著者
Yoshiki Murakami Masaya Shinohara Yosuke Oka Ryo Wada Ryota Noike Hiroshi Ohara Tadashi Fujino Takanori Ikeda
出版者
The Japanese Society of Internal Medicine
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
pp.8731-21, (Released:2021-11-27)
参考文献数
14
被引用文献数
11

COVID-19 vaccine-related myocarditis has been reported worldwide. We herein report two Japanese cases with suspected vaccine-related myocarditis. A 27-year-old man was admitted with chest pain 4 days after the second vaccination. An electrocardiogram (ECG) did not reveal any significant abnormalities. The second patient, a 37-year-old man, was admitted with chest pain 9 days after the first vaccination. His ECG exhibited ST-elevation in multiple leads. In both cases, cardiac magnetic resonance imaging findings were consistent with myocarditis. They recovered with symptomatic relief within a few days. These cases suggest that the benefit of COVID-19 vaccination exceeds the risk of vaccine-related myocarditis.
著者
Hiroaki Kawano Nobu Yamamoto Hirokazu Kurohama Shinji Okano Masaya Kurobe Tomohiro Honda Ryohei Akashi Tsuyoshi Yonekura Satoshi Ikeda Koichi Izumikawa Koji Maemura
出版者
The Japanese Society of Internal Medicine
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
pp.0680-22, (Released:2022-11-23)
参考文献数
37
被引用文献数
3

A 19-year-old Japanese man was hospitalized for cardiogenic shock 28 days after receiving a second dose of the COVID-19 mRNA-1273 vaccine. He had had a high fever for three days with vomiting and abdominal pain before arriving at our hospital. The patient visited a local hospital and was diagnosed with heart failure and acute appendicitis. An endomyocardial biopsy specimen showed myocarditis. Thereafter, Impella CP left ventricular assist device implantation and venoarterial peripheral extracorporeal membranous oxygenation were initiated immediately along with inotropic support and steroid pulse therapy. Given these findings, he was finally diagnosed with multiple inflammatory syndrome and fulminant myocarditis.
著者
木村 妙子 木村 昭一 自見 直人 倉持 利明 藤田 敏彦 駒井 智幸 吉田 隆太 田中 隼人 岡西 政典 小川 晟人 小林 格 小玉 将史 齋藤 礼弥 清野 裕暉 片平 浩孝 中野 裕昭 吉川 晟弘 上野 大輔 田中 正敦 大矢 佑基 前川 陽一 中村 亨 奥村 順哉 田中 香月 Kimura Taeko Kimura Shoichi Jimi Naoto Kuramochi Toshiaki Fujita Toshihiko Komai Tomoyuki Yoshida Ryuta Tanaka Hayato Okanishi Masanori Ogawa Akito Kobayashi Itaru Kodama Masafumi Saito Masaya Kiyono Yuki Katahira Hirotaka Nakano Hiroaki Yoshikawa Akihiro Uyeno Daisuke Tanaka Masaatsu Oya Yuki Maekawa Yoichi Nakamura Toru Okumura Junya Tanaka Kazuki
出版者
三重大学大学院生物資源学研究科
雑誌
三重大学大学院生物資源学研究科紀要 = The bulletin of the Graduate School of Bioresources Mie University
巻号頁・発行日
vol.45, pp.11-50, 2019-09

Preliminary results of the deep-sea faunal survey conducted from the TR/V Seisui-maru of Mie University in April 2018 are presented. 18 taxonomists and ecologists working on a wide variety of animal taxa participated in this survey. Surveyed areas included the Kumano Sea (off Mie Prefecture) and south of the Kii Strait (off Tanabe Bay, Wakayama Prefecture), at depths of 80-821 m. Sampling gears employed were beam trawl and biological dredge. The collection is represented by macrobenthos and meiobenthos from 11 animal phyla, including arthropods, echinoderms, annelids and molluscans. The number of phyla occurring in each station varied from 3 to 7. The station with most diverse fauna at the phylum level was St. 3B (south of the Kii Strait, 421-543 m depth, sandy mud bottom). Meiofauna includes priapulids and small arthropods, such as ostracods, tanaidaceans, isopods, cumaceans and acarus. In addition to free-living species, parasitic crustaceans, platyhelminthes, acanthocephalans, annelids and cnidarians were also collected from fishes, ascidians, urchins, holothurians, crustaceans and polychaetes. Preliminary identifications are given for Ostracoda, Cirripedia, Amphipoda, Decapoda, Asteroidea,Ophiuroidea, Holothuroidea, polychaetes, Echiura, Mollusca and Xenoturbellida.
著者
Shotaro Hoi Masaya Ogawa Chishio Munemura Tomoaki Takata Hajime Isomoto
出版者
Tottori University Medical Press
雑誌
Yonago Acta Medica (ISSN:13468049)
巻号頁・発行日
vol.66, no.2, pp.300-305, 2023 (Released:2023-05-25)
参考文献数
11
被引用文献数
4

Atypical anti-glomerular basement membrane (GBM) nephritis is a slowly progressive characterized by linear deposition of immunoglobulin (Ig) G in the GBM without circulating anti-GBM antibodies or lung involvement. There is no established therapy for this disease, and efficacy of the immunosuppressive treatment is questionable. A few cases of atypical anti-GBM nephritis have been reported after administration of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine. Classic anti-GBM disease has also been reported after the administration of the second dose of the SARS-CoV-2 vaccine. Herein, we present the case of a SARS-CoV-2 vaccine-induced atypical anti-GBM nephritis that developed after the first dose and was unresponsive to immunosuppressive therapy. A 57-year-old Japanese woman developed edema 11 days after the first dose of the SARS-CoV-2 mRNA vaccine. She developed nephrotic-range proteinuria and microscopic hematuria. Renal biopsy revealed endocapillary proliferative glomerulonephritis with linear IgG deposition. However, electron-dense deposits were not detected on electron microscopy. The patient tested negative for circulating anti-GBM antibodies and was diagnosed with atypical anti-GBM nephritis. Although steroids and mizoribine were administered, the patient’s renal function deteriorated. In conclusion, atypical anti-GBM nephritis may have earlier onset than the classic anti-GBM disease. Given its uncertainty of effectiveness, immunosuppressive agents should be carefully used for SARS-CoV-2 mRNA vaccine-induced atypical anti-GBM nephritis.
著者
Takeshi Miyamoto Eri Katsuyama Hiroya Kanagawa Atsuhiro Fujie Hiroya Miyamoto Shigeyuki Yoshida Tomoaki Mori Kana Miyamoto Yuiko Sato Tami Kobayashi Masaya Nakamura Morio Matsumoto Yuji Nishiwaki Hiroshi Hirose Takeshi Kanda Ikuo Saito Yoshiaki Toyama
出版者
The Keio Journal of Medicine
雑誌
The Keio Journal of Medicine (ISSN:00229717)
巻号頁・発行日
vol.65, no.2, pp.33-38, 2016 (Released:2016-06-25)
参考文献数
24
被引用文献数
11 13

Low serum 25-hydroxyvitamin D (25(OH)D) levels are implicated as a risk factor for hip and spine fractures. Studies of the relation between 25(OH)D levels and fractures have primarily involved elderly osteoporosis patients or patients with fractures; however, the serum 25(OH)D and parathyroid hormone (PTH) status in younger adult populations remains largely unknown. We evaluated serum 25(OH)D and intact PTH levels in 411 women aged 39–64 years who were not receiving medication for osteoporosis or other bone diseases. Serum 25(OH)D levels were positively correlated with age (P = 0.019), whereas intact PTH levels were inversely correlated with 25(OH)D levels (P < 0.001). Thus, low vitamin D levels with high intact PTH levels were more common in younger than in older women. Our data show that serum 25(OH)D insufficiency could be a more serious concern in the younger population than had been previously anticipated. Because serum 25(OH)D insufficiency is reportedly a risk factor for hip and spine fracture, the number of fracture patients could increase in the future, suggesting that we may need to correct the serum vitamin D/intact PTH status to prevent future osteoporosis.
著者
Masaya Iwamuro Takehiro Tanaka Sakiko Kuraoka Kenta Hamada Makoto Abe Yoshiyasu Kono Hiromitsu Kanzaki Seiji Kawano Yoshiro Kawahara Hiroyuki Okada
出版者
The Japanese Society of Internal Medicine
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
vol.61, no.13, pp.1931-1938, 2022-07-01 (Released:2022-07-01)
参考文献数
16
被引用文献数
4

Objective This study aimed to determine the prevalence and endoscopic features of zinc acetate dihydrate tablet-associated gastric lesions. Methods We retrospectively examined the endoscopic features of 47 patients taking zinc acetate dihydrate tablets who underwent esophagogastroduodenoscopy. Results Gastric mucosal alterations, including redness, erosions, ulcers, and adhesion of the white coat, were observed in 29 of 47 patients (61.7%). Among patients with gastric lesions (group A), there was a significantly higher percentage of symptomatic patients in comparison to patients without lesions (group B) (65.5% vs. 22.2%; p<0.01). The background characteristics of the two groups did not differ to a statistically significant extent. On esophagogastroduodenoscopy, mucosal redness (n=27, 93.1%), erosions (n=26, 90.0%), adhesion of the white coat (n=25, 86.2%), and ulcers (n=9, 31.0%) were observed. None of the 19 patients who previously underwent esophagogastroduodenoscopy had gastric lesions before starting zinc acetate dihydrate. Esophagogastroduodenoscopy was performed after the cessation of zinc acetate dihydrate intake in six patients, and revealed the resolution of gastric lesions. Conclusion Gastric lesions were observed in 29 of 47 patients who were taking zinc acetate dihydrate tablets. The most common endoscopic findings were mucosal redness (93.1%), erosions (90.0%), adhesion of the white coat (86.2%), and ulcers (31.0%). Although the exact pathogenesis is uncertain, we believe that understanding the unique manifestations of this gastric lesion will help physicians manage adverse events in patients taking zinc acetate dihydrate tablets.
著者
Kazuya Nagasawa Masaya Fujimoto
出版者
Carcinological Society of Japan
雑誌
Crustacean Research (ISSN:02873478)
巻号頁・発行日
vol.47, pp.29-33, 2018 (Released:2018-03-31)
参考文献数
14
被引用文献数
2

Anilocra prionuri Williams & Bunkley-Williams, 1986, is reported based on a female specimen collected from the skin below the nostril of a scalpel sawtail, Prionurus scalprum Valenciennes, 1835, in the southern East China Sea off Kuchinoerabu-jima Island, one of the northern Ryukyu Islands, southern Japan. Anilocra prionuri was previously reported only from off the Pacific coast of central Hon­shu, Japan, but the present collection extends the geographical distribution range of the species from central Honshu southwest to the northern Ryukyu Islands and represents its first record from the East China Sea. The fish had a wound with heavily damaged epidermis at the attachment site of A. prionuri. It was a rare parasite of P. scalprum at the collection site.
著者
Jumpei Yamamoto Masao Moroi Hiromasa Hayama Masaya Yamamoto Hisao Hara Yukio Hiroi
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-23-0238, (Released:2023-07-11)
参考文献数
40

Background: Patients with atrial fibrillation (AF) and heart failure (HF) have elevated left ventricular end-diastolic pressure in addition to decreased left atrial (LA) function, but there are few reports of useful prognostic indices that can be seen on echocardiography. In this study, we investigated the association between LA reservoir strain (LARS) and prognosis in this group of patients.Methods and Results: We retrospectively enrolled patients with acute HF complicated by AF who were consecutively admitted to hospital between January 2014 and December 2018. A total of 320 patients (mean age 79±12 years, 163 women) were included in the analysis. During a median follow-up of 473 days, 92 cardiovascular deaths and 113 all-cause deaths occurred. In the multivariate analysis, LARS was an independent predictor of all-cause death (hazard ratio [HR] 0.94, 95% confidence interval [CI] 0.90–0.99, P=0.016). Multivariate analysis also showed that the patients in the lowest LARS tertile (<7.16%) had a significantly increased risk of cardiovascular death (HR 1.76, 95% CI 1.05–2.96; P=0.033) and all-cause death (HR 1.90, 95% CI 1.17–3.08; P=0.009) in comparison with patients in the highest LARS tertile (>10.52%).Conclusions: We found a significant association between LARS and death in patients with AF and HF. Patients with reduced LARS had poor prognosis, suggesting the need for aggressive therapy to improve their LA dysfunction.
著者
Hiroaki Ueda Mikihiro Yokoi Masaya Kuramochi
出版者
Meteorological Society of Japan
雑誌
SOLA (ISSN:13496476)
巻号頁・発行日
vol.17B, no.Special_Edition, pp.14-18, 2021 (Released:2021-09-09)
参考文献数
28
被引用文献数
7

During the early summer of 2020, a stagnation of the Meiyu-Baiu front brought torrential rainfall over East Asia. Meanwhile, the anticyclone was much enhanced over the subtropical western Pacific (SWP), which contributed abundant moisture to the Meiyu-Baiu rainband along the western rim of the anticyclone. Based on the sensitivity experiments of the linear baroclinic model by prescribing the observed diabatic heating anomalies, a combination of anomalous convection over the Indian Ocean and reduced rainfall over the western Pacific can account for the maintenance of zonally elongated SWP anticyclone. Interestingly, this period corresponded to the developing stage of La Niña, while the convective activities were notably suppressed over the warmed western Pacific. The sensitivity experiments to SST anomalies using the atmospheric general circulation model shows that the attenuated convection over the western Pacific can be ascribed to the warmed Indian Ocean associated with an atmospheric Kelvin wave wedge from the Indian Ocean. Overall, the suppressant SST effect of the Indian Ocean opposes and is greater than that of tropical Pacific. We issue a caveat regarding the additivity of the remote influence across the maritime continent. These results have important implications for the predictability of early summer rainfall over East Asia.
著者
Masaya Kuramochi Hiroaki Ueda Chiaki Kobayashi Youichi Kamae Koutarou Takaya
出版者
Meteorological Society of Japan
雑誌
SOLA (ISSN:13496476)
巻号頁・発行日
vol.17B, no.Special_Edition, pp.9-13, 2021 (Released:2021-08-26)
参考文献数
29
被引用文献数
7

The anomalous warm winter from December 2019 to February 2020 over East Asia, particularly the anticyclonic anomaly around Japan, was examined from the teleconnection perspective anchored by a warmed Indian Ocean and the El Niño Modoki. In the upper troposphere, high–low–high wave patterns progressing from the Arabian Sea toward Japan via the southern region of China, coupled with the wave-activity flux diagnosis, implicate the propagation of stationary Rossby waves caused by enhanced convection in the western Indian Ocean and suppressed convection around the Maritime Continent. These anomalous convective activities could be responsible for the northward displacement of the subtropical jet and the ensuing warm conditions over East Asia. The atmospheric response to the observed diabatic heating by means of the linear baroclinic model well reproduced the observations. Moreover, sensitivity experiments of the atmospheric general circulation model to sea surface temperature (SST) anomalies, especially in the warmed western Indian and central Pacific oceans, can help understand the anomalous subsidence over the Maritime Continent sector and subsequently weakened convection. The warmer SST observed around the Maritime Continent alone reproduces the enhancement of rainfall and subsequent cold anomalies around Japan, suggesting the importance of trans-basin interaction for teleconnection towards East Asia.
著者
Ida Takanori Suda Masaya
出版者
京都大学大学院経済学研究科
雑誌
京都大学大学院経済学研究科Working Paper
巻号頁・発行日
no.59, 2002-07

It is said that the privatization of the Japanese National Railway is a success since the management, productivity, and service have improved. However, as expected, the gap of both management and productivity tends to widen between the larger main-island JRs and the smaller three-island JRs. This paper will estimate the cost structure of the six JRs after the privatization. The main points we will make are as follows: first, the economies of scale exist in both the incumbent railway service and the Shinkansen service; second, there is no conclusive evidence to show that the economies of scope exist between them; third, the cost gap between the main-island JRs and the three-island JRs is large; and fourth, the cost gaps within them are also large.
著者
Masahiro SHINADA Daiki KATO Masaya TSUBOI Namiko IKEDA Susumu AOKI Takaaki IGUCHI Toshio LI Yuka KODERA Ryosuke OTA Shoma KOSEKI Hayato SHIBAHARA Yosuke TAKAHASHI Yuko HASHIMOTO James CHAMBERS Kazuyuki UCHIDA Shunsuke NOGUCHI Yukinari KATO Ryohei NISHIMURA Takayuki NAKAGAWA
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.23-0062, (Released:2023-08-04)
被引用文献数
1

Podoplanin (PDPN) is a prognostic factor and is involved in several mechanisms of tumor progression in human squamous cell carcinoma (SCC). Canine non-tonsillar SCC (NTSCC) is a common oral tumor in dogs and has a highly invasive characteristic. In this study, we investigated the function of PDPN in canine NTSCC. In canine NTSCC clinical samples, PDPN overexpression was observed in 80% of dogs with NTSCC, and PDPN expression was related to ki67 expression. In PDPN knocked-out canine NTSCC cells, cell proliferation, cancer stemness, and migration were suppressed. As the mechanism of PDPN-mediated cell proliferation, PDPN knocked-out induced apoptosis and G2/M cell cycle arrest in canine NTSCC cells. These findings suggest that PDPN promotes tumor malignancies and may be a novel biomarker and therapeutic target for canine NTSCC.
著者
Satoshi KAMBAYASHI Masaya IGASE Kosuke KOBAYASHI Ayana KIMURA Takako SHIMOKAWA-MIYAMA Kenji BABA Shunsuke NOGUCHI Takuya MIZUNO Masaru OKUDA
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.15-0258, (Released:2015-06-06)
被引用文献数
1 12

Hypoxic conditions in various cancers are believed to relate with their malignancy, and hypoxia inducible factor-1α (HIF-1α) has been shown to be a major regulator of the response to low oxygen. In this study, we examined HIF-1α expression in canine lymphoma using cell lines and clinical samples and found that these cells expressed HIF-1α. Moreover, the HIF-1α inhibitors, echinomycin, YC-1 and 2-methoxyestradiol, suppressed the proliferation of canine lymphoma cell lines. In a xenograft model using NOD/scid mice, echinomycin treatment resulted in a dose-dependent regression of the tumor. Our results suggest that HIF-1α contributes to the proliferation and/or survival of canine lymphoma cells. Therefore, HIF-1α inhibitors may be potential agents to treat canine lymphoma.
著者
加藤 のぞみ 小沼 純一 生島 美紀子 沖 あかね 高木 雅也 奥平 一 林 淑姫 Nozomi Kato Jun'ichi Konuma Mikiko Ikushima Akane Oki Masaya Takagi Hajime Okudaira Shu ji Lin
出版者
東京音楽大学付属図書館
雑誌
ライブラリーレポート (ISSN:21884706)
巻号頁・発行日
no.2, pp.3-17, 2014

シンポジウム主催:東京音楽大学付属図書館、オーケストラ・ニッポニカ開催日時:2013年12月7日 (東京音楽大学付属図書館5階)総合司会:林淑姫
著者
Kayoko Hayakawa Satoshi Kutsuna Takeo Kawamata Yuko Sugiki Chiharu Nonaka Keiko Tanaka Michi Shoji Masaki Nagai Shunsuke Tezuka Kazuyuki Shinya Hiroki Saito Takahiro Harada Nin Moriya Motoyuki Tsuboi Masataro Norizuki Yasuo Sugiura Yasuyo Osanai Masaya Sugiyama Ayako Okuhama Kohei Kanda Yuji Wakimoto Mugen Ujiie Shinichiro Morioka Kei Yamamoto Noriko Kinoshita Masahiro Ishikane Sho Saito Yuki Moriyama Masayuki Ota Keiji Nakamura Takato Nakamoto Satoshi Ide Hidetoshi Nomoto Yutaro Akiyama Tetsuya Suzuki Yusuke Miyazato Yoshiaki Gu Nobuaki Matsunaga Shinya Tsuzuki Yumiko Fujitomo Yoshiki Kusama Hiroyuki Shichino Masao Kaneshige Junko Yamanaka Miki Saito Masayuki Hojo Masao Hashimoto Shinyu Izumi Jin Takasaki Manabu Suzuki Keita Sakamoto Yukio Hiroi Sakurako Emoto Makoto Tokuhara Toshiaki Kobayashi Koichiro Tomiyama Fumihiko Nakamura Norio Ohmagari Haruhito Sugiyama
出版者
National Center for Global Health and Medicine
雑誌
Global Health & Medicine (ISSN:24349186)
巻号頁・発行日
vol.2, no.2, pp.107-111, 2020-04-30 (Released:2020-05-10)
参考文献数
11
被引用文献数
25

Due to the significant spread of a new type of coronavirus (SARS-CoV-2) infection (COVID-19) in China, the Chinese government blockaded several cities in Hubei Province. Japanese citizens lost a means of transportation to return back to Japan. The National Center for Global Health and Medicine (NCGM) helped the operation of charter flights for evacuation of Japanese residents from Hubei Province, and this article outlines our experiences. A total of five charter flights were dispatched, and the majority of returnees (793/829 [95.7%]) were handled at NCGM. A large number of personnel from various departments participated in this operation; 107 physicians, 115 nurses, 110 clerical staff, and 45 laboratory technicians in total. Several medical translators were also involved. In this operation, we conducted airborne precautions in addition to contact precautions. Eye shields were also used. The doctors collecting the pharyngeal swab used a coverall to minimize the risk of body surface contamination from secretions and droplets. Enhanced hand hygiene using alcohol hand sanitizer was performed. Forty-eight persons were ultimately hospitalized after the triage at NCGM operation, which was more than the number of persons triaged at the airport (n = 34). Of those hospitalized after NCGM triage, 8.3% (4/48 patients) ultimately tested positive for SARS-CoV-2, significantly higher than the positive rate among subjects not triaged (4/48 [8.3%] vs. 9/745 [1.2%]: p = 0.0057). NCGM participated in a large-scale operation to evacuate Japanese nationals from the COVID-19 epidemic area. We were able to establish a scheme through this experience that can be used in the future.
著者
Masaya Kuramochi Hiroaki Ueda Chiaki Kobayashi Youichi Kamae Koutarou Takaya
出版者
Meteorological Society of Japan
雑誌
SOLA (ISSN:13496476)
巻号頁・発行日
pp.17B-001, (Released:2021-08-05)
被引用文献数
7

The anomalous warm winter from December 2019 to February 2020 over East Asia, particularly the anticyclonic anomaly around Japan, was examined from the teleconnection perspective anchored by a warmed Indian Ocean and the El Niño Modoki. In the upper troposphere, high–low–high wave patterns progressing from the Arabian Sea toward Japan via the southern region of China, coupled with the wave-activity flux diagnosis, implicate the propagation of stationary Rossby waves caused by enhanced convection in the western Indian Ocean and suppressed convection around the Maritime Continent. These anomalous convective activities could be responsible for the northward displacement of the subtropical jet and the ensuing warm conditions over East Asia. The atmospheric response to the observed diabatic heating by means of the linear baroclinic model well reproduced the observations. Moreover, sensitivity experiments of the atmospheric general circulation model to sea surface temperature (SST) anomalies, especially in the warmed western Indian and central Pacific oceans, can help understand the anomalous subsidence over the Maritime Continent sector and subsequently weakened convection. The warmer SST observed around the Maritime Continent alone reproduces the enhancement of rainfall and subsequent cold anomalies around Japan, suggesting the importance of trans-basin interaction for teleconnection towards East Asia.