著者

Jae-Suk Choi Min-Hee Jeon Woi-Sook Moon Jin-Nam Moon Eun Jin Cheon Joo-Wan Kim Sung Kyu Jung Yi-Hwa Ji Sang Wook Son Mi-Ryung Kim

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.37, no.1, pp.44-53, 2014-01-01 (Released:2014-01-01)

参考文献数

45

被引用文献数

19 32

---

The potential hair growth-promoting activity of rice bran supercritical CO2 extract (RB-SCE) and major components of RB-SCE, linoleic acid, policosanol, γ-oryzanol, and γ-tocotrienol, were evaluated with the histological morphology and mRNA expression levels of cell growth factors using real-time reverse transcriptase-polymerase chain reaction (PCR) in C57BL/6 mice. RB-SCE showed hair growth-promoting potential to a similar extent as 3% minoxidil, showing that the hair follicles were induced to be in the anagen stage. The numbers of the hair follicles were significantly increased. In addition, mRNA expression levels of vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), and keratinocyte growth factor (KGF) were also significantly increased and that of transforming growth factor-β (TGF-β) decreased in RB-SCE-treated groups. Among the major components of RB-SCE, linoleic acid and γ-oryzanol induced the formation of hair follicles according to examination of histological morphology and mRNA expression levels of cell growth factors. In conclusion, our results demonstrate that RB-SCE, particularly linoleic acid and γ-oryzanol, promotes hair growth and suggests RB-SCE can be applied as hair loss treatment.

著者

Li Min-Yi Zhang Jing Feng Gang Satyanandamurty Tirumani Wu Jun

出版者

日本農薬学会

雑誌

日本農薬学会誌(Journal of Pesticide Science) (ISSN:1348589X)

巻号頁・発行日

vol.36, no.1, pp.22-26, 2011

被引用文献数

10

---

熱帯地域において,Brontispa longissima(Gestro)はヤシの木に重大な被害をもたらす害虫である。我々は,熱帯マングローブの潜在的殺虫剤リード化合物探索研究において,インドマングローブXylocarpus moluccensisの種子からΔ8,14二重結合をもつメキシカノライドであるカヤシンと2'S-メチルブタノイルプロセラノリドを単離した。これらの化合物の構造は文献データと比較して同定した。50μg/mlの濃度では,カヤシンはB. longissimaの2齢から5齢幼虫に対して強い殺虫効果を示し,2'S-メチルブタノイルプロセラノリドは5齢幼虫に対して顕著な殺虫効果を示した。B. longissimaの5齢幼虫に対する24時間と48時間暴露のLC50(半数致死濃度)は,カヤシンは7.27と3.39μg/ml,2'S-メチルブタノイルプロセラノリドは10.57と4.03μg/mlであった。2種の化合物のB. longissimaの5齢幼虫に対する殺虫活性は,アザジラクチンとトオセンダニンよりも強く,ロテノンと同程度であった。しかし,Prodenia litura(Fabricius)の3齢幼虫に対しては,これらの化合物は中程度の摂食阻害活性しか示さなかった。以上の結果は,カヤシンと2'S-メチルブタノイルプロセラノリドは,B. longissimaの幼虫に対して選択的な殺虫活性を持っていることを示唆しており,B. longissima防除用の有力な殺虫剤候補になると思われる。

著者

XIAO Hua-liang EYDEN Brian YAN Xiao-chu WANG Yi ZHANG Rong BIAN Xiu-wu

雑誌

Neuropathology : official journal the Japanese Society of Neuropathology (ISSN:09196544)

巻号頁・発行日

vol.30, no.3, pp.288-293, 2010-06-01

参考文献数

11

著者

Yuqin Zhou Weitong Hu Xiangli Zhang Yi Wang Wenya Zhuang Fengzhi Li Qingyong Li

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.69, no.11, pp.1054-1060, 2021-11-01 (Released:2021-11-01)

参考文献数

42

被引用文献数

11

---

In the evaluation of the druggability of candidate compounds, it was vital to predict the oral bioavailability of compounds from apparent permeability (Papp) across Caco-2 cell-culture model of intestinal epithelium cultured on commercial transwell plate inserts. The study was to investigate the transport characteristics and permeability of FL118 (10, 11-Methylenedioxy-20(S)-camptothecin) derivatives 7-Q6 (7-(4-Ethylphenyl)-10, 11-methylenedioxy-20(S)-camptothecin) and 7-Q20 (7-(4-Trifluoromethylphenyl)-10, 11-methylenedioxy-20(S)-camptothecin). Transport characteristics and permeability of the tested compounds to the small intestine were assessed at different concentrations (0.5, 1 µM) via Caco-2 cell monolayers model in vitro. Uptake studies based on Caco-2 cells, including temperatures, concentrations, and the influence of efflux transporters, were combined to confirm the transport characteristics of the tested compounds. Furthermore, cytotoxicity results showed that the concentrations used in the experiments were non-toxic and harmless to cells. In addition, The Papp of 7-Q6 was (3.69 ± 1.07) × 10−6 cm/s with efflux ratio (ER) 0.98, while the Papp of 7-Q20 was (7.78 ± 0.89) × 10−6 cm/s with ER 1.05 for apical-to-basolateral (AP→BL) at 0.5 µM, suggesting that 7-Q20 might possess higher oral bioavailability in vivo. Furthermore, P-glycoprotein (P-gp) was proved to slightly affect the accumulations of 7-Q20, while the absorption of 7-Q6 was irrelevant with P-gp and breast cancer resistant protein (BCRP) based on the cellular uptake assays. Accordingly, 7-Q6 was completely absorbed by passive diffusion, and 7-Q20 was mainly dependent on passive diffusion with being effluxed by P-gp slightly. Meanwhile, both 7-Q6 and 7-Q20 were potential antitumor drugs that might exhibit high oral bioavailability in the body.

著者

Kong Xiangfei Gan Huachen Hao Yuqing CHENG Chunming JIANG Jianhai HONG Yi YANG Junwu ZHU Hao CHI Yayun YUN Xiaojing GU Jianxin

出版者

Japanese Biochemical Society

雑誌

The journal of biochemistry (ISSN:0021924X)

巻号頁・発行日

vol.146, no.3, pp.417-427, 2009-09-01

参考文献数

50

著者

王 怡人 Wang Yi-Jen

出版者

国際地域創造学部 経営プログラム

雑誌

琉球大学経営研究 = University of the Ryukyus Management Research (ISSN:24361380)

巻号頁・発行日

no.1, pp.1-25, 2021-01

---

デジタル社会において,企業はインターネットを活用した様々なマーケティング活動を行っている。本稿は,製造企業のこのようなマーケティング活動に焦点を当て,統計データおよびネットワーク理論の概念を使って,企業の試みと産業特性とのマッチング度を検証し,さらに製造企業にとって今後の展開の課題を整理した。

著者

Xiao-cong ZUO Ya-nan ZHOU Bi-kui ZHANG Guo-ping YANG Ze-neng CHENG Hong YUAN Dong-sheng OUYANG Shi-kun LIU Jeffrey S. BARRETT Pei-jiong LI Zhi LIU Hong-yi TAN Ren GUO Ling-yun ZHOU Yue-liang XIE Zuo-jun LI Jing LI Chun-jiang WANG Jiang-lin WANG

出版者

The Japanese Society for the Study of Xenobiotics

雑誌

Drug Metabolism and Pharmacokinetics (ISSN:13474367)

巻号頁・発行日

vol.28, no.5, pp.398-405, 2013 (Released:2013-10-25)

参考文献数

51

被引用文献数

19

---

The objective of this study was to evaluate the effect of the CYP3A5*3 allele on the pharmacokinetics of tacrolimus and amlodipine, and drug-drug interactions between them in healthy subjects. Pharmacokinetic drug interactions between tacrolimus and amlodipine were evaluated in a randomized, 3-period, 6-sequence crossover study in healthy Chinese volunteers according to CYP3A5 genotype. A single-dose and multiple-dose study were designed. A 96-h pharmacokinetic study followed either tacrolimus or amlodipine dose, and the washout periods between the study phases were 14 days. In the single-dose study, apparent oral clearance (CL/F) of tacrolimus (5 mg) in CYP3A5 expressers was 3.8-fold (p = 0.008) higher than that in CYP3A5 non-expressers. Amlodipine decreased mean tacrolimus CL/F in CYP3A5 expressers by 2.2-fold (p = 0.005), while it had no effect on that in CYP3A5 non-expressers. The CL/F of amlodipine in CYP3A5 non-expressers was 2.0-fold (p = 0.001) higher than that in CYP3A5 expressers. Tacrolimus increased mean amlodipine CL/F in CYP3A5 expressers by 1.4-fold (p = 0.016) while it had no effect on that in CYP3A5 non-expressers. Tacrolimus slightly reduced the AUC0–∞ of amlodipine in both CYP3A5 expressers and non-expressers. Dose adjustment of tacrolimus should be considered according to CYP3A5*3 genetic polymorphism when tacrolimus is coadministered with amlodipine.

著者

蔡 毅 Yi Cai

雑誌

日本漢文学研究 = The Journal of Kanbun Studies

巻号頁・発行日

vol.11, pp.27-50,

著者

Yu-Feng Hu Wen-Han Cheng Yuan Hung Wen-Yu Lin Tze-Fan Chao Jo-Nan Liao Yenn-Jiang Lin Wei-Shiang Lin Yi-Jen Chen Shih-Ann Chen

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.84, no.10, pp.1679-1685, 2020-09-25 (Released:2020-09-25)

参考文献数

64

被引用文献数

3 17

---

The health crisis due to coronavirus disease 2019 (COVID-19) has shocked the world, with more than 1 million infections and casualties. COVID-19 can present from mild illness to multi-organ involvement, but especially acute respiratory distress syndrome. Cardiac injury and arrhythmias, including atrial fibrillation (AF), are not uncommon in COVID-19. COVID-19 is highly contagious, and therapy against the virus remains premature and largely unknown, which makes the management of AF patients during the pandemic particularly challenging. We describe a possible pathophysiological link between COVID-19 and AF, and therapeutic considerations for AF patients during this pandemic.

著者

Yi-Deun Jung Kung Ahn Yun-Ji Kim Jin-Han Bae Ja-Rang Lee Heui-Soo Kim

出版者

The Genetics Society of Japan

雑誌

Genes & Genetic Systems (ISSN:13417568)

巻号頁・発行日

vol.88, no.1, pp.31-43, 2013 (Released:2013-05-14)

参考文献数

148

被引用文献数

4 5

---

Eukaryotic genomes comprise numerous retroelements that have a major impact on the structure and regulation of gene function. Retroelements are regulated by epigenetic controls, and they generate multiple miRNAs that are involved in the induction and progression of genomic instability. Elucidation of the biological roles of retroelements deserves continuous investigation to better understand their evolutionary features and implications for disease.

著者

Chung-Yi Lo Hsueh-Ling Cheng Jue-Liang Hsu Ming-Hui Liao Rong-Lang Yen Yo-Chia Chen

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.61, no.6, pp.604-610, 2013-06-01 (Released:2013-06-01)

参考文献数

28

被引用文献数

2 4

---

Three phenyl derivatives of butyrate, 2-phenylbutyrate (2-PB), 3-phenylbutyrate (3-PB) and 4-phenylbutyrate (4-PB), were evaluated in terms of their antibacterial and cytotoxic activities. Our results indicated that PBs demonstrated specific inhibitory activity against Helicobacter pylori and Escherichia coli but did not influence the growth of Bifidobacterium bifidium and Lactobacillus reuteri. PBs also exhibited synergistic effects on H. pylori ATCC 43504 especially at pH 5.5. In the protein expression profiles in H. pylori treated by phenylbutyrates, we also found that three protein spots identified as oxidative stress-related proteins were significantly up-regulated, confirming the response of H. pylori when exposed to PBs. Due to their antibacterial activities and low or slight cytotoxicities, PBs are potential candidates for the treatment of H. pylori infection. This is the first study to discover the antibiotic effects of 2-PB, 3-PB and 4-PB (Buphenyl).

著者

李 容喜 大谷 育恵(訳) YI Yong-hee OTANI Ikue [trans.]

出版者

金沢大学人文学類考古学研究室

雑誌

金大考古 = The Archaeological Journal of Kanazawa University

巻号頁・発行日

no.78, pp.173-188, 2020-06-30

著者

Xi Ding Yang Zhao Chun-Ying Zhu Li-Ping Wu Yue Wang Zhao-Yi Peng Cuomu Deji Feng-Yi Zhao Bing-Yin Shi

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ20-0796, (Released:2021-04-21)

被引用文献数

19

---

The association between subclinical hypothyroidism (SCH) and metabolic syndrome (MetS) has been widely discussed. This study aimed to conduct an update and comprehensive meta-analysis to reveal the risk of MetS and its components in SCH. PubMed, Embase and ISI Web of Knowledge were searched to identify relevant studies through February 20th, 2020. Review Manager 5.3 and Stata 14.0 were used to conduct the meta-analysis. Both fixed-effects and random-effects models were used. In total, 18 articles (19 studies) incorporating 79,727 participants were included. The pooled OR for MetS comparing subjects with SCH with euthyroid subjects was 1.28 (95% CI: 1.19 to 1.39, p = 0.04, I2 = 40%). Subgroup analysis results showed significant associations of SCH and MetS in the adult subgroup (OR = 1.28, 95% CI: 1.18–1.40), Asian population subgroup (OR = 1.30, 95% CI: 1.19–1.42) and cross-sectional study design subgroup (OR = 1.31, 95% CI: 1.16–1.47). Significant associations of SCH and MetS also existed in all MetS definition criteria subgroups except the Chinese Diabetes Society (CDS) subgroup. SCH was correlated with MetS and was not affected by the subgroup analysis stratified by the proportion of females in the total population, the TSH cutoff value in SCH diagnostic criteria, or the adjustment for confounding factors. SCH was identified to be associated with an increased risk of obesity, hypertension, high triglyceride (TG) levels and low high-density lipoprotein cholesterol (HDL-C) levels. In conclusion, SCH is significantly associated with an increased risk of MetS and four out of five components of MetS.

著者

Chaoxin Fan Fang Tian Xin Zhao Yi Sun Xiaogai Yang Hongbin Han Xiaoping Pu

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.43, no.9, pp.1306-1314, 2020-09-01 (Released:2020-09-01)

参考文献数

22

被引用文献数

1 6

---

The extracellular space (ECS) is the space between the neurons and the capillaries in the brain. The volume fraction (α) and the tortuosity (λ) are the main parameters used to describe its characteristics. Thymoquinone has been proved to possess anti-oxidant and anti-inflammatory activity. In this study, we used a gadolinium-diethylenetriaminepentacetate (Gd-DTPA)-enhanced magnetic resonance imaging (MRI) system to determine the effects of thymoquinone on ECS parameters in transient middle cerebral artery occlusion rats (tMCAO) to prove the neuroprotective effect of thymoquinone on brain tissue damage caused by ischemic stroke. Neurological examinations, 2,3,5-triphenyltetrazolium chloride (TTC) staining, hematoxylin–eosin (H&E) staining and assaying of ECS parameters using MRI were performed 24 h after surgery. We found that thymoquinone could improve the behavioural performance by neurological examinations. TTC staining indicated that thymoquinone significantly decreased the percentage of hemi-cerebral infarction. Also, H&E staining showed that thymoquinone could inhibit the neuron necrosis in the hippocampal CA1 region. We found that thymoquinone treatment could inhibit the changes in ECS diffusion parameters, which might prove that thymoquinone might protect brain tissue damage caused by ischemic stroke. Thymoquinone can protect the brain against cerebral ischemia–reperfusion injury, effectively ameliorate abnormalities in characteristics of ECS and decrease cerebral infarction in tMCAO rats.

著者

李 修京 金 炫佑 石黒 みのり 蔡 光華 袁 立 YI Sookyung KIM Hyunwoo ISHIGURO Minori CAI Guanghua YUAN Li 李 修京(東京学芸大学 外国語・外国文化研究講座 アジア言語・文化研究分野) 金 炫佑(韓国昌原東鎮女子中学校社会科教員。韓国教員大学校大学院博士課程在籍中。) 石黒 みのり(東京学芸大学大学院 連合学校教育学研究科(博士課程)学校教育学専攻 言語文化系教育講座在籍中。) 蔡 光華(東京学芸大学大学院 教育学研究科(修士課程)総合教育開発専攻 国際理解教育コース在籍中。) 袁 立(東京学芸大学大学院 教育学研究科(修士課程)教育支援協働実践開発専攻 教育AI研究プログラム在籍中。)

出版者

東京学芸大学教育実践研究推進本部

雑誌

東京学芸大学紀要. 人文社会科学系. I (ISSN:24349364)

巻号頁・発行日

no.72, pp.73-94, 2021-01-29

著者

石黒 洋 山本 明子 中莖 みゆき 衣 蘭娟 石黒 真理子 山口 誠 近藤 志保 持丸 由香 Ishiguro Hiroshi Yamamoto Akiko Nakakuki Miyuki Yi Lanjuan Ishiguro Mariko Yamaguchi Makoto Kondo Shiho Mochimaru Yuka

出版者

名古屋大学総合保健体育科学センター

雑誌

総合保健体育科学 (ISSN:02895412)

巻号頁・発行日

vol.35, no.1, pp.9-15, 2012-03-30

---

Excretion of hypotonic sweat by eccrine sweat gland is achieved by re-absorption of NaCl by sweat duct which is an important function to prevent the salt loss and heat prostration. The Cl– transport by sweat duct is mediated by cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. CFTR is the causative gene for cystic fibrosis, an autosomal recessive genetic disease. CFTR functions as a cAMP-dependent anion channel localized in the apical membrane of various epithelia. Loss of function due to severe mutations in both alleles causes typical cystic fibrosis characterized by dehydrated, thick, and viscous luminal fluid/mucus in the respiratory and gastrointestinal tract, pancreatic duct, and vas deferens. Cystic fibrosis is the most common genetic disease in Caucasians (1 per ~3,000 births) but it is rare in the Asian population including Japanese (1 per ~1.5 million). A compound heterozygote of mutations/polymorphisms (causing a mild dysfunction of CFTR) involves a risk of developing CFTR-related diseases (or atypical cystic fibrosis) such as chronic pancreatitis and male infertility due to congenital bilateral absence of the vas deferens (CBAVD). Recent studies suggest that CFTR mutations/polymorphisms are frequently found in Japanese patients with chronic pancreatitis, CBAVD and diffuse panbronchiolitis. Cl– concentration in the sweat is a useful measure of CFTR function in human. The sweat [Cl–] in healthy subjects is correlated with ages. High levels (>60 mM) of sweat [Cl–] suggest the dysfunction of CFTR.

著者

Xiangxiang Lin Xueping Yi Sui Ni

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.70, no.1, pp.39-49, 2021 (Released:2021-01-08)

参考文献数

28

被引用文献数

11

---

Response surface methodology (RSM) was applied to optimize the effects of extraction parameters including time, power, temperature and liquid-to-solid ratio on peony seed oil yield. Box-Behnken design (BBD) was employed for optimization of extraction parameters in oil yield that extracted assisting by ultrasonic while petroleum ether as solvent. The chemical composition of peony seed oil under optimal condition in ultrasonic-assisted extract method was analyzed by gas chromatography-mass spectrometry (GC-MS). The optimal conditions were that extraction time 45 min, extraction temperature 45°C, extraction power 90 W and liquid-to-solid ratio 7:1, respectively. Under this condition, the extraction yield value was 33.90% which was with 95% confidence level, hence indicated the reliability of RSM in optimizing ultrasonic-assisted extraction of oil from Paeonia suffruticosa Andr. seed. Three unsaturated fatty acid of peony oil such as n-3 α-linolenic acid (39.75%), n-6 linoleic acid (26.32%) and the oleic acid (23.66%), totally more than 89.00% was determined at optimum condition.

著者

杉山 文博 高橋 智 水野 聖哉 Channabasavaiah B. Gurumurthy Aidan R. O'Brien Rolen M. Quadros John Adams Pilar Alcaide Shinya Ayabe Johnathan Ballard Surinder K. Batra Marie-Claude Beauchamp Kathleen A. Becker Guillaume Bernas David Brough Francisco Carrillo-Salinas Wesley Chan Hanying Chen Ruby Dawson Victoria DeMambro Jinke D'Hont Katharine M. Dibb James D. Eudy Lin Gan Jing Gao Amy Gonzales Anyonya R. Guntur Huiping Guo Donald W. Harms Anne Harrington Kathryn E. Hentges Neil Humphreys Shiho Imai Hideshi Ishii Mizuho Iwama Eric Jonasch Michelle Karolak Bernard Keavney Nay-Chi Khin Masamitsu Konno Yuko Kotani Yayoi Kunihiro Imayavaramban Lakshmanan Catherine Larochelle Catherine B. Lawrence Lin Li Volkhard Lindner Xian-De Liu Gloria Lopez-Castejon Andrew Loudon Jenna Lowe Loydie A. Jerome-Majewska Taiji Matsusaka Hiromi Miura Yoshiki Miyasaka Benjamin Morpurgo Katherine Motyl Yo-ichi Nabeshima Koji Nakade Toshiaki Nakashiba Kenichi Nakashima Yuichi Obata Sanae Ogiwara Mariette Ouellet Leif Oxburgh Sandra Piltz Ilka Pinz Moorthy P. Ponnusamy David Ray Ronald J. Redder Clifford J. Rosen Nikki Ross Mark T. Ruhe Larisa Ryzhova Ane M. Salvador Sabrina Shameen Alam Radislav Sedlacek Karan Sharma Chad Smith Katrien Staes Lora Starrs Fumihiro SUGIYAMA Satoru TAKAHASHI Tomohiro Tanaka Andrew W. Trafford Yoshihiro Uno Leen Vanhoutte Frederique Vanrockeghem Brandon J. Willis Christian S. Wright Yuko Yamauchi Xin Yi Kazuto Yoshimi Xuesong Zhang Yu Zhang Masato Ohtsuka Satyabrata Das Daniel J. Garry Tino Hochepied Paul Thomas Jan Parker-Thornburg Antony D. Adamson Atsushi Yoshiki Jean-Francois Schmouth Andrei Golovko William R. Thompson K. C. Kent Lloyd Joshua A. Wood Mitra Cowan Tomoji Mashimo Seiya MIZUNO Hao Zhu Petr Kasparek Lucy Liaw Joseph M. Miano Gaetan Burgio

出版者

BMC

雑誌

Genome Biology (ISSN:1474760X)

巻号頁・発行日

vol.20, no.1, 2019-08

---

BackgroundCRISPR-Cas9 gene-editing technology has facilitated the generation of knockout mice, providing an alternative to cumbersome and time-consuming traditional embryonic stem cell-based methods. An earlier study reported up to 16% efficiency in generating conditional knockout (cKO or floxed) alleles by microinjection of 2 single guide RNAs (sgRNA) and 2 single-stranded oligonucleotides as donors (referred herein as "two-donor floxing" method).ResultsWe re-evaluate the two-donor method from a consortium of 20 laboratories across the world. The dataset constitutes 56 genetic loci, 17,887 zygotes, and 1718 live-born mice, of which only 15 (0.87%) mice contain cKO alleles. We subject the dataset to statistical analyses and a machine learning algorithm, which reveals that none of the factors analyzed was predictive for the success of this method. We test some of the newer methods that use one-donor DNA on 18 loci for which the two-donor approach failed to produce cKO alleles. We find that the one-donor methods are 10- to 20-fold more efficient than the two-donor approach.ConclusionWe propose that the two-donor method lacks efficiency because it relies on two simultaneous recombination events in cis, an outcome that is dwarfed by pervasive accompanying undesired editing events. The methods that use one-donor DNA are fairly efficient as they rely on only one recombination event, and the probability of correct insertion of the donor cassette without unanticipated mutational events is much higher. Therefore, one-donor methods offer higher efficiencies for the routine generation of cKO animal models.

著者

阮 毅 Yi RUAN

出版者

創価大学日本語日本文学会

雑誌

日本語日本文学 (ISSN:09171762)

巻号頁・発行日

no.24, pp.29-43, 2014-03-20

---

『金瓶梅』は、明の万暦年間中頃に書かれた長編小説である。正保元年に日本に入り、儒者の間に流行した。優れた漢学素養をもつ森鷗外が、その『金瓶梅』にいかに影響され、また、どのようにそれを作品創作に生かしたのかを考えるのが小論の目的である。三好行雄氏をはじめとする先行研究では、森鷗外の『雁』と『金瓶梅』のかかわりを、西門慶、潘金蓮、武大郎三者の関係を岡田、お玉、末造の関係に見立てているが、そこから一歩踏み込んでの研究はされなかった。果たして、それは「見立て」の関係であるかどうかを考えなければならない。小論は鷗外のその他の作品をふれながら、比較文学見地から、『雁』と『金瓶梅』との関係をより綿密な考察によって、明らかにしていくものである。

著者

Yu-Feng Hu Wen-Han Cheng Yuan Hung Wen-Yu Lin Tze-Fan Chao Jo-Nan Liao Yenn-Jiang Lin Wei-Shiang Lin Yi-Jen Chen Shih-Ann Chen

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-20-0566, (Released:2020-09-09)

参考文献数

64

被引用文献数

17

---

The health crisis due to coronavirus disease 2019 (COVID-19) has shocked the world, with more than 1 million infections and casualties. COVID-19 can present from mild illness to multi-organ involvement, but especially acute respiratory distress syndrome. Cardiac injury and arrhythmias, including atrial fibrillation (AF), are not uncommon in COVID-19. COVID-19 is highly contagious, and therapy against the virus remains premature and largely unknown, which makes the management of AF patients during the pandemic particularly challenging. We describe a possible pathophysiological link between COVID-19 and AF, and therapeutic considerations for AF patients during this pandemic.