著者

Shunsuke Murata Misa Takegami Daisuke Onozuka Yuriko Nakaoku Akihito Hagihara Kunihiro Nishimura

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20200113, (Released:2020-06-27)

参考文献数

19

被引用文献数

5

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Background. Dementia-related missing and subsequent deaths are becoming serious problems with increases in people with dementia. However, there are no sufficient studies investigating the incidence rate, the mortality rate, and their risk factors.Methods. An ecological study aggregated at the Japanese prefectural level was conducted. Dementia-related missing persons cases and deaths in 2018 were extracted from the statistics of the National Police Agency in Japan. We extracted variables about older adults’ characteristics, care, and safety as candidate variables considered to be relevant to dementia-related missing persons cases and deaths. Associations of the candidate variables with the incidence and mortality rates were analyzed using the generalized linear model (family: quasi-poisson, link: log) adjusted for confounding factors (proportion of older adults and gross prefectural product).Results. The incidence rate and mortality rate per 100,000 person-year was 21.72 and 0.652 in Japan, respectively. One facility increase in the number of nursing care facilities for older adults per 100,000 persons aged 65-years-old or more was associated with a 7.9% (95% confidence interval, 3.3–12.4) decrease in the incidence rate. One increase in the number of public health nurses per 100,000 persons was associated with a 3.2% (1.6–4.9) decrease in the incidence rate. A ten percent increase in the proportion of people who live in an urban area was associated with a 20.3% (8.7–33.2) increase in the incidence rate and a 12.9% (5.6–19.8) decrease in the mortality rate.Conclusions. Identified associated factors may be useful for managing or predicting dementia-related missing persons cases and associated deaths.

著者

Tatsuya Noda Toshiyuki Ojima Shinya Hayasaka Chiyoe Murata Akihito Hagihara

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.22, no.1, pp.45-49, 2012-01-05 (Released:2012-01-05)

参考文献数

25

被引用文献数

6 11

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Background: Fever is one of the most common symptoms among children and is usually caused by respiratory infections. Although Japanese health authorities have long recommended gargling to prevent respiratory infections, its effectiveness among children is not clear.Methods: The children in this observational study were enrolled from 145 nursery schools in Fukuoka City, Japan. Children in the exposure group were instructed to gargle at least once a day. The endpoints of this study were incidence of fever during the daytime and incidence of sickness absence. Differences among gargling agents for each endpoint were also analyzed.Results: A total of 19 595 children aged 2 to 6 years were observed for 20 days (391 900 person-days). In multivariate logistic regression, the overall odds ratio (OR) for fever onset in the gargling group was significantly lower (OR = 0.68). In age-stratified analysis, ORs were significantly lower at age 2 (OR = 0.67), 4 (OR = 0.46), and 5 (OR = 0.41) years. Regarding sickness absence, the overall OR was 0.92 (not significant) in the gargling group. In age-stratified analysis, ORs were significantly lower at age 4 (OR = 0.68), 5 (OR = 0.59), and 6 (OR = 0.63) years. In subgroup analysis, significantly lower ORs for fever onset were observed for children who gargled with green tea (OR = 0.32), functional water (OR = 0.46), or tap water (OR = 0.70). However, the ORs were not significant for sickness absence.Conclusions: Gargling might be effective in preventing febrile diseases in children.

著者

Yasutomo HORI Yasuhiro HEISHIMA Yohei YAMASHITA Noriko ISAYAMA Nobuyuki KANNO Kensuke NAKAMURA Masayuki IGUCHI Toshiki IBARAGI Hideyuki ONODERA Yoshitaka ARAMAKI Atsushi HIRAKAWA Shigeki YAMANO Michio KATAGI Akihito KITADE Tamotsu SAWADA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0620, (Released:2018-01-03)

被引用文献数

6

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Chronic kidney disease (CKD) is a common cause of secondary systemic hypertension in cats. We investigated the relationship between indirect blood pressure and the prevalence of systemic hypertension in various CKD stages in cats. Client-owned cats (24 control cats and 77 cats with CKD) were included. Biochemical examinations of plasma were conducted by a commercial laboratory. Diseased cats were divided into two groups based on the International Renal Interest Society (IRIS) guidelines (II and III–IV). Indirect blood pressure was measured using an oscillometric technique. Severe hypertension was diagnosed if systolic blood pressure (SBP) was ≥180 mmHg. Indirect blood pressures were significantly higher in IRIS stage III–IV than in the control cats. Of 77 cats with CKD, 25 (32.5%) had severe hypertension. The frequency of severe hypertension increased with an increase in IRIS stage; 0% in the controls, 27.6% in the IRIS stage II, and 47.4% in the IRIS stage III–IV, respectively. The indirect SBP was weakly correlated with urea nitrogen (r=0.27) and creatinine (r=0.23) concentrations in plasma. Binary logistic regression analysis showed that if plasma creatinine concentration is >3.7 mg/dl, cats with CKD had an increased risk for developing severe hypertension (P<0.001). Our results suggest that indirect blood pressure was correlated with the severity of CKD, and the prevalence of severe hypertension increased in cats with severe CKD. The risk of severe hypertension may be high in cats with severe CKD.

著者

Shunji Sugai Nobuyuki Kaji Akihito Osuka Koshi Takenaka Shigeru Horii Hiroshi Ikuta

出版者

THE PHYSICAL SOCIETY OF JAPAN

雑誌

Journal of the Physical Society of Japan (ISSN:00319015)

巻号頁・発行日

vol.74, no.3, pp.871-874, 2005-03-15 (Released:2007-12-06)

参考文献数

26

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Optical reflection spectroscopy perpendicular to the double-chain of PrBa2Cu4O8 clarified that carriers in the plane transfer to the chain almost completely as temperature decreases from 295 to 150 K. Many anomalies around 150 K can be explained by the transfer of carriers. The temperature and Zn substitution effects suggest that the chains are in the Fermi liquid state when the carrier density is close to 0.5/Cu(1) and in the Tomonaga–Luttinger liquid state when the carrier density is 0.4/Cu(1).

著者

Fumio Terasaki Arata Azuma Toshihisa Anzai Nobukazu Ishizaka Yoshio Ishida Mitsuaki Isobe Takayuki Inomata Hatsue Ishibashi-Ueda Yoshinobu Eishi Masafumi Kitakaze Kengo Kusano Yasushi Sakata Noriharu Shijubo Akihito Tsuchida Hiroyuki Tsutsui Takatomo Nakajima Satoshi Nakatani Taiko Horii Yoshikazu Yazaki Etsuro Yamaguchi Tetsuo Yamaguchi Tomomi Ide Hideo Okamura Yasuchika Kato Masahiko Goya Mamoru Sakakibara Kyoko Soejima Toshiyuki Nagai Hiroshi Nakamura Takashi Noda Takuya Hasegawa Hideaki Morita Tohru Ohe Yasuki Kihara Yoshihiko Saito Yukihiko Sugiyama Shin-ichiro Morimoto Akira Yamashina on behalf of the Japanese Circulation Society Joint Working Group

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.83, no.11, pp.2329-2388, 2019-10-25 (Released:2019-10-25)

参考文献数

355

被引用文献数

95 237

著者

Akihito Umehara Toru Adachi Wataru Mashiko Hiroshi Yamauchi

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.17, pp.196-201, 2021 (Released:2021-11-25)

参考文献数

19

被引用文献数

2

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The tornadic debris signatures (TDSs) of the Ichihara Tornado associated with Typhoon Hagibis (2019) were observed using two operational C-band dual-polarization weather radars and an X-band phased-array weather radar (PAWR). This TDS observation was the first to be made over Japan in a typhoon environment. The TDS bins spread over time, and the maximum vertical and aerial extents reached 2.4 km and 9.41 km2, respectively. The estimated rise velocity of the TDS was 8 m s−1. The first TDS was detected ∼1 min before damage reporting began. The TDSs became clearer along with the rotational velocity of the near-surface vortex detected by PAWR. The copolar correlation coefficient reached a minimum (0.27) ∼1 min after the tornado passed the most severely damaged area and increased gradually over 4 min. This suggests that heavy and/or dense debris was lofted and immediately fell out and/or diffused, whereas light debris remained aloft for ≥ 4 min. By comparing the PAWR-detected vortex signatures with aerial photographs, we inferred that the first TDS comprised vegetated debris, the clearest TDS mainly comprised destroyed manmade structures. These results indicate that TDS detection is effective both for investigating damage and for recognizing tornado's occurrence even in a typhoon environment.

著者

Atsushi IIDA Hitomi SAITO Akihito AMAO Takuya FUJITA Atsushi KATO Fumitaka UEDA

出版者

Japanese Society of Equine Science

雑誌

Journal of Equine Science (ISSN:13403516)

巻号頁・発行日

vol.31, no.1, pp.11-15, 2020 (Released:2020-03-19)

参考文献数

21

被引用文献数

1

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A nutritional supplement containing salacinol (NSS) was administered to Thoroughbred foals daily beginning 21 days after birth, and clinical signs and intestinal microbiota were analyzed. The average number of days for which foals exhibited a fever between 21 and 110 days after birth was determined. The number of days was significantly reduced, by approximately 1/3, in the NSS group compared with the control group. Furthermore, improved weight gain was observed in the NSS group compared with the control group. By analyzing the intestinal microbiota, it was determined that the ratio of Clostridium cluster XIVa increased after 3 weeks of NSS administration. These results demonstrate that the daily administration of NSS might improve the intestinal environment of neonatal foals and be useful for health.

著者

Hisashi Eguchi Akihito Shimazu Arnold B. Bakker Maria Tims Kimika Kamiyama Yujiro Hara Katsuyuki Namba Akiomi Inoue Masakatsu Ono Norito Kawakami

出版者

Japan Society for Occupational Health

雑誌

Journal of Occupational Health (ISSN:13419145)

巻号頁・発行日

vol.58, no.3, pp.231-240, 2016-05-20 (Released:2016-06-16)

参考文献数

35

被引用文献数

15

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Objectives: The aim of this study was to validate the Japanese version of the job crafting scale (JCS-J). JCS measures four independent job crafting dimensions, namely increasing structural job resources, decreasing hindering job demands, increasing social job resources, and increasing challenging job demands. Methods: The translated and back-translated JCS-J questionnaires were administered online to 972 employees of a Japanese manufacturing company. The data were then divided into independent explorative and confirmative samples. Exploratory and confirmatory factor analyses were performed to evaluate the factorial validity of JCS-J. The relationship with potential consequences of job crafting (e.g., job demands, job resources, and psychological well-being) was investigated to evaluate construct validity. Internal consistency was examined to evaluate the reliability of the four JCSs. Results: An exploratory factor analysis extracted a five-factor solution. Decreasing hindering job demands was further split into two separate dimensions supporting a five- rather than four-factor structure. A series of confirmatory factor analyses revealed that the modified five-factor model that allows covariance between items fits the data best. Construct validity was generally supported by the expected correlations of each job crafting dimension with each corresponding job resource (+), job demand (+), and psychological well-being (+). Cronbach's α coefficient was sufficient for each of the four dimensions of job crafting (α ranged between 0.76 and 0.90). Conclusions: This study confirmed that JCS-J is an adequate measure of job crafting that can be used in the Japanese context.

著者

Tanaka Akihito Woltjen Knut Miyake Katsuya Hotta Akitsu Ikeya Makoto Yamamoto Takuya Nishino Tokiko Shoji Emi Sehara-Fujisawa Atsuko Manabe Yasuko Fujii Nobuharu Hanaoka Kazunori Era Takumi Yamashita Satoshi Isobe Ken-ichi Kimura En Sakurai Hidetoshi

出版者

Public Library of Science

雑誌

PLoS ONE (ISSN:19326203)

巻号頁・発行日

vol.8, no.4, 2013-04-23

被引用文献数

153

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効率よく、再現性高くヒトiPS細胞から筋肉細胞を作製 -筋肉疾患の創薬プラットフォームの開発に向けて-. 京都大学プレスリリース. 2013-04-24.

著者

Akihito Konishi Yasukazu Hirao Kouzou Matsumoto Hiroyuki Kurata Takashi Kubo

出版者

The Chemical Society of Japan

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

pp.130153, (Released:2013-05-18)

被引用文献数

52

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The improved Scholl reaction allows for the direct cyclization of anthracene oligomers to give bisanthene, teranthene, and quarteranthene. Furthermore, a variety of π-expanded bisanthenes are obtained by the Diels–Alder cycloaddition of bisanthene with several arynes. These reactions would allow us to synthesize various size- and shape-controlled polyperiacenes.

著者

Takashi Unuma Hiroshi Yamauchi Akihito Umehara Teruyuki Kato

出版者

公益社団法人 日本気象学会

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.19, pp.150-156, 2023 (Released:2023-07-22)

参考文献数

28

被引用文献数

1

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We investigated the microphysical mechanisms for the enhancement of rainfall in a precipitating system that spawned heavy rainfall over the central part of the Kanto Plain in eastern Japan on 12 July 2022. Optical disdrometer observations confirmed the existence of an equilibrium state in the raindrop size distribution, especially when the precipitation intensity was high (e.g., 20 mm hr−1). As the raindrop size distribution approached equilibrium, raindrop sizes centered around 1.5 mm were observed initially, and then the number concentration of smaller and larger size raindrops increased simultaneously. The raindrop size distribution was closely related to the vertical profile of the parameters of raindrop size distribution that were estimated from polarimetric radar observations. These results suggest that the formation of equilibrium raindrop size distributions is important to produce substantial rainfall in the midlatitude as well as in the tropics.

著者

Kazuhiro WATANABE Kotaro IMAMURA Akiomi INOUE Yasumasa OTSUKA Akihito SHIMAZU Hisashi EGUCHI Hidehiko ADACHI Asuka SAKURAYA Yuka KOBAYASHI Hideaki ARIMA Norito KAWAKAMI

出版者

National Institute of Occupational Safety and Health

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

vol.58, no.2, pp.107-131, 2020 (Released:2020-04-02)

参考文献数

58

被引用文献数

5 9

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Although the eudemonic perspective seems to be a promising in considering vocational identity among working population, well-being at work has been discussed primarily in terms of subjective/hedonic well-being. This study aimed to develop a new tool to measure eudemonic well-being at work (The University of Tokyo Occupational Mental Health [TOMH] well-being 24 scale)and investigate its validity in a collectivist culture. Two online surveys were conducted with a total of 1,760 workers in Japan. We created 89 potential items from existing scales. An exploratory factor analysis indicated eight factors for the dimensions of measurement. After item selection based on item response theory, the factor structure with three items from each of the eight dimensions indicated an excellent fit for another sample. Cronbach’s α and intra-class coefficients ranged from 0.671 to 0.845. The scores of the tool were more strongly associated with subjective well-being in the work context rather than well-being in general. In addition, the participants in the group demonstrating a higher risk for mental illness and a more stressful work environment indicated significantly lower scores, even after adjusting for general eudemonic well-being. The new measurement may be useful both for academic and practical applications for measuring eudemonic well-being at work, independent from general eudemonic well-being.

著者

Koyama Yutaka Kojima Keisuke Fukamachi Daisuke Ohgaku Akihito Fujito Hidesato Ebuchi Yasunari Arai Riku Morikawa Tomoyuki Monden Masaki Migita Suguru Takei Norio Tamaki Takehiro Akutsu Naotaka Murata Nobuhiro Takayama Tadateru Okumura Yasuo

出版者

日本大学医学会

雑誌

日大医学雑誌 (ISSN:00290424)

巻号頁・発行日

vol.80, no.3, pp.127-130, 2021-06-01 (Released:2021-08-06)

参考文献数

13

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Allergic reactions to iodine contrast agent rarely lead to anaphylactic shock affecting hemodynamics. We treated two cases of anaphylactic shock during coronary angiography, which did not respond to adrenaline because thepatients had taken beta-blockers. Instead, glucagon relieved their conditions. If patients treated with beta-blockersexperience anaphylactic shock during coronary angiography, we should consider glucagon as a treatment optionbecause the persistence of shock refractory to adrenaline leads to unfavorable outcomes.

著者

崔 哲暢 堅田 和弘 山内 克真 竹谷 祐栄 福居 顕文 春里 暁人 岡山 哲也 中井 理絵 住吉 秀太郎 原田 恭一 竹本 健一 越野 勝博 當麻 敦史 落合 登志哉 伊藤 義人 Akinobu Sai Kazuhiro Katada Katsuma Yamauchi Hiroyoshi Taketani Akifumi Fukui Akihito Harusato Tetsuya Okayama Rie Nakai Shutaro Sumiyoshi Kyoichi Harada Kenichi Takemoto Katsuhiro Koshino Atsushi Toma Toshiya Ochiai Yoshito Itoh

出版者

京都府立医科大学附属北部医療センター

雑誌

京都府立医科大学附属北部医療センター誌 = Journal of North Medical Center Kyoto Prefectural University of Medicine (ISSN:21885400)

巻号頁・発行日

vol.7, no.1, pp.39-43, 2021-03-31

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京都府立医科大学附属北部医療センター 消化器内科

著者

Shun Yasuda Kanako Okazaki Hironori Nakano Kayoko Ishii Hyo Kyozuka Tsuyoshi Murata Keiya Fujimori Aya Goto Seiji Yasumura Misao Ota Kenichi Hata Kohta Suzuki Akihito Nakai Tetsuya Ohira Hitoshi Ohto Kenji Kamiya

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.32, no.Supplement_XII, pp.S104-S114, 2022-12-05 (Released:2022-12-05)

参考文献数

51

被引用文献数

3

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Background: This study aimed to investigate the effects of maternal exposure to external radiation on perinatal outcomes among women who experienced the Fukushima Daiichi Nuclear Disaster (FDND) using the Fukushima Health Management Survey (FHMS).Methods: Data from the Pregnancy and Birth Survey and Basic Survey in the FHMS were combined to analyze external maternal radiation exposure following the FDND, and the relationship between radiation dose and perinatal outcomes was analyzed using binomial logistic regression analysis. Missing dose data were supplemented using multiple imputation.Results: A total of 6,875 individuals responded to the survey. Congenital anomalies occurred in 2.9% of patients, low birth weight (LBW) in 7.6%, small for gestation age (SGA; <10th percentile) in 8.9%, and preterm birth in 4.1%. The median maternal external radiation dose was 0.5 mSv (maximum, 5.2 mSv). Doses were classified as follows: <1 mSv (reference), 1 to <2 mSv, and ≥2 mSv. For congenital anomalies, the crude odds ratio for 1 to <2 mSv was 0.81 (95% confidence interval [CI], 0.56–1.17) (no participants with congenital anomaly were exposed to ≥2 mSv). At 1 to <2 mSv and ≥2 mSv, the respective adjusted odds ratios were 0.91 (95% CI, 0.71–1.18) and 1.21 (95% CI, 0.53–2.79) for LBW, 1.14 (95% CI, 0.92–1.42) and 0.84 (95% CI, 0.30–2.37) for SGA, and 0.91 (95% CI, 0.65–1.29) and 1.05 (95% CI, 0.22–4.87) for preterm birth.Conclusion: External radiation dose due to the FDND was not associated with congenital anomalies, LBW, SGA, or preterm birth.

著者

Kazuo Kimura Takeshi Kimura Masaharu Ishihara Yoshihisa Nakagawa Koichi Nakao Katsumi Miyauchi Tomohiro Sakamoto Kenichi Tsujita Nobuhisa Hagiwara Shunichi Miyazaki Junya Ako Hirokuni Arai Hideki Ishii Hideki Origuchi Wataru Shimizu Hirofumi Takemura Yoshio Tahara Yoshihiro Morino Kenji Iino Tomonori Itoh Yoshitaka Iwanaga Keiji Uchida Hirohisa Endo Ken Kongoji Kenji Sakamoto Hiroki Shiomi Takao Shimohama Atsushi Suzuki Jun Takahashi Ichiro Takeuchi Akihito Tanaka Toshihiro Tamura Takahiro Nakashima Teruo Noguchi Daisuke Fukamachi Tomohiro Mizuno Junichi Yamaguchi Kenji Yodogawa Masami Kosuge Shun Kohsaka Hideaki Yoshino Satoshi Yasuda Hiroaki Shimokawa Atsushi Hirayama Takashi Akasaka Kazuo Haze Hisao Ogawa Hiroyuki Tsutsui Tsutomu Yamazaki on behalf of the Japanese Circulation Society Joint Working Group

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-19-0133, (Released:2019-03-29)

参考文献数

1064

被引用文献数

31 315

著者

Akihito Miyoshi Nobuhiro Nishii Yoji Okamoto Shinpei Fujita Kenji Kawamoto Keisuke Okawa Shigeki Hiramatsu Kazufumi Nakamura Hiroshi Morita Hiroshi Ito

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.84, no.3, pp.456-462, 2020-02-25 (Released:2020-02-25)

参考文献数

21

被引用文献数

1 5

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Background:In heart failure (HF) patients implanted with high-energy devices, worsening of HF can be diagnosed from intrathoracic impedance (ITI) before symptoms appear. Early therapeutic intervention can prevent HF worsening, but the optimal intervention remains unknown. This study aimed to examine which lifestyle modifications or medications can improve HF indicators in asymptomatic HF patients diagnosed from ITI.Methods and Results:This multicenter, prospective, randomized study included patients with high-energy devices, left ventricular ejection fraction <40%, or with a history of HF hospitalization. After the OptiVol alert was evoked by decreased ITI, patients underwent examinations. If they were diagnosed with HF, they were randomly assigned to 3 groups: lifestyle modification, diuretic, or nitrate. After 1 week, they underwent the same examinations. The primary endpoint was change in ITI and serum B-type natriuretic peptide (BNP). Totally, 57 patients were randomized. In all 3 groups, ITI was significantly increased post-intervention compared with pre-intervention. In the diuretic and nitrate groups, logBNP post-intervention was significantly lower than pre-intervention, but not in the lifestyle modification group.Conclusions:Compared with lifestyle modifications, diuretic and nitrate therapy for 1 week may be more effective management of HF detected by decreased ITI. However, lifestyle modification may have the additional benefits of reducing the workload or cost.

著者

Kotaro Imamura Yumi Asai Kazuhiro Watanabe Akizumi Tsutsumi Akihito Shimazu Akiomi Inoue Hisanori Hiro Yuko Odagiri Toru Yoshikawa Etsuko Yoshikawa Norito Kawakami

出版者

Japan Society for Occupational Health

雑誌

Journal of Occupational Health (ISSN:13419145)

巻号頁・発行日

vol.60, no.4, pp.298-306, 2018-07-20 (Released:2018-07-25)

参考文献数

29

被引用文献数

16

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Objectives: This retrospective cohort study evaluated the impact of the Stress Check Program, a recently introduced national policy and program aimed at reducing psychological distress among Japanese workers. Methods: A baseline survey was conducted from November 2015 to February 2016, the period when Japan began enforcing the Stress Check Program. A one-year follow-up survey was conducted in December 2016. In the follow-up survey, two exposure variables were collected: having taken the annual stress survey, and experiencing an improvement in the psychosocial work environment. Psychological distress was assessed using the Brief Job Stress Questionnaire (BJSQ) at baseline and 1-year follow-up. The two exposure variables were used to define four groups: "Neither", "Stress survey (SS) only", "Psychosocial work environment improvement (WI) only", and "Both". BJSQ results were analyzed using repeated measures general linear modeling (GLM). Results: The study included 2,492 participants: 1,342 in the "Neither" group, 1,009 in the "SS only" group, 76 in the "WI only" group, and 65 in the "Both" group. Overall time-group interaction effects were not significant. The "Both" group showed significantly greater improvements in psychological distress than the "Neither" group (p = 0.02) at the 1-year follow-up, although the effect size was small (d = -0.14). Conclusions: Combination of the annual stress survey and improvement in psychosocial work environment may have been effective in reducing psychological distress in workers, although the effect size was small.

著者

Yurie Hirata Shinji Kamei Fuminori Tatsumi Masashi Shimoda Akihito Tanabe Junpei Sanada Yoshiro Fushimi Shintaro Irie Tomoatsu Mune Kohei Kaku Hideaki Kaneto

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.56, no.12, pp.1527-1529, 2017-06-15 (Released:2017-06-15)

参考文献数

11

被引用文献数

1

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Succinic acid cibenzoline (CZ) is an antiarrhythmic agent often used for the treatment of tachyarrhythmia. However, hypoglycemia should be avoided in the treatment of diabetes. We herein report two late-stage elderly subjects who experienced a severe and prolonged hypoglycemic coma after the usage of CZ. These cases suggest that, when CZ is administered to elderly subjects with renal dysfunction and/or frailty, we should be aware of the possibility that this medicine may induce hypoglycemia and should adjust the dose as appropriate and monitor the concentration of CZ to avoid severe hypoglycemia.

著者

Akihito Tanaka Hideki Ishii Yosuke Tatami Yohei Shibata Naohiro Osugi Tomoyuki Ota Yoshihiro Kawamura Susumu Suzuki Yoshimasa Nagao Tadashi Matsushita Toyoaki Murohara

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.55, no.4, pp.333-337, 2016 (Released:2016-02-15)

参考文献数

23

被引用文献数

5

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Objective Heparin is not recommended to be administered during the interruption of antiplatelet therapy for non-cardiac surgery. However, there are insufficient data to determine the value. The purpose of the present study was to evaluate the clinical results of the administration of unfractionated heparin during the interruption of antiplatelet therapy in non-cardiac surgery patients who had previously undergone drug-eluting stent (DES) implantation. Methods We retrospectively identified 210 elective non-cardiac surgical procedures that were performed with the administration of unfractionated heparin during interruption of all antiplatelet therapies in patients who had previously undergone DES implantation. Heparin was administered during the perioperative period in accordance with the local practice guideline at out institution. We examined the clinical outcomes within 30 days of surgery. Results The mean number of implanted DESs was 2.1±1.3. No major adverse cardiac events (including cardiac death, definite stent thrombosis, and non-fatal myocardial infarction) occurred in any of the 210 cases within 30 days of surgery. Four of the 210 cases (1.9%) required reoperation for bleeding within 30 days of surgery. Conclusion Our data showed the potential for the perioperative management with unfractionated heparin administration in Japanese patients who had previously undergone DES implantation who required non-cardiac surgery with the interruption of all antiplatelet therapies.