著者

Petrini Marcia A.

出版者

日本赤十字広島看護大学

雑誌

日本赤十字広島看護大学紀要 (ISSN:13465945)

巻号頁・発行日

vol.4, pp.51-59, 2004

著者

A.マタイス 井上英治共編

出版者

南窓社

巻号頁・発行日

1974

著者

Miguel Ruiz-Canela Miguel A. Martínez-González

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-14-0062, (Released:2014-02-01)

参考文献数

101

被引用文献数

9 36

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Peripheral artery disease (PAD) usually refers to ischemia of the lower limb vessels. Currently, the estimated number of cases in the world is 202 million. PAD is the third leading cause of atherosclerotic cardiovascular morbidity. The measurement of the ankle-brachial index (ABI) is recommended as a first-line noninvasive test for screening and diagnosis of PAD. An ABI <0.90 is an independent predictor of cardiovascular events and this measurement is useful to identify patients at moderate to high risk of cardiovascular disease. However, there is insufficient evidence to assess the benefits and harms of screening for PAD with the ABI in asymptomatic adults. Lifestyle modifications, including smoking cessation, dietary changes and physical activity, are currently the most cost-effective interventions. Inverse associations with PAD have been reported for some subtypes of dietary fats, fiber, antioxidants (vitamins E and C), folate, vitamins B6, B12 and D, flavonoids, and fruits and vegetables. A possible inverse association between better adherence to the Mediterranean diet and the risk of symptomatic PAD has also been reported in a large randomized clinical trial. Therefore, a Mediterranean-style diet could be effective in the primary and secondary prevention of PAD, although further experimental studies are needed to better clarify this association.

著者

Vladisavljević Goran T. Khalid Nauman Neves Marcos A. Kuroiwa Takashi Nakajima Mitsutoshi Uemura Kunihiko Ichikawa Sosaku Kobayashi Isao

出版者

Elsevier B.V.

雑誌

Advanced drug delivery reviews (ISSN:0169409X)

巻号頁・発行日

vol.65, no.11-12, pp.1626-1663, 2013-11

被引用文献数

248 9

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Microfluidics is an emerging and promising interdisciplinary technology which offers powerful platforms for precise production of novel functional materials (e.g., emulsion droplets, microcapsules, and nanoparticles as drug delivery vehicles- and drug molecules) as well as high-throughput analyses (e.g., bioassays, detection, and diagnostics). In particular, multiphase microfluidics is a rapidly growing technology and has beneficial applications in various fields including biomedicals, chemicals, and foods. In this review, we first describe the fundamentals and latest developments in multiphase microfluidics for producing biocompatible materials that are precisely controlled in size, shape, internal morphology and composition. We next describe some microfluidic applications that synthesize drug molecules, handle biological substances and biological units, and imitate biological organs. We also highlight and discuss design, applications and scale up of droplet- and flow-based microfluidic devices used for drug discovery and delivery.

著者

Wahyudi A'an Johan

巻号頁・発行日

2013

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Thesis (Doctor of Environmental Studies)--University of Tsukuba, (A), no. 6536, 2013.3.25

著者

Ariana Ardeshir Tadauchi Osamu Shebl Mohamed A.

出版者

Entomological Laboratory, Faculty of Agriculture, Kyushu University

雑誌

ESAKIA (ISSN:00711268)

巻号頁・発行日

vol.49, pp.63-70, 2009-12-21

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The subgenus Andrena (Osychnyukandrena) is revised and a key to species of the subgenus is provided. One species, Andrena (Lepidandrena) gamskrucki Warncke, 1965 is transfered to this subgenus. Andrena laticalcar from Iran and A. cochlearicalcar from Central Asia are reported as new records.

著者

北畑 信隆 早瀬 大貴 Bisson Melanie M. A. 湯本 弘子 中野 雄司 中山 真義 Groth Gerog 浅見 忠男

出版者

植物化学調節学会

雑誌

植物化学調節学会研究発表記録集 (ISSN:09191887)

巻号頁・発行日

no.46, 2011-10-03

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The gaseous hormone ethylene plays important roles in many physiological and developmental processes in plants. To regulate ethylene signaling, we screened novel chemicals with ethylene mimic activity that induce triple response phenotype of etiolated seedlings. Finally we identified a compound with ethylene mimic activity, named HJ2. Ethylene biosynthetic inhibitor did not suppress HJ2-induced phenotype. On the other hand, ethylene insensitive mutant, ein2, suppressed HJ2-induced phenotype. Moreover, antagonist of ethylene receptor, STS, suppressed HJ2-induced phenotype in dose-dependent manner. These results suggested that HJ2 is an agonist of ethylene receptor. To improve ethylene activity of HJ2, we designed and synthesized HJ2 derivatives. As a result, we developed more effective ethylene agonists. At present, we examine binding of these chemicals to ETR1 protein in detail.

著者

Sekimoto S. Watanabe C. Minami H. Yamamoto T. Kashiwagi T. Klemm Richard A. Kadowaki K.

出版者

American Institute of Physics

雑誌

Applied physics letters (ISSN:00036951)

巻号頁・発行日

vol.103, no.18, pp.182601, 2013-10

被引用文献数

67 5

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Using a modified mesa structure of high-Tc superconducting Bi2Sr2CaCu2O8+δ with a thin underlaying base superconductor (∼3 μm), the effective working temperature of the continuous and monochromatic terahertz emitter is extended up to 70 K, and the maximum power of ∼30 μW at 0.44 THz is achieved at the relatively high temperature of T b = 55 K in a low bias current retrapping region. The diverging behavior of the intensity occurring at 55 K in the low current regime without hot spot formation may provide us an important clue for the stronger THz radiation from intrinsic Josephson junction devices.

著者

ゴラム サルワル A. K. M. 伊藤 利章 高橋 英樹

出版者

日本花粉学会

雑誌

日本花粉学会会誌 (ISSN:03871851)

巻号頁・発行日

vol.52, no.1, pp.15-34, 2006-06-30

被引用文献数

3

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光学顕微鏡(LM)・走査型電子顕微鏡(SEM)・透過型電子顕微鏡(TEM)により,スノキ属Vaccinium内に認められている30節のうち18節,合計37種の花粉形態を観察し,本属花粉形態の多様性の概要を明らかにした.SEMによる花粉の溝間極域の外壁模様とLMによる花粉形態計測値の類似性を基にして,各種が置かれている属内分類体系について評価した.四集粒花粉の溝間極域の外壁表面模様は,種類により微細いぼ状模様〜しわ状模様〜平滑模様と変異し,しわ状模様単位にはさらに「二次的な模様」:不明瞭〜微細で明瞭な縞模様があり,縞模様単位は更にビーズ状にくびれているものがあった.外壁模様は大きく7型に分けられ,1-3型はさらに12亜型に分けられた.花粉形態形質はスノキ属内で現在認められている節分類と明瞭に連関している訳ではなかったが,類縁関係に有意義な情報を与え,属内の分類学的な問題にも新しい見方を与えてくれた.アクシバ節のアクシバ花粉ははっきりした微細いぼ状模様(6型)を持ち花粉サイズも本属では最小であり,花粉形態形質は本種をスノキ属から分類する考えを支持する.地理分布と対応した四集粒サイズと花粉外壁模様の若干の差違が認められた.一般的に新世界産スノキ属種は花粉サイズが大きく,外壁模様は粗しわ状模様〜粗しわ状-平滑模様とまとまっている.一方で,旧大陸産種はサイズがより小さい傾向があり,外壁模様は微細いぼ状模様〜しわ状模様〜平滑模様とより広い変異を示す.

著者

SHELLY A. M.

雑誌

Biol. Psychiatry

巻号頁・発行日

vol.30, pp.1059-1062, 1991

被引用文献数

9 308

著者

Jae Jin KO F. A. (Tony) MANN

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0220, (Released:2014-01-16)

被引用文献数

1 16

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Barium peritonitis is extremely rare, but is difficult to treat and may be life-threatening. Barium suspension leakage from the gastrointestinal tract into the abdominal cavity has a time-dependent and synergistically deleterious effect in patients who have generalized bacterial peritonitis. The severity of barium peritonitis is dependent on the quantity of barium in the abdominal cavity. Barium sulfate leakage results in hypovolemia and hypoproteinemia by worsening the exudation of extracellular fluid and albumin. Abdominal fluid analysis is a useful and efficient method to diagnose barium peritonitis. Serial radiographs may not be a reliable or timely diagnostic technique. Initial aggressive fluid resuscitation and empirical broad-spectrum antibiotic treatment should be instituted promptly, followed quickly by celiotomy. During exploratory surgical intervention, copious irrigation and direct wiping with gauze are employed to remove as much barium as possible. Omentectomy should be considered when needed to expedite barium removal. Despite aggressive medical and surgical treatments, postoperative prognosis is guarded to poor due to complications such as acute vascular shock, sepsis, diffuse peritonitis, hypoproteninemia, electrolyte imbalance, cardiac arrest, small bowel obstruction related to progression of granulomas, and adhesions in the abdominal cavity. Therefore, intensive postoperative monitoring and prompt intervention are necessary to maximize chances for a positive outcome. For those that do survive, small bowel obstruction is a potential consequence due to progression of abdominal adhesions.

著者

A. Mosca Conte O. Pulci R. Del Sole A. Knapik J. Bagniuk J. Lojewska L. Teodonio M. Missori

出版者

公益社団法人 日本表面科学会

雑誌

e-Journal of Surface Science and Nanotechnology (ISSN:13480391)

巻号頁・発行日

vol.10, pp.569-574, 2012-10-13 (Released:2012-10-13)

参考文献数

29

被引用文献数

4 15

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Paper is the most widely used writing support due to the remarkable properties of its principal component - cellulose - one of the most abundant biomaterials present on Earth. However, due to the complexity of the material, an exhaustive picture of its degradation pathways is still missing. In this paper, we will present recent results and progresses obtained in the comprehension of the role of cellulose oxidation in the yellowing of ancient paper. Visible and ultraviolet spectra of cellulose in ancient paper samples and reference modern samples artificially aged have been interpreted with the aid of ab-initio Time-Dependent Density Functional Theory calculations. Through the comparison of measured and calculated absorption spectra, several oxidized forms of cellulose polymers, acting as chromophores, and responsible for ancient paper yellowing were identified. The relative concentration of ketones and aldehydic groups depends on the environmental conditions in which samples were stored along their life. [DOI: 10.1380/ejssnt.2012.569]

著者

a translation from the Coptic transcript and commentary by Charlotte A. Baynes

出版者

Cmbridge University Press

巻号頁・発行日

2013

著者

edited by A. Shisha-Halevy

出版者

Peeters

巻号頁・発行日

1988

著者

by A. Shisha-Halevy

出版者

Peeters

巻号頁・発行日

2007

著者

by A.Ya. Gutman(Anatoly Gan) Ella Lury Wiswell米訳 Manabu Saito和訳

出版者

ユーラシア貨幣歴史研究所

巻号頁・発行日

2001

著者

by Henry Power a reprint of the 1664 edition with the addition of Power's notes corrections and emendations and a new introd. by Marie Boas Hall

出版者

Johnson Reprint Corp

巻号頁・発行日

1966

著者

Long A. A. 金澤 修

出版者

岩波書店

雑誌

思想 (ISSN:03862755)

巻号頁・発行日

no.971, pp.45-78, 2005-03

著者

Hans P.A. VAN DONGEN Gregory BELENKY

出版者

独立行政法人 労働安全衛生総合研究所

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

vol.47, no.5, pp.518-526, 2009 (Released:2009-10-15)

参考文献数

61

被引用文献数

20 74

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There are considerable individual differences in cognitive performance deficits resulting from extended work hours and shift work schedules. Recent progress in sleep and performance research has yielded new insights into the causes and consequences of these individual differences. Neurobiological processes of sleep/wake regulation underlie trait individual variability in vulnerability to performance impairment due to sleep loss. Trait vulnerability to sleep loss is observed in the laboratory and in the work environment, even in occupational settings where (self-)selection pressures are high. In general, individuals do not seem to accurately assess the magnitude of their own vulnerability. Methods for identifying workers who are most at risk of sleep loss-related errors and accidents would therefore be helpful to target fatigue countermeasure interventions at those needing them most. As yet, no reliable predictors of vulnerability to sleep loss have been identified, although candidate genetic predictors have been proposed. However, a Bayesian forecasting technique based on closed-loop feedback of measured performance has been developed for individualized prediction of future performance impairment during ongoing operations. Judiciously selecting or monitoring individuals in specific tasks or occupations, within legally and ethically acceptable boundaries, has the potential to improve operational performance and productivity, reduce errors and accidents, and save lives. Trait individual variability in responses to sleep loss represents a major complication in the application of one-size-fits-all hours of service regulations―favoring instead modern fatigue risk management strategies, because these allow flexibility to account for individual vulnerability or resilience to the performance consequences of extended work hours and shift work schedules.

著者

S.ノラ A.マンク著 輿寛次郎監訳

出版者

産業能率大学出版部

巻号頁・発行日

1980