著者

Masaya Ohta Atsuo Iwase Katsumi Yamashita

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE Electronics Express (ISSN:13492543)

巻号頁・発行日

vol.7, no.18, pp.1354-1358, 2010 (Released:2010-09-25)

参考文献数

7

被引用文献数

4 6

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N-continuous OFDM is a modulation technique that has a lower sidelobe than the original OFDM as a result of the continuous connection with its higher-order derivatives between the OFDM symbols. However, N-continuous OFDM has a high symbol error rate. In the present paper, we improve N-continuous OFDM without increasing the symbol error rate by using a selected mapping technique.

著者

Masaya Takumida Kohji Yajin Mamoru Suzuki Shigeharu Takeuchi Yasuo Harada

出版者

Japan Audiological Society

雑誌

AUDIOLOGY JAPAN (ISSN:03038106)

巻号頁・発行日

vol.26, no.2, pp.152-156, 1983 (Released:2010-04-30)

参考文献数

6

被引用文献数

1

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Tinnitus matching was performed in 24 patients with various types of etiology using a commercially available music synthesizer. Pure tone tinnitus was synthesized either by sine or pulse wave. In some cases, tinnitus was matched by band noise, but its band width varied considerably among individuals. In 17 out of 24 cases, tinnitus disappeared or decreased after masking by the synthesizer. Masking was the most effective when the tinnitus was high-pitched pure tone, and had small loudness and low masking level. In contrast, tinnitus of pulsating nature showed no effect of synthesizer masking.

著者

Hajime ASADA Masaya TSUBOI James K. CHAMBERS Kazuyuki UCHIDA Hirotaka TOMIYASU Yuko GOTO-KOSHINO Koichi OHNO Hajime TSUJIMOTO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0197, (Released:2017-09-01)

被引用文献数

12

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Canine histiocytic sarcoma (HS) is a malignancy originating from the histiocytic cell lineage and characterized by poor response to chemotherapy and short survival time. Mutation of the TP53 gene and its association with poor prognosis has been reported in several canine tumors. However, the mutation of this gene has not been investigated in canine HS. The aim of this study was to examine a TP53 gene mutation in dogs with HS. Aberrations of the TP53 gene were examined by polymerase chain reaction-single strand conformational polymorphism analysis and DNA sequence analysis, revealing mutations of the TP53 gene in 12 (46%) of 26 dogs affected by HS. The incidence of the TP53 gene mutation was relatively high in canine HS compared with other canine tumors. Among these mutations, 10 of 12 dogs (83%) with a TP53 gene mutation harbored the same mutation: a 2-base (AT) insertion in exon 5, resulting in the introduction of a stop codon (c.446_447insAT, p.Tyr150SerfsX8). Further studies are needed to examine the functional change due to the mutation and its association with the pathogenesis of canine HS.

著者

Daiki KATO Mariko OISHI Koichi OHNO Ko NAKASHIMA Atsuhito WADA Shin-ichiro FUKUMOTO Tatsushi MORITA Soichi IMAI Masaya TSUBOI James K. CHAMBERS Kazuyuki UCHIDA Hajime TSUJIMOTO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.79, no.8, pp.e1, 2017 (Released:2017-08-04)

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NOTE Internal Medicine The first report of the ante-mortem diagnosis of Ollulanus tricuspis infection in two dogs Daiki KATO1), Mariko OISHI1), Koichi OHNO1)*, Ko NAKASHIMA1), Atsuhito WADA1), Tatsushi MORITA2), Soichi IMAI2), Masaya TSUBOI3), James K. CHAMBERS3), Kazuyuki UCHIDA3) and Hajime TSUJIMOTO1) 1)Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan 2)Division of Veterinary Infectious Disease, Department of Veterinary Pathobiology, Nippon Veterinary and Life Science University, 1–7–1 Kyonanchyo Musashino, Tokyo 180–8602, Japan 3)Department of Veterinary Pathology, Graduate School of Agricultural Should have been NOTE Internal Medicine The first report of the ante-mortem diagnosis of Ollulanus tricuspis infection in two dogs Daiki KATO1), Mariko OISHI1), Koichi OHNO1)*, Ko NAKASHIMA1), Atsuhito WADA1), Shin-ichiro FUKUMOTO2), Tatsushi MORITA3), Soichi IMAI3), Masaya TSUBOI4), James K. CHAMBERS4), Kazuyuki UCHIDA4) and Hajime TSUJIMOTO1) 1),Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan 2)Laboratory of Veterinary Parasitology, Department of Pathobiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan 3)Division of Veterinary Infectious Disease, Department of Veterinary Pathobiology, Nippon Veterinary and Life Science University, 1–7–1 Kyonanchyo Musashino, Tokyo 180–8602, Japan 4)Department of Veterinary Pathology, Graduate School of Agricultural

著者

Hirata Kei Yamashita Akihiro Tanaka Takayuki Arai Masaya Ono Ryota Kawamura Hidenori Suzuki Keiji

出版者

日本知能情報ファジィ学会

雑誌

SCIS & ISIS

巻号頁・発行日

vol.2010, pp.1015-1019, 2010

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Cloud computer technologies are advanced better, and web service like IaaS is used as businesses for its easiness and flexibility. But people concern about security on the cloud service and still feel resident to storing enterprise data in external server. So people interest in private cloud environment. In this paper, we evaluate private cloud system including Eucalyptus, an open-source software implementation of cloud computing system like Amazon EC2. Evaluations are about basic performance, management and recovery, web application performance for this system. Finally, we conclude if limited to small-scale, enterprise private infrastructure for short time use, it can be a good private cloud system

著者

Wakamatsu Takamichi Nagao Kazunori Ohmiya Hirohisa Sawamura Masaya

出版者

Beilstein-Institut

雑誌

Beilstein journal of organic chemistry (ISSN:18605397)

巻号頁・発行日

vol.11, pp.2444-2450, 2015-12-04

被引用文献数

8

---

A copper-catalyzed conjugate addition of alkylboron compounds (alkyl-9-BBN, prepared by hydroboration of alkenes with 9-BBN-H) to alkynoates to form beta-disubstituted acrylates is reported. The addition occurred in a formal syn-hydroalkylation mode. The syn stereoselectivity was excellent regardless of the substrate structure. A variety of functional groups were compatible with the conjugate addition.

著者

Deguchi Yuichi Harada Masaya Shinohara Ryota Lazarus Michael Cherasse Yoan Urade Yoshihiro Yamada Daisuke Sekiguchi Masayuki Watanabe Dai Furuyashiki Tomoyuki Narumiya Shuh

出版者

Elsevier B.V.

雑誌

Cell Reports (ISSN:22111247)

巻号頁・発行日

vol.17, no.9, pp.2405-2417, 2016-11-22

被引用文献数

35

---

社会からの隔絶が不安を招く神経メカニズム、マウスで発見 : 引きこもりからの社会復帰へ向けた神経科学からのアプローチ. 京都大学プレスリリース. 2016-11-24.

著者

Shota Fujii Masaya Sato Toshihiro Yamauchi Hideo Taniguchi

雑誌

情報処理学会論文誌 (ISSN:18827764)

巻号頁・発行日

vol.57, no.9, 2016-09-15

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The leaking of information has increased in recent years. To address this problem, we previously proposed a function for tracing the diffusion of classified information in a guest OS using a virtual machine monitor (VMM). This function makes it possible to grasp the location of classified information and detect information leakage without modifying the source codes of the guest OS. The diffusion of classified information is caused by a file operation, child process creation, and inter-process communication (IPC). In a previous study, we implemented the proposed function for a file operation and child process creation excluding IPC using a kernel-based virtual machine (KVM). In this paper, we describe the design of the proposed function for IPC on a KVM without modifying the guest OS. The proposed function traces the local and remote IPCs inside the guest OS from the outside so as to trace the information diffusion. Because IPC with an outside computer might cause information leakage, tracing the IPCs enables the detection of such a leakage. We also report the evaluation results including the traceability and performance of the proposed function.------------------------------This is a preprint of an article intended for publication Journal ofInformation Processing(JIP). This preprint should not be cited. Thisarticle should be cited as: Journal of Information Processing Vol.24(2016) No.5 (online)DOI http://dx.doi.org/10.2197/ipsjjip.24.781------------------------------

著者

Hideharu Hagiya Masaya Iwamuro Takehiro Tanaka Kou Hasegawa Yoshihisa Hanayama Maya Kimura Fumio Otsuka

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.55, no.13, pp.1769-1774, 2016-07-01 (Released:2016-07-01)

参考文献数

27

被引用文献数

1 11

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A 74-year-old man who had been administered trimethoprim-sulfamethoxazole for three weeks suffered from drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). In the early stage of the clinical course, he developed renal dysfunction. A renal biopsy showed granulomatous tubulointerstitial nephritis accompanying the proliferation of human herpes virus (HHV)-6 in tubular epithelial cells. With corticosteroid therapy, the systemic rash and renal function gradually improved. The present patient is the second case of DIHS/DRESS demonstrating a possible reactivation of HHV-6 in the renal tissue. The clinical role of viral reactivation in DIHS/DRESS must be further elucidated.

著者

Kenji IWASAKI Masaya TAKAHASHI Akinori NAKATA

出版者

独立行政法人 労働安全衛生総合研究所

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

vol.44, no.4, pp.537-540, 2006 (Released:2006-11-02)

参考文献数

27

被引用文献数

58 134

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Late in the 1970s, serious social concern over health problems due to long working hours has arisen in Japan. This report briefly summarizes the Japanese circumstances about long working hours and what the Government has achieved so far. The national statistics show that more than 6 million people worked for 60 h or more per week during years 2000 and 2004. Approximately three hundred cases of brain and heart diseases were recognized as labour accidents resulting from overwork (Karoshi) by the Ministry of Health, Labour and Welfare (MHLW) between 2002 and 2005. Consequently, the MHLW has been working to establish a more appropriate compensation system for Karoshi, as well as preventive measures for overwork related health problems. In 2001, the MHLW set the standards for clearly recognizing Karoshi in association with the amount of overtime working hours. These standards were based on the results of a literature review and medical examinations indicating a relationship between overwork and brain and heart diseases. In 2002, the MHLW launched the program for the prevention of health impairment due to overwork, and in 2005 the health guidance through an interview by a doctor for overworked workers has been enacted as law. Long working hours are controversial issues because of conflicts between health, safety, work-life balance, and productivity. It is obvious that we need to continue research regarding the impact on worker health and the management of long working hours.

著者

Kyoichi ASANO Masaya YAMANO Kiyoshi HARUYAMA Etuo IKAWA Kazumasa NAKANO Masayasu KURONO Osamu WADA

出版者

日本毒性学会

雑誌

The Journal of Toxicological Sciences (ISSN:03881350)

巻号頁・発行日

vol.19, no.SupplementII, pp.131-143, 1994-10-15 (Released:2008-02-21)

参考文献数

15

被引用文献数

3 4 6

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A histopathological study was performed to examine the influence of propagermanium and germanium dioxide (GeO2) on chemically induced renal lesions in rats. Animals were treated with adriamycin or mercuric chloride to induce glomerular or proximal tubular damage, and then given drinking water containing propagermanium (480 or 2, 400 ppm solution) or GeO2 (300 or 1, 500 ppm solution: equivalent to propagermanium in terms of germanium contents). The distal tubular epithelium after 8 weeks dosage with the 1, 500 ppm solution of GeO2 was characterized by vacuolization and deposits of PAS-positive material not only in adriamycin-treated rats, but also in normal rats. In contrast, propagermanium administration was not associated with any alteration in the changes induced by adriamycin or mercuric chloride. We previously clarified that propagermanium had no biochemical influence on the renal function of these renal injured rats. The histological demonstration that this compound does not exert renal toxicity, even when given at a high dosage to renal injured rats, further indicates that it would not exacerbate renal dysfunction already present. This confirms that propagermanium may be a safe compound for use in individuals with compromised kidneys.

著者

Mitsuteru OKAWAUCHI Masaya TSUBOI Kazumi NIBE Eiji NAGAMINE Hideaki IWANE Kazuyuki UCHIDA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0721, (Released:2016-01-29)

被引用文献数

3

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An intraocular mass lesion was found in the left eyeball in a spayed female Pembroke Welsh Corgi dog. The surgically resected left eyeball was pathologically examined. Histologically, the mass lesion consisted of proliferation of the atypical cuboidal or columnar epithelial cells, arranging in papillary, tubular or solid form. In addition, some neoplastic cells showed oncocytic change characterized as large oval cells with numerous eosinophilic intracytoplasmic granules. Cytoplasm of the oncocytic cells showed dark blue granules by phosphotungstic acid-hematoxylin stain. Immunohistochemically, the oncocytic cells were intensely positive for cytochrome C. Based on these findings, the ocular mass was diagnosed as iridociliary adenocarcinoma with oncocytic change. The findings indicate that the oncocytic changes of the neoplastic epithelial cells might be caused by mitochondrial accumulation.

著者

友岡 雅弥 トモオカ マサヤ Tomooka Masaya

出版者

大阪大学文学部

雑誌

待兼山論叢. 哲学篇 (ISSN:03874818)

巻号頁・発行日

vol.18, pp.49-67, 1985-01

著者

Masahito HARA Yusuke NISHIMURA Yasuhiro NAKAJIMA Daisuke UMEBAYASHI Masaya TAKEMOTO Yuu YAMAMOTO Shoichi HAIMOTO

出版者

社団法人 日本脳神経外科学会

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

vol.55, no.7, pp.547-556, 2015 (Released:2015-07-15)

参考文献数

32

被引用文献数

2 7

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Minimally invasive transforaminal lumbar interbody fusion (TLIF) as a short fusion is widely accepted among the spine surgeons. However in the long fusion for degenerative kyphoscoliosis, corrective spinal fixation by an open method is thought to be frequently selected. Our objective is to study whether the mini-open TLIF and corrective TLIF contribute to the improvement of the spinal segmental and global alignment. We divided the patients who performed lumbar fixation surgery into three groups. Group 1 (G1) consisted of mini-open TLIF procedures without complication. Group 2 (G2) consisted of corrective TLIF without complication. Group 3 (G3) consisted of corrective TLIF with instrumentation-related complication postoperatively. In all groups, the lumbar lordosis (LL) highly correlated with developing surgical complications. LL significantly changed postoperatively in all groups, but was not corrected in the normal range in G3. There were statistically significant differences in preoperative and postoperative LL and mean difference between the pelvic incidence (PI) and LL between G3 and other groups. The most important thing not to cause the instrumentation-related failure is proper correction of the sagittal balance. In the cases with minimal sagittal imbalance with or without coronal imbalance, short fusion by mini-open TLIF or long fusion by corrective TLIF contributes to good clinical results if the lesion is short or easily correctable. However, if the patients have apparent sagittal imbalance with or without coronal imbalance, we should perform proper correction of the sagittal spinal alignment introducing various technologies.

著者

Masaya IGASE Kenji BABA Takako SHIMOKAWA-MIYAMA Shunsuke NOGUCHI Takuya MIZUNO Masaru OKUDA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0180, (Released:2015-06-11)

被引用文献数

5

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A 6-year-old spayed female Jack Russell Terrier presented with a 1-month history of lethargy, anorexia, vomiting, and weight loss. The dog was fed beef and chicken jerky treats daily in addition to a commercial diet. Laboratory tests revealed azotemia, hypokalemia, hyperchloremia, metabolic acidosis, and glucosuria with normoglycemia. Urine amino acid analysis showed significant amino acid loss into the urine. Thus, Fanconi syndrome was diagnosed, and based on the case history and extensive diagnostic testing, excessive consumption of jerky treats was strongly suspected as the cause. Glucosuria resolved 7 days after the withdrawal of jerky treats and fluid therapy. Aminoaciduria was substantially, but not completely, improved 3 months after diagnosis. Mild azotemia remained, suggesting chronic renal disease. To the best of our knowledge, this is the first reported case of Fanconi syndrome following the consumption of jerky treats in Japan.

著者

Daiki KATO Mariko OISHI Koichi OHNO Ko NAKASHIMA Atsuhito WADA Tatsushi MORITA Soichi IMAI Masaya TSUBOI James Kenn CHAMBERS Kazuyuki UCHIDA Hajime TSUJIMOTO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0158, (Released:2015-06-05)

被引用文献数

1 6

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Ollulanus tricuspis is a small nematode parasite of the stomach, and its infection has been reported worldwide in cats but only one report in dogs as post-mortem diagnosis. Two dogs, kept in the Tokyo area, were presented for chronic vomiting. Chronic gastritis was diagnosed histologically, and many nematodes were detected in endoscopically-biopsied gastric samples and in the mucus of vomitus in both dogs. The parasites were small (<1 mm), and their morphological characteristics were consistent with those previously reported for O. tricuspis. The symptoms in one dog completely disappeared after anthelmintic therapy. To our knowledge, this is the first report describing ante-mortem diagnosis of spontaneous gastric O. tricuspis infection in dogs in which infectivity and pathogenicity of the nematode are suggested.

著者

Mari Ogura Masayuki Yagi Keitaro Nomoto Ryo Miyazaki Masaya Kongoji Show Watanabe Umenoi Hamada Yoshikazu Yonei

出版者

Japanese Society of Anti-Aging Medicine

雑誌

ANTI-AGING MEDICINE (ISSN:18822762)

巻号頁・発行日

vol.8, no.5, pp.60-68, 2011 (Released:2011-09-17)

参考文献数

58

被引用文献数

1

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Objective: Previous epidemiological surveys of diet indicated a potential relationship between fruit intake and the pathogenesis of lifestyle-related disease. Recent reports indicate grapefruit (GF) may affect sugar metabolism. The present study measured glucose, triglyceride and insulin levels in human blood after GF ingestion with and without other foods.Methods: Twelve healthy, non-smoking female volunteers, non-obese (age 40.5 ± 4.2 years old, BMI 22.0 ± 0.9) were provided with five different breakfasts on successive days: GF, bread or fried vegetables alone, GF + bread, GF + fried vegetables. In meals that included GF, the GF was eaten before the bread or fried vegetables. Blood samples were taken after meals to measure plasma glucose, immuno reactive insulin (IRI), triglyceride and vitamin C.Results: Plasma glucose following a meal of bread or fried vegetables or a meal of bread and fried vegetables with GF was similar. Insulin secretion was slower after a meal of GF alone compared to bread alone (p < 0.001) and the area under curve (AUC) of glucose per carbohydrate intake was lower when GF was eaten prior to bread or fried vegetables than after a single intake of bread or fried vegetables alone (p < 0.001). The AUC of triglyceride after a prior intake of GF before fried vegetables was slower than that after an intake of fried vegetables alone (p < 0.05). Blood vitamin C concentration increased after GF intake (p < 0.001).Conclusion: GF contains saccharides and a variety of dietary elements, including fiber, vitamins, citric acid, naringenin and bergamottin. It is possible that these compounds may affect sugar and lipid metabolism.

著者

Tomohiro Iwai Masaya Sawamura

出版者

(社)日本化学会

雑誌

Bulletin of the Chemical Society of Japan (ISSN:00092673)

巻号頁・発行日

vol.87, no.11, pp.1147-1160, 2014-11-15 (Released:2014-11-15)

参考文献数

107

被引用文献数

12

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Triethynylphosphines with bulky end caps such as triarylsilyl and triarylmethyl groups at alkyne termini have a novel molecular shape presenting a large, deep metal-binding cavity. The hollow-shaped triethynylphosphines functioned as effective ligands in the rhodium-catalyzed hydrosilylation of ketones with triorganosilanes due to the preferential formation of a mono-P-ligated rhodium species. Furthermore, the phosphines displayed remarkable rate enhancement in the gold(I)-catalyzed alkyne cyclization constructing six- to eight-membered ring compounds. It is proposed that the cavity in the ligand forces a nucleophilic center of the acetylenic compounds close to the gold-bound alkyne, making ring-closing anti attack feasible.

著者

Kondo Takayuki Funayama Misato Tsukita Kayoko Hotta Akitsu Yasuda Akimasa Nori Satoshi Kaneko Shinjiro Nakamura Masaya Takahashi Ryosuke Okano Hideyuki Yamanaka Shinya Inoue Haruhisa

出版者

Elsevier B.V.

雑誌

Stem Cell Reports (ISSN:22136711)

巻号頁・発行日

2014-06

被引用文献数

116

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ヒトiPS細胞由来のグリア系神経前駆細胞移植でALSモデルマウスの生存期間を延長. 京都大学プレスリリース. 2014-06-27.

著者

Tomohiro Iwai Tomoya Harada Ryotaro Tanaka Masaya Sawamura

出版者

(社)日本化学会

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

pp.131161, (Released:2014-01-09)

被引用文献数

19

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Silica-supported tripod triarylphosphines that have a Ph3P-type core tripodally immobilized on silica surface enabled Pd-catalyzed borylation of chloroarenes with bis(pinacolato)diboron under mild conditions. The immobilization in tripod was crucial for the excellent performance of the Ph3P-based ligands.