著者

Keitaro CHIBA Takashi SUGAWARA Daisuke KOBAYASHI Akihito SATO Yasuhiro MUROTA Taketoshi MAEHARA

出版者

The Japan Neurosurgical Society

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

vol.61, no.11, pp.647-651, 2021 (Released:2021-11-15)

参考文献数

22

被引用文献数

3

---

The significance of atypical histological features (AHF) as risk factors for recurrence in benign meningioma is not well understood. This study examined risk factors of World Health Organization (WHO) Grade I meningioma (GIM) recurrence, focusing on AHF. We investigated 150 consecutive newly diagnosed GIM patients who had more than one year of follow-up after resection in our hospital between January 2007 and March 2018. The following factors were reviewed retrospectively: age, sex, tumor location, extent of resection, MIB-1 index, mitotic figures, number and distribution of AHF, and recurrence. The patients were grouped according to the presence or absence of recurrence and comparatively examined. Recurrence was observed in 10 cases (6.7%). Univariate analysis showed that patients with recurrence had a significantly higher MIB-1 index (2.0 vs. 4.3; p = 0.006) and a significantly higher proportion of male patients (21.4% vs. 70.0%; p = 0.002) and patients with sheet-like growth (6.42% vs. 30.0%; p = 0.04). In multivariate analysis, skull base location (odds ratio [OR] 31.424; 95% confidence interval [CI] 1.74–569), gross total resection (OR 0.130; 95% CI 0.0189–0.897), and MIB-1 index (OR 1.939; 95% CI 1.19–3.15) were significantly associated with recurrence. Our study revealed that skull base location, subtotal resection, and high MIB-1 index were independent risk factors for recurrence. Only the presence of sheet-like growth had a significantly higher incidence in patients with recurrence in univariate analysis of AHF. Multivariate analysis found no significant association. Sheet-like growth may be involved in malignancy and recurrence of benign meningioma.

著者

Hiroshi Kurazumi Ryo Suzuki Bungo Shirasawa Yosuke Miyazaki Hiroki Tateishi Tetsuro Oda Takayuki Okamura Akihito Mikamo Masafumi Yano Kimikazu Hamano

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-21-0949, (Released:2022-02-09)

参考文献数

23

被引用文献数

2

---

Background:Transcatheter aortic valve implantation (TAVI) is increasingly being performed in very elderly patients, although its efficacy and validity remain unclear. This study evaluated real-world TAVI outcomes in Japanese nonagenarians with severe aortic stenosis.Methods and Results:This single-center study retrospectively assessed the early and long-term clinical outcomes of TAVI in nonagenarians (n=35) and in patients aged <90 years (group Y; n=171). There were no in-hospital deaths in either group. The device success rate and early safety were comparable between the 2 groups. The 5-year rates of freedom from cardiac events and deaths were equivalent in both groups. The cumulative survival rate at 5 years was non-significantly lower in nonagenarians (32.6% in nonagenarians vs. 57.5% in patients aged <90 years, P=0.49). There were no differences in the 5-year survival between nonagenarians after TAVI and the sex- and age-matched populations (P=0.18). The Cox regression model revealed that lower hemoglobin levels were associated with all-cause mortality (P=0.02), and age ≥90 years was not associated with all-cause mortality.Conclusions:The early and long-term clinical outcomes of TAVI for selected Japanese nonagenarians were comparable to those in patients aged <90 years. Nonagenarians who underwent TAVI achieved an acceptable prognosis compared to the sex- and age-matched population; thus, TAVI appears to be effective for treating aortic stenosis in Japanese nonagenarians.

著者

Hiroko Deguchi Masataka Ikeda Tomomi Ide Tomonori Tadokoro Soichiro Ikeda Kosuke Okabe Akihito Ishikita Keita Saku Shouji Matsushima Hiroyuki Tsutsui

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.84, no.6, pp.1028-1033, 2020-05-25 (Released:2020-05-25)

参考文献数

20

被引用文献数

9 36

---

Background:Ischemic preconditioning (IPC) is an effective procedure to protect against ischemia/reperfusion (I/R) injury. Hypoxia-inducible factor-1α (Hif-1α) is a key molecule in IPC, and roxadustat (RXD), a first-in-class prolyl hydroxylase domain-containing protein inhibitor, has been recently developed to treat anemia in patients with chronic kidney disease. Thus, we investigated whether RXD pretreatment protects against I/R injury.Methods and Results:RXD pretreatment markedly reduced the infarct size and suppressed plasma creatinine kinase activity in a murine I/R model. Analysis of oxygen metabolism showed that RXD could produce ischemic tolerance by shifting metabolism from aerobic to anaerobic respiration.Conclusions:RXD pretreatment may be a novel strategy against I/R injury.

著者

Jiro Aoyama Mizuko Osaka Michiyo Deushi Shoichi Hosoya Akihito Ishigami Taketoshi Maehara Masayuki Yoshida

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.63237, (Released:2021-12-08)

参考文献数

27

被引用文献数

5

---

Aims: Vascular inflammation is critical for the development and progression of atherosclerosis. Previously, we reported that neutrophils adhere to the vascular endothelium in low-density lipoprotein receptor null mice fed a high-fat diet through hypercitrullination of histone H3 by peptidylarginine deiminase 4 (PAD4) in neutrophils. However, the involvement of PAD4 and citrullination of proteins other than histone H3 in neutrophil adhesion is not well known. In this study, we investigated the function of PAD4 and identified citrullinated proteins during vascular inflammation. Methods: We pefformed flow assay under physiological flow conditions using differentiated HL-60 (dHL-60) cells stimulated with CXCL1 and human umbilical vein endothelial cells (HUVECs). Furthermore, phalloidin stain for dHL-60 stimulated with CXCL1 to observe F-actin polymerization and immunohistochemistry for the activated β2-integrin was conducted. To identify a target of citrullination in the cytoplasm of dHL-60 cells, liquid chromatography-mass spectrometry (LC-MS/MS) for dHL-60 stimulated with CXCL1 was performed. Results: Inhibition or knockdown of PAD4 significantly decreased adhesion of under physiological flow conditions. Thr-Asp-F-amidine trifluoroacetate salt (TDFA), a PAD4 inhibitor, inhibited cytoplasmic translocation of PAD4 by CXCL1. TDFA or knockdown of PAD4 significantly decreased expression of β2-integrin and F-actin polymerization activated by CXCL1. Moreover, LC-MS/MS identified protein disulfide isomerase A1 (PDIA1) as a target of citrullination in the cytoplasm of dHL-60 cells. Knockdown of PDIA1 significantly decreased adhesion of dHL-60 cells to HUVECs, expression of β2-integrin, and F-actin polymerization. Conclusions: Cytoplasmic translocation of PAD4 by CXCL1 induces neutrophil adhesion to vascular endothelial cells and citrullination of PDIA1.

著者

鈴江 美秋 脇川 千恵 安井 まゆみ 井出 真紀子 大竹 美智子 仲村 敦子 河合 昭人 阿部 正樹 杉本 健一 スズエ ミアキ ワキカワ チエ ヤスイ マユミ イデ マキコ オオタケ ミチコ ナカムラ アツコ カワイ アキヒト アベ マサキ スギモト ケンイチ Suzue Miaki Wakikawa Chie Yasui Mayumi Ide Makiko Ootake Michiko Nakamura Atsuko Kawaki Akihito Abe Masaki Sugimoto Kenichi

雑誌

東京慈恵会医科大学雑誌 (ISSN:03759172)

巻号頁・発行日

vol.130, no.5, pp.150-151, 2015-09-15

著者

立川 陽仁 Tachikawa Akihito

出版者

三重大学人文学部文化学科

雑誌

人文論叢 (ISSN:02897253)

巻号頁・発行日

no.24, pp.179-192, 2007

著者

Kazuto Kuribayashi Kotaro Imamura Masahito Tokita Akihito Shimazu Norito Kawakami

出版者

Japan Society for Occupational Health

雑誌

Environmental and Occupational Health Practice (ISSN:24344931)

巻号頁・発行日

pp.2019-0020-OA, (Released:2020-03-20)

参考文献数

41

---

Objectives: To preliminarily determine the effects of an Internet-based cognitive behavioral therapy program for the stress management of new graduate nurses on improving depressive symptoms and other psychological outcomes using a pre-post experimental design. Methods: A 6-week, six-lesson Internet-based cognitive behavioral therapy program was developed through an extensive interviewing of nurses. The program utilized major cognitive behavioral therapy skills (self-monitoring, cognitive restructuring, assertiveness, problem-solving, and relaxation). We administered the Internet-based cognitive behavioral therapy program to participants who were at 5 months after starting their job. At baseline and post-intervention, we measured the primary outcome of depressive symptoms along with the secondary outcomes of psychological distress, dysfunctional attitude, and knowledge of and self-efficacy for the components of cognitive behavioral therapy. Results: Twenty-three new graduate nurses were recruited, although only 21 actually took part in the program. Twelve (57%) participants completed all six lessons, and about one-third of participants completed less than three lessons. At post-intervention, only 12 of the 21 participants had completed the post-intervention survey. The program failed to show significant intervention effects on depressive symptoms, psychological distress, and dysfunctional attitude, but it did show significant or marginally significant improvements in knowledge of and self-efficacy for most cognitive behavioral therapy components. Conclusions: The relatively low intensity of the program may explain the null findings. This suggests a need for further improvement of the content and mode of delivery. Nevertheless, the program was able to improve knowledge of and self-efficacy for most cognitive behavioral therapy components.

著者

Shunsuke Murata Misa Takegami Daisuke Onozuka Yuriko Nakaoku Akihito Hagihara Kunihiro Nishimura

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.31, no.6, pp.361-368, 2021-06-05 (Released:2021-06-05)

参考文献数

19

被引用文献数

5

---

Background: Dementia-related missing and subsequent deaths are becoming serious problems with increases in people with dementia. However, there are no sufficient studies investigating the incidence rate, the mortality rate, and their risk factors.Methods: An ecological study aggregated at the Japanese prefectural level was conducted. Dementia-related missing persons cases and deaths in 2018 were extracted from the statistics of the National Police Agency in Japan. We extracted variables about older adults’ characteristics, care, and safety as candidate variables considered to be relevant to dementia-related missing persons cases and deaths. Associations of the candidate variables with the incidence and mortality rates were analyzed using the generalized linear model (family: quasi-poisson, link: log) adjusted for confounding factors (proportion of older adults and gross prefectural product).Results: The incidence rate and mortality rate per 100,000 person-year was 21.72 and 0.652 in Japan, respectively. One facility increase in the number of nursing care facilities for older adults per 100,000 persons aged 65-years-old or more was associated with a 7.9% (95% confidence interval [CI], 3.3–12.4%) decrease in the incidence rate. One increase in the number of public health nurses per 100,000 persons was associated with a 3.2% (95% CI, 1.6–4.9%) decrease in the incidence rate. A ten percent increase in the proportion of people who live in an urban area was associated with a 20.3% (95% CI, 8.7–33.2%) increase in the incidence rate and a 12.9% (95% CI, 5.6–19.8%) decrease in the mortality rate.Conclusions: Identified associated factors may be useful for managing or predicting dementia-related missing persons cases and associated deaths.

著者

Daisuke Asaoka Tsutomu Takeda Yoshihiro Inami Daiki Abe Yuji Shimada Kenshi Matsumoto Hiroya Ueyama Kohei Matsumoto Hiroyuki Komori Yoichi Akazawa Taro Osada Mariko Hojo Akihito Nagahara

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.59, no.14, pp.1677-1685, 2020-07-15 (Released:2020-07-15)

参考文献数

33

被引用文献数

8

---

Objective The association between frailty and abdominal symptoms has not been evaluated. Methods We conducted a hospital-based, retrospective cross-sectional study of consecutive outpatients ≥65 years old at the Department of Gastroenterology, Juntendo Tokyo Koto Geriatric Medical Center from 2017 to 2019. Patients were included in the study if all of the following information was available from their medical records: patient's profile, the evaluation of osteoporosis, sarcopenia, frailty, nutritional status, findings of upper gastrointestinal endoscopy, and questionnaire results for abdominal symptoms [Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease (FSSG) and Constipation Scoring System (CSS)]. We divided the subjects into frailty and non-frailty groups and investigated the risk factors for frailty. Results Of the 313 eligible study subjects [134 men (42.8%) and 179 women (57.2%); mean age, 75.7±6.0 years; mean body mass index, 22.8±3.6 kg/m2], frailty was noted in 71 cases (22.7%). In a univariate analysis, an older age (p<0.001), female gender (p=0.010), successful eradication of Helicobacter pylori (p=0.049), proton pump inhibitor (PPI) use (p<0.001), laxative/prokinetics use (p=0.008), sarcopenia (p<0.001), osteoporosis (p<0.001), hypozincemia (p=0.002), hypoalbuminemia (p<0.001), low lymphocytes (p=0.004), a high CONUT score (p<0.001), a high FSSG score (p=0.001), and a high CSS score (p<0.001) were significantly associated with frailty. A multivariate logistic regression analysis showed that an older age [odds ratio (OR) 1.16; 95% confidence interval (CI) 1.08-1.24, p<0.001], PPI use (OR 2.42; 95% CI 1.18-4.98, p=0.016), sarcopenia (OR 7.35; 95% CI 3.30-16.40, p<0.001), hypozincemia (OR 0.96; 95% CI 0.92-0.99, p=0.027), a high FSSG score (OR 1.08; 95% CI 1.01-1.16, p=0.021), and a high CSS score (OR 1.13; 95% CI 1.03-1.23, p=0.007) were significantly associated with frailty. Conclusion Advanced age, PPI user, sarcopenia, hypozincemia, a high FSSG score, and high CSS score are associated with frailty.

著者

熊野 陽人 Kumano Akihito 湘北短期大学

巻号頁・発行日

no.35, pp.131-136, 2014-03-31

---

本研究の目的は,女子学生を対象に,立ち幅とび跳躍距離と体格の関係性を検討し,立ち幅とびを体力テスト項目として行う有用性を検討することであった.検討の結果,以下のことが明らかになった.女子学生において,立ち幅とびの跳躍距離と身長,体重,BMI の間に有意な相関関係は認められなかった.また,女子学生において,立ち幅とびの跳躍距離と5 種目 (握力,上体起こし,長座体前屈,反復横とび,20m シャトルラン) 合計得点の間に,有意な正の相関関係 (r=0.555,p<0.01) が認められた.

著者

Naoki Shibata Norio Umemoto Akihito Tanaka Kensuke Takagi Makoto Iwama Yusuke Uemura Yosuke Inoue Yosuke Negishi Taiki Ohashi Miho Tanaka Ruka Yoshida Kiyokazu Shimizu Hiroshi Tashiro Naoki Yoshioka Itsuro Morishima Toshiyuki Noda Masato Watarai Hiroshi Asano Toshikazu Tanaka Yosuke Tatami Yasunobu Takada Hideki Ishii Toyoaki Murohara on behalf of N-Registry Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-20-0545, (Released:2021-03-20)

参考文献数

39

被引用文献数

3

---

Background:Data regarding the clinical features, outcomes and prognostic factors in patients presenting with acute total/subtotal occlusion of the unprotected left main coronary artery (LMCA) remain limited.Methods and Results:From a multi-center registry, 134 patients due to acute total/subtotal occlusion of the unprotected LMCA were reviewed. Emergency room (ER) status classification was defined according to the presence of cardiogenic shock and cardiopulmonary arrest (CPA) in the ER (class 1=no cardiogenic shock; class 2= cardiogenic shock but not CPA; and class 3=CPA). In-hospital mortality and cerebral performance category (CPC) as the endpoints were evaluated. One-half (67/134) of the enrolled patients presented with total occlusion of the unprotected LMCA. Regarding ER status classification, class 1, 2, and 3 were observed in 30.6%, 45.5%, and 23.9% of the patients, respectively. In-hospital mortality occurred in 73 (54.5%) patients; of the remaining patients, 52 (85.3%) could be discharged with a CPC 1 or 2. ER status classification (odds ratio 4.4 [95% confidence interval: 2.33–10.67]; P<0.001) and total occlusion of the unprotected LMCA (odds ratio 8.29 [95% confidence interval 2.93–23.46]; P<0.001) were strong predictors of in-hospital mortality.Conclusions:Acute total/subtotal occlusion involving the unprotected LMCA appeared to be associated with high in-hospital mortality. ER status classification and initial flow in the unprotected LMCA were significant predictive factors of in-hospital mortality.

著者

Hidenori OKAHASHI Shigeru SHIRASAKA Yoshihisa FUJITA Toshimichi MIYAGUCHI Toshiaki NISHINO Hiroyasu KAMO Megumi OHASHI Tetsuo SUYAMA Kenji TSUTSUMI Akihito NAKAJO Carolin FUNCK Doo-Chul KIM

出版者

The Association of Japanese Geographers

雑誌

地理学評論 (ISSN:13479555)

巻号頁・発行日

vol.76, no.5, pp.377-381, 2003-04-01 (Released:2008-12-25)

著者

Toshihiko Nishi Yoshiyuki Tokuda Akihito Tanaka Kenji Furusawa Yusuke Miki Akihiro Tobe Toyoaki Murohara Akihiko Usui

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.2, no.11, pp.701-702, 2020-11-10 (Released:2020-11-10)

参考文献数

1

著者

Akihito KAWANISHI Masaki NAKAYAMA Koki KADOTA

出版者

The Japan Neurosurgical Society

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

vol.39, no.3, pp.231-233, 1999 (Released:2007-08-17)

参考文献数

15

被引用文献数

27 34

---

A 14-year-old boy and a 11-year-old boy presented with subdural hematomas as complications of preexisting arachnoid cysts in the middle cranial fossa, manifesting as symptoms of raised intracranial pressure. Both had a history of heading the ball in a soccer game about 7 weeks and 2 days before the symptom occurred. There was no other head trauma, so these cases could be described as “heading injury.” Arachnoid cysts in the middle cranial fossa are often associated with subdural hematomas. We emphasize that mild trauma such as heading of the ball in a soccer game may cause subdural hematomas in patients with arachnoid cysts.

著者

安藤 明人 Akihito Ando

雑誌

武庫川女子大学紀要. 人文・社会科学編 (ISSN:09163115)

巻号頁・発行日

vol.48, pp.21-28, 2001-03-31

---

In Japan, soccer lottery is scheduled to start in 2001 as a new type of publicly-managed gambling. Relatively little is known about the effects of the advent of sports betting on youth gambling. The purposes of this study were to examine the prevalence of gambling and pseudgambling games among college students in Japan. 384 college students (aged 18-28) were administered questionnaire that inquires multiple domains of gambling behavior such as participation in gambling, dependency in gambling and cognition of gambling. Also was measured the desire for control to explore the possible relation between personality characteristics and gambling dependency. The majority of students gambled at least once in their life. However, most did not play any gamble or pseud-gambling game on a weekly/daily rate. The proportion of regular and problem gamblers found in this study were lower than prevalence rates reported in the US and Canada. Gender effect was found for gambling frequency and dependency. Male students gambled more often than female students. Cognitive factors seemed to be important in the explanation of gambling activity. Factors related to cognitive biases on gambling were discussed with reference to cognitive influences such as illusion of control, biased evaluations, and desire for control. College students will be the first generation of youth to be exposed to official sports betting and it will be important to continue monitoring the prevalence of youth gambling.

著者

Kaori IDE Mikako SHINOHARA Shohei YAMAGISHI Akihito ENDO Koji NISHIFUJI Takumi TOCHIO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.19-0071, (Released:2019-11-25)

被引用文献数

22

---

Kestose, a fructooligosaccharide (FOS) with one fructose monomer linked to sucrose, is a key component of the prebiotic activity of FOS. This study aimed to evaluate the prebiotic potential of Kestose in terms of the impact on population change in the intestinal microbiota and fecal short-chain fatty acid (SCFA) concentration in dogs. Kestose 2 g per dog was administered daily with conventional diet to 6 healthy, adult beagle dogs for 8 weeks followed by 4 weeks of follow-up period without Kestose supplementation. Fresh fecal samples were obtained before and every 4 weeks until the end of the follow-up period. Genomic DNA extracted from the fecal samples was subjected to 16S rRNA gene analysis using next generation sequencer and to quantitative polymerase chain reaction (qPCR). Fecal acetate, propionate, butyrate, lactate and ethanol concentrations were measured by high-performance liquid chromatography. 16S rRNA gene analysis and qPCR showed increasing trend of genus Bifidobacterium after Kestose supplementation while genera Bacteroides and Sutterella decreased. Clostridium perfringens decreased below the detection limit within first 4 weeks after starting Kestose supplementation. Fecal butyrate concentration was significantly increased at week 8 and returned to the base level after 4 weeks of the washing period. To the best of our knowledge, this is the first study to reveal effect of Kestose on the populational changes in fecal microbiota and fecal butyrate concentration in dogs.

著者

Tomoaki Tochitani Akihito Yamashita Izumi Matsumoto Mami Kouchi Yuta Fujii Toru Yamada Izuru Miyawaki

出版者

The Japanese Society of Toxicology

雑誌

The Journal of Toxicological Sciences (ISSN:03881350)

巻号頁・発行日

vol.44, no.9, pp.575-584, 2019 (Released:2019-09-02)

参考文献数

26

被引用文献数

2

---

The adrenal gland is the most common toxicological target of drugs within the endocrine system, and inhibition of adrenal steroidogenesis can be fatal in humans. However, methods to evaluate the adrenal toxicity are limited. The aim of the present study was to verify the usefulness of simultaneous measurement of blood levels of multiple adrenal steroids, including precursors, as a method to evaluate drug effects on adrenal steroidogenesis in cynomolgus monkeys. With this aim, physiological and drug-induced changes in blood levels of adrenal steroids, including cortisol, aldosterone, androgen, and their precursors were examined. First, for physiological changes, intraday and interday changes in blood steroid levels were examined in male and female cynomolgus monkeys. The animals showed circadian changes in steroid levels that are similar to those in humans, while interday changes were relatively small in males. Next, using males, changes in blood steroid levels induced by ketoconazole and metyrapone were examined, which suppress adrenal steroidogenesis via inhibition of CYP enzymes. Consistent with rats and humans, both ketoconazole and metyrapone increased the deoxycorticosterone and deoxycortisol levels, probably via CYP11B1 inhibition, and the increase was observed earlier and with greater dynamic range than the changes in cortisol level. Changes in other steroid levels reflecting the drug mechanisms were also observed. In conclusion, this study showed that in cynomolgus monkeys, simultaneous measurement of blood levels of adrenal steroids, including precursors, can be a valuable method to sensitively evaluate drug effects on adrenal steroidogenesis and to investigate the underlying mechanisms.

著者

Kanami Tsuno Norito Kawakami Akihito Shimazu Kyoko Shimada Akiomi Inoue Michael P. Leiter

出版者

Japan Society for Occupational Health

雑誌

Journal of Occupational Health (ISSN:13419145)

巻号頁・発行日

vol.59, no.3, pp.237-246, 2017-05-20 (Released:2017-05-25)

参考文献数

33

被引用文献数

25

---

Objectives: Although incivility is a common interpersonal mistreatment and associated with poor mental health, there are few studies about it in Asian countries. The aim of this study was to develop the Japanese version of the modified Work Incivility Scale (J-MWIS), investigate its reliability and validity, and reveal the prevalence of incivility among Japanese employees in comparison with data on Canadian employees. Methods: A total of 2,191 Japanese and 1,071 Canadian employees were surveyed, using either the J-MWIS or MWIS. Japanese employees additionally answered questions on civility, worksite social support, workplace bullying, psychological distress, intention to leave, and work engagement to investigate construct validity. Results: At least one form of workplace incivility was experienced by both Japanese (52.3%) and Canadian (86.0%) employees in the previous month. Internal consistency reliability of the J-MWIS was acceptable (α=0.71-0.81), and correlation analyses also confirmed its construct validity as expected. Workplace incivility was associated with lower workgroup civility, lower supervisor and coworker support, higher workplace bullying, higher psychological distress, higher intention to leave, and lower work engagement. Confirmatory factor analyses showed that the original three-factor model (supervisor incivility, coworker incivility, and instigated incivility) fitted moderately in both Japan and Canada data, though the privacy/overfamiliarity factor was additionally extracted from exploratory factor analysis for the J-MWIS. Conclusions: The results of this study suggested that the J-MWIS has moderate internal consistency reliability and good construct validity.

著者

Yasutomo HORI Yasuhiro HEISHIMA Yohei YAMASHITA Masayuki IGUCHI Kensuke NAKAMURA Noriko ISAYAMA Hideyuki ONODERA Akihito KITADE Nobuyuki KANNO Atsushi HIRAKAWA Michio KATAGI Toshiki IBARAGI Shigeki YAMANO Yoshitaka ARAMAKI Tamotsu SAWADA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.18-0187, (Released:2019-02-12)

被引用文献数

7

---

We investigated the clinical characteristics of healthy cats in accordance with the target organ damage (TOD) risk category, on the basis of systolic blood pressure (SBP). This prospective multi-center study included 137 healthy cats. Indirect blood pressure was measured using an oscillometric technique. The median SBP in all cats was 147 mmHg (interquartile range: 134‒158). On the basis of the TOD risk category, 57.7, 19.7, 21.9, and 0.7% of the cats were classified into categories I–IV, respectively. Age, sex, and body weight did not affect the SBP. This study provides basic information on the distribution of TOD risk categories in clinically healthy cats.

著者

Satoshi Suda Yuki Sakamoto Seiji Okubo Junya Aoki Takashi Shimoyama Takuya Kanamaru Kentaro Suzuki Akihito Kutsuna Noriko Matsumoto Chikako Nito Yasuhiro Nishiyama Masahiro Mishina Kazumi Kimura

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.82, no.10, pp.2647-2654, 2018-09-25 (Released:2018-09-25)

参考文献数

22

被引用文献数

1 7

---

Background: This study investigated changes in anticoagulant use, treatment, and functional outcomes in acute ischemic stroke (AIS) patients with non-valvular atrial fibrillation (NVAF) over a 6-year period. Methods and Results: Patients with AIS and NVAF admitted to our department from April 2011 to March 2017 were analyzed retrospectively. Patients were divided into 3 groups based on the time of the initial visit (Periods 1–3, corresponding to April 2011–March 2013, April 2013–March 2015, and April 2015–March 2017, respectively). Associations between prescribed medication prior to event and stroke severity, reperfusion therapy, and outcomes were assessed. There was no significant change in the rate of insufficient warfarin and inappropriately lowered doses of direct oral anticoagulant (DOAC) treatment over time. The number of patients receiving prior DOAC treatment increased, but neurological severity on admission was milder than in the other 2 groups. The rate of reperfusion therapy increased from 19.9% (Period 1) to 42.7% (Period 3) for moderate-to-severe stroke patients. Multivariate logistic regression analysis revealed that reperfusion therapy was independently positively associated with good functional outcomes, but negatively associated with mortality (odds ratios [95% confidence intervals] 7.14 [3.34–15.29] and 0.13 [0.008–0.69], respectively). Conclusions: Inappropriate anticoagulant use for stroke patients with NVAF did not decrease over time. An increase in reperfusion therapy was a strong factor in improved functional outcomes and mortality.