著者

Ami Takeuchi Yuna Akatsu Takahiro Asahi Yukino Okubo Mariko Ohnuma Hiroshi Teramura Koji Tamura Hiroaki Shimada

出版者

Japanese Society for Plant Biotechnology

雑誌

Plant Biotechnology (ISSN:13424580)

巻号頁・発行日

vol.39, no.2, pp.195-197, 2022-06-25 (Released:2022-06-25)

参考文献数

6

被引用文献数

3

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Potato, Solanum tuberosum L. is an important crop. However, it is difficult to breed potato cultivars by applying conventional crossing methods because potato has a tetraploid genome and is vegetatively propagated. Flower formation and tuber development occur simultaneously. Many potato cultivars hardly produce any fruits after crossing and fail to produce seeds. We report an improved procedure for obtaining progeny seeds by grafting potatoes onto tomatoes. The rate of fruit formation was more than 19% when the grafted potatoes were used for the crossing experiments, whereas crossing using the ungrafted plants showed a rate of 1.1%. This result suggests that our procedure results in the easy acquisition of null-segregant progenies by crossing mutant lines. It is also expected to improve conventional potato breeding.

著者

Asami Yoshimura Noriko Kikuchi Satoshi Saito Atsushi Suzuki Hidetoshi Hattori Morio Shoda Yuki Ichihara Hiroshi Niinami Nobuhisa Hagiwara Junichi Yamaguchi Shinichi Nunoda

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.4, no.9, pp.405-411, 2022-09-09 (Released:2022-09-09)

参考文献数

23

被引用文献数

1

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Background: For elderly patients with refractory heart failure (HF), destination therapy (DT) with a continuous-flow left ventricular assist device (LVAD) is a possible treatment. The aim of DT is for long-term, satisfying quality of life on LVAD support. Previously, elderly non-responders to cardiac resynchronization therapy (CRT) were primarily destined for palliative care, but DT has been available in Japan since April 30, 2021. This study investigated the prognosis of elderly CRT non-responders and assessed the feasibility of DT in these patients based on the J-HeartMate Risk Score (J-HMRS).Methods and Results: Of the 559 patients who underwent CRT at Tokyo Women’s Medical University between 2000 and 2018, 198 were aged 65–75 years. Among these, 76 were identified as non-responders based on echocardiographic data, and were included in this study. We calculated patients’ J-HMRS and investigated associations between the J-HMRS and cardiac events after CRT. Patients were divided into 3 groups according to the J-HMRS: low (n=23), medium (n=29), and high (n=24) risk. Patients in the low-risk group experienced as many HF rehospitalizations and ventricular arrhythmia events as those in the other groups. However, survival analysis revealed that, after CRT, survival was higher for patients in the low- compared with high-risk group (P=0.04).Conclusions: The J-HMRS classified 30% of elderly CRT non-responders as low risk and as suitable candidates for DT in Japan.

著者

Yusuke Konta Eiichiro Saito Koji Sato Kyohei Furuta Kenichiro Miyauchi Akiko Furukawa Hiroshi Sato Tae Yamamoto

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.61, no.21, pp.3239-3243, 2022-11-01 (Released:2022-11-01)

参考文献数

18

被引用文献数

7

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We herein report a case of acute kidney injury (AKI) due to tubulointerstitial nephritis (TIN) after starting empagliflozin in a diabetic patient. The patient developed stage 1 AKI with proteinuria and elevated tubulointerstitial markers. A renal biopsy showed acute TIN with lymphocytic infiltration into the interstitium. The patient's renal function improved after discontinuation of empagliflozin and steroid administration. Sodium-glucose cotransporter 2 (SGLT2) inhibitor-induced AKI has been reported, but the underlying mechanism remains unclear, potentially because few patients with SGLT2-inhibitor-induced AKI have undergone a renal biopsy. We report the present case in the hope that it will help clarify the mechanism.

著者

小林 寛 金 河守 Hiroshi Kobayashi Ha-soo Kim

雑誌

研究紀要 = Bulletin of Tsukuba International University (ISSN:13412382)

巻号頁・発行日

vol.20, pp.63-76, 2014

著者

李 培徳 Lee PuiTak 村井 寛志 Murai Hiroshi

出版者

神奈川大学日本常民文化研究所 非文字資料研究センター

雑誌

年報 非文字資料研究 第9号 (ISSN:18839169)

巻号頁・発行日

no.9, pp.27-50, 2013-03-20

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Advertising calendars were first created at the end of the 19th century and became phenomenally popular in the 1920s. Market players in emerging industries including tobacco, pharmaceuticals, cosmetics, insurance and food extensively used them to expand their sales channels. Illustrations with the elements of advertising, art and a calendar were extremely well received and even spread to Chinese communities overseas. British American Tobacco Co. tried to take every opportunity to force its major competitor Nanyang Brothers Tobacco Co, Ltd. out of the Chinese market and dominate it. To this end, the former invested an enormous amount of money. In the 1920s and 1930s, the two were in an intense advertising war, desperately trying to outperform each other. Amid this competition, illustrators of advertising calendars did their best to draw consumer attention and created innovative images of modern girls. Image advertisements are different from other types in that they mainly consist of illustrations, not text. Thus, illustrators made the most of their creativity to attract consumers. Following the trend of the time, they came up with illustrations of various types of women - playing a sport, smoking, posing sexily, and so on. The images express illustratorsʼ artistic creativity and what companies wanted in advertisements to win a competition. This suggests that images of modern girls were fully commercialized. Advertising calendars have not really been studied. Even though visual materials have been attracting the interest of scholars lately, most studies are on art history, visual culture, modernity in Chinese society, the image of Chinese women, and the identity of women. This paper will discuss how the influence of the competition in the tobacco industry on the development of advertising calendars affected the creation of various images of modern girls, based on 284 advertising calendars for tobacco companies collected through different routes.

著者

Masamitsu Maekawa Keitaro Miyoshi Aya Narita Toshihiro Sato Yu Sato Masaki Kumondai Masafumi Kikuchi Katsumi Higaki Torayuki Okuyama Yoshikatsu Eto Hiroshi Sakamaki Nariyasu Mano

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.45, no.9, pp.1259-1268, 2022-09-01 (Released:2022-09-01)

参考文献数

65

被引用文献数

3

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As Niemann–Pick disease type C (NPC) is difficult to diagnose owing to its various clinical symptoms; biomarker tests have been developed. Previously, we revealed urinary sulfated cholesterol metabolites as noninvasive biomarkers for NPC. However, LC/tandem mass spectrometry (LC/MS/MS) requires long separation time and large urine volumes. Recently, a basic mobile phase was reported to increase the MS intensity. Thus, we developed a highly sensitive and rapid LC/MS/MS method for analyzing urinary cholesterol metabolites using a basic mobile phase additive. 3β-Sulfooxy-7β-N-acetylglucosaminyl-5-cholenic acid, its glycine and taurine conjugates, 3β-sulfooxy-7β-hydroxy-5-cholenic acid, and 7-oxo form were measured, with selected reaction monitoring in negative ion mode. Oasis HLB and L-column 3 were used for column-switching LC/MS/MS and urine diluted 10-fold was employed as the sample. After trapping, gradient separation was performed using solutions containing 1% (v/v) ammonium solution. On average, a 16-fold increase in peak areas was observed compared to that obtained at pH 5.5 with the mobile phases. Although the previous method needed 60 min for separation from interference peaks, we succeeded to separate them in 7 min with optimized LC condition. Further, all compounds showed good linearity from 0.3–1000 ng/mL, with satisfactory intra- and inter-day reproducibility. The developed method was applied to the urinalysis of healthy participants and NPC patients. Overall, the concentrations of metabolites correlated with those obtained using the previous method. Therefore, we succeeded to increasing MS intensity and shorten LC running time; and the method is useful for the noninvasive diagnostic screening of patients with NPC.

著者

Yoshitaka NAGASHIMA Yusuke NISHIMURA Hiroshi ITO Tomoya NISHII Takahiro OYAMA Ryuta SAITO

出版者

The Japan Neurosurgical Society

雑誌

NMC Case Report Journal (ISSN:21884226)

巻号頁・発行日

vol.9, pp.295-299, 2022-12-31 (Released:2022-09-15)

参考文献数

20

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Arachnoiditis ossificans (AO) is a rare disease, wherein ossified lesions in the subarachnoid space obstruct the flow of spinal fluid or compress the spinal cord, thereby causing myelopathy. Here we describe a rare case of AO and discuss the diagnosis and treatment strategies for this disease. A 66-year-old man with a history of subarachnoid hemorrhage presented with gait disturbance and dysuria for 7 months. Spinal magnetic resonance imaging and computed tomography (CT) myelography showed syringomyelia at the T5-T8 level and dorsally tethered spinal cord at the T8-T10 level. Preoperative noncontrast CT was not performed. The patient was diagnosed with adhesive arachnoiditis and underwent arachnoidolysis. However, intraoperative findings showed the presence of ossification lesions on the dorsal surface of the spinal cord, and intraoperative ultrasound (IOU) showed a hyperintense lesion with acoustic shadowing on the dorsal surface of the spinal cord, with limited visibility of the spinal cord. After removal of the lesions, IOU showed untethered and well-decompressed spinal cord and restoration of cerebrospinal fluid pulsation. Based on these findings, the patient was finally diagnosed with AO, which is an extremely rare disease, with an unknown frequency of occurrence. Therefore, all patients with adhesive spinal arachnoiditis require a preoperative noncontrast CT scan to evaluate for ossification lesions. In this case, we were fortunate to be able to treat AO with IOU, which demonstrated specific findings.

著者

Osamu Kontani Takashi Okayasu Keishi Kawasumi Shunsuke Ishikawa Hiroshi Masaki Norihiko Tanaka Yasuyuki Goto Shinichi Ishioka

出版者

Japan Concrete Institute

雑誌

Journal of Advanced Concrete Technology (ISSN:13473913)

巻号頁・発行日

vol.20, no.7, pp.444-483, 2022-07-27 (Released:2022-07-27)

参考文献数

46

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The Fukushima Daiichi Nuclear Power Plant lost its core cooling function due to the massive tsunami generated by the 2011 off the Pacific coast of Tohoku Earthquake, which caused core meltdown, resulting in high temperature inside the containment vessel and exposing the RPV pedestal, a reinforced concrete structure, to an unusually high temperature environment. After the earthquake, water was poured into the containment vessel to cool the molten core, and the con-crete structure was gradually cooled in the process. Since it will take at least 40 years to remove the fuel from the core, the integrity of the RPV pedestal is a major concern for the decommissioning of the Fukushima Daiichi Nuclear Power Plant. In order to assess the long-term integrity of the RPV pedestal, a horizontal loading test was conducted using a 1/6 scaled model of the RPV pedestal of Unit 1 considering the effect of the high temperature heating and subsequent wet conditions. And then, the static stress analysis of the RPV pedestal was performed considering the degradation phenomena revealed by the experiments. As a result, it was confirmed that the RPV pedestal of Unit 1 would be structurally sound for 40 years against the current design basis earthquake even if the material degradation due to severe accident and aging was considered.

著者

Sho Nakakubo Keisuke Kamada Yu Yamashita Junichi Nakamura Munehiro Matsumoto Hiroshi Horii Kazuki Sato Daisuke Morinaga Masaru Suzuki Nanase Okazaki Emi Takakuwa Yoshihiro Matsuno Satoshi Konno

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.9016-21, (Released:2022-03-05)

参考文献数

22

被引用文献数

3

---

We present three cases with an atypical clinical course of organizing pneumonia (OP) secondary to COVID-19. Three patients were discharged with satisfactory improvement after standard steroid therapy for COVID-19. Shortly after the completion of treatment, the patients experienced a flare-up of symptoms. Imaging results showed new lesions in the lungs. Transbronchial lung cryobiopsy showed histological findings consistent with OP in all cases. Steroids were administered, and a good therapeutic response was observed. This report is the first to describe pathologically confirmed OP that developed after recovery from COVID-19. Careful follow-up is advisable for patients who have recovered from COVID-19.

著者

横山 博 Hiroshi Yokoyama

出版者

甲南大学人間科学研究所

雑誌

心の危機と臨床の知

巻号頁・発行日

vol.7, pp.69-85, 2006

著者

Takashi ZAITSU Toshiko OHTA Hiroshi OHSHIMA Chiaki MUKAI

出版者

THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES

雑誌

TRANSACTIONS OF THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES, AEROSPACE TECHNOLOGY JAPAN (ISSN:18840485)

巻号頁・発行日

vol.12, no.ists29, pp.Tp_7-Tp_9, 2014 (Released:2014-11-27)

被引用文献数

1 1

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Occurrences of dental/oral diseases have been reported in the space environment and pre- or post-spaceflight and the deteriorations of oral defensive functions are evident in the space environment simulated experiments. NASA has identified 6 dental problems (Abscess, Avulsion/Tooth Loss, Caries, Crown Replacement, Exposed Pulp/Pulpitis and Filling Replacement) as the most important dental incidents to be dealt with in the long-term mission. To focus on the dental/oral health management for astronauts, dental examination and dental orthopantomogram are conducted as dental diagnosis. In addition, dental nerve block, dental prosthesis replacement and dental pain control are described in the treatment manual on the International Space Station (ISS). However, the systematic program to evaluate the risk of dental/oral problems in spacecraft and the manual to prevent the dental/oral problems in the space environment are still far from sufficient. To promote the dental/oral health of astronauts, the authors are going to launch “Space Oral Health Promotion (SOHP) project” which will tackle the research tasks and the operational countermeasures in space dentistry.

著者

Natsuki SUGIYAMA Hiroshi HASEGAWA Kentaro KUDO Ryo MIYAHARA Rikizo SAITO Chikashi MARUKI Masaru TAKASE Akihide KONDO Hidenori OISHI

出版者

The Japan Neurosurgical Society

雑誌

NMC Case Report Journal (ISSN:21884226)

巻号頁・発行日

vol.9, pp.225-230, 2022-12-31 (Released:2022-07-27)

参考文献数

18

---

There are only a few case reports in which cholesterol crystals were found in the thrombus retrieved by mechanical thrombectomy for cryptogenic stroke, leading to a definitive diagnosis. We herein report a case of aortogenic embolic stroke diagnosed by the presence of rich cholesterol crystals in the retrieved thrombus and review the previously reported cases. A woman in her 80s was transferred as an emergency due to consciousness disturbance, right conjugate deviation, and severe left hemiparesis. Magnetic resonance imaging showed occlusion of the right middle cerebral artery (MCA) and acute infarction in the territory. The MCA was recanalized by thrombectomy using an aspiration catheter and stent retriever, and the symptoms improved. Although the physiological examination did not detect the embolic source during hospitalization, pathological examination of the thrombus revealed atheroma with numerous cholesterol crystal clefts and intermixing of fibrin. Contrast-enhanced computed tomography performed based on the pathological results showed atheromatous lesions in the aortic arch as the embolic source. As a subsequent treatment, medications of a strong statin and an antiplatelet agent were continued, and the patient had no recurrence. The finding that the retrieved thrombus is a simple atheroma containing cholesterol crystals with poor hemocytes suggests embolism due to plaque rupture. Pathological examination of the thrombus obtained by thrombectomy is one of the useful diagnostic approaches for stroke etiology and the determination of its treatment.

著者

Hiroshi YAMADA Takashi DAIMON Katsuhiko MATSUDA Masayuki YOSHIDA Norikata TAKUMA Yukihiko HARA

出版者

The Japanese Society of Clinical Pharmacology and Therapeutics

雑誌

臨床薬理 (ISSN:03881601)

巻号頁・発行日

vol.38, no.5, pp.323-330, 2007-09-30 (Released:2008-10-31)

参考文献数

30

被引用文献数

11 14

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Experimental studies have revealed that tea catechins prevent influenza virus infection ; however, the clinical effects have been inconclusive. At the onset of the influenza season, a randomized, double-blind, placebo-controlled study was conducted from December 2005 to March 2006 in Japan. A total of 404 healthy volunteers, 20-65 years of age, were enrolled and randomly assigned to two groups : the catechin group gargling with tea catechin extract solution (approximately 400 μg/mL catechins) or the placebo group gargling without tea catechin extracts. In both groups, gargling was performed three times daily for 90 days. All participants were inoculated with the influenza vaccine before participating in the study. The primary outcome measure was the incidence rate of influenza infection during the study identified by a rapid assay for influenza virus antigens. On an intention to treat basis, 195 participants in the catechin group and 200 in the placebo group who started the intervention were included in the analysis. Of the participants, 6 (1.5%) were infected with influenza. The incidence rate of influenza infection in the catechin group (1.0%, 2 participants) was half that in the control group (2.0%, 4 participants), but not significant between the two groups. We could not find significant effects of gargling with tea catechin on prevention of influenza in the healthy adults inoculated with the influenza vaccine of the 2005-2006 season. However, the effects in more susceptible groups, i.e., those not vaccinated against the influenza virus, children, elderly or immunosuppressed people remain inconclusive.

著者

宮岡 宏 野澤 悟徳 小川 泰信 中村 卓司 大山 伸一郎 藤井 良一 Heinselman C. Miyaoka Hiroshi Nozawa Satonori Ogawa Yasunobu Nakamura Takuji Oyama Shinichiro Fujii Ryoichi Heinselman C.

出版者

宇宙航空研究開発機構(JAXA)

雑誌

宇宙航空研究開発機構特別資料: 第11回宇宙環境シンポジウム講演論文集 = JAXA Special Publication: Proceedings of the 11th Spacecraft Environment Symposium (ISSN:1349113X)

巻号頁・発行日

vol.JAXA-SP-14-012, pp.211-219, 2015-03-20

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第11回宇宙環境シンポジウム (2014年12月10日-11日. 大阪府立大学 I-siteなんば), 大阪

著者

Keita Yaginuma Shuichi Tanabe Takuya Miyano Hiroshi Nakagawa Satoshi Suzuki Shuichi Ando Manabu Kano

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.68, no.9, pp.855-863, 2020-09-01 (Released:2020-09-01)

参考文献数

24

被引用文献数

3

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In-line monitoring of granule water content during fluid bed granulation is important to control drug product qualities. In this study, a practical scale-free soft sensor to predict water content was proposed to cope with the manufacturing scale changes in drug product development. The proposed method exploits two key ideas to construct a scale-free soft sensor. First, to accommodate the changes in the manufacturing scale, the process parameters (PPs) that are critical to water content at different manufacturing scales were selected as input variables. Second, to construct an accurate statistical model, locally weighted partial least squares regression (LW-PLSR), which can cope with collinearity and nonlinearity, was utilized. The soft sensor was developed using both laboratory (approx. 4 kg) data and pilot (approx. 25 kg) scale data, and the prediction accuracy in the commercial (approx. 100 kg) scale was evaluated based on the assumption that the process was scaled-up from the pilot scale to the commercial scale. The developed soft sensor exhibited a high prediction accuracy, which was equivalent to the commonly used near-infrared (NIR) spectra-based method. The proposed method requires only standard instruments; therefore, it is expected to be a cost-effective alternative to the NIR spectra-based method.

著者

Abubakr Ahmed Abdullah Al-shoaibi Yuanying Li Zean Song Chifa Chiang Yoshihisa Hirakawa KM Saif-Ur-Rahman Masako Shimoda Yoshihisa Nakano Masaaki Matsunaga Atsuko Aoyama Koji Tamakoshi Atsuhiko Ota Hiroshi Yatsuya

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.63519, (Released:2022-07-13)

参考文献数

48

被引用文献数

4

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Aims: The associations between low-density lipoprotein cholesterol (LDL-C) and the risk of cardiovascular disease (CVD) subtypes are not well established among the Japanese population. This study used longitudinal data from the Aichi Workers' Cohort Study to explore the association between LDL-C levels and the risk of coronary heart disease (CHD) and stroke subtypes. Methods: Pooled data of 8966 adults (7093men and 1903 women) who were recruited between (2002) and (2008) were used for the current analysis. Propensity scores for the LDL-C categories were generated using multinomial logistic regression. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from the inverse probability weighted Cox proportional hazards model for LDL-C category associations with risks of CHD, stroke subtypes, and CVD. Results: During a median follow-up of 12 years, 122 strokes (57 ischemic strokes, 25 intracerebral hemorrhage, and 40 unknown subtypes) and 82 cases of CHD were observed. LDL-C 160- mg/dL compared to LDL-C 100-119 mg/dL was positively and significantly associated with the risk of CHD (HR: 4.56; 95% CI: 1.91-10.9) but not with ischemic stroke (HR: 0.99; 95% CI: 0.44-2.22). LDL-C was inversely associated with the risk of intracerebral hemorrhage (P for trend=0.009). Conclusion: In middle-aged Japanese workers, LDL-C was significantly and positively associated with CHD, but not with ischemic stroke. LDL-C was inversely significantly associated with intracerebral hemorrhage.

著者

Hiroshi SASAKI Naohisa TESHIROGI

出版者

The Japan Society of Mechanical Engineers

雑誌

JSME international journal. Ser. 2, Fluids engineering, heat transfer, power, combustion, thermophysical properties (ISSN:09148817)

巻号頁・発行日

vol.33, no.3, pp.599-605, 1990-08-15 (Released:2008-02-18)

参考文献数

9

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This paper gives the experimental results obtained with a two-stroke cycle single-cylinder research engine using an electrically heated combustion chamber to simulate the combustion chamber of a low-heat-rejection(LHR) DI diesel engine with the M-combustion system. In this report, the experiment was performed to investigate the influences of combustion chamber surface temperature and swirl ratio on the combustion of a LHR DI diesel engine with the M-conbustion system. It is found that the combustion of fuel deposited on the surface is greatly affected by the combustion chamber surface temperature, and the diesel combustion is controlled by the swirl and the surface temperature of the combustion chamber.

著者

Shahrzad Mahboubi Indrapriyadarsini S Hiroshi Ninomiya Hideki Asai

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

Nonlinear Theory and Its Applications, IEICE (ISSN:21854106)

巻号頁・発行日

vol.12, no.3, pp.554-574, 2021 (Released:2021-07-01)

参考文献数

33

被引用文献数

1 4

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This paper describes a momentum acceleration technique for quasi-Newton (QN) based neural network training and verifies its performance and computational complexity. Recently, Nesterov's accelerated quasi-Newton method (NAQ) has been introduced and shown that the momentum term is effective in reducing the number of iterations and the total training time by incorporating Nesterov's accelerated gradient into QN. However, the gradients had to be calculated two times in one iteration in the NAQ training. This increased the computation time of a training loop compared with the conventional QN. The proposed technique is an improvement to NAQ done by approximating the Nesterov's accelerated gradient as a linear combination of the current and previous gradients. As a result, the gradient is calculated only once per iteration similar to that of QN. The performance of the proposed algorithm is evaluated in comparison to conventional algorithms in neural networks training on two types of problems - function approximation problems with high nonlinearity and classification problems. The results show a significant acceleration in the computation time without losing the quality of the solution compared with conventional training algorithms.

著者

Shintaro Ichikawa Utaroh Motosugi Kazuyuki Sato Tatsuya Shimizu Tetsuya Wakayama Hiroshi Onishi

出版者

Japanese Society for Magnetic Resonance in Medicine

雑誌

Magnetic Resonance in Medical Sciences (ISSN:13473182)

巻号頁・発行日

pp.mp.2020-0064, (Released:2020-08-28)

参考文献数

30

被引用文献数

11

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Purpose: To investigate whether shortened acquisition or multiple arterial phase acquisition improves image quality of the arterial phase compared with conventional protocol.Methods: This retrospective study was approved by the relevant Institutional Review Board. A total of 615 consecutive patients who underwent gadoxetate disodium-enhanced MRI including one of the following three sequences in three different periods were included: (i) conventional liver acquisition with volume acceleration (LAVA) (between October 2014 and January 2015, n = 149), (ii) Turbo-LAVA (between March and August 2016, n = 216), and (iii) differential sub-sampling with Cartesian ordering (DISCO) (between January and September 2015, n = 250). We monitored the respiratory bellows waveform during breath holding for each patient and recorded breath-hold fidelity of the patients. Two radiologists independently evaluated the degree of respiratory artifact and scan timing on the arterial phase and compared them between the three protocols (i.e., conventional LAVA, Turbo-LAVA, and DISCO), with conventional LAVA as control.Results: The ratio of patients with breath-hold failure was not significantly different among the three protocols (P = 0.6340 and 0.1085). Respiratory artifact was significantly lower in DISCO than in conventional LAVA (P = 0.0424), while there was no significant difference between Turbo-LAVA and conventional LAVA (P = 0.2593). The ratio of adequate scan timing and diagnosable image defined as no or mild artifact and adequate scan timing were higher in DISCO than in conventional LAVA (P = 0.0025 and 0.0019), while there was no significant difference between Turbo-LAVA and conventional LAVA (P = 0.0780 and 0.0657).Conclusion: Compared with conventional protocol, multiple arterial phase acquisition (DISCO) obtained a higher number of diagnosable images by reducing respiratory motion artifact and optimizing the scan timing of arterial phase.

著者

Keiko SAKAMOTO Yoshinobu SHINAGAWA Kimiyo INOUE Ayako MORITA Hiroshi URAKAWA Ritsuko FUJIMITSU Kouichi TAKANO Kengo YOSHIMITSU

出版者

Japanese Society for Magnetic Resonance in Medicine

雑誌

Magnetic Resonance in Medical Sciences (ISSN:13473182)

巻号頁・発行日

vol.15, no.1, pp.137-143, 2016-01-01 (Released:2016-01-12)

参考文献数

14

被引用文献数

3 4

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Purpose: We retrospectively evaluated the incidence and related factors of obliteration of the lower bile duct after oral administration of contrast medium (OCM) probably resulting from its regurgitation into the biliary system (OCMRB) as observed on images of MR cholangiopancreatography (MRCP).Methods: We retrospectively analyzed 305 MRCP images in 278 patients obtained between February 2010 and March 2011 using negative OCM with 1.0- and 1.5-tesla clinical units. OCMRB was defined as positive when visualization of the common bile duct was clear on precontrast 2-dimensional (2D) MRCP but obliterated on postcontrast 3-dimensional (3D) MRCP. Two abdominal radiologists reviewed all images in consensus. The incidence of OCMRB was correlated to various clinicoradiological factors.Results: We observed OCMRB on 11 MRCP images in 10 patients (3.6%). Among various clinicoradiological factors, the presence of juxtapapillary diverticula, pneumobilia, and history of intervention to the papilla were suggested as significant factors related to positive OCMRB with multivariate analysis (P < 0.05).Conclusion: OCMRB occurs in about 4% of the patients who undergo MRCP, typically in those with juxtapapillary diverticula, pneumobilia, and history of papillary intervention. Acquisition of MRCP images before OCM may secure visualization of the common bile duct in these patients.