著者

Takufumi YANAGISAWA Ryohei FUKUMA Ben SEYMOUR Koichi HOSOMI Haruhiko KISHIMA Takeshi SHIMIZU Hiroshi YOKOI Masayuki HIRATA Toshiki YOSHIMINE Yukiyasu KAMITANI Youichi SAITOH

出版者

The Japan Neurosurgical Society

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

pp.st.2018-0099, (Released:2018-07-12)

参考文献数

41

被引用文献数

6

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A brachial plexus root avulsion (BPRA) causes intractable pain in the insensible affected hands. Such pain is partly due to phantom limb pain, which is neuropathic pain occurring after the amputation of a limb and partial or complete deafferentation. Previous studies suggested that the pain was attributable to maladaptive plasticity of the sensorimotor cortex. However, there is little evidence to demonstrate the causal links between the pain and the cortical representation, and how much cortical factors affect the pain. Here, we applied lesioning of the dorsal root entry zone (DREZotomy) and training with a brain–machine interface (BMI) based on real-time magnetoencephalography signals to reconstruct affected hand movements with a robotic hand. The DREZotomy successfully reduced the shooting pain after BPRA, but a part of the pain remained. The BMI training successfully induced some plastic changes in the sensorimotor representation of the phantom hand movements and helped control the remaining pain. When the patient tried to control the robotic hand by moving their phantom hand through association with the representation of the intact hand, this especially decreased the pain while decreasing the classification accuracy of the phantom hand movements. These results strongly suggested that pain after the BPRA was partly attributable to cortical representation of phantom hand movements and that the BMI training controlled the pain by inducing appropriate cortical reorganization. For the treatment of chronic pain, we need to know how to modulate the cortical representation by novel methods.

著者

Takayama Hiroshi

出版者

English Literary Society of Japan

雑誌

Studies in English literature

巻号頁・発行日

vol.1977, pp.175-182, 1977

著者

TAKAHASHI Hiroshi G. DADO Julie Mae B.

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2018-031, (Released:2018-03-09)

被引用文献数

7

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We offer a new perspective on a relationship between sea surface temperature (SST) over the windward region of the Philippines and rainfall in the western Philippines during the Asian summer monsoon season, which has been known as the negative correlation, using observational daily SST, rainfall, and atmospheric circulation datasets. This study focuses on the local SST effect rather than the remote effect. A warmer local SST results in greater rainfall over the western Philippines under similar monsoon westerlies conditions, particularly during moderate and relatively stronger monsoon regimes. This result is obtained after selecting only the moderate or relatively stronger monsoon days, because the positive effect of SST on rainfall is masked by the apparent negative correlation between SST and rainfall. The warmer SSTs being associated with less rainfall correspond to weaker cooling by weaker monsoon westerlies and the cooler SSTs being associated with more rainfall correspond to stronger cooling by stronger monsoon westerlies. The cooler SSTs are the result of stronger monsoon cooling and are not the cause of the greater rainfall, which is the apparent statistical relationship. This also implies that the monsoon westerly is the primary driver of the variation in rainfall in this region. We conclude that the local SST makes a positive contribution toward rainfall, although it does not primarily control rainfall. This conclusion can be applicable to coastal regions where, climatologically, rainfall is controlled by winds from the ocean.

著者

Masaharu Oshima Daisuke Mori Aki Takigawa Akihiko Otsuki Naoka Nagamura Shun Konno Yoshinobu Takahashi Masato Kotsugi Hiroshi Nohira

出版者

The Japan Society of Vacuum and Surface Science

雑誌

e-Journal of Surface Science and Nanotechnology (ISSN:13480391)

巻号頁・発行日

vol.16, pp.257-261, 2018-06-09 (Released:2018-06-09)

参考文献数

21

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SiC trench structures having a width of 0.6 μm and a depth of 2.0 μm are fabricated by reactive ion etching (RIE) using a gas mixture of SF6, Ar, and O2. Further, SiC trench structures are cleaved to expose the sidewall for the channel region of a trench MOSFET. These structures were analyzed by pin-point photoelectron spectroscopy using a 100 nm soft-X-ray beam. It is observed that around 2 nm-thick homogeneous carbon-rich layer containing 1—2% F forms on the SiC sidewalls. This may be caused due to the re-deposition of RIE reaction products, CF4 and SiF4, under appropriate conditions to fabricate the trench walls that are approximately vertical using RIE. Further, a carbon-rich layer having a thickness of about 2.4 nm is also formed on the bottom of the SiC trench, suggesting the possibility of selective etching of Si from the SiC substrates. The position of the dominant peak that is associated with the SiC component remains constant regardless of the trench depth, suggesting homogeneous band bending due to the RIE defects, which may explain the reason for no variation being observed in the gate oxide/SiC interface trap density values. Further, the band bending of 1.50 eV that is observed on the sidewall can be attributed to a positively charged carbon vacancy (VC+). [DOI: 10.1380/ejssnt.2018.257]

著者

Fumihiro Asano Naofumi Shinagawa Takashi Ishida Akifumi Tsuzuku Motoko Tachihara Kenya Kanazawa Noriyuki Yamada Satoshi Oizumi Hiroshi Moriya

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.54, no.9, pp.1021-1025, 2015 (Released:2015-05-01)

参考文献数

19

被引用文献数

6 28 4

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Objective Bronchoscopy using radial-endobronchial ultrasound (R-EBUS) and virtual bronchoscopic navigation (VBN) is a promising method for diagnosing peripheral pulmonary lesions. We previously performed a randomized comparative trial (RCT) (i.e., VBN combined with EBUS RCT) involving patients with 30-mm or smaller peripheral pulmonary lesions and found that the addition of VBN to R-EBUS improved the diagnostic yield. In the present study, we performed a retrospective subanalysis in order to identify patients for whom VBN is useful. Methods The per-protocol population (194 cases) of the VBN combined with EBUS RCT was divided into subgroups based on the lesion size, lung lobe containing the lesion, lesion location, presence or absence of involved bronchi (bronchus sign) on thin-section CT and whether the lesion was detected on posterior-anterior (P-A) radiographs. The difference in the diagnostic yield between the VBN-assisted (VBNA) and non-VBN-assisted (NVBNA) groups was investigated. Results Within the bronchus sign-positive subgroup, the diagnostic yield in the VBNA and NVBNA groups was 94.4% (68/72) and 77.8% (56/72), respectively, showing a significantly higher yield in the VBNA group (p=0.004; odds ratio: 4.9). The yield was particularly high for lesions smaller than 20 mm (94.6% vs. 70.7%; p=0.006), lesions located in the peripheral third of the lung field (95.1% vs. 71.4%; p=0.005) and lesions invisible on P-A radiographs (90.0% vs. 41.7%; p=0.026). Conclusion VBN improves the diagnostic yield when combined with R-EBUS to assess lesions exhibiting involved bronchi on CT images.

著者

Hiroshi Kajihara Kotaro Tamura Shinri Tomioka

出版者

The Japanese Society of Systematic Zoology

雑誌

Species Diversity (ISSN:13421670)

巻号頁・発行日

vol.23, no.1, pp.13-37, 2018-05-25 (Released:2018-05-26)

参考文献数

39

被引用文献数

10

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Seven (including six new) species of interstitial hoplonemerteans in the genus Ototyphlonemertes Diesing, 1863 are described from southern Vietnam. The descriptions are based on light microscopic examination of internal structures as well as three methods of molecular species delimitation analyses, i) Automatic Barcode Gap Discovery (ABGD), ii) Poisson Tree Process (PTP), and iii) statistical parsimony, on the basis of ~658-bp cytochrome c oxidase subunit I gene sequences that have been i) newly determined from the Vietnamese specimens and ii) deposited in the public databases for other Ototyphlonemertes species. Three taxa are circumscribed as ‘species groups’ and placed at an infra-subgeneric, supra-specific rank, each represented by O. duplex Bürger, 1895, O. macintoshi Bürger, 1895, and O. parmula Corrêa, 1950. Of the seven Vietnamese species, one is identified as Ototyphlonemertes (species group macintoshi) ani Chernyshev, 2007, which is molecularly confirmed to be distributed from Vietnam (Phu Quoc and Nha Trang) to Japan (Okinawa and Wakayama). The other six are new to science, to which formal taxonomic descriptions are given: these are O. (duplex) chernyshevi sp. nov., O. (duplex) envalli sp. nov., O. (duplex) norenburgi sp. nov., O. (parmula) lei sp. nov., O. (parmula) nakaoae sp. nov., and O. (parmula) tsukagoshii sp. nov.

著者

Ichiro TSUDA Edgar KOERNER Hiroshi SHIMIZU Bioholonics Research Project Research Development Corporation of Japan Bioholonics Research Project Research Development Corporation of Japan Faculty of Pharmaceutical Sciences Department of Biophysics University of Tokyo

雑誌

Progress of theoretical physics = Progress of theoretical physics (ISSN:0033068X)

巻号頁・発行日

vol.78, no.1, pp.51-71, 1987-07-25

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A model which can perform learning, formation of memory without teacher for successive memory recalls is presented. The philosophical background of the study is summarized. The investigated network consists of two sets both composed of asynchronously firing model neurons. One set of neurons is responsible for the field effect, and the other is introduced as an input/output module. The field effect is given in the form of the system's self-response. It is shown that positive end negative global feedbacks by the field effect play an essential role in the successive recall of stored patterns. The possibility that these proposed mechanisms are implemented in the brain is discussed. We obtained a quasi-deterministic law on the level of a macrovariable concerning a random successive recall of memory representations by taking a Lorenz-plot of this macrovariable. We show that this macroscopic order is deterministic chaos steming from collapse of tori and this type of chaos can be an effective gadget of memory traces.

著者

Ken Harada Hitomi Suzuki Shun Matsunaga Tomohiro Onishi Yoshinori Nishikawa Hiroshi Funakubo Kumiko Mamiya Tomoyuki Nagao Norihiro Shinoda Shinichi Sakai Masataka Kato Nobuyuki Marui Hideki Ishii Tetsuya Amano Tatsuaki Matsubara Toyoaki Murohara

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.42663, (Released:2018-02-01)

参考文献数

30

被引用文献数

1

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Aim: Increased epicardial fat volume (EFV) is an independent risk factor for acute coronary syndrome (ACS). Although EFV increases with body mass index (BMI), some ACS patients have an increased EFV but normal BMI. We here investigated the clinical characteristics of nonobese ACS patients with an increased EFV.Methods: A total of 197 Japanese patients hospitalized for ACS was evaluated for EFV, abdominal visceral fat area (VFA), and lipid and glucose profiles. Control subjects comprised 141 individuals who were suspected of having ACS but whose coronary computed tomography findings were normal.Results: EFV was increased in ACS patients compared with control subjects (120±47 versus 95±45 mL, P<0.01). ACS patients were divided into four groups based on average EFV (120 mL) and a BMI obesity cutoff of 25 kg/m2. For the 30 nonobese ACS patients with an above-average EFV, EFV was positively correlated with VFA (r=0.23, P=0.031). These individuals were significantly older (74±10 years) and tended to have a higher homeostasis model assessment–insulin resistance value (5.5±3.8) compared with other ACS patients. Among nonobese study subjects, EFV was independently associated with ACS (odds ratio=2.01, P=0.021) and correlated with abdominal circumference (r=0.26, P=0.017).Conclusion: Nonobese ACS patients with an increased EFV were elderly and tended to manifest insulin resistance. Measurement of EFV may prove informative for evaluation of ACS risk among elderly nonobese individuals with an increased abdominal girth.

著者

Shuri Kato Asako Matsumoto Kensuke Yoshimura Toshio Katsuki Kojiro Iwamoto Yoshiaki Tsuda Shogo Ishio Kentaro Nakamura Kazuo Moriwaki Toshihiko Shiroishi Takashi Gojobori Hiroshi Yoshimaru

出版者

日本育種学会

雑誌

Breeding Science (ISSN:13447610)

巻号頁・発行日

vol.62, no.3, pp.248-255, 2012 (Released:2012-11-01)

参考文献数

36

被引用文献数

4 18

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Numerous cultivars of Japanese flowering cherry (Prunus subgenus Cerasus) are recognized, but in many cases they are difficult to distinguish morphologically. Therefore, we evaluated the clonal status of 215 designated cultivars using 17 SSR markers. More than half the cultivars were morphologically distinct and had unique genotypes. However, 22 cultivars were found to consist of multiple clones, which probably originate from the chance seedlings, suggesting that their unique characteristics have not been maintained through propagation by grafting alone. We also identified 23 groups consisting of two or more cultivars with identical genotypes. Most members of these groups were putatively synonymously related and morphologically identical. However, some of them were probably derived from bud sport mutants and had distinct morphologies. SSR marker analysis provided useful insights into the clonal status of the examined Japanese flowering cherry cultivars and proved to be a useful tool for cultivar characterization.

著者

Yuji Nagatomo Tsutomu Yoshikawa Hiroshi Okamoto Akira Kitabatake Masatsugu Hori on behalf of J-CHF Investigators

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-0442, (Released:2017-09-07)

参考文献数

33

被引用文献数

18

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Background:Anemia portends a poor clinical outcome in patients with chronic heart failure (CHF). However, its mechanism remains unknown. We sought to elucidate the effect of anemia on patients with HF with reduced ejection fraction (HFrEF) who receive carvedilol therapy.Methods and Results:J-CHF study was a prospective, randomized, multicenter trial that assigned 360 HFrEF patients to 2.5 mg/5 mg/20 mg carvedilol groups according to the target dose. At baseline 70 patients (19%) had anemia ([A]) defined as hemoglobin level (Hb) <13 g/dL (male) or <12 g/dL (female) and the remaining 290 did not ([N]). Allocated and achieved doses of carvedilol were similar. Left ventricular ejection fraction (LVEF) and plasma B-type natriuretic peptide (BNP) level significantly improved in both groups over 56 weeks, but they were smaller in [A] than in [N] (LVEF, P=0.046; BNP, P<0.0001 by ANOVA). Baseline Hb was an independent predictor of absolute change in LVEF (β=0.13, P=0.047) and BNP (β=−0.10, P=0.01). Presence of chronic kidney disease defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2at baseline was not associated with differential response to carvedilol therapy. During 3.8±1.4 years follow-up, group [A] had a higher incidence of the composite endpoint of death, hospitalization for cardiovascular causes including HF compared with [N] (P=0.006). Baseline Hb was an independent predictor of the composite endpoint (hazard ratio 0.86, P=0.04), whereas baseline eGFR was not.Conclusions:Our data suggested that anemia was associated with a blunted response to carvedilol in HFrEF patients.

著者

Nishiwaki Hiroshi

出版者

島根大学山陰地域研究総合センター

雑誌

山陰地域研究 (ISSN:0911615X)

巻号頁・発行日

vol.8, pp.伝統文化1[223]-25[247], 1992-03

著者

松尾 博史 Hiroshi Matsuo Matsuyama University Faculty of Business Administration

出版者

松山大学総合研究所

雑誌

言語文化研究 (ISSN:02862093)

巻号頁・発行日

vol.29, no.1, pp.159-202, 2009-09

著者

Yuki SAITO Shinnosuke TAKAMICHI Hiroshi SARUWATARI

出版者

一般社団法人 電子情報通信学会

雑誌

IEICE Transactions on Information and Systems (ISSN:09168532)

巻号頁・発行日

vol.E100.D, no.8, pp.1925-1928, 2017-08-01 (Released:2017-08-01)

参考文献数

20

被引用文献数

19

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This paper proposes Deep Neural Network (DNN)-based Voice Conversion (VC) using input-to-output highway networks. VC is a speech synthesis technique that converts input features into output speech parameters, and DNN-based acoustic models for VC are used to estimate the output speech parameters from the input speech parameters. Given that the input and output are often in the same domain (e.g., cepstrum) in VC, this paper proposes a VC using highway networks connected from the input to output. The acoustic models predict the weighted spectral differentials between the input and output spectral parameters. The architecture not only alleviates over-smoothing effects that degrade speech quality, but also effectively represents the characteristics of spectral parameters. The experimental results demonstrate that the proposed architecture outperforms Feed-Forward neural networks in terms of the speech quality and speaker individuality of the converted speech.

著者

Hiroki Namikawa Koichi Yamada Hiroki Fujimoto Ken-Ichi Oinuma Yoshihiro Tochino Yasuhiko Takemoto Yukihiro Kaneko Taichi Shuto Hiroshi Kakeya

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.56, no.14, pp.1807-1815, 2017-07-15 (Released:2017-07-15)

参考文献数

37

被引用文献数

18

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Objective In recent years, infection caused by extended-spectrum beta-lactamase (ESBL)-producing organisms has become an important issue. However, comparative studies of the bacteremia caused by ESBL Enterobacteriaceae and non-ESBL Enterobacteriaceae are extremely rare in Japan. This study aimed to assess the risk factors and prognosis of patients with bacteremia due to ESBL Escherichia coli (E. coli). Methods The medical records of 31 patients with ESBL E. coli bacteremia and 98 patients with non-ESBL E. coli bacteremia who had been admitted to Osaka City University Hospital between January 2011 and June 2015 were retrospectively reviewed. The patient backgrounds, risk factors for infection, and prognosis were evaluated. Results The male-to-female ratio, mean age, underlying disease, leukocyte count, and C-reactive protein (CRP) level did not differ between the patients in the ESBL E. coli bacteremia and non-ESBL E. coli bacteremia groups. The mean Sequential Organ Failure Assessment (SOFA) score for patients with ESBL and non-ESBL E. coli bacteremia were 3.6 and 3.8, respectively. Further, the mortality did not differ between the two groups (9.7% vs 9.2%). However, the independent predictors associated with ESBL E. coli bacteremia according to a multivariate analysis were the use of immunosuppressive drugs or corticosteroids (p=0.048) and quinolones (p=0.005) prior to isolation. The mortality did not differ between the carbapenem and tazobactam/piperacillin (TAZ/PIPC) or cefmetazole (CMZ) groups for the patients with ESBL E. coli bacteremia. Conclusion Whenever we encountered patients with a history of immunosuppressive drug, corticosteroid, quinolone administration, it was necessary to perform antibiotic therapy while keeping the risk of ESBL E. coli in mind.

著者

Naka Makiko Naoi Hiroshi

出版者

Psychonomic Society

雑誌

Memory &amp; Cognition

巻号頁・発行日

vol.23, no.1, pp.201-212, 1995

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Repeated writing, or rehearsal by writing, is a common memory strategy for the Japanese, especially when learning new logographic characters. The to-be-remembered items are written down not as external prompts, as with reminder notes, but to be memorized in the course of writing them down over and over again. In this study, we investigated whether the strategy was effective, and if so, in which condition. Experiment I showed that repeated writing improved memory for graphic designs but not for Chinese characters, words, or syllables. Experiment 2 showed that the effect occurred for both Japanese and American subjects, suggesting that it was not the result of a cultural background associated with a logographic language, Instead, the effect seemed to be accounted for by the encoding specificity of visual-motor information, because repeated writing improved free recall— that included writing----but did not improve recognition (Experiment 3). In Experiment 4, the strategy was applied to learning the Arabic alphabet. Finally, similarities between repeated writing and 'I\-pe 1 rehearsal are discussed .

著者

Ishikura Yukiko Yabuta Yukihiro Ohta Hiroshi Hayashi Katsuhiko Nakamura Tomonori Okamoto Ikuhiro Yamamoto Takuya Kurimoto Kazuki Shirane Kenjiro Sasaki Hiroyuki Saitou Mitinori

出版者

Elsevier B.V.

雑誌

Cell Reports (ISSN:22111247)

巻号頁・発行日

vol.17, no.10, pp.2789-2804, 2016-12-06

被引用文献数

134

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マウス多能性幹細胞から精子幹細胞を試験管内で誘導 : 精子形成全過程の試験管内誘導の基盤形成. 京都大学プレスリリース. 2016-12-07.

著者

高橋 裕 Hiroshi Takahashi

雑誌

法と政治 (ISSN:02880709)

巻号頁・発行日

vol.62, no.1(下), pp.157(784)-195(746), 2011-04-20

著者

Chizuko Maruyama Rena Nakano Mitsuha Shima Asumi Mae Yuri Shijo Eri Nakamura Yuuna Okabe Sunmi Park Noriko Kameyama Satomi Hirai Mamoru Nakanishi Kagehiro Uchida Hiroshi Nishiyama

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.36780, (Released:2016-09-21)

参考文献数

27

被引用文献数

19

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Aim: We conducted a pilot study to clarify the effects of the Japan Diet nutritional education program on metabolic risk factors for atherosclerotic cardiovascular disease in middle-aged men who were brought up in the westernized dietary environment of modern Japan.Methods: Thirty-three men, 30–49 years of age, attended a nutrition education class to learn food items and recommended volumes comprising the Japan Diet (more fish, soybeans and soy products, vegetables, seaweed, mushrooms and unrefined cereals, and less animal fat, meat and poultry with fat, sweets, desserts and snacks, and alcoholic drinks), and were encouraged to consume the Japan Diet for 6 weeks. Anthropometric and biochemical parameters were measured and 3-day weighted dietary records were kept before and at completion of the intervention.Results: Ninety-one percent of participants showed improvements in more than one cardiovascular risk factor after 6 weeks. Body weight, serum low density lipoprotein (LDL) cholesterol, malondialdehyde modified (MDA)-LDL and triglyceride concentrations decreased significantly, while high density lipoprotein cholesterol was unchanged. Fish, soy, and sum of seaweed, mushrooms and konjak intakes doubled, and green and yellow vegetable intakes also increased as compared to baseline. Meanwhile, intakes of refined cereals, meat and poultry, sweets, desserts and snacks, and margarine and shortening decreased. Total energy, lipid, and saturated and monounsaturated fatty acid intakes decreased, while n-3 polyunsaturated fatty acid, dietary fiber, beta-carotene, vitamins D and K, potassium, and magnesium increased, with no change in sodium intake.Conclusions: The Japan Diet is suggested to improve atherosclerotic cardiovascular disease risk factors in middle-aged Japanese men.The clinical trial registration number: UMIN000020639.

著者

常松 洋 TSUNEMATSU Hiroshi

出版者

京都女子大学史学会

雑誌

史窓 (ISSN:03868931)

巻号頁・発行日

no.72, pp.136-123, 2015-02

著者

ITO Yuko NAGANO Hiroshi

出版者

GRIPS Policy Research Center

雑誌

GRIPS Discussion Papers

巻号頁・発行日

vol.16-11, 2016-08

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Japan’s cabinet has been pushing forward with economic policy knowns as Abenomics since December 26 in 2012. Abenomics also includes the promotion of R&D in the medical field and related legislative reforms. The Headquarters for Healthcare and Medical Strategy Promotion was established in the cabinet in 2013. In 2014, “Act to Promote Healthcare and Medical Strategy” was promulgated and included for the formulation of the Health and Medical Strategy, the creation of the Plan for Promotion of medical R&D by the Headquarters, and the newly establishment for Japan Agency for Medical Research and Development. In 2014 the Pharmaceutical Affairs Law was revised and it newly contains the strengthening of safety measures for pharmaceuticals and medical devices, the construction of regulations taking into account the characteristics of medical devices, and a new definition for regenerative medicine along with approvals for manufacturing and sales in light of its special characteristics. Further, “Sakigake Package Strategy” formulated in 2014, which included an “advanced review designation system” as a fast-track- applications. With only three years having passed since the implementation of the policies related to Abenomics in 2013, it may be premature to judge their outcome, but several positive signs are appearing.