques were developed. Due to their simplicity and low operation cost, rapid and on-site clinical mass spectrometry analysis becomes real. In this review, we will highlight some of the most widely used ambient ionization mass spectrometry approaches and their applications in clinical study.

著者

Mai KISHIMOTO Shinobu TSUCHIAKA Sayed Samim RAHPAYA Ayako HASEBE Keiko OTSU Satoshi SUGIMURA Suguru KOBAYASHI Natsumi KOMATSU Makoto NAGAI Tsutomu OMATSU Yuki NAOI Kaori SANO Sachiko OKAZAKI-TERASHIMA Mami OBA Yukie KATAYAMA Reiichiro SATO Tetsuo ASAI Tetsuya MIZUTANI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.16-0489, (Released:2017-01-08)

被引用文献数

56

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Bovine respiratory disease complex (BRDC) is frequently found in cattle worldwide. The etiology of BRDC is complicated by infections with multiple pathogens, making identification of the causal pathogen difficult. Here, we developed a detection system by applying TaqMan real-time PCR (Dembo respiratory-PCR) to screen a broad range of microbes associated with BRDC in a single run. We selected 16 bovine respiratory pathogens (bovine viral diarrhea virus, bovine coronavirus, bovine parainfluenza virus 3, bovine respiratory syncytial virus, influenza D virus, bovine rhinitis A virus, bovine rhinitis B virus, bovine herpesvirus 1, bovine adenovirus 3, bovine adenovirus 7, Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, Trueperella pyogenes, Mycoplasma bovis and Ureaplasma diversum) as detection targets and designed novel specific primer-probe sets for nine of them. The assay performance was assessed using standard curves from synthesized DNA. In addition, the sensitivity of the assay was evaluated by spiking solutions extracted from nasal swabs that were negative by Dembo respiratory-PCR for nucleic acids of pathogens or synthesized DNA. All primer-probe sets showed high sensitivity. In this study, a total of 40 nasal swab samples from cattle on six farms were tested by Dembo respiratory-PCR. Dembo respiratory-PCR can be applied as a screening system with wide detection targets.

著者

稲葉 振一郎 INABA Shin-ichiro

出版者

明治学院大学社会学部付属研究所

雑誌

研究所年報 (ISSN:09114831)

巻号頁・発行日

no.43, pp.27-43, 2013-03

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本稿では、「政治」という言葉、概念の自分なりの定義を試みる。ここでの「政治」という言葉は、現代英語の"politics"という言葉の対応語、翻訳語と考えていただいて構わない。現代の日本語における通常の使われ方から極端に外れることなく、しかもある程度明晰で厳密な思考を可能とするような定義づけをここでは試みていく。 そこでは当然、我々の日常的な言葉づかい、更にはジャーナリズムでの政治談議を意識しつつも、もう少し厳密な言葉づかいを行っている領域を参考にする。その場合当然ながらアカデミックな政治科学や公法学の用語法は念頭に置かれるだろう。しかし更にとりわけ本稿で重要な手掛かりとして用いられるのは、ハンナ・アレントとミシェル・フーコーの言葉づかいである。

著者

Miyako Ariga Yosuke Yoneyama Toshiaki Fukushima Yuri Ishiuchi Takayuki Ishii Hitoshi Sato Fumihiko Hakuno Taku Nedachi Shin-Ichiro Takahashi

出版者

(社)日本内分泌学会

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ16-0319, (Released:2016-12-13)

被引用文献数

12

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In skeletal muscle, sortilin plays a predominant role in the sorting of glucose transporter 4 (Glut4), thereby controlling glucose uptake. Moreover, our previous study suggested that the sortilin expression levels are also implicated in myogenesis. Despite the importance of sortilin in skeletal muscle, however, the regulation of sortilin expression has not been completely understood. In the present study, we analyzed if the sortilin expression is regulated by glucose in C2C12 myocytes and rat skeletal muscles in vivo. Sortilin protein expression was elevated upon C2C12 cell differentiation and was further enhanced in the presence of a high concentration of glucose. The gene expression and protein degradation of sortilin were not affected by glucose. On the other hand, rapamycin partially reduced sortilin induction by a high concentration of glucose, which suggested that sortilin translation could be regulated by glucose, at least in part. We also examined if the sortilin regulation by glucose was also observed in skeletal muscles that were obtained from fed or fasted rats. Sortilin expression in both gastrocnemius and extensor digitorum longus (EDL) muscle was significantly decreased by 17-18h of starvation. On the other hand, pathological levels of high blood glucose did not alter the sortilin expression in rat skeletal muscle. Overall, the present study suggests that sortilin protein levels are reduced under hypoglycemic conditions by post-transcriptional control in skeletal muscles.

著者

Yuka Watanabe Yuko Miyagoe-Suzuki

出版者

一般社団法人日本体力医学会

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.4, no.1, pp.73-82, 2015-03-25 (Released:2015-03-23)

参考文献数

114

被引用文献数

2

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Muscle mass and strength decline with age. When severe, the loss is called sarcopenia. Sarcopenia is drawing attention worldwide, especially in highly aged societies, as a disease that should be treated. At present, we have limited tools to combat sarcopenia (e.g. resistance training and nutritional intervention), but accumulating knowledge of the molecular and cellular mechanisms of sarcopenia is accelerating the development of pharmacological therapies for sarcopenia. Because sarcopenia is a complicated pathological condition caused and modified by many aging-related factors, such as inactivity, loss of motor neurons, poor nutrition, decline of anabolic hormones, chronic inflammation, oxidative stress, impaired stem cell function, and comorbidity, the proposed target molecules or pathways for pharmacological intervention are diverse. Here we review recent progress in drug development with emphasis on small-molecule compound-based therapies and review the literature to identify new therapeutic targets to prevent, delay, or reverse sarcopenia.

著者

Ohta Ryo Niwa Akira Taniguchi Yukimasa Suzuki Naoya M Toga Junko Yagi Emiko Saiki Norikazu Nishinaka-Arai Yoko Okada Chihiro Watanabe Akira Nakahata Tatsutoshi Sekiguchi Kiyotoshi Saito Megumu K

出版者

Springer Nature

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.6, 2016-11-02

被引用文献数

36

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細胞外マトリックスを用いてヒト多能性幹細胞から高効率に血管内皮細胞の誘導に成功. 京都大学プレスリリース. 2016-11-09.

著者

番原 睦則 姜 京順 田村 直之 Mutsunori Banbara Kyoung-Sun Kang Naoyuki Tamura 奈良工業高等専門学校 釜山外国語大学校(韓国)コンピュータ電子工学部コンピュータ工学科 神戸大学工学部情報知能工学科 Nara National College of Technology Department of Computer Engineering Division of Electronic and Computer Engineering Pusan University of Foreign Studies Department of Computer and Systems Engineering Kobe University

出版者

日本ソフトウェア科学会

雑誌

コンピュータソフトウェア (ISSN:02896540)

巻号頁・発行日

vol.18, no.1, pp.39-60, 2001-01-15

参考文献数

29

被引用文献数

4

著者

Suetsugu Noriyuki Takemiya Atsushi Kong Sam-Geun Higa Takeshi Komatsu Aino Shimazaki Ken-ichiro Kohchi Takayuki Wada Masamitsu

出版者

National Academy of Sciences

雑誌

Proceedings of the National Academy of Sciences of the United States of America (ISSN:10916490)

巻号頁・発行日

vol.113, no.37, 2016-08-30

被引用文献数

33

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葉緑体が光に集まる反応を制御する新たな因子の発見. 京都大学プレスリリース. 2016-08-30.

著者

Takeshi Otsuki Kazuhiro Shimizu Asako Zempo-Miyaki Seiji Maeda

出版者

日本酸化ストレス学会

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.59, no.1, pp.45-48, 2016 (Released:2016-07-01)

参考文献数

22

被引用文献数

5

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Decreases in saliva secretion compromise food mastication and swallowing, reduce mucosal immune function, and increase the risk for oral diseases like dental caries. Chlorella is a green alga that contains a variety of nutrients including amino acids, vitamins, and minerals. In our previous study, Chlorella-derived multicomponent supplementation did not affect salivary flow rates in healthy young individuals, but Chlorella-derived supplementation attenuated a decrease in saliva secretion that was observed during a kendo training camp. Hence, we hypothesized that Chlorella-derived supplementation increases saliva secretion in individuals with lower rates of saliva flow. Sixty-four subjects took Chlorella-derived tablets for four weeks. Before and after supplementation, saliva samples were collected by chewing cotton. In the complete study group, there was no difference in saliva production before and after supplementation (1.91 ± 0.11 ml/min before vs 2.01 ± 0.12 ml/min after). Analysis of subgroups based on saliva production before supplementation found an increase in saliva secretion in the lower saliva flow group (1.18 ± 0.06 vs 1.38 ± 0.08 ml/min), but no change in the higher saliva flow group (2.63 ± 0.11 vs 2.64 ± 0.15 ml/min). These results suggest that Chlorella-derived multicomponent supplementation increases saliva production in individuals with lower levels of saliva secretion.

著者

Hwi-Young Cho Ki-Tae Kim Jin-Hwa Jung

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.28, no.7, pp.2154-2158, 2016 (Released:2016-07-29)

参考文献数

17

被引用文献数

18

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[Purpose] This study investigated the effects of neurofeedback (NFB) and computer-assisted cognitive rehabilitation (CACR) on the relative brain wave ratios and activities of daily living (ADL) of stroke patients. [Subjects and Methods] Forty-four participants were randomly allocated to the NFB (n=14), CACR (n=14), or control (CON) (n=16) groups. Two expert therapists provided the NFB, CACR, and CON groups with traditional rehabilitation therapy in 30-minute sessions, 5 times a week, for 6 weeks. NFB training was provided only to the NFB group and CACR training was provided only to the CACR group. The CON group received traditional rehabilitation therapy only. Before and after 6 weeks of intervention, brain wave and ADL evaluations were performed, and the results were analyzed. [Results] The relative ratio of beta waves, only showed a significant increase in the frontal and parietal areas of the NFB group. Significant changes in ADL were shown by all three groups after the intervention. However, there were no significant differences between the NFB and CACR groups and the CON group. [Conclusion] Our results suggest that CACR and NFB are effective at improving cognitive function and ADL of stroke patients.

著者

Jones Mark-Eric

出版者

日経BP社

雑誌

日経エレクトロニクス (ISSN:03851680)

巻号頁・発行日

no.783, pp.171-178, 2000-11-20

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米MoSys,Inc.は,DRAMと同じメモリ・セル構造を採りながらSRAM並みのアクセス性能を実現したメモリ「1T—SRAM」を開発した。ネットワーク機器や民生機器などに搭載するシステムLSIへの埋め込みを想定する。0.18nmルールのプロセス技術で作るLSIに埋め込んだ際のランダム・アクセス時間は5ns未満と短い。

著者

Daniel C. Fickle Danny W. Scott Jeanine Peters-Kennedy Hollis N. Erb

出版者

日本獣医皮膚科学会

雑誌

獣医臨床皮膚科 (ISSN:13476416)

巻号頁・発行日

vol.22, no.2, pp.97-103, 2016 (Released:2016-07-09)

参考文献数

9

被引用文献数

1

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今回の研究目的は,犬の酵母による皮膚炎における毛嚢脂腺の異形成の病理組織学的所見,出現率そして関連性についてである。670頭の犬の非腫瘍性皮膚症および28頭の健常犬からのHE染色した皮膚生検試料について,光学顕微鏡学的に行った回顧的な研究である。犬の酵母による皮膚炎,正常皮膚,非酵母性皮膚症における毛嚢脂腺の異形成の発生率および存在量を比較するために,カイ二乗および順位和検定を行った。犬の酵母による皮膚炎における毛嚢脂腺の異形成は,98頭中76頭(78%;95%の信頼水準で,68~85%の信頼区間)で,非酵母性皮膚症では14頭中572頭(2.4%;95%の信頼水準で,1.4~4.2%の信頼区間)であった。毛嚢脂腺の異形成は,正常犬では認められなかった(95%の信頼水準で,0~15%の信頼区間)であった。毛嚢脂腺の異形成の発生率(存在する/しない)は,非酵母性皮膚症および正常犬に比べて,酵母による皮膚炎において顕著に有意差が認められた(カイ二乗検定=424.49;自由度2;p<0.0001)。またこれらの群における毛嚢脂腺の異形成の病変単位の%は,非酵母性皮膚症(一頭当たりの病変単位,最少3%;平均30%;最大100%)に比べて,酵母による皮膚炎(最少12%;平均75%;最大100%)において顕著に多かった。毛嚢脂腺の異形成の発生率は,非酵母性皮膚症および正常犬において有意な差は存在しなかった(p≥0.05)。犬の皮膚生検試料の毛嚢脂腺の異形成の存在についてのこれらの所見は,酵母性皮膚症が顕著に関連し,そして組織学的診断になると考えられた。

著者

Rafael Timon Javier Tejero Javier Brazo-Sayavera Carmen Crespo Guillermo Olcina

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.28, no.6, pp.1781-1785, 2016 (Released:2016-06-24)

参考文献数

30

被引用文献数

20

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[Purpose] The aim of this study was to investigate whether or not a single whole-body vibration treatment after eccentric exercise can reduce muscle soreness and enhance muscle recovery. [Subjects and Methods] Twenty untrained participants were randomly assigned to two groups: a vibration group (n=10) and control group (n=10). Participants performed eccentric quadriceps training of 4 sets of 5 repetitions at 120% 1RM, with 4 min rest between sets. After that, the vibration group received 3 sets of 1 min whole body vibration (12 Hz, 4 mm) with 30 s of passive recovery between sets. Serum creatine kinase, blood urea nitrogen, muscle soreness (visual analog scale) and muscle strength (peak isometric torque) were assessed. [Results] Creatine kinase was lower in the vibration group than in the control group at 24 h (200.2 ± 8.2 vs. 300.5 ± 26.1 U/L) and at 48 h (175.2 ± 12.5 vs. 285.2 ± 19.7 U/L) post-exercise. Muscle soreness decreased in vibration group compared to control group at 48 h post-exercise (34.1 ± 11.4 vs. 65.2 ± 13.2 mm). [Conclusion] Single whole-body vibration treatment after eccentric exercise reduced delayed onset muscle soreness but it did not affect muscle strength recovery.

著者

Ken Okumura Kazuo Matsumoto Yoshinori Kobayashi Akihiko Nogami Robert B Hokanson Fred Kueffer for the CRYO-Japan PMS Study Investigators

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-16-0285, (Released:2016-06-30)

参考文献数

17

被引用文献数

2 31

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Background:Outcomes of cryoballoon ablation for paroxysmal atrial fibrillation (PAF) have been reported in the Western countries but not in Japan. The CRYO-Japan PMS study was a single-arm, observational, multicenter, prospective study of the 2nd-generation cryoballoon Arctic Front AdvanceTM. We evaluated device- and procedure-related complications and clinical outcomes at 6 months.Methods and Results:The 616 patients (male, 72%; mean age, 63±11 years) were enrolled from 33 Japanese hospitals. Of all patients, 610 had PAF, and procedural data were analyzed in 607. A subset of 328 patients was followed for 6 months for the primary efficacy analysis. AF recurrence outside the 3-month blanking period or repeat ablation was considered treatment failure. Pulmonary vein isolation was achieved in 606/607 patients (99.8%); 1 patient (0.3%) had a repeat ablation during the blanking period. Freedom from AF at 6 months was 88.4% (95% CI: 84.1–91.6%). Device- and/or procedure-related adverse events included phrenic nerve injury unresolved at hospital discharge in 9/616 patients (1.5%), which resolved within 6 months in 7, pericardial effusion in 5/616 (0.8%), and tamponade in 4/616 (0.6%). One non-device-related death from pneumonia was reported 6 days post-procedure.Conclusions:Cryoballoon ablation is safe and effective for Japanese PAF patients, with 88.4% AF freedom at 6 months post-ablation.

著者

Hisashi Kai Takeshi Kimura Kenji Fukuda Yoshihiro Fukumoto Tatsuyuki Kakuma Yutaka Furukawa on behalf of CREDO-Kyoto Investigators

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-15-1151, (Released:2016-04-06)

参考文献数

21

被引用文献数

9

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Background:We investigated the effects of age and low diastolic blood pressure (DBP) on cardiovascular death in patients with coronary artery disease (CAD) after coronary revascularization.Methods and Results:Stable, chronic CAD patients after coronary revascularization in the CREDO-Kyoto registry cohort-1 were allocated to the Young (≤64 years, n=2,619), Young-Old (65–74 years, n=2,932), and Old-Old (≥75 years, n=1,629) groups. Kaplan-Meier analysis showed that the crude cumulative incidence of cardiovascular death was higher in Young-Old patients with DBP <70 mmHg (P<0.001) and in Old-Old patients with DBP <60 mmHg (P=0.017), but not <70 mmHg (P=0.629), compared with each counterpart. Low DBP did not increase cardiovascular death in young patients. After adjustments with independent predictors, DBP <60 mmHg did not increase the cardiovascular death in the Old-Old group (HR=1.579 [95% CI, 0.944–2.642], P=0.082) and DBP <70 mmHg remained a predictor in the Young-Old group (HR=1.665 [1.094–2.532], P=0.017). On multivariate stepwise Cox proportional hazard regression analysis, independent predictors for cardiovascular death in low DBP patients were creatinine clearance (CCr; inversely), prior cerebrovascular disease, and aortic disease in the Young-Old group and CCr (inversely) and malignancy in the Old-Old group.Conclusions:DBP <60 mmHg was not an independent factor for predicting cardiovascular death in Old-Old revascularized CAD patients, whereas DBP <70 mmHg remained a predictor in the Young-Old.