著者

KEIYA FUJIMORI HYO KYOZUKA SHUN YASUDA AYA GOTO SEIJI YASUMURA MISAO OTA AKIRA OHTSURU YASUHISA NOMURA KENICHI HATA KOUTA SUZUKI AKIHITO NAKAI MIEKO SATO SHIRO MATSUI KYOKO NAKANO MASAFUMI ABE FOR THE PREGNANCY AND BIRTH SURVEY GROUP OF THE FUKUSHIMA HEALTH MANAGEMENT SURVEY

出版者

福島医学会

雑誌

FUKUSHIMA JOURNAL OF MEDICAL SCIENCE (ISSN:00162590)

巻号頁・発行日

pp.2014-9, (Released:2014-07-15)

参考文献数

29

被引用文献数

8 47

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Background: On 11 March 2011, the Great East Japan Earthquake followed by a powerful tsunami hit the Pacific Coast of Northeast Japan and damaged Tokyo Electric Power Company’s Fukushima Daiichi Nuclear Power Plant, causing a radiation hazard in Fukushima Prefecture. The objective of this report is to describe some results of a questionnaire-based pregnancy and birth survey conducted by the Radiation Medical Science Center for the Fukushima Health Management Survey.Materials and Methods: Questionnaires were sent to women who received maternal and child health handbooks from municipal officers in Fukushima Prefecture between 1 August 2010 and 31 July 2011, with the aim of reaching those who were pregnant at the time of the disaster. Mailing began 18 January 2012. Data were analyzed separately for six geographic areas in Fukushima Prefecture.Results: The total number of women meeting survey criteria was 15,972. The number of responses received to date is 9,298 (58.2%). Data from 8602 respondents were analyzed after excluding 634 invalid responses and 5 induced and 57 spontaneous abortions (less than 22 gestational weeks). The incidences of stillbirth (over 22 completed gestational weeks), preterm birth, low birth weight and congenital anomalies were 0.25%, 4.4%, 8.7% and 2.72%, respectively. These incidences are similar to recent averages elsewhere in Japan.Conclusion: Considering the pregnancy and birth survey data in aggregate, our disaster seemed to provoke no significant adverse outcomes over the whole of Fukushima prefecture. But post-disaster prenatal care and support intended for patients’ safety and security should be coupled with ongoing surveillance and rigorous data analysis.

著者

Seiji Hokimoto Koichi Kaikita Satoshi Yasuda Kenichi Tsujita Masaharu Ishihara Tetsuya Matoba Yasushi Matsuzawa Yoshiaki Mitsutake Yoshihide Mitani Toyoaki Murohara Takashi Noda Koichi Node Teruo Noguchi Hiroshi Suzuki Jun Takahashi Yasuhiko Tanabe Atsushi Tanaka Nobuhiro Tanaka Hiroki Teragawa Takanori Yasu Michihiro Yoshimura Yasuhide Asaumi Shigeo Godo Hiroki Ikenaga Takahiro Imanaka Kohei Ishibashi Masanobu Ishii Takayuki Ishihara Yunosuke Matsuura Hiroyuki Miura Yasuhiro Nakano Takayuki Ogawa Takashi Shiroto Hirofumi Soejima Ryu Takagi Akihito Tanaka Atsushi Tanaka Akira Taruya Etsuko Tsuda Kohei Wakabayashi Kensuke Yokoi Toru Minamino Yoshihisa Nakagawa Shozo Sueda Hiroaki Shimokawa Hisao Ogawa on behalf of the Japanese Circulation Society and Japanese Association of Cardiovascular Intervention and Therapeutics and Japanese College of Cardiology Joint Working Group

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-22-0779, (Released:2023-03-10)

被引用文献数

39

著者

KEIYA FUJIMORI HYO KYOZUKA SHUN YASUDA AYA GOTO SEIJI YASUMURA MISAO OTA AKIRA OHTSURU YASUHISA NOMURA KENICHI HATA KOUTA SUZUKI AKIHITO NAKAI MIEKO SATO SHIRO MATSUI KYOKO NAKANO MASAFUMI ABE FOR THE PREGNANCY AND BIRTH SURVEY GROUP OF THE FUKUSHIMA HEALTH MANAGEMENT SURVEY

出版者

福島医学会

雑誌

FUKUSHIMA JOURNAL OF MEDICAL SCIENCE (ISSN:00162590)

巻号頁・発行日

vol.60, no.1, pp.75-81, 2014 (Released:2014-08-08)

参考文献数

29

被引用文献数

8 47

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Background: On 11 March 2011, the Great East Japan Earthquake followed by a powerful tsunami hit the Pacific Coast of Northeast Japan and damaged Tokyo Electric Power Company’s Fukushima Daiichi Nuclear Power Plant, causing a radiation hazard in Fukushima Prefecture. The objective of this report is to describe some results of a questionnaire-based pregnancy and birth survey conducted by the Radiation Medical Science Center for the Fukushima Health Management Survey.Materials and Methods: Questionnaires were sent to women who received maternal and child health handbooks from municipal officers in Fukushima Prefecture between 1 August 2010 and 31 July 2011, with the aim of reaching those who were pregnant at the time of the disaster. Mailing began 18 January 2012. Data were analyzed separately for six geographic areas in Fukushima Prefecture.Results: The total number of women meeting survey criteria was 15,972. The number of responses received to date is 9,298 (58.2%). Data from 8602 respondents were analyzed after excluding 634 invalid responses and 5 induced and 57 spontaneous abortions (less than 22 gestational weeks). The incidences of stillbirth (over 22 completed gestational weeks), preterm birth, low birth weight and congenital anomalies were 0.25%, 4.4%, 8.7% and 2.72%, respectively. These incidences are similar to recent averages elsewhere in Japan.Conclusion: Considering the pregnancy and birth survey data in aggregate, our disaster seemed to provoke no significant adverse outcomes over the whole of Fukushima prefecture. But post-disaster prenatal care and support intended for patients’ safety and security should be coupled with ongoing surveillance and rigorous data analysis.

著者

Takahiro Nakashima Katsutaka Hashiba Migaku Kikuchi Junichi Yamaguchi Sunao Kojima Hiroyuki Hanada Toshiaki Mano Takeshi Yamamoto Akihito Tanaka Kunihiro Matsuo Naoki Nakayama Osamu Nomura Tetsuya Matoba Yoshio Tahara Hiroshi Nonogi for the Japan Resuscitation Council (JRC) Acute Coronary Syndrome (ACS) Task Force and the Guideline Editorial Committee on behalf of the Japanese Circulation Society (JCS) Emergency and Critical Care Committee

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.4, no.5, pp.187-193, 2022-05-10 (Released:2022-05-10)

参考文献数

30

被引用文献数

4

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Background: To achieve early reperfusion therapy for ST-elevation myocardial infarction (STEMI), proper and prompt patient transportation and activation of the catheterization laboratory are required. We investigated the efficacy of prehospital 12-lead electrocardiogram (ECG) acquisition and destination hospital notification in patients with STEMI.Methods and Results: This is a systematic review of observational studies. We searched the PubMed database from inception to March 2020. Two reviewers independently performed literature selection. The critical outcome was short-term mortality. The important outcome was door-to-balloon (D2B) time. We used the GRADE approach to assess the certainty of the evidence. For the critical outcome, 14 studies with 29,365 patients were included in the meta-analysis. Short-term mortality was significantly lower in the group with prehospital 12-lead ECG acquisition and destination hospital notification than in the control group (odds ratio 0.72; 95% confidence interval [CI] 0.61–0.85; P<0.0001). For the important outcome, 10 studies with 2,947 patients were included in the meta-analysis. D2B time was significantly shorter in the group with prehospital 12-lead ECG acquisition and destination hospital notification than in the control group (mean difference −26.24; 95% CI −33.46, −19.02; P<0.0001).Conclusions: Prehospital 12-lead ECG acquisition and destination hospital notification is associated with lower short-term mortality and shorter D2B time than no ECG acquisition or no notification among patients with suspected STEMI outside of a hospital.

著者

Eriko Uchida Yoshitaka Kondo Akiko Amano Shingo Aizawa Takayuki Hanamura Hitoshi Aoki Kenichi Nagamine Takeshi Koizumi Naoki Maruyama Akihito Ishigami

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.34, no.11, pp.1744-1747, 2011-11-01 (Released:2011-11-01)

参考文献数

20

被引用文献数

7 18

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It has been suggested that some food components, such as bioflavonoids, affect the bioavailability of ascorbic acid in humans. Since little is known in Japan about the effective intake of this dietary requirement, we tested young Japanese males after the ingestion of commercial ascorbic acid or acerola (Malpighia emarginata DC.) juice to compare the quantities absorbed and excreted. Healthy Japanese subjects received a single oral dose of ascorbic acid solution (50, 100, 200 or 500 mg) and received distilled water as a reference at intervals of 14 d or longer. All subjects were collected blood and urine until 6 h after ingestion and evaluated for time-dependent changes in plasma and urinary ascorbic acid levels. Predictably, the area under the curve (AUC) values in plasma and urine after ingestion increased dose-dependently. Next, each subject received diluted acerola juice containing 50 mg ascorbic acid. Likewise, their plasma and urinary ascorbic acid concentrations were measured. In plasma, the AUC value of ascorbic acid after ingestion of acerola juice tended to be higher than that from ascorbic acid alone. In contrast, the urinary excretion of ascorbic acid at 1, 2 and 5 h after ingestion of acerola juice were significantly less than that of ascorbic acid. These results indicate that some component of acerola juice favorably affected the absorption and excretion of ascorbic acid.

著者

Akihito

出版者

日本学士院

雑誌

Proceedings of the Japan Academy, Series B (ISSN:03862208)

巻号頁・発行日

vol.86, no.3, pp.143-146, 2010 (Released:2010-03-13)

被引用文献数

1

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(Communicated by Koichiro TSUNEWAKI, M.J.A.)

著者

田村 幸雄 松井 正宏 吉田 昭仁 小原 久典 Yukio TAMURA Masahiro MATSUI Akihito YOSHIDA Hisanori OHARA 東京工芸大学工学部建築学科 東京工芸大学工学部建築学科 東京工芸大学工学部建築学科 ウインディ

雑誌

東京工芸大学工学部紀要 = The Academic Reports, the Faculty of Engineering, Tokyo Polytechnic University (ISSN:03876055)

巻号頁・発行日

vol.26, no.1, pp.148-159, 2003

著者

Yuhi SAITO Toshihiro MIHARA Kentaro MARUYAMA Jiro SAITO Masumi IKEDA Akihito TOMONAGA Takehisa KUMAGAI

出版者

BMFH出版会

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

pp.16-031, (Released:2017-04-14)

被引用文献数

17

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Lactic acid bacteria are gut flora that play key roles in intestinal homeostasis, which may affect a variety of physiological functions. Our preliminary double-blind, placebo-controlled, parallel-group trials have suggested that intake of heat-killed Lactobacillus casei subsp. casei 327 (designated lactobacillus K-1) is effective for improving skin conditions. The aim of this study was to confirm the effect of lactobacillus K-1 intake in a randomized, double-blind, placebo-controlled, parallel-group study in healthy female volunteers. Sixty-four subjects were allocated to either the placebo food group (group P, n=32) or active food group (group A, n=32), in which subjects consumed lactobacillus K-1 50 mg (approximately 1 × 1011 bacteria) daily for 8 weeks. After excluding subjects who declined to participate (n=1), violated restrictions (n=4), or were judged ineligible by the principal investigators (n=1), data obtained with 58 subjects (30 in group A and 28 in group P) were analyzed for efficacy by comparing differences from pretrial levels between the two groups. When the level of transepidermal water loss (TEWL) was measured at the arm, the level of TEWL at week 4 of the intake period was significantly lower in group A than group P (p=0.021), suggesting an improvement of skin barrier function. Analysis of skin condition questionnaire data revealed a significant reduction in skin flakiness on the face (week 4). No adverse events were associated with intake of the test foods. The safety of lactobacillus K-1 was also confirmed in an independent open-label trial in 11 healthy subjects who consumed excessive amounts of lactobacillus K-1 250 mg (approximately 5 × 1011 bacteria). Intake of lactobacillus K-1 may therefore be beneficial to skin condition improvement.

著者

Akihito Sako Takako Teduka Makito Kawada Shin-ichiro

出版者

National Museum of Nature and Science

雑誌

Bulletin of the National Museum of Nature and Science. Series A, Zoology (ISSN:18819052)

巻号頁・発行日

vol.42, no.3, pp.143-161, 2016-08

著者

Akihito SHIMAZU Keiko SAKAKIBARA Fuad HAMSYAH Michiko KAWADA Daisuke MIYANAKA Naana MORI Masahito TOKITA

出版者

National Institute of Occupational Safety and Health

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

pp.2023-0085, (Released:2023-12-29)

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Laughter is associated with better health and occurs most frequently during casual conversations. However, the COVID-19 pandemic has impaired social interactions, which may have reduced the frequency of laughter and led to poor well-being among workers. This study investigated the relationship between laughter frequency and work engagement among Japanese employees during the pandemic. We conducted a web-based survey among Japanese employees (20–59 years) via an internet survey company in December 2021; 1,058 valid data were analysed. Of the respondents, 65.1% laughed at least once a week, but the frequency was much lower than that reported in previous studies conducted before the pandemic. Additionally, those who laughed at least once a week had significantly higher work engagement scores than those who laughed less than once a month. Although employees reduced their frequency of laughter during the pandemic, a certain frequency of laughter may be important for maintaining their work engagement.

著者

Akizumi Tsutsumi Akihito Shimazu Hisashi Eguchi Akiomi Inoue Norito Kawakami

出版者

Japan Society for Occupational Health

雑誌

Journal of Occupational Health (ISSN:13419145)

巻号頁・発行日

vol.60, no.1, pp.55-63, 2018-01-20 (Released:2018-01-25)

参考文献数

19

被引用文献数

46

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Objectives: On December 1, 2015, the Japanese government launched the Stress Check Program, a new occupational health policy to screen employees for high psychosocial stress in the workplace. As only weak evidence exists for the effectiveness of the program, we sought to estimate the risk of stress-associated long-term sickness absence as defined in the program manual. Methods: Participants were 7356 male and 7362 female employees in a financial service company who completed the Brief Job Stress Questionnaire (BJSQ). We followed them for 1 year and used company records to identify employees with sickness absence of 1 month or longer. We defined high-risk employees using the BJSQ and criteria recommended by the program manual. We used the Cox proportional regression model to evaluate the prospective association between stress and long-term sickness absence. Results: During the follow-up period, we identified 34 male and 35 female employees who took long-term sickness absence. After adjustment for age, length of service, job type, position, and post-examination interview, hazard ratios (95% confidence intervals) for incident long-term sickness absence in high-stress employees were 6.59 (3.04-14.25) for men and 2.77 (1.32-5.83) for women. The corresponding population attributable risks for high stress were 23.8% (10.3-42.6) for men and 21.0% (4.6-42.1) for women. Conclusions: During the 1-year follow-up, employees identified as high stress (as defined by the Stress Check Program manual) had significantly elevated risks for long-term sickness absence.

著者

牧 麦 鳥羽 瑛仁 船木 一幸 山極 芳樹 Maki Mugi Toba Akihito Funaki Ikkoh Yamagiwa Yoshiki

出版者

宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)

雑誌

平成30年度宇宙輸送シンポジウム: 講演集録 = Proceedings of Space Transportation Symposium FY2018

巻号頁・発行日

2019-01

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平成30年度宇宙輸送シンポジウム(2019年1月17日-18日. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)), 相模原市, 神奈川県

著者

Akihito Yokoyama Hiroshi Okazaki Naoyuki Makita Ayako Fukui Yi Piao Yoshifumi Arita Yohji Itoh Naoki Tashiro

出版者

Japanese Society of Allergology

雑誌

Allergology International (ISSN:13238930)

巻号頁・発行日

vol.71, no.1, pp.47-54, 2022 (Released:2022-01-27)

参考文献数

18

被引用文献数

7

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Background: In Japan, regional differences in asthma mortality have been reported; however, regional differences in asthma exacerbations have not been studied extensively. Therefore, using a health insurance claims database, we investigated the regional differences in the incidence of asthma exacerbations in Japan.Methods: This study used data from Medi-Scope (Japan Medical Information Research Institute Inc., Japan)-a nationwide health insurance claims database. Patients with asthma at the index date (the latest date of an asthma-related prescription with an asthma diagnosis before October 1, 2018) were included in the analysis. The pre-index period was defined as 1 year before the index date, and the follow-up period as 1 year after the index date. The incidence of asthma exacerbation events was analyzed for each region.Results: The primary analysis population comprised 24,883 patients who were continuously prescribed ICS or ICS/LABA at least four times during the pre-index period. The incidence rate of asthma exacerbations with hospitalization was the highest in Chugoku (2.95/100 person-years [95% CI, 1.97-4.43]) and the lowest in Kanto (1.52/100 person-years [95% CI, 1.26-1.83]). The incidence rate of asthma exacerbations for the composite outcome of hospitalization, injectable corticosteroid prescription, and oral corticosteroid burst was the highest in Fukui (105.00/100 person-years [95% CI, 64.53-170.85]) and the lowest in Nagasaki (15.69/100 person-years [95% CI, 10.84-22.72]).Conclusions: Regional differences in the incidence of asthma exacerbations as well as their treatments were observed in Japan.

著者

Takashi Unuma Hiroshi Yamauchi Akihito Umehara Teruyuki Kato

出版者

公益社団法人 日本気象学会

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

pp.2023-020, (Released:2023-06-09)

被引用文献数

1

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We investigated the microphysical mechanisms for the enhancement of rainfall in a precipitating system that spawned heavy rainfall over the central part of the Kanto Plain in eastern Japan on 12 July 2022. Optical disdrometer observations confirmed the existence of an equilibrium state in the raindrop size distribution, especially when the precipitation intensity was high (e.g., 20 mm hr−1). As the raindrop size distribution approached equilibrium, raindrop sizes centered around 1.5 mm were observed initially, and then the number concentration of smaller and larger size raindrops increased simultaneously. The raindrop size distribution was closely related to the vertical profile of the parameters of raindrop size distribution that were estimated from polarimetric radar observations. These results suggest that the formation of equilibrium raindrop size distributions is important to produce substantial rainfall in the midlatitude as well as in the tropics.

著者

Migaku Kikuchi Yoshio Tahara Junichi Yamaguchi Takahiro Nakashima Osamu Nomura Akihito Tanaka Sunao Kojima Katsutaka Hashiba Naoki Nakayama Hiroyuki Hanada Toshiaki Mano Takeshi Yamamoto Kunihiro Matsuo Ichiro Takeuchi Tetsuya Matoba Hiroshi Nonogi for the Japan Resuscitation Council (JRC) Acute Coronary Syndrome (ACS) Task Force and the Guideline Editorial Committee on behalf of the Japanese Circulation Society (JCS) Emergency and Critical Care Committee

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0096, (Released:2023-04-20)

参考文献数

23

被引用文献数

4

著者

Yu Mizutani Shinichiro Kawamoto Michiko Takahashi Hisayo Doi Kumiko Wakida Satoko Tabuchi Masaaki Tanda Akihiro Soga Ruri Chijiki Hidetomo Takakura Koji Kawaguchi Ako Higashime Marika Watanabe Hiroya Ichikawa Sakuya Matsumoto Rina Sakai Hideaki Goto Keiji Kurata Seiji Kakiuchi Yoshiharu Miyata Kiyoaki Uryu Yumiko Inui Akihito Kitao Kimikazu Yakushijin Hiroshi Matsuoka Hironobu Minami

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.1314-22, (Released:2023-02-15)

参考文献数

41

被引用文献数

1

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Objective High-dose chemotherapy with autologous hematopoietic stem cell transplantation (auto-HSCT) is an effective treatment option for relapsed and refractory aggressive malignant lymphoma. However, patients frequently experience treatment-induced gastrointestinal symptoms. Synbiotics, including live microorganisms and nondigestible food ingredients, reportedly ameliorate chemotherapy-induced mucosal damage. In this study, we assessed the efficacy and safety of synbiotics in patients undergoing auto-HSCT. Methods This randomized, double-blinded study included patients with malignant lymphoma eligible for auto-HSCT. The patients were randomly assigned to either a synbiotic group receiving Bifidobacterium longum (BB536) and guar gum or a placebo group receiving a placebo containing dextrin. The supplements were administered twice daily from the start of conditioning chemotherapy up to 28 days after auto-HSCT. The primary endpoint was the duration of total parenteral nutrition (TPN). Results In total, 12 patients were included and randomized. The median duration of TPN was 15 (range, 12-33) days in the synbiotic group and 17.5 (range, 0-32) days in the placebo group. The median duration of grade ≥3 diarrhea was shorter in the synbiotic group than in then placebo group (2.5 vs. 6.5 days), as was the duration of hospital stay (31.5 vs. 43 days). The oral intake and quality of life regarding diarrhea and anorexia improved in the synbiotic group after engraftment. Synbiotic infections, including bacteremia, were not observed. Conclusion Synbiotics may reduce gastrointestinal toxicity, thereby reducing nutritional problems and improving the quality of life of patients undergoing auto-HSCT, without severe adverse events.

著者

Yuka TAKINO Hitoshi AOKI Yoshitaka KONDO Akihito ISHIGAMI

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.66, no.4, pp.296-299, 2020-08-31 (Released:2020-08-31)

参考文献数

12

被引用文献数

2 2

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Acerola (Malpighia emarginata DC.) is a fruit containing abundant ascorbic acid (AsA) and numerous functional phytochemicals. We previously reported that the intake of acerola juice increased the absorption of AsA in plasma of healthy Japanese subjects. The functional phytochemicals in acerola may influence the intestinal epithelial cells to increase the cellular uptake of AsA. Therefore, in this study, we compared the AsA uptake into Caco-2 cells between AsA alone and that in acerola juice at the same concentration using a human intestinal model. Caco-2 cells were incubated with 3 mM AsA and 3 mM AsA in acerola juice. Intracellular AsA contents gradually increased until 24 h upon incubation with both AsA alone and AsA in acerola juice; however, these contents when incubated with AsA in acerola juice, were significantly higher than those incubated with AsA alone at 2, 3, 4, 8, and 24 h. Furthermore, the mRNA expression level of the sodium-dependent vitamin C transporter (SVCT) 1 was significantly higher in the cells incubated with AsA in acerola juice than those incubated with AsA alone. Moreover, polyphenols such as cyanidin-3-glucoside chloride and quercetin enhanced the SVCT1 gene expression in Caco-2 cells. Collectively, these results suggest that acerola polyphenols enhances the SVCT1 gene expression in Caco-2 cells and promotes AsA uptake.

著者

杉原 アフマッド清志 松下 将典 森 治 松本 純 中条 俊大 佐伯 孝尚 津田 雄一 川口 淳一郎 奥泉 信克 宮崎 康行 古谷 寛 坂本 啓 松永 三郎 谷 義隆 清水 裕介 岡田 達明 岩田 隆浩 川崎 繁男 西山 和孝 月崎 竜童 神田 大樹 細田 聡史 高尾 勇輝 久保 勇貴 柏岡 秀哉 名田 悠一郎 豊田 裕之 佐藤 泰貴 田中 孝治 中村 徹哉 柴田 優一 中尾 達郎 森 一之 後藤 亜紀 藤井 さなえ 渡邊 秋人 酒井 良次 伊藤 裕明 SUGIHARA Ahmed Kiyoshi MATSUSHITA Masanori MORI Osamu MATSUMOTO Jun CHUJO Toshihiro SAIKI Takanao TSUDA Yuichi KAWAGUCHI Jun'ichiro OKUIZUMI Nobukatsu MIYAZAKI Yasuyuki FURUYA Hiroshi SAKAMOTO Hiraku MATUNAGA Saburo TANI Yoshitaka SHIMIZU Yusuke OKADA Tatsuaki IWATA Takahiro KAWASAKI Shigeo NISHIYAMA Kazutaka TSUKIZAKI Ryudo KODA Daiki HOSODA Satoshi TAKAO Yuki KUBO Yuki KASHIOKA Shuya NADA Yuichiro TOYOTA Hiroyuki SATO Yasutaka TANAKA Koji AKAMURA Tetsuya SHIBATA Yuichi NAKAO Tatsuro MORI Kazuyuki GOTO Aki FUJII Sanae WATANABE Akihito SAKAI Ryoji ITOH Hiroaki

出版者

宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)

雑誌

第20回宇宙科学シンポジウム 講演集 = Proceedings of the 20th Space Science Symposium

巻号頁・発行日

2020-01

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第20回宇宙科学シンポジウム (2020年1月8日-9日. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)相模原キャンパス), 相模原市, 神奈川県

著者

Akihito Umehara Toru Adachi Wataru Mahiko Hiroshi Yamauchi

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

pp.2021-034, (Released:2021-10-04)

被引用文献数

3

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The tornadic debris signatures (TDSs) of the Ichihara Tornado associated with Typhoon Hagibis (2019) were observed using two operational C-band dual-polarimetric weather radars and an X-band phased-array weather radar (PAWR). This TDS observation was the first to be made over Japan in a typhoon environment. The TDS bins spread over time, and the maximum vertical and aerial extents reached 2.4 km and 9.41 km2, respectively. The estimated rise velocity of the TDS was 8 m s−1. The first TDS was detected ∼1 min before damage reporting began. The TDSs became clearer along with the rotational velocity of the near-surface vortex detected by PAWR. The copolar correlation coefficient reached a minimum (0.27) ∼1 min after the tornado passed the most severely damaged area and increased gradually over 4 min. This suggests that heavy and/or dense debris was lofted and immediately fell out and/or diffused, whereas light debris remained aloft for ≥ 4 min. By comparing the PAWR-detected vortex signatures with aerial photographs, we inferred that the first TDS comprised vegetated debris, the clearest TDS mainly comprised destroyed manmade structures. These results indicate that TDS detection is effective both for investigating damage and for recognizing tornado's occurrence even in a typhoon environment.

著者

Hiroko Deguchi Masataka Ikeda Tomomi Ide Tomonori Tadokoro Soichiro Ikeda Kosuke Okabe Akihito Ishikita Keita Saku Shouji Matsushima Hiroyuki Tsutsui

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-19-1039, (Released:2020-03-24)

参考文献数

20

被引用文献数

2 36

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Background:Ischemic preconditioning (IPC) is an effective procedure to protect against ischemia/reperfusion (I/R) injury. Hypoxia-inducible factor-1α (Hif-1α) is a key molecule in IPC, and roxadustat (RXD), a first-in-class prolyl hydroxylase domain-containing protein inhibitor, has been recently developed to treat anemia in patients with chronic kidney disease. Thus, we investigated whether RXD pretreatment protects against I/R injury.Methods and Results:RXD pretreatment markedly reduced the infarct size and suppressed plasma creatinine kinase activity in a murine I/R model. Analysis of oxygen metabolism showed that RXD could produce ischemic tolerance by shifting metabolism from aerobic to anaerobic respiration.Conclusions:RXD pretreatment may be a novel strategy against I/R injury.