著者

Imayoshi Itaru Isomura Akihiro Harima Yukiko Kawaguchi Kyogo Kori Hiroshi Miyachi Hitoshi Fujiwara Takahiro Ishidate Fumiyoshi Kageyama Ryoichiro

出版者

American Association for the Advancement of Science

雑誌

Science (ISSN:00368075)

巻号頁・発行日

vol.342, no.6163, pp.1203-1208, 2013-10-31

被引用文献数

433

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神経幹細胞の自己複製および分化決定メカニズムの解明と、その操作に成功 -再生医療研究への貢献に期待-. 京都大学プレスリリース. 2013-11-01.

著者

酒井 邦夫 北村 達夫 日向 浩 山下 久雄 サカイ クニオ キタムラ タツオ ヒナタ ヒロシ ヤマシタ ヒサオ Sakai Kunio Kitamura Tatsuo Hinata Hiroshi Yamashita Hisao

出版者

日本医学放射線学会

雑誌

日本医学放射線学会雑誌 (ISSN:00480428)

巻号頁・発行日

vol.46, no.6, pp.811-818, 1986-06-25

著者

Yoichi Takaya Reon Kumasaka Tetsuo Arakawa Takahiro Ohara Michio Nakanishi Teruo Noguchi Masanobu Yanase Hiroshi Takaki Yuhei Kawano Yoichi Goto

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.78, no.2, pp.377-384, 2014 (Released:2014-01-24)

参考文献数

36

被引用文献数

6 42

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Background: Although there is a general fear that exercise training might deteriorate renal function in chronic kidney disease (CKD) patients, the effect of cardiac rehabilitation (CR) on renal function in acute myocardial infarction (AMI) patients with CKD remains unknown. We sought to determine whether CR is associated with amelioration or deterioration of renal function in such patients. Methods and Results: We enrolled 528 AMI patients who participated in a 3-month CR program. Clinical data before and after CR were compared according to participation in CR and comorbidities. In patients without CKD (estimated glomerular filtration rate [eGFR] ≥60ml·min−1·1.73m−2, n=348), peak oxygen uptake (VO2) and B-type natriuretic peptide (BNP) improved without a change in eGFR. In contrast, in patients with CKD (eGFR <60ml·min−1·1.73m−2, n=180), eGFR improved (48±12 to 53±15ml·min−1·1.73m−2, P<0.001), together with improvements in peak VO2 and BNP. When patients with CKD were divided into non-active (≤1time/week, n=70) and active participants (≥1.1time/week, n=110) according to attendance in CR, active participants showed an improvement in eGFR (50±10 to 53±13ml·min−1·1.73m−2, P<0.001), whereas eGFR did not change in non-active participants. Similar results were obtained in each subgroup of patients with hypertension, dyslipidemia, or diabetes mellitus. Conclusions: In AMI patients with CKD, active participation in CR was associated with improved peak VO2, BNP, and eGFR.  (Circ J 2014; 78: 377–384)

著者

Pandian Ganesh N Taniguchi Junichi Junetha Syed Sato Shinsuke Han Le Saha Abhijit Anandhakumar Chandran Bando Toshikazu Nagase Hiroki Vaijayanthi Thangavel Taylor Rhys D Sugiyama Hiroshi

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.4, 2014-01-24

被引用文献数

61

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人工スイッチを使った遺伝子コントロールに成功 -治療に役立つ可能性も- 京都大学プレスリリース. 2014-01-24.

著者

OSAFUNE Tetsuaki MITSUBOSHI Masahiro ITO Takashi AOKI Shigeji EHARA Tomoko HASHIGUCHI Hiroshi MINAMI Kazufumi

出版者

日本衛生学会

雑誌

Environmental health and preventive medicine (ISSN:1342078X)

巻号頁・発行日

vol.12, no.1, pp.11-16, 2007-01

参考文献数

11

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Objectives: Sumo wrestling is one of the most popular sports in Japan. Injuries are not uncommon as this is a vigorous contact sport. Sumo wrestlers have little in the way of protective clothing; their main garb is the mawashi, making them prone to exposure to any microorganisms in the dohyo. The bacterial flora of the dohyo has received little attention. If the constituent flora is identified, then appropriate treatment or prevention of any bacterial lesions or infections incurred by the wrestlers is possible. Methods: The Vitek AMS system used in this study was developed by McDonnell Douglas Corporation. In this system, the physiological and biochemical properties of Gram-positive and -negative bacilli, Gram-positive and -negative cocci, and fungi isolated from clinical materials and environments are examined using test cards specifically for each microorganism group, and the results are automatically read by a computer and encoded. Obtained codes are compared with a built-in database, and bacterial species of test strains are identified. Results: In this study, using the automatic identification kit VITEK or ATB, we describe the aerobic bacterial flora found in the dohyo over the four seasons of the year. We also investigated the effect of salt on the bacterial flora as sumo wrestlers toss salt on the dohyo before each match. We show the relationship between salinity changes and variations in the flora observed upon the addition of salt. Without salt, at the beginning of a match, Gram-negative bacteria predominate. When salt is added, there is a transient decrease in the incidence of flora followed by an increase in the incidence Grampositive cocci. Conclusions: Sixteen bacterial genera were identified using the bacterial identification systems in dohyo soil samples during the year. The number of identified bacterial species was 32. Even in the presence of salt, there is a measurable amount of bacterial flora in dohyo soil; salt does not act as an antibacterial agent.

著者

Kentaro Asayama Hiroshi Yamadera Takao Ito Hideaki Suzuki Yoshihisa Kudo Shunkichi Endo

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.70, no.4, pp.334-341, 2003 (Released:2003-08-29)

参考文献数

29

被引用文献数

73 173

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Previously, we reported that morning bright light therapy improved sleep time and cognitive function in Alzheimer type of dementia. We conducted a double blind study to examine the effects of melatonin on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type of dementia. The subjects were 9 persons given a placebo (PLA), and 11 given melatonin (3 mg)(MLT). The mean age was 79.2±6.4 (17 females and 3 males). The drugs were given at 20: 30 each day for 4 weeks. We checked sleep time and activity by Actigraph through one week before and the 4th week after drug administration. Cognitive and non-cognitive functions were evaluated with the clinical dementia rating scale (CDR), and Mini Mental State Examination (MMSE), and the Alzheimer's Disease Assessment Scale (ADAS). We successfully recorded Actigraph data from 18 patients (PLA8, MLT10). The mean sleep time change ratio and SD of the administration of PLA in the night was-0.2±13.7%, and MLT was 33.2±37.6%. The mean activity counts and SD of the administration of PLA in the night was 29.8±77.0%; in MLT it was-44.9±21.9%. Melatonin significantly prolonged the sleep time (p=0.017) and decreased activity (p=0.014) in the night (21: 00∼6: 00) in the MLT group, although no significant difference in sleep time or activity in the daytime (6: 00∼21: 00) was recognized between the two groups. In comparison with ADAS cognition score changes, the mean change and SD in the PLA was 0.3±3.7; in MLT it was-4.3±3.6 points. In comparison with ADAS non-cognition score, the mean change and SD in the PLA group was-0.8±1.0, in the MLT group it was-4.1±2.2 points. There were also significant differences between the PLA and the MLT groups in the comparison with the score improvement of ADAS cognition (p=0.017) and non-cognition (p=0.002), otherwise there was no significant difference in improvement of MMSE between both groups.Melatonin administration had effect to improve sleep time and night activity, but no significant effect to improve daytime naps and activity. Although melatonin administration might has less strong effect on circadian rhythm than morning bright light therapy we previously reported, cognitive and non-cognitive functions were improved. Melatonin seemed to be useful for care of the Alzheimer type of dementia patients.

著者

Ishikawa Atsushi Nakashima Hiroyuki Nakatsuji Hiroshi

出版者

American Institute of Physics

雑誌

JOURNAL OF CHEMICAL PHYSICS (ISSN:00219606)

巻号頁・発行日

vol.128, no.12, 2008-03-28

被引用文献数

29

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The nonrelativistic Schrödinger equation and the relativistic four-component Dirac equation of H2+ were solved accurately in an analytical expansion form by the free iterative complement interaction (ICI) method combined with the variational principle. In the nonrelativistic case, we compared the free ICI wave function with the so-called "exact" wave function as two different expansions converging to the unique exact wave function and found that the free ICI method is much more efficient than the exact method. In the relativistic case, we first used the inverse Hamiltonian to guarantee Ritz-type variational principle and obtained accurate result. We also showed that the ordinary variational calculation also gives a nice convergence when the g function is appropriately chosen, since then the free ICI calculation guarantees a correct relationship between the large and small components of each adjacent order, which we call ICI balance. This is the first application of the relativistic free ICI method to molecule. We calculated both ground and excited states in good convergence, and not only the upper bound but also the lower bound of the ground-state energy. The error bound analysis has assured that the present result is highly accurate.

著者

Hidenori Arai Akira Yamamoto Yuji Matsuzawa Yasushi Saito Nobuhiro Yamada Shinichi Oikawa Hiroshi Mabuchi Tamio Teramoto Jun Sasaki Noriaki Nakaya Hiroshige Itakura Yuichi Ishikawa Yasuyoshi Ouchi Hiroshi Horibe Nobuo Shirahashi Toru Kita

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.13, no.4, pp.202-208, 2006 (Released:2006-08-15)

参考文献数

15

被引用文献数

87 126

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To determine the prevalence of metabolic syndrome in the Japanese general population, we analyzed data from a nationwide survey conducted in 2000. According to the Japanese new diagnostic criteria for metabolic syndrome in 2005, we analyzed 3,264 people aged from 20 to 79 (men, 1,917; women, 1,347) from the total participants. The incidence of metabolic syndrome was 7.8%. Men had a higher incidence (12.1%) than women (1.7%). Most of the women satisfying the criteria were 50 years old or over, while the incidence in men started to rise from their 30s. When we applied the criteria of Adult Treatment Panel III, the incidence was about 3-fold higher. In this population visceral obesity was associated with metabolic abnormalities, such as higher LDL-cholesterol, triglyceride, glucose, and blood pressure and lower HDL-cholesterol. Thus we determined the incidence of metabolic syndrome and each metabolic abnormality in the Japanese general population in 2000 and found an association of visceral obesity with metabolic abnormalities. Intervention to reduce the incidence of metabolic syndrome in Japan is necessary to reduce the risk of cardiovascular disease.

著者

Yosuke AMAGAI Akane TANAKA Akira MATSUDA Kumiko OIDA Kyungsook JUNG Sho NISHIKAWA Hyosun JANG Saori ISHIZAKA Hiroshi MATSUDA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0025, (Released:2013-02-22)

被引用文献数

1 4

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Myeloid cell leukemia sequence 1 (MCL1) is a potent antiapoptotic protein that plays a critical role in cell survival and drug resistance in various cancers. However, to the best of our knowledge, the role of MCL1 in mast cell tumors (MCTs) has not been investigated in dogs. Here, we detected increased MCL1 expression in MCT cell lines, regardless of the presence of a c-kit mutation. MCL1 expression increased when the cells were exposed to specific inhibitors of mitogen-activated protein kinase or Janus kinase-signaling pathways, thus protecting the cells from apoptosis, but not when KIT or phosphatidylinositol-3 kinase signaling cascades were inhibited. These results indicate that MCL1 expression may contribute to MCT survival and confer drug resistance.

著者

油川 洋 Hiroshi Aburakawa

出版者

尚絅学院大学

雑誌

尚絅学院大学紀要 (ISSN:13496883)

巻号頁・発行日

vol.51, pp.103-114, 2005-01

著者

Fumio Terasaki Hiroshi Okamoto Katsuya Onishi Akira Sato Hiroaki Shimomura Bin Tsukada Kyoko Imanaka-Yoshida Michiaki Hiroe Toshimichi Yoshida Yasushi Kitaura Akira Kitabatake Study Group for Intractable Diseases by a Grant from the Ministry of Health Labor and Welfare of Japan

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.71, no.3, pp.327-330, 2007 (Released:2007-02-25)

参考文献数

29

被引用文献数

60 72

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Background Tenascin-C (TN-C), an extracellular matrix glycoprotein, is specifically expressed at high levels during embryonic development, but not in the adult heart. TN-C reappears at sites of inflammatory tissue remodeling or wound healing under various pathologic conditions, such as acute myocardial infarction, acute myocarditis, and some cases of cardiomyopathy. Therefore, the expression of TN-C might be useful for detecting the clinical characteristics of, and ventricular remodeling in, dilated cardiomyopathy (DCM). Methods and Results Circulating serum TN-C levels in 107 patients with DCM were measured using an ELISA kit. Clinical data were also assessed by Pearson's or Spearman's correlation analysis to estimate correlations between variables. Serum TN-C levels in DCM patients were higher than those in normal controls (p<0.001). TNC levels showed a significantly positive correlation with New York Heart Association functional class (p<0.001), B-type natriuretic peptide level (p<0.001), cardiothoracic ratio on chest X-ray (p<0.01), left ventricular end-diastolic diameter (p<0.05) and left ventricular end-systolic diameter (p<0.01), and a significantly negative correlation with left ventricular ejection fraction (p<0.01). Conclusions The findings suggest that increased serum TN-C levels indicate the severity of heart failure, left ventricular dysfunction and remodeling in patients with DCM. (Circ J 2007; 71: 327 - 330)

著者

Tamie Nakajima Setsuko Ohta Hiroshi Morita Youko Midorikawa Shohei Mimura Nobuo Yanagisawa

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.8, no.1, pp.33-41, 1998 (Released:2007-11-30)

参考文献数

24

被引用文献数

21 32

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On the night of June 27, 1994, about 12 liters of sarin were released by terrorists in Matsumoto City, Japan. In order to investigate the epidemic, community-based questionnaire surveys were conducted. The subjects were all inhabitants (2052 people) living and staying in an area of 1050 meters from north to south and 850 meters from east to west including the sarin release site. Participants included 1743 people who answered the questionnaire at the first survey; those with symptoms were contacted for follow-up at four months and one year after the episode. The number of sarin victims were 471 persons. Muscarinic signs were common to all victims; nicotinic signs were only seen in severely affected victims. The geographical distribution of sarin victims was closely related to the direction of the wind. Three weeks after the intoxication, 129 victims still had some symptoms such as dysesthesia of the extremities. At that time, many victims had begun to experience asthenopia, which was even more frequent at four months. Although victims who felt sarin-related symptoms had decreased by a year, some still had symptoms such as asthenopia. Sarin released in a suburban area affected approximately 500 inhabitants living nearby; some still had symptoms a year after the intoxication. J Epidemiol, 1998; 8 : 33-41.

著者

Shuhei ENOMOTO Hiroki KUZUNO Hiroshi YAMADA

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE Transactions on Information and Systems (ISSN:09168532)

巻号頁・発行日

vol.E105.D, no.11, pp.1890-1899, 2022-11-01 (Released:2022-11-01)

参考文献数

32

被引用文献数

3

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CPU flush instruction-based cache side-channel attacks (cache instruction attacks) target a wide range of machines. For instance, Meltdown / Spectre combined with FLUSH+RELOAD gain read access to arbitrary data in operating system kernel and user processes, which work on cloud virtual machines, laptops, desktops, and mobile devices. Additionally, fault injection attacks use a CPU cache. For instance, Rowhammer, is a cache instruction attack that attempts to obtain write access to arbitrary data in physical memory, and affects machines that have DDR3. To protect against existing cache instruction attacks, various existing mechanisms have been proposed to modify hardware and software aspects; however, when latest cache instruction attacks are disclosed, these mechanisms cannot prevent these. Moreover, additional countermeasure requires long time for the designing and developing process. This paper proposes a novel mechanism termed FlushBlocker to protect against all types of cache instruction attacks and mitigate against cache instruction attacks employ latest side-channel vulnerability until the releasing of additional countermeasures. FlushBlocker employs an approach that restricts the issuing of cache flush instructions and the attacks that lead to failure by limiting control of the CPU cache. To demonstrate the effectiveness of this study, FlushBlocker was implemented in the latest Linux kernel, and its security and performance were evaluated. Results show that FlushBlocker successfully prevents existing cache instruction attacks (e.g., Meltdown, Spectre, and Rowhammer), the performance overhead was zero, and it was transparent in real-world applications.

著者

Mizuki Sata Kazumasa Yamagishi Toshimi Sairenchi Fujiko Irie Keiko Sunou Hiroshi Watanabe Hiroyasu Iso Hitoshi Ota

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.33, no.2, pp.63-67, 2023-02-05 (Released:2023-02-05)

参考文献数

29

被引用文献数

1

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Background: Breastfeeding is said to prevent overweight and obesity in childhood but the evidence about its long-term impact on body size into adolescence and adulthood is scarce. We sought to examine the association between feeding types and subsequent physical size at the ages of 3, 6, 12, and 22 years.Methods: The Ibaraki Children’s Cohort (IBACHIL) Study, which began in 1992, involved a cohort of 4,592 Japanese children from 87 communities of a single prefecture whose parents answered health questionnaires about their child’s health and life habits at the age of 3 years. Follow-up questionnaires were distributed to the same cohort when they were 6, 12, and 22 years old. Self-reported height and weight, body mass index (BMI), and overweight status at ages of 3 (n = 4,290), 6 (n = 1,999; proportion of participants analyzed = 47%), 12 (n = 2,227; 52%), and 22 (n = 1,459; 34%) years were compared according to feeding type (breastfeeding, formula feeding, and mixed feeding) during infancy.Results: At the age of 3 years, multivariable adjusted-mean weight and prevalence of overweight were less for breastfed children than those formula-fed in both boys (weight: 14.6 kg vs 14.7 kg, P = 0.07, overweight: 6.3% vs 9.3%, P = 0.03) and in girls (14.0 kg vs 14.2 kg, P = 0.01 and 10.4% vs 13.6%, P = 0.06). However, there were no statistically significant differences in weight, BMI, and overweight at the ages of 6, 12, and 22 years according to feeding type.Conclusion: Breastfeeding may prevent overweight in childhood, but its impact is not significant in adolescence and adulthood.

著者

Yumi Matsushita Tetsuji Yokoyama Kayoko Hayakawa Nobuaki Matsunaga Hiroshi Ohtsu Sho Saito Mari Terada Setsuko Suzuki Shinichiro Morioka Satoshi Kutsuna Shinya Tsuzuki Hisao Hara Akio Kimura Norio Ohmagari

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.33, no.1, pp.38-44, 2023-01-05 (Released:2023-01-05)

参考文献数

27

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Background: Prioritization for novel coronavirus disease 2019 (COVID-19)-related health policies usually considers age and certain other characteristics, but sex is rarely included, despite the higher risk of severe disease in men. The aim of this study was to compare the impact of sex and age on the severity of COVID-19 by estimating the age difference in years for which the risk for men versus women is the same.Methods: We analyzed 23,414 Japanese COVID-19 inpatients aged 20–89 years (13,360 men and 10,054 women). We graded the severity of COVID-19 (0 to 5) according to the most intensive treatment required during hospitalization. The risk of grade 2/3/4/5 (non-invasive positive pressure ventilation/invasive mechanical ventilation/extracorporeal membrane oxygenation/death), grade 3/4/5, and separately grade 5 was analyzed using a multiple logistic regression model.Results: The odds ratio (OR) of grades 2/3/4/5, 3/4/5 (primary outcome), and 5 for men relative to women was 2.76 (95% CI, 2.44–3.12), 2.78 (95% CI, 2.42–3.19), and 2.60 (95% CI, 2.23–3.03), respectively, after adjustment for age and date of admission. These risks for men were equivalent to those for women 14.1 (95% CI, 12.3–15.8), 11.2 (95% CI, 9.7–12.8), and 7.5 (95% CI, 6.3–8.7) years older, respectively.Conclusion: The risks of worse COVID-19 prognosis (grades 3/4/5) in men were equivalent to those of women 11.2 years older. Reanalyzing data extracted from four previous studies also revealed a large impact of sex difference on the severity of COVID-19. We should pay more attention to sex differences to predict the risk of COVID-19 severity and to formulate public health policy accordingly.

著者

Yurika Tahara Mikako Fujita Tianli Zhang Dongxing Wang Hiroshi Tateishi Akihiro Togami Perpetual Nyame Hiromi Terasawa Nami Monde Joyce Appiah-Kubi Wright Ofotsu Amesimeku Doaa Husham Majeed Alsaadi Mikiyo Wada Koji Sugimura Sevgi Gezici Halilibrahim Ciftci Faruk Karahan Nazim Sekeroglu Masami Otsuka Tomohiro Sawa Yosuke Maeda Takashi Watanabe Kazuaki Monde

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.46, no.11, pp.1535-1547, 2023-11-01 (Released:2023-11-01)

参考文献数

67

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The introduction of combined anti-retroviral therapy (cART) in 1996, along with a continual breakthrough in anti-human immunodeficiency virus-1 (HIV-1) drugs, has improved the life expectancies of HIV-1-infected individuals. However, the incidence of drug-resistant viruses between individuals undergoing cART and treatment-naïve individuals is a common challenge. Therefore, there is a requirement to explore potential drug targets by considering various stages of the viral life cycle. For instance, the late stage, or viral release stage, remains uninvestigated extensively in antiviral drug discovery. In this study, we prepared a natural plant library and selected candidate plant extracts that inhibited HIV-1 release based on our laboratory-established screening system. The plant extracts from Epilobium hirsutum L. and Chamerion angustifolium (L.) Holub, belonging to the family Onagraceae, decreased HIV-1 release and accelerated the apoptosis in HIV-1-infected T cells but not uninfected T cells. A flavonol glycoside quercetin with oenothein B in Onagraceae reduced HIV-1 release in HIV-1-infected T cells. Moreover, extracts from Chamerion angustifolium (L.) Holub and Senna alexandrina Mill. inhibited the infectivity of progeny viruses. Together, these results suggest that C. angustifolium (L.) Holub contains quercetin with oenothein B that synergistically blocks viral replication and kills infected cells via an apoptotic pathway. Consequently, the plant extracts from the plant library of Turkey might be suitable candidates for developing novel anti-retroviral drugs that target the late phase of the HIV-1 life cycle.

著者

Naoko Kosaka Yusuke Umemiya Naoto Endou Tsuneko Kura Hiroshi Matsubara Masaki Hisada Akinori Murata Satoshi Mitarai

出版者

公益社団法人 日本気象学会

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.19, pp.116-125, 2023 (Released:2023-07-04)

参考文献数

35

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This paper presents experimental observations to improve typhoon prediction accuracy and to understand interactions between atmosphere and ocean directly under typhoons. Two unmanned surface vehicles (Wave Gliders (WGs)) equipped with interchangeable sensors were sailed toward the path of an approaching Category 5 typhoon (Hinnamnor), which began on 29 August 2022 and subsided on 6 September, reaching a minimum pressure of 920 hPa and a maximum wind speed of 55 m/s (105 knots). Sensors on WGs measured atmospheric pressure, wind speed, atmospheric and seawater temperature, wave height, currents, salinity, and chlorophyll-a concentrations in different parts of the typhoon. These observations made it possible to clarify changes in various phenomena as the typhoon approached and to compare differences in storm characteristics measured by the two WGs. Sea surface pressure in the core of a typhoon is useful as an initial predictor of its intensity. Data assimilation into numerical models and other observations are expected to improve prediction accuracy of typhoon phenomena. Furthermore, simultaneous observations of atmosphere and ocean will also be useful for modeling interactions.

著者

Hiroshi Yokomichi Mie Mochizuki Reiji Kojima Sayaka Horiuchi Tadao Ooka Yuka Akiyama Kunio Miyake Megumi Kushima Sanae Otawa Ryoji Shinohara Zentaro Yamagata

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.69, no.1, pp.9-21, 2022 (Released:2022-01-28)

参考文献数

36

被引用文献数

1 4

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In this study, we aimed to determine the association of neonatal/post-neonatal hypothyroidism with mother’s iodine exposure, especially povidone iodine disinfection, and hysterosalpingography. Participants were mother–child pairs in a Japanese birth cohort (n = 100,286). Risk factors of hypothyroidism were supplement intake, seaweed intake, other daily iodine intake, povidone iodine disinfection at delivery, and maternal history of hysterosalpingography, thyroid disease (Graves’ disease and Hashimoto’s thyroiditis), and medication (thiamazole and levothyroxine). Congenital hypothyroidism (CH) at age 1 year was assessed using a questionnaire. Transient hypothyroidism was defined as elevated thyroid stimulating hormone level at birth and absence of CH at age 1 year. The incidence of CH at age 1 year per 100 children was 1.1 for those born at 22–30 weeks’ gestation, 0.17 following povidone iodine disinfection, and 0.07, 0.95, 0.81, 1.17, and 1.15 with a maternal history of hysterosalpingography, Graves’ disease, Hashimoto’s thyroiditis, thiamazole use, and levothyroxine use, respectively. Odds ratios (95% confidence intervals) of CH at age 1 year for povidone iodine disinfection, hysterosalpingography history, maternal Graves’ disease, and maternal Hashimoto’s thyroiditis were 1.13 (0.71–1.79), 0.47 (0.07–3.36), 7.06 (3.70–13.5), and 5.93 (2.90–12.1), respectively. For transient hypothyroidism for povidone iodine disinfection and hysterosalpingography history, these values were 1.99 (1.51–2.62) and 0.63 (0.20–1.96), respectively. Maternal thyroid disease greatly increased neonatal/post-neonatal hypothyroidism risk. Povidone iodine disinfection may increase transient hypothyroidism risk but not the risk at 1 year of age. Hysterosalpingography does not increase hypothyroidism risk from birth to age 1 year.

著者

The Working Group for Renaming Diabetes Insipidus Hiroshi Arima Timothy Cheetham Mirjam Christ-Crain Deborah Cooper Mark Gurnell Juliana B Drummond Miles Levy Ann I McCormack Joseph Verbalis John Newell-Price John A H Wass

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.69, no.11, pp.1281-1284, 2022 (Released:2022-11-28)

参考文献数

10

被引用文献数

1 5

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“What’s in a name? That which we call a rose/By any other name would smell as sweet.” (Juliet, from Romeo and Juliet by William Shakespeare). Shakespeare’s implication is that a name is nothing but a word and it therefore represents a convention with no intrinsic meaning. Whilst this may be relevant to romantic literature, disease names do have real meanings, and consequences, in medicine. Hence, there must be a very good rational for changing the name of a disease that has a centuries-old historical context. A working group of representatives from national and international endocrinology and pediatric endocrine societies now proposes changing the name of “diabetes insipidus” to “Arginine Vasopressin Deficiency (AVP-D)” for central etiologies, and “Arginine Vasopressin Resistance (AVP-R)” for nephrogenic etiologies. This editorial provides both the historical context and the rational for this proposed name change.

著者

Takashi Unuma Hiroshi Yamauchi Akihito Umehara Teruyuki Kato

出版者

公益社団法人 日本気象学会

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.19, pp.150-156, 2023 (Released:2023-07-22)

参考文献数

28

被引用文献数

1

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We investigated the microphysical mechanisms for the enhancement of rainfall in a precipitating system that spawned heavy rainfall over the central part of the Kanto Plain in eastern Japan on 12 July 2022. Optical disdrometer observations confirmed the existence of an equilibrium state in the raindrop size distribution, especially when the precipitation intensity was high (e.g., 20 mm hr−1). As the raindrop size distribution approached equilibrium, raindrop sizes centered around 1.5 mm were observed initially, and then the number concentration of smaller and larger size raindrops increased simultaneously. The raindrop size distribution was closely related to the vertical profile of the parameters of raindrop size distribution that were estimated from polarimetric radar observations. These results suggest that the formation of equilibrium raindrop size distributions is important to produce substantial rainfall in the midlatitude as well as in the tropics.