著者

Mitsuru Yagi Nobuyuki Fujita Tomohiko Hasegawa Gen Inoue Yoshihisa Kotani Seiji Ohtori Sumihisa Orita Yasushi Oshima Daisuke Sakai Toshinori Sakai Hiroshi Taneichi Daisuke Togawa Kazuo Nakanishi Hiroaki Nakashima Toshitaka Yoshii Masaya Nakamura Motoki Iwasaki Masahiko Watanabe Hirotaka Haro Tokumi Kanemura Naobumi Hosogane New Technology Assessment Committee of The Japanese Society for Spine Surgery and Related Research

出版者

The Japanese Society for Spine Surgery and Related Research

雑誌

Spine Surgery and Related Research (ISSN:2432261X)

巻号頁・発行日

pp.2022-0194, (Released:2022-12-12)

被引用文献数

1

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IntroductionLateral lumbar interbody fusion (LLIF) has been introduced in Japan in 2013. Despite the effectiveness of this procedure, several considerable complications have been reported. This study reported the results of a nationwide survey performed by the Japanese Society for Spine Surgery and Related Research (JSSR) on the complications associated with LLIF performed in Japan.MethodsJSSR members conducted a web-based survey following LLIF between 2015 and 2020. Any complications meeting the following criteria were included: (1) major vessel, (2) urinary tract, (3) renal, (4) visceral organ, (5) lung, (6) vertebral, (7) nerve, and (8) anterior longitudinal ligament injury; (9) weakness of psoas; (10) motor and (11) sensory deficit; (12) surgical site infection; and (13) other complications. The complications were analyzed in all LLIF patients, and the differences in incidence and type of complications between the transpsoas (TP) and prepsoas (PP) approaches were compared.ResultsAmong the 13,245 LLIF patients (TP 6,198 patients [47%] and PP 7,047 patients [53%]), 389 complications occurred in 366 (2.76%) patients. The most common complication was sensory deficit (0.5%), followed by motor deficit (0.43%) and weakness of psoas muscle (0.22%). Among the patient cohort, 100 patients (0.74%) required revision surgery during the survey period. Almost half of the complications developed in patients with spinal deformity (183 patients [47.0%]). Four patients (0.03%) died from complications. Statistically more frequent complications occurred in the TP approach than in the PP approach (TP vs. PP, 220 patients [3.55%] vs. 169 patients [2.40%]; p < 0.001).ConclusionsThe overall complication rate was 2.76%, and 0.74% of the patients required revision surgery because of complications. Four patients died from complications. LLIF may be beneficial for degenerative lumbar conditions with acceptable complications; however, the indication for spinal deformity should be carefully determined by the experience of the surgeon and the extent of the deformity.

著者

Takashi TOMITA Shigeki HAGIHARA Masaya SHIMAKAWA Naoki YONEZAKI

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE TRANSACTIONS on Information and Systems (ISSN:09168532)

巻号頁・発行日

vol.E105-D, no.10, pp.1665-1677, 2022-10-01

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This paper focuses on verification for reactive system specifications. A reactive system is an open system that continuously interacts with an uncontrollable external environment, and it must often be highly safe and reliable. However, realizability checking for a given specification is very costly, so we need effective methods to detect and analyze defects in unrealizable specifications to refine them efficiently. We introduce a systematic characterization on necessary conditions of realizability. This characterization is based on quantifications for inputs and outputs in early and late behaviors and reveals four essential aspects of realizability: exhaustivity, strategizability, preservability and stability. Additionally, the characterization derives new necessary conditions, which enable us to classify unrealizable specifications systematically and hierarchically.

著者

Chiori Kamiya Kuriko Kagitani-Shimono Yoshiko Iwatani Masaya Tachibana Ikuko Mohri Masako Taniike

出版者

Japan Brain Science society

雑誌

脳科学誌 (ISSN:13415301)

巻号頁・発行日

vol.50, pp.63-100, 2021 (Released:2022-01-13)

参考文献数

60

著者

Yuki Miyatake Shinsuke Matsuzaki Manabu Taniguchi Hironori Takamura Kohei Yamada Tsuyoshi Hattori Toshiki Kameyama Takayuki Manabe Masaya Tohyama Taiichi Katayama

出版者

Japan Brain Science society

雑誌

脳科学誌 (ISSN:13415301)

巻号頁・発行日

vol.45, pp.5-34, 2015-03-30 (Released:2017-06-01)

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Alternative splicing (AS) contributes to the generation of distinct mRNAs from the same pre-mRNA. This mechanism is highly conserved in eukaryotes and yields proteomic diversity. Furthermore, AS can be tissue- and developmental stage-specific and is an important process in the development of the central nervous system. Although these features suggest that AS variants contribute the complexity of the brain, the characteristics of most AS variants are unclear. Therefore, it is important to identify and examine novel AS variants in neuronal tissues to fully understand neuronal functions. We have identified a novel AS variant of murine disrupted in schizophrenia 1 (Disc1), a neural developmental gene. This variant lacks exon 2 and is named 'ΔE2'. We also show differences in the expression levels and localization patterns between ΔE2 and full length Disc1 (FL) in the murine brain. Differences in the subcellular localization patterns of both isoforms in cultured SK-N-SH cells suggest that ΔE2 has different functions compared with those of FL. Further functional analysis of ΔE2 may indicate additional roles of Disc1, and may further our understanding of the developmental mechanisms for neurodevelopmental disorders such as schizophrenia.

著者

Mika Kimura Ryuzo Hanaie Ikuko Mohri Kuriko Kagitani-Shimono Masaya Tachibana Junko Matsuzaki Norihiko Fujita Yoshiyuki Watanabe Masako Taniike

出版者

Japan Brain Science society

雑誌

脳科学誌 (ISSN:13415301)

巻号頁・発行日

vol.42, pp.21-42, 2013-09-30 (Released:2017-06-01)

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Autism spectrum disorder (ASD) is a neuro-developmental disorder characterized by a number of functional abnormalities including disruptions to language. Recently, abnormal connectivity in the brain has been reported as a neuronal basis of functional impairments in ASD. Using tractographical analysis of the arcuate fasciculus (AF) by Diffusion Tensor Imaging (DTI), we attempted to clarify the neuropsychological basis for the language impairment in ASD by investigating thirteen school-aged children with ASD and eleven age- and IQ-matched control subjects. As a result of the DTI examination, no statistically significant differences in the values of fractional anisotropy (FA), axial diffusivity, radial diffusivity, and mean diffusivity were found. In both TD and ASD groups, the FA score of the AF was higher in the left hemisphere than it was in the right. We revealed that in children with ASD, the FA values of the left AF showed a positive correlation between age, verbal intelligence quotient (VIQ), and full-scale intelligence quotient (FSIQ). In addition, a negative correlation was found between RD values on the left AF with VIQ, FSIQ, and age in children with ASD. This is the first report to reveal a correlation between microconnectivity of the AF and VIQ in children diagnosed with ASD. Therefore, these findings suggest that the altered microstructural integrity of the AF may be related to verbal ability in ASD.

著者

Taro Uchiyama Yusuke Nakano Osamu Ueda Hiroshi Mori Masaya Nakashima Akira Noda Chiaki Ishizaki Masako Mizoguchi

出版者

The Pharmaceutical Society of Japan

雑誌

Journal of Health Science (ISSN:13449702)

巻号頁・発行日

vol.54, no.5, pp.559-566, 2008 (Released:2008-10-01)

参考文献数

19

被引用文献数

63 73

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We examined the effect of oral intake of pure glucosylceramide derived from konjac extract on skin barrier function evaluated by transepidermal water loss (TEWL) in hairless mice with sodium dodecyl sulfate (SDS)-induced skin roughness. The difference of TEWL between SDS-treated site and untreated sites in the pure glucosylceramide-fed group was significantly lower than that in control group on day 14 of ingestion. We investigated interleukin-1α (IL-1α) production in the hairless mouse skin, and it was significantly lower in the glucosylceramide-fed group than that of control animals. This reduced IL-1α production should contribute to improvement of skin barrier function. To investigate the effect of oral intake of glucosylceramide in human, we conducted a randomized double-blind placebo-controlled study including 100 healthy subjects whose TEWL in cheek was relatively high. As a result, cheek TEWL was significantly lower in the test product group as compared with the control group in weeks 8 and 12 of ingestion (p=0.023 and p=0.002 respectively).

著者

Keiko MAEKAWA Masaya ITODA Kimie SAI Yoshiro SAITO Nahoko KANIWA Kuniaki SHIRAO Tetsuya HAMAGUCHI Hideo KUNITOH Noboru YAMAMOTO Tomohide TAMURA Hironobu MINAMI Kaoru KUBOTA Atsushi OHTSU Teruhiko YOSHIDA Nagahiro SAIJO Naoyuki KAMATANI Shogo OZAWA Jun-ichi SAWADA

出版者

The Japanese Society for the Study of Xenobiotics

雑誌

Drug Metabolism and Pharmacokinetics (ISSN:13474367)

巻号頁・発行日

vol.21, no.2, pp.109-121, 2006 (Released:2006-05-10)

参考文献数

35

被引用文献数

36

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The ATP-binding cassette transporter, ABCG2, which is expressed at high levels in the intestine and liver, functions as an efflux transporter for many drugs, including clinically used anticancer agents such as topotecan and the active metabolite of irinotecan (SN-38). In this study, to elucidate the linkage disequilibrium (LD) profiles and haplotype structures of ABCG2, we have comprehensively searched for genetic variations in the putative promoter region, all the exons, and their flanking introns of ABCG2 from 177 Japanese cancer patients treated with irinotecan. Forty-three genetic variations, including 11 novel ones, were found: 5 in the 5′-flanking region, 13 in the coding exons, and 25 in the introns. In addition to 9 previously reported nonsynonymous single nucleotide polymorphisms (SNPs), 2 novel nonsynonymous SNPs, 38C>T (Ser13Leu) and 1060G>A (Gly354Arg), were found with minor allele frequencies of 0.3%. Based on the LD profiles between the SNPs and the estimated past recombination events, the region analyzed was divided into three blocks (Block -1, 1, and 2), each of which spans at least 0.2 kb, 46 kb, and 13 kb and contains 2, 24, and 17 variations, respectively. The two, eight, and five common haplotypes detected in 10 or more patients accounted for most (>90%) of the haplotypes inferred in Block -1, Block 1, and Block 2, respectively. The SNP and haplotype distributions in Japanese were different from those reported previously in Caucasians. This study provides fundamental information for the pharmacogenetic studies investigating the relationship between the genetic variations in ABCG2 and pharmacokinetic/pharmacodynamic parameters.

著者

Yusuke SAKAMOTO Kenko MAEDA Masaya TAKEMOTO Jungsu CHOO Mizuka IKEZAWA Ohju FUJITA Fumihiro SAGO Daiki SOMIYA Akira IKEDA

出版者

The Japan Neurosurgical Society

雑誌

NMC Case Report Journal (ISSN:21884226)

巻号頁・発行日

vol.9, pp.129-133, 2022-12-31 (Released:2022-05-31)

参考文献数

11

被引用文献数

4

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Posterior inferior cerebellar artery (PICA) aneurysms often require cerebral vascular reconstruction for surgical treatment because of their characteristic morphology. Despite its potential complications, the occipital artery-to-posterior inferior cerebellar artery (OA-PICA) bypass is a typical treatment because of its versatility. Although a few cases of intracranial-to-intracranial bypass have been reported, this type of vascular reconstruction is only regarded as an alternative to the OA-PICA bypass because of the uncertainty of bypass feasibility and potential risk of ischemic complications. In this article, we report a case of proximal PICA ruptured aneurysm that was treated with a PICA-to-PICA (PICA-PICA) bypass. A 79-year-old man presented with a chief complaint of sudden, severe headache and disturbances in consciousness. Radiological examination revealed a right proximal PICA fusiform aneurysm. The patient had many systemic disorders such as microscopic polyangiitis and steroid-induced diabetes mellitus that could have caused wound dehiscence and cerebrospinal fluid (CSF) leakage. We performed the PICA-PICA bypass and trapping surgery rather than the OA-PICA bypass to avoid skin problems and CSF leakage. The postoperative course was uneventful, and the patient was discharged on day 64 without any neurological disorders. In comparison with the OA-PICA bypass, the PICA-PICA bypass is less likely to cause CSF leakage and skin complications, although it carries the risk of specific ischemic complications and requires advanced surgical techniques. For some patients with systemic disorders, the PICA-PICA bypass could be an optimal treatment option for proximal fusiform PICA aneurysms rather than as an alternative to the OA-PICA bypass.

著者

Masamichi YANO Masaya KATO Yoshinori IKOMA Akemi KAWASAKI Yoshino FUKAZAWA Minoru SUGIURA Hikaru MATSUMOTO Yumiko OOHARA Akihiko NAGAO Kazunori OGAWA

出版者

Japanese Society for Food Science and Technology

雑誌

Food Science and Technology Research (ISSN:13446606)

巻号頁・発行日

vol.11, no.1, pp.13-18, 2005 (Released:2006-11-01)

参考文献数

18

被引用文献数

51 71

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To obtain the quantitative and qualitative data available for estimating the intake of carotenoids from fruits in Japan, carotenoids were analyzed with reversed phase high-performance liquid chromatography (HPLC). Ten carotenoids were examined in 75 raw fruits and 15 processed fruits, all of which were harvested or purchased in Japan. Phytoene was detected in 58 of 90 fruit samples ; ζ-carotene, in 50 of 90 ; lycopene, in 13 of 90 ; α-carotene, in 18 of 90 ; lutein, in 56 of 90 ; β-carotene, in 80 of 90 ; β-cryptoxanthin, in 68 of 90 ; zeaxanthin, in 58 of 90 ; all-trans-violaxanthin, in 55 of 90 ; and 9-cis-violaxanthin, in 47 of 90 samples. Citrus fruits of the mandarin type (Satsuma mandarin and its hybrids, such as tangor) were rich in β-cryptoxanthin, β-carotene, all-trans-violaxanthin, and 9-cis-violaxanthin ; ‘Star ruby’ grapefruit in lycopene ; loquat, Japanese persimmon, and peach in β-cryptoxanthin, β-carotene, all-trans-violaxanthin, and 9-cis-violaxanthin ; mango in β-carotene, all-trans-violaxanthin, and 9-cis-violaxanthin ; acerolas in phytoene ; passion fruits in ζ-carotene. Carotenoid levels in common fruits, such as apple, grape, lemon, pear, strawberry, kiwifruit, cherry, pineapple, and banana, were low.

著者

Masaya Inoue Junji Kitao Yoshihiro Miyama Moriyuki Hazeyama Hitoshi Isoda Hideaki Arita Koji Nishizawa Tatsuo Nishimura Masatsugu Nakano

出版者

The Institute of Electrical Engineers of Japan

雑誌

IEEJ Journal of Industry Applications (ISSN:21871094)

巻号頁・発行日

vol.11, no.3, pp.388-395, 2022-05-01 (Released:2022-05-01)

参考文献数

20

被引用文献数

6

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This paper presents the development of a 48V integrated starter generator (ISG) for mild hybrid vehicles. The motor needs to satisfy power and torque performances requirements under the 48V system voltage as well as the passenger vehicle's specific requirements, such as acoustic noise and layout space. Several processes have been explored to obtain a 48V ISG such as the pole number selection process, the electromagnetic design approach for reducing acoustic noise, and a novel position sensor topology. By using the developed technologies, a 48V ISG motor is designed, built, and tested. Furthermore, the developed motor is demonstrated to achieve 180Nm, 15kW exceeding the 95% motor efficiency with acoustic noise reduction design and thin axial motor length.

著者

Kei Funada Ryosaku Shirahashi Toshikuni Suda Yoshinori Gyotoku Masaya Tamano

出版者

Dokkyo Medical Society

雑誌

Dokkyo Medical Journal (ISSN:24365211)

巻号頁・発行日

vol.1, no.1, pp.30-38, 2022-03-25 (Released:2022-05-06)

参考文献数

18

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Background: The coronavirus disease 2019 (COVID-19) pandemic has caused many people mental distress. Negative changes have been reported in physical activity, sleep, alcohol consumption, and smoking. Many patients with alcoholic liver disease (ALD) have a tendency for alcohol dependence, but there are no reports on how the COVID-19 pandemic has affected ALD patients.Aims: The purpose of this study was to clarify the effects of the COVID-19 pandemic on ALD patients.Methods: The study consisted of two parts. In the first part, changes in the alcohol consumption and blood biochemistry of ALD patients who continued to visit our hospital as outpatients before and during the COVID-19 pandemic were compared. In the second part, the clinical backgrounds at the time of the initial examination of ALD patients who were first examined in the year before the COVID-19 pandemic (before outbreak group) and ALD patients who were first examined in the six months after the start of the COVID-19 pandemic (after outbreak group) were compared. Patients in the after outbreak group were asked whether their motivation to drink was related to the COVID-19 pandemic.Results: In part 1, of the 95 ALD patients surveyed, alcohol consumption increased after the start of the pandemic in 20 (21.1%) patients, and 13 (65%) of these 20 patients blamed the increase on the COVID-19 pandemic. Gamma-glutamyltransferase levels increased and prothrombin activity (PT%) decreased markedly after the start of the pandemic in the 20 patients in this increased alcohol consumption group. Although 32 patients reported that their alcohol consumption remained unchanged, liver function appeared to deteriorate after the start of the pandemic, which suggests that ALD patients' self-reports of alcohol consumption were inaccurate. In part 2, the clinical backgrounds of 28 ALD patients first examined in our hospital in the year before the COVID-19 pandemic and 12 ALD patients first examined in the six months after the start of the pandemic were compared. Liver damage was more severe in the after outbreak group, and 8 of these 12 patients (66.7%) blamed their drinking on the COVID-19 pandemic. Although the difference was not significant, there tended to be more employed people among the ALD patients who were first examined after the start of the COVID-19 pandemic.Conclusion: Liver function in ALD worsened due to the COVID-19 pandemic. In some ALD patients who were first examined for ALD after the start of the pandemic, the motive for drinking was associated with the COVID-19 pandemic.

著者

Yoshiki Murakami Masaya Shinohara Yosuke Oka Ryo Wada Ryota Noike Hiroshi Ohara Tadashi Fujino Takanori Ikeda

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.61, no.4, pp.501-505, 2022-02-15 (Released:2022-02-15)

参考文献数

14

被引用文献数

11

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COVID-19 vaccine-related myocarditis has been reported worldwide. We herein report two Japanese cases with suspected vaccine-related myocarditis. A 27-year-old man was admitted with chest pain 4 days after the second vaccination. An electrocardiogram (ECG) did not reveal any significant abnormalities. The second patient, a 37-year-old man, was admitted with chest pain 9 days after the first vaccination. His ECG exhibited ST-elevation in multiple leads. In both cases, cardiac magnetic resonance imaging findings were consistent with myocarditis. They recovered with symptomatic relief within a few days. These cases suggest that the benefit of COVID-19 vaccination exceeds the risk of vaccine-related myocarditis.

著者

Takuro NAGAHARA Koichi OHNO Itsuma NAGAO Taisuke NAKAGAWA Yuko GOTO-KOSHINO Masaya TSUBOI James K. CHAMBERS Kazuyuki UCHIDA Hirotaka TOMIYASU Hajime TSUJIMOTO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.21-0257, (Released:2022-03-14)

被引用文献数

1

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Intestinal lymphangiectasia (IL) is often observed in dogs with chronic small intestinal diseases. Hypoplasia of the lymphatic vessel due to decreased lymphangiogenesis, which has been suggested in human idiopathic IL, may contribute to the pathogenesis of canine IL. This study aimed to evaluate the diameter and number of lymphatic vessels in full-thickness small intestinal specimens of dogs with IL. Immunohistochemical labeling of lymphatic endothelial cell markers was performed on retrospectively retrieved full-thickness small intestinal specimens. Sixteen dogs with histologically confirmed IL were included, of which 10 had lymphoplasmacytic enteritis (LPE), and six had granulomatous lymphangitis (GL). Nine dogs that died from non-gastrointestinal disorders and with little or no abnormalities in the small intestine were used as controls. Lymphatic vessel diameters in dogs with IL were significantly increased in all layers of the small intestine, including the villus lacteal, lamina propria, submucosa, muscularis, and mesentery, compared with controls (all P<0.01). There was no significant difference in the lymphatic vessel diameters between dogs with LPE and GL (all P>0.05). There was no significant difference in the number of lymphatic vessels between dogs with IL and the controls in all layers of the small intestine (all P>0.05). This study demonstrated that IL was observed in all layers of the small intestine, including the submucosa, muscularis, and mesentery, independent of the underlying disease. Factors other than reduced lymphatic vessels would contribute to the pathogenesis of IL in dogs.

著者

Yui HIROSE Mona UCHIDA Masaya TSUBOI Takayuki NAKAGAWA Leo YAGA Shingo MAEDA Yasuyuki MOMOI Yugo KURIKI Mako KAMIYA Yasuteru URANO Tomohiro YONEZAWA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.22-0003, (Released:2022-03-07)

被引用文献数

3

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Since gamma-glutamyl transpeptidase (GGT) is highly and locally expressed in human breast cancer, a GGT-enzymatically activatable fluorescent probe, gamma-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG), has been developed to detect the human breast cancer area with high performance. In this study, GGT expression and the efficacy of gGlu-HMRG on visualization were investigated in canine mammary gland tumors (MGT). Seventeen non-fixed fresh-frozen MGT specimens and each peritumoral control tissue were utilized. The GGT mRNA levels were highly observed in the tumor specimens compared with the control. GGT immunostaining was mostly observed on the cell membrane and cytosol of the alveolar and duct mammary epithelium of MGT tissues. These signals were strongly positive in several cases while they were mild to not observed in other cases. When gGlu-HMRG solution was dropped to the non-fixed tissue pieces of MGT or control tissues, the fluorescence intensities (FIs) were measured using Maestro in-vivo imaging device. FIs in MGT tissues were significantly higher than each control tissue 20 min after treatment. Based on Youden index method said that the maximum sensitivity and specificity of FI was 82.4% and 82.4%. These findings suggest that GGT is highly expressed in several MGTs in dogs and gGlu-HMRG could visualize at least a part of MGT tissues in dogs. Nevertheless, it should be needed to assess the false-negative areas more carefully in canine than human cases.

著者

Takumi YOSHIDA Md Emtiaj ALAM Keisuke HANAFUSA Yasunori TSUJIMOTO Masaya TSUKAMOTO Ryoji KANEGI Toshio INABA Kikuya SUGIURA Shingo HATOYA

出版者

The Society for Reproduction and Development

雑誌

Journal of Reproduction and Development (ISSN:09168818)

巻号頁・発行日

pp.2021-084, (Released:2022-01-07)

被引用文献数

2

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We examined the effectiveness of saline, Euro-Collins solution (EC), and ET-Kyoto solution (ET-K) as preservation media for the cold storage of feline ovaries. Ovaries were maintained in these media at 4°C for 24, 48, or 72 h until oocyte retrieval. The ET-K group exhibited a higher oocyte maturation rate than the saline group after 72 h of storage. Moreover, ET-K could sustain the competence of the feline oocytes to cleave after 48 h, and the morula formation rate of the ET-K group was higher than that of the other groups after 24 and 48 h. Furthermore, the ET-K group exhibited a higher blastocyst formation rate than the other groups after storage for 24 h, and only ET-K retained the developmental competence in blastocysts after 48 h of storage. In addition, regarding the cell numbers of the blastocysts, there was no significant difference among the tested groups. In conclusion, our results indicate that ET-K is a suitable preservation medium for feline ovaries.

著者

Andrew H. Baird Alasdair J. Edwards James R. Guest Saki Harii Masayuki Hatta Liam Lachs Hanaka Mera Frederic Sinniger David Abrego Or Ben-Zvi Omri Bronstein Patrick C. Cabaitan Vivian R. Cumbo Gal Eyal Lee Eyal-Shaham Bar Feldman Joana Figueiredo Jean-François Flot Mila Grinblat Andrew Heyward Michio Hidaka Mamiko Hirose Akira Iguchi Naoko Isomura Robert A. Kinzie Seiya Kitanobo Alyson Kuba Oren Levy Yossi Loya Takuma Mezaki Amin R. Mohamed Masaya Morita Satoshi Nojima Yoko Nozawa Rian Prasetia Eneour Puill-Stephan Catalina Ramirez-Portilla Hanna Rapuano Yaeli Rosenberg Yusuke Sakai Kazuhiko Sakai Tom Shlesinger Tullia I. Terraneo Irina Yakovleva Hiromi H. Yamamoto Kiyoshi Yamazato

出版者

The Japanese Coral Reef Society

雑誌

Galaxea, Journal of Coral Reef Studies (ISSN:18830838)

巻号頁・発行日

pp.G2021_S10O, (Released:2021-11-19)

参考文献数

27

被引用文献数

11

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Sesoko Station, Okinawa, has been the site of many significant advances in coral reproductive research and it continues to be a preferred destination for both Japanese and international researchers. Consequently, there are decades of spawning observations, which we present and explore here with the aim of making it easier to predict when species spawn at Sesoko Station. The data include over 700 spawning observations from 87 species of reef-building hermatypic corals. Almost all spawning occurred between dusk and dawn, with most spawning activity concentrated in the 2 to 4 hours after sunset. Some phylogenetic patterns were evident: most Acropora species spawn on or around the 6th full moon after December 21st (the northern hemisphere winter solstice); spawning in common species of merulinids and Porites appears to be concentrated around the 7th full moon and spawning in the fungiids around the 8th and subsequent full moons. The night of peak spawning with respect to the night of the full moon varied considerably among years in common Acropora species, but was dependent on the calendar date of the full moon in May or June. Therefore, despite an extended spawning season of over three months and considerable variation in the calendar date of spawning in many species among years, the month and night of spawning are reasonably predictable for many species enhancing the value of Sesoko Station as a site for coral reproductive research.

著者

飯塚 雅哉 早川 由紀夫 IIDUKA Masaya HAYAKAWA Yukio

出版者

群馬大学共同教育学部

雑誌

群馬大学共同教育学部紀要. 自然科学編 = Science reports of the Cooperative Faculty of Education, Gunma University (ISSN:00175668)

巻号頁・発行日

vol.69, pp.13-26, 2021

著者

Masaya Takahashi

出版者

Japan Society for Occupational Health

雑誌

Journal of Occupational Health (ISSN:13419145)

巻号頁・発行日

vol.61, no.4, pp.269-277, 2019-07-20 (Released:2019-07-25)

参考文献数

48

被引用文献数

35

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Objectives: Cerebrovascular and cardiovascular diseases (CCVDs) and mental disorders, including suicide, are prevalent among overworked individuals in Japan. The 2014 legislation regarding the prevention of overwork-related deaths and disorders has accelerated the research in this field and ultimately the implementation of preventive actions.Methods: To understand the current problematic situations, the Research Center for Overwork-Related Disorders of the National Institute of Occupational Safety and Health, Japan, conducted analyses of compensated claims for overwork-related CCVDs and mental disorders that were recognized from January 2010 to March 2015.Results: The majority of CCVD cases were the men in their 50s. Transport and postal activities was the highest risk industry. Cerebrovascular cases were higher than cardiovascular ones. Long working hours was the principal factor for CCVDs. The mental disorder cases comprised approximately 70% men and affected younger age groups (peak in the third decade) with various industries at risk. In men, there was an almost equal number of F3 (Mood [affective] disorders) and F4 (Neurotic, stress-related, and somatoform disorders) diagnoses according to the 10th revision of the International Classification of Diseases and Related Health Problems. A larger number of women were diagnosed to have F4. The mental disorder cases were associated not only with long working hours, but also with injuries and disasters as well as interpersonal conflict at work.Conclusions: Multiple, simultaneous actions need to be made by employees, employers, researchers, and the authorities to achieve the goal of reducing the number of workers suffering from the overwork-related CCVDs and mental disorders.

著者

Satoshi KAMOTO Masahiro SHINADA Daiki KATO Masaya TSUBOI Sho YOSHIMOTO Ryohei YOSHITAKE Shotaro ETO Namiko IKEDA Yosuke TAKAHASHI Yuko HASHIMOTO James CHAMBERS Kazuyuki UCHIDA Shinji YAMADA Mika K. KANEKO Ryohei NISHIMURA Yukinari KATO Takayuki NAKAGAWA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.83, no.11, pp.1795-1799, 2021 (Released:2021-11-24)

参考文献数

37

被引用文献数

2

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Podoplanin is expressed in various human tumors where it promotes tumor progression, epithelial-mesenchymal transition, and distant metastasis. Podoplanin is also expressed in cancer-associated fibroblasts and induces tumor malignancy. The objective of this study was to evaluate podoplanin expression in various types of feline tumor tissues. Immunohistochemical analysis revealed that podoplanin was expressed in cells of 13/15 (87%) squamous cell carcinomas and 5/19 (26%) fibrosarcomas. Moreover, cancer-associated fibroblasts expressed podoplanin in most tumor types, including 18/21 (86%) mammary adenocarcinoma tissues. Our findings demonstrate that various types of feline tumor tissues expressed podoplanin, indicating the importance of the comparative aspects of podoplanin expression, which may be used as a novel research model for podoplanin biology.

著者

Sang-il LEE Takeshi NISHI Masaya TAKAHASHI Shigekazu HIGUCHI

出版者

National Institute of Occupational Safety and Health

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

vol.59, no.6, pp.393-402, 2021-09-27 (Released:2021-11-29)

被引用文献数

4

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A nighttime nap is expected to mitigate melatonin suppression during night work by blocking light input to the retina, but it is unclear. In the present study, we investigated the effects of a nap break on melatonin level, subjective sleepiness, and vigilance performance during simulated night work. Eleven healthy young males (mean ± SD age: 22.2 ± 4.1 years) participated in counterbalanced crossover design experiments with two conditions (nap vs. no nap). The subjects performed 12-hour simulated night work from 21:00 to 09:00 h (illuminance: ~500 lx). Subjects with a nap condition took a nap for 2 hours in a dark room from 03:00, while subjects with a no nap condition continued the simulated night work. The results showed that immediately after the 2-h nap break, the melatonin level at 05:00 h temporarily recovered from light-induced melatonin suppression during the simulated night work but significantly suppressed again at 07:00 and 09:00 h. Subjective alertness and vigilance performance were impaired immediately after the nap break but subsequently enhanced. The results suggest that a single nap break for 2 hours could be a strategy to enhance alertness during the last part of night shift but inadequate for mitigating melatonin suppression.