著者

Akihito Meguro Katsusuke Sakamoto Katsuichi

出版者

Ichthyological Society of Japan

雑誌

Ichthyological research formerly Japanese Journal of Ichthyology (ISSN:13418998)

巻号頁・発行日

vol.50, no.2, pp.117-122, 2003-05-23

著者

Yanai Goichi Hayashi Takashi Zhi Qi Yang Kai-Chiang Shirouzu Yasumasa Shimabukuro Takashi Hiura Akihito Inoue Kazutomo Sumi Shoichiro

出版者

Public Library of Science

雑誌

PLoS ONE (ISSN:19326203)

巻号頁・発行日

vol.8, no.5, 2013-05-28

被引用文献数

31

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膵島細胞と間葉系幹細胞の融合細胞を用いた糖尿病治療実験に成功 -新しい重症糖尿病治療法の開発に期待-. 京都大学プレスリリース. 2013-05-29.

著者

Kota Kera Shohei Makino Risako Takeda Aoi Shimeno Masaya Hojo Sadahiro Hamasaki Akihito Endo Masumi Iijima Tsutomu Nakayama

出版者

Japanese Society for Food Science and Technology

雑誌

Food Science and Technology Research (ISSN:13446606)

巻号頁・発行日

pp.FSTR-D-23-00189, (Released:2023-12-27)

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The astringency of persimmon fruits is a significant factor for consumers and the nutritional industry. To date, astringents, such as polyphenols, specifically persimmon condensed tannins, have been assessed using polyphenol quantification assays, such as the Folin–Ciocalteu method, based on their reducing power. However, these methods are influenced by the presence of other reducing substances. In this study, we developed a cost-effective liposome turbidity analysis using a portable visible spectrophotometer based on the interaction between liposomes and astringents. Authentic astringents, such as catechins and theaflavin-3-O-gallate, were analyzed, and their half-maximal effective concentrations (EC50) were calculated. These results indicated that the affinity to the membrane was similar to that of astringency, as determined by sensory analysis. Additionally, the EC50 values of partially purified tannins from non-astringent and astringent persimmons were calculated. In conclusion, we determined the application methods to assess astringent persimmon fruits with and without the removal of astringency.

著者

Akihito SHIMAZU Ko MATSUDAIRA Jan DE JONGE Naoya TOSAKA Kazuhiro WATANABE Masaya TAKAHASHI

出版者

National Institute of Occupational Safety and Health

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

vol.54, no.3, pp.282-292, 2016-05-31 (Released:2016-06-10)

参考文献数

54

被引用文献数

32 36

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This study examined whether a higher level of psychological detachment during non-work time is associated with better employee mental health (Hypothesis 1), and examined whether psychological detachment has a curvilinear relation (inverted U-shaped pattern) with work engagement (Hypothesis 2). A large cross-sectional Internet survey was conducted among registered monitors of an Internet survey company in Japan. The questionnaire included scales for psychological detachment, employee mental health, and work engagement as well as for job characteristics and demographic variables as potential confounders. The hypothesized model was tested with moderated structural equation modeling techniques among 2,234 respondents working in the tertiary industries with regular employment. Results showed that psychological detachment had curvilinear relations with mental health as well as with work engagement. Mental health improved when psychological detachment increased from a low to higher levels but did not benefit any further from extremely high levels of psychological detachment. Work engagement showed the highest level at an intermediate level of detachment (inverted U-shaped pattern). Although high psychological detachment may enhance employee mental health, moderate levels of psychological detachment are most beneficial for his or her work engagement.

著者

Akiomi Inoue Yuko Kachi Hisashi Eguchi Akihito Shimazu Norito Kawakami Akizumi Tsutsumi

出版者

Japan Society for Occupational Health

雑誌

Environmental and Occupational Health Practice (ISSN:24344931)

巻号頁・発行日

vol.2, no.1, pp.2020-0002-OA, 2020 (Released:2020-06-30)

参考文献数

35

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Objectives: We prospectively examined the combined effect of high stress (i.e., being under great work-related stress), as defined in the Japanese Stress Check Program manual using the Brief Job Stress Questionnaire (BJSQ), and job dissatisfaction on long-term sickness absence lasting 1 month or more. Methods: Participants were 7,343 male and 7,344 female financial service company employees who completed the BJSQ. We obtained personnel records covering a 1-year period to identify employees with long-term sickness absence, which was treated as a dichotomous variable. Participants were classified into four groups (high-stress+dissatisfied, high-stress+satisfied, not high-stress+dissatisfied, and not high-stress+satisfied groups) to calculate the hazard ratios (HRs) of long-term sickness absence for these groups using Cox’s proportional hazard regression analysis. Furthermore, to examine whether the combined effect of high stress and job dissatisfaction is synergistic or additive, we calculated relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), synergy index (SI), and their 95% confidence intervals (CIs). Results: After adjustment for covariates, the HR of long-term sickness absence was highest among the high-stress+dissatisfied group (HR 6.49; 95% CI, 3.42–12.3) followed by the high-stress+satisfied group (HR 5.01; 95% CI, 1.91–13.1). The combined effect of high stress and job dissatisfaction was additive (95% CIs of RERI and AP included 0 and that of SI included 1). Conclusions: Our findings suggest incorporating high stress with job dissatisfaction improves the predictability of long-term sickness absence. However, employees reporting high stress but satisfaction with their jobs may still at increased risk of developing long-term sickness absence.

著者

柿本 昭人 Akihito Kakimoto

出版者

同志社大学政策学会

雑誌

同志社政策研究 = Doshisha University Policy Studies (ISSN:18818625)

巻号頁・発行日

no.2, pp.33-45, 2008-03-15

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論説(Article)

著者

Haruna Fujisawa Yurika Mitsui Kensuke Narukawa Yukari Shirasugi Shogo Komaki Akihito Hao Hideyuki Matsumoto Tsuyoshi Takahashi

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.0855-22, (Released:2022-12-07)

参考文献数

16

被引用文献数

1

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A 21-year-old woman was diagnosed with acute lymphoblastic leukemia. After the administration of intrathecal methotrexate (MTX), the patient experienced dysarthria and paralysis for one hour. Magnetic resonance imaging (MRI) performed one hour from the onset and just before symptoms disappeared revealed no abnormalities. The next day, the symptoms appeared again, and diffusion-weighed MRI revealed a high-intensity area in the left frontal lobe. The patient was diagnosed with MTX-induced encephalopathy. This case suggested that MRI performed as soon as symptoms appear might show normal findings in MTX-induced encephalopathy.

著者

Masahito Katsuki Yasuhiko Matsumori Kenta Kashiwagi Shin Kawamura Akihito Koh

出版者

Societas Neurologica Japonica

雑誌

臨床神経学 (ISSN:0009918X)

巻号頁・発行日

pp.cn-001812, (Released:2023-01-31)

参考文献数

26

被引用文献数

1

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Objectives: Tension-type headache (TTH) is the most prevalent type of primary headache disorder. Its acute pharmacotherapy is acetaminophen or non-steroidal anti-inflammatory drugs based on the Japanese Clinical Practice Guideline for Headache Disorders 2021. With Japan’s aging population, however, the number of TTH patients with comorbidities that have been treated by analgesics is increasing. Under this context, it is sometimes difficult to select an acute pharmacotherapy for TTH. Kakkonto, Japanese traditional herbal kampo medicine, is empirically used for TTH. We hypothesized that kakkonto has efficacy for TTH with painful comorbidities. Materials and Methods: We prospectively collected 10 consecutive TTH patients who had already taken analgesics for comorbidities. We prescribed 2.5 g of kakkonto (TJ-1), and patients took it. A numerical rating scale for pain before and 2 hours after kakkonto intake was evaluated. Results: Eight women and 2 men were included. The mean age was 71.0 ± 13.4 years old. Four patients had lower back pain, 2 had lumbar spinal stenosis, 2 had knee pain, 1 had neck pain, and 1 had shoulder myofasciitis. Celecoxib was used for 4 patients, acetaminophen for 3, loxoprofen for 2, and a combination of tramadol and acetaminophen for 1, as routinely used analgesics. The median numerical rating scale statistically improved from the median of 4 to that of 0. There were no side effects of kakkonto. Conclusion: Kakkonto showed efficacy as an acute medication for TTH with comorbidities that have been treated by analgesic.

著者

Naoki Nakayama Takeshi Yamamoto Migaku Kikuchi Hiroyuki Hanada Toshiaki Mano Takahiro Nakashima Katsutaka Hashiba Akihito Tanaka Kunihiro Matsuo Osamu Nomura Sunao Kojima Junichi Yamaguchi Tetsuya Matoba Yoshio Tahara Hiroshi Nonogi for the Japan Resuscitation Council (JRC) Acute Coronary Syndrome (ACS) Task Force and the Guideline Editorial Committee on behalf of the Japanese Circulation Society (JCS) Emergency and Critical Care Committee

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.4, no.10, pp.449-457, 2022-10-07 (Released:2022-10-07)

参考文献数

20

被引用文献数

1 7

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Background: Recent guidelines for acute coronary syndrome (ACS) recommend prehospital administration of aspirin and nitroglycerin for ACS patients. However, there is no clear evidence to support this. We investigated the benefits and harms of prehospital administration of aspirin and nitroglycerin by non-physician healthcare professionals in patients with suspected ACS.Methods and Results: We searched the PubMed database and used the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach to assess the certainty of evidence. Three retrospective studies for aspirin and 1 for nitroglycerin administered in the prehospital setting to patients with acute myocardial infarction were included. Prehospital aspirin administration was associated with significantly lower 30-day and 1-year mortality compared with aspirin administration after arrival at hospital, with odds ratios (OR) of 0.59 (95% confidence interval [CI] 0.35–0.99) and 0.47 (95% CI 0.36–0.62), respectively. Prehospital nitroglycerin administration was also associated with significantly lower 30-day and 1-year mortality compared with no prehospital administration (OR 0.34 [95% CI 0.24–0.50] and 0.38 [95% CI 0.29–0.50], respectively). The certainty of evidence was very low in both systematic reviews.Conclusions: Our systematic reviews suggest that prehospital administration of aspirin and nitroglycerin by non-physician healthcare professionals is beneficial for patients with suspected ACS, although the certainty of evidence is very low. Further investigation is needed to determine the benefit of the prehospital administration of these agents.

著者

Hyo Kyozuka Tsuyoshi Murata Shun Yasuda Kayoko Ishii Keiya Fujimori Aya Goto Seiji Yasumura Misao Ota Kenichi Hata Kohta Suzuki Akihito Nakai Tetsuya Ohira Hitoshi Ohto Kenji Kamiya

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.32, no.Supplement_XII, pp.S57-S63, 2022-12-05 (Released:2022-12-05)

参考文献数

42

被引用文献数

5

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There are limited studies on the long-term effects of natural/environmental disasters, especially nuclear disasters, on obstetric outcomes. This study aimed to review the results of perinatal outcomes immediately after the Great East Japan Earthquake (GEJE) and the Fukushima Daiichi Nuclear Power Plant accident, as well as their long-term trends over 8 years, in the Fukushima Health Management Survey. The annual population-based Pregnancy and Birth Survey is conducted as part of the Fukushima Health Management Survey. The Fukushima Prefecture government launched it to assess the health conditions of pregnant women and their neonates after the GEJE. The self-reported questionnaire was sent to 115,976 pregnant women by mail from January 2012, with 58,344 women responding to the questionnaire (50.3% response rate). Pregnancy complications, such as gestational hypertension, respiratory diseases, and mental disorders, increased in some women who were pregnant at the time of the earthquake and immediately after the earthquake. However, the direct effects on newborns, such as preterm birth, low birth weight, and congenital anomalies, were not immediately clear after the earthquake. Although there were significant differences in the occurrence of preterm birth and low birth weight among the districts, there was no change in the occurrences of preterm birth, low birth weight, or anomalies in newborns in Fukushima Prefecture from the fiscal year 2011 to the fiscal year 2018. Therefore, the long-term effects of the post-disaster radiation accident on perinatal outcomes are considered to be very small.

著者

Atsushi Watanabe Shigeki Yoneyama Mikio Nakajima Norihiro Sato Ryoko Takao-Kawabata Yukihiro Isogai Aki Sakurai-Tanikawa Kazuhiro Higuchi Akihito Shimoi Hideyuki Yamatoya Kenji Yoshida Terutomo Kohira

出版者

The Japanese Society of Toxicology

雑誌

The Journal of Toxicological Sciences (ISSN:03881350)

巻号頁・発行日

vol.37, no.3, pp.617-629, 2012-06-01 (Released:2012-06-01)

参考文献数

14

被引用文献数

57 69

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Teriparatide, a therapeutic agent for osteoporosis, has been reported to increase the incidences of bone neoplasms such as osteosarcoma when administered subcutaneously to Fischer 344 (F344) rats for a long term, but its non-carcinogenic dose level following 2-year daily administration has not been established. Here we report detailed studies on the carcinogenicity of teriparatide following long-term administration. When teriparatide was administered subcutaneously to male and female Sprague-Dawley (SD) rats daily for 2 years, the incidence of osteosarcoma was increased at 13.6 μg/kg/day. The non-carcinogenic dose level was 4.5 μg/kg/day for both males and females. The development of osteosarcoma in SD rats depends on the dose level of, and treatment duration with, teriparatide. Responses of the bones to teriparatide were similar between F344 and SD rats in many aspects. These results suggested that the carcinogenic potential of teriparatide in SD rats is essentially the same as in F344 rats.

著者

Akihito Kawai Sachiko Kawasaki Tomoko Nishimura Hideki Shigematsu Masato Tanaka Yasuhito Tanaka

出版者

The Japanese Society for Spine Surgery and Related Research

雑誌

Spine Surgery and Related Research (ISSN:2432261X)

巻号頁・発行日

vol.6, no.6, pp.721-724, 2022-11-27 (Released:2022-11-27)

参考文献数

10

著者

富田 昌平 田中 伸明 松本 昭彦 杉澤 久美子 河内 純子 辻 彰士 湯田 綾乃 松尾 美保奈 松浦 忍 松岡 ちなみ Tomita Shohei Tanaka Nobuaki Matsumoto Akihiko Sugisawa Kumiko kawachi Junko Tsuji Akihito Yuta Ayano Matsuo Mihona Matsuura Shinobu Matsuoka Chinami

出版者

三重大学教育学部

雑誌

三重大学教育学部研究紀要 自然科学・人文科学・社会科学・教育科学・教育実践 = Bulletin of the Faculty of Education, Mie University. Natural Science, Humanities, Social Science, Education, Educational Practice (ISSN:18802419)

巻号頁・発行日

vol.71, pp.493-502, 2020-02-28

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本研究では,幼稚園のカリキュラムの中にさりげなく埋め込まれている数学的活動に焦点を当て,幼児教育と数学教育という2つの異なる専門的視点から,幼児による経験や学び,実践の意味について分析し考察した。具体的には,幼稚園のクリスマス行事におけるサンタクロースからの贈り物に見られる幼児の分配行動を観察し,その記録を分析の対象とした。3歳児では1対1対応の分離量の分配,4歳児では集合した分離量の分配,5歳児では連続量の分配が課題として与えられた。新しい幼稚園教育要領(2017年3月改訂,2018年4月施行)のもと,「幼児期の終わりまでに育ってほしい10の姿」の設定に見られるように,幼児教育と小学校教育との円滑な接続はより一層求められている。本稿で取り上げた数学的活動は,10の姿のうちの「数量や図形,標識や文字などへの関心・感覚」に関わるものであり,そこで見られた幼児の姿は小学校以降の算数教育へとつながっていく姿である。本稿では,小学校教育とは異なる幼児教育の独自性について改めて確認するとともに,今後,こうした具体的な姿を小学校側にいかに伝え,つなげていくかがが議論された。

著者

Tomoko Kobayashi Mika Kobayashi Naoko Minegishi Masahiro Kikuya Taku Obara Mami Ishikuro Chizuru Yamanaka Tomomi Onuma Keiko Murakami Fumihiko Ueno Aoi Noda Akira Uruno Junichi Sugawara Kichiya Suzuki Eiichi N. Kodama Yohei Hamanaka Naho Tsuchiya Mana Kogure Naoki Nakaya Makiko Taira Mika Sakurai-Yageta Toru Tamahara Junko Kawashima Maki Goto Akihito Otsuki Ritsuko Shimizu Soichi Ogishima Hiroaki Hashizume Fuji Nagami Tomohiro Nakamura Atsushi Hozawa Tadao Kobayashi Nobuo Fuse Shinichi Kuriyama Shigeo Kure Masayuki Yamamoto

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

pp.2022.J103, (Released:2022-12-01)

被引用文献数

1

著者

Takamori Kakino Ichiro Sakamoto Akiko Nishizaki Akihito Ishikita Ayako Ishikita Hiromichi Sonoda Akira Shiose Hiroyuki Tsutsui

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-22-0497, (Released:2022-12-01)

参考文献数

1

著者

Akihito Shimazu Sabine Sonnentag Kazumi Kubota Norito Kawakami

出版者

Japan Society for Occupational Health

雑誌

Journal of Occupational Health (ISSN:13419145)

巻号頁・発行日

vol.54, no.3, pp.196-205, 2012 (Released:2012-07-06)

参考文献数

42

被引用文献数

64

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Objectives: The aim of this study was to validate the Japanese version of the Recovery Experience Questionnaire (REQ-J), which assesses how individuals unwind and recuperate from work during leisure time (i.e., psychological detachment, relaxation, mastery and control). Methods: The translated and back-translated REQ was administered via the Internet to 2,520 Japanese employees from various occupations. Exploratory and confirmatory factor analyses were conducted to evaluate factorial validity. The relationship with potential predictors and consequences of recovery experiences were investigated to evaluate construct validity. Internal consistency was examined to evaluate its reliability. Results: A series of confirmatory factor analyses revealed that the hypothesized four-factor model fit the data best. Construct validity was generally supported by expected correlations of recovery experiences with possible predictors and consequences. Cronbach’s alpha coefficient for each of the four subscales was sufficient (0.85—0.89). Conclusions: This study confirmed that the REQ-J is an adequate measure of recovery experiences that can be used in the Japanese context.

著者

AKIHITO OZAWA TETSU JOHKE KOICHI HODATE

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.41, no.6, pp.725-730, 1994 (Released:2011-01-25)

参考文献数

12

被引用文献数

3 4

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Information about the plasma IGF-I concentrations in domestic animals in a cold environment is still limited. And mechanisms to change plasma IGF-I concentrations in cold environments are not fully elucidated. In this study, plasma insulin-like growth factor-I (IGF-I) in relation to plasma growth hormone (GH) and metabolite concentrations was investigated in pigs living at 20°C and at 4°C. Six pigs (Landrase breed; barrows, 118 days old, 51.0±3.5 kg body weight) were maintained for 2 weeks at 20°C in a climatic room. Then a placebo or recombinant bovine GH (100μg/kg body weight) was injected subcutaneously. Blood samples were taken through a catheter at -2, 0, 1, 2, 3, 4, 5, 6, 9, 12, 22, and 24 h after the injections. The same experiments were conducted on days 5 and 6 after the room temperature was changed to 4°C. Mean (±SD) basal plasma GH concentrations in pigs without bovine GH administration living at 20°C and at 4°C were 4.8±1.7 ng/ml and 4.6±2.8ng/ml, respectively. There were no significant differences between GH concentrations. On the other hand, the mean plasma IGF-I concentrations were 80.8±25.1ng/ml and 57.3±14.3ng/ml respectively. Plasma IGF-I concentrations in pigs living at 4°C were significantly lower than in pigs living at 20°C (P<0.05). Plasma glucose and non-esterified fatty acid (NEFA) concentrations in pigs at 4°C were significantly higher than in pigs at 20°C (P<0.05). Blood urea nitrogen (BUN) concentrations in pigs at 4°C were also higher than in pigs at 20°C. In an experiment on GH administration, the plasma GH concentrations in pigs at both 20°C and 4°C were increased to the peak (49.1±2.5ng/ml and 43.0±23.6 ng/ml, respectively) 2h after the GH injection. They then gradually decreased to the basal level within 22 h. Plasma IGF-I concentrations were significantly increased 3 or 4h after the GH injection, and they reached to the maximum 9 or 12h after GH injection. No statistical significance was observed in the increase in the plasma IGF-I concentrations between pigs living at 20°C and at 4°C after GH injection. These results indicate that basal plasma IGF-I concentrations in pigs living at 4°C were lower than at 20°C. And the increase in the plasma IGF-I after the bovine GH injection were not different at the two environmental temperatures.

著者

Sunao Kojima Takeshi Yamamoto Migaku Kikuchi Hiroyuki Hanada Toshiaki Mano Takahiro Nakashima Katsutaka Hashiba Akihito Tanaka Junichi Yamaguchi Kunihiro Matsuo Naoki Nakayama Osamu Nomura Tetsuya Matoba Yoshio Tahara Hiroshi Nonogi for the Japan Resuscitation Council (JRC) Acute Coronary Syndrome (ACS) Task Force and the Guideline Editorial Committee on behalf of the Japanese Circulation Society (JCS) Emergency and Critical Care Committee

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.4, no.8, pp.335-344, 2022-08-10 (Released:2022-08-10)

参考文献数

24

被引用文献数

3

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Background: In Japan, oxygen is commonly administered during the acute phase of myocardial infarction (MI) to patients without oxygen saturation monitoring. In this study we assessed the effects of supplemental oxygen therapy, compared with ambient air, on mortality and cardiac events by synthesizing evidence from randomized controlled trials (RCTs) of patients with suspected or confirmed acute MI.Methods and Results: PubMed was systematically searched for full-text RCTs published in English before June 21, 2020. Two reviewers independently screened the search results and appraised the risk of bias. The estimates for each outcome were pooled using a random-effects model. In all, 2,086 studies retrieved from PubMed were screened. Finally, 7,322 patients from 9 studies derived from 4 RCTs were analyzed. In-hospital mortality in the oxygen and ambient air groups was 1.8% and 1.6%, respectively (risk ratio [RR] 0.90; 95% confidence interval [CI] 0.38–2.10]); 0.8% and 0.5% of patients, respectively, experienced recurrent MI (RR 0.44; 95% CI 0.12–1.54), 1.5% and 1.6% of patients, respectively, experienced cardiac shock (RR 1.10; 95% CI 0.77–1.59]), and 2.4% and 2.0% of patients, respectively, experienced cardiac arrest (RR 0.91; 95% CI 0.43–1.94).Conclusions: Routine supplemental oxygen administration may not be beneficial or harmful, and high-flow oxygen may be unnecessary in normoxic patients in the acute phase of MI.

著者

Katsutaka Hashiba Takahiro Nakashima Migaku Kikuchi Sunao Kojima Hiroyuki Hanada Toshiaki Mano Takeshi Yamamoto Akihito Tanaka Junichi Yamaguchi Kunihiro Matsuo Naoki Nakayama Osamu Nomura Tetsuya Matoba Yoshio Tahara Hiroshi Nonogi for the Japan Resuscitation Council (JRC) Acute Coronary Syndrome (ACS) Task Force and the Guideline Editorial Committee on behalf of the Japanese Circulation Society (JCS) Emergency and Critical Care Committee

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

pp.CR-22-0034, (Released:2022-07-13)

参考文献数

19

被引用文献数

4

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Background: In the management of patients with ST-elevation myocardial infarction (STEMI), system delays for reperfusion therapy are still a matter of concern. We investigated the impact of prehospital activation of the catheterization laboratory in the management of STEMI patients.Methods and Results: This is a systematic review of observational studies. A search was conducted of the PubMed database from inception to July 2020 to identify articles for inclusion in the study. The critical outcomes were short- and long-term mortality. The important outcome was door-to-balloon time. The GRADE approach was used to assess the certainty of the evidence. Seven studies assessed short-term mortality; 1,541 were assigned to the prehospital activation (PH) group and 1,191 were assigned to the emergency department activation (ED) group. There were 26 fewer deaths per 1,000 patients in the PH group. Three studies assessed long-term mortality; 713 patients were assigned to the PH group and 1,026 were assigned to the ED group. There were 54 fewer deaths per 1,000 patients among the PH group. Five studies assessed door-to-balloon time; 959 were assigned to the PH group and 631 to the ED group. Door-to-balloon time was 33.1 min shorter in the PH group.Conclusions: Prehospital activation of the catheterization laboratory resulted in lower mortality and shorter door-to-balloon time for patients with suspected STEMI outside of a hospital.

著者

Sunao Kojima Takeshi Yamamoto Migaku Kikuchi Hiroyuki Hanada Toshiaki Mano Takahiro Nakashima Katsutaka Hashiba Akihito Tanaka Junichi Yamaguchi Kunihiro Matsuo Naoki Nakayama Osamu Nomura Tetsuya Matoba Yoshio Tahara Hiroshi Nonogi for the Japan Resuscitation Council (JRC) Acute Coronary Syndrome (ACS) Task Force and the Guideline Editorial Committee on behalf of the Japanese Circulation Society (JCS) Emergency and Critical Care Committee

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

pp.CR-22-0031, (Released:2022-07-06)

参考文献数

24

被引用文献数

3

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Background: In Japan, oxygen is commonly administered during the acute phase of myocardial infarction (MI) to patients without oxygen saturation monitoring. In this study we assessed the effects of supplemental oxygen therapy, compared with ambient air, on mortality and cardiac events by synthesizing evidence from randomized controlled trials (RCTs) of patients with suspected or confirmed acute MI.Methods and Results: PubMed was systematically searched for full-text RCTs published in English before June 21, 2020. Two reviewers independently screened the search results and appraised the risk of bias. The estimates for each outcome were pooled using a random-effects model. In all, 2,086 studies retrieved from PubMed were screened. Finally, 7,322 patients from 9 studies derived from 4 RCTs were analyzed. In-hospital mortality in the oxygen and ambient air groups was 1.8% and 1.6%, respectively (risk ratio [RR] 0.90; 95% confidence interval [CI] 0.38–2.10]); 0.8% and 0.5% of patients, respectively, experienced recurrent MI (RR 0.44; 95% CI 0.12–1.54), 1.5% and 1.6% of patients, respectively, experienced cardiac shock (RR 1.10; 95% CI 0.77–1.59]), and 2.4% and 2.0% of patients, respectively, experienced cardiac arrest (RR 0.91; 95% CI 0.43–1.94).Conclusions: Routine supplemental oxygen administration may not be beneficial or harmful, and high-flow oxygen may be unnecessary in normoxic patients in the acute phase of MI.