著者

Yi Su Yun Ling Yuyan Ma Lili Tao Qing Miao Qingfeng Shi Jue Pan Hongzhou Lu Bijie Hu

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

BioScience Trends (ISSN:18817815)

巻号頁・発行日

pp.2020.03340, (Released:2020-12-18)

参考文献数

22

被引用文献数

4

---

The aim of this study is to assess the efficacy of multiple treatments, especially hydroxychloroquine, used in different disease stages of coronavirus disease 2019 (COVID-19). All consecutive patients with COVID-19 admitted to Shanghai Public Health Clinical Center (Shanghai, China) between January 20, 2020, and April 30, 2020, were enrolled, and their clinical data were retrospectively collected. Binary logistic regression was used to screen the factors associated with disease aggravation, and multivariable analyses with the Cox proportional hazards model were used to estimate the effects of prognostic factors on the improvement time and PCR conversion days in throat swabs and stool swabs. A total of 616 patients, including 50 (8.11%) severe and 18 (2.92%) critical patients, were enrolled in our retrospective cohort study. The early use of hydroxychloroquine was a protective factor associated with disease aggravation (95% CI: 0.040-0.575, p = 0.006). Clinical improvement by 20 days was significantly different between patients with hydroxychloroquine used early and those with hydroxychloroquine not used (p = 0.016, 95% CI: 1.052-1.647). The median time to clinical improvement was 6 days in the hydroxychloroquine used early group, compared with 9 days in the without hydroxychloroquine used group and 8 days in the with hydroxychloroquine not used early group (p < 0.001). Hydroxychloroquine used early was associated with earlier PCR conversion in both throat swabs (HR = 1.558, p = 0.001) and stool swabs (HR = 1.400, p = 0.028). The use of hydroxychloroquine at an early stage is a potential therapeutic strategy for treating patients before irreversible severe respiratory complications occur. The early use of hydroxychloroquine decreased the improvement time and the duration of COVID-19 detection in throat and stool swabs.

著者

Xuejiao Liao Yuan Guan Qibin Liao Zhenghua Ma Liping Zhang Jingke Dong Xiaojuan Lai Guoqin Zheng Sumei Yang Cheng Wang Zhonghui Liao Shuo Song Hongyang Yi Hongzhou Lu

出版者

National Center for Global Health and Medicine

雑誌

Global Health & Medicine (ISSN:24349186)

巻号頁・発行日

vol.4, no.6, pp.322-326, 2022-12-25 (Released:2022-12-26)

参考文献数

19

被引用文献数

8

---

Although Omicron appears to cause less severe acute illness than the original strain, the potential for large numbers of patients to experience long COVID is a major concern. Little is known about the recovery phase in cases of Omicron, highlighting the importance of dynamically monitor long COVID in those patients. Subjects of the current study were patients available for a three-month follow-up who were admitted from January 13 to May 22, 2020 (period of the original strain) and from January 1 to May 30, 2022 (period of Omicron). Twenty-eight-point-four percent of patients infected with the original strain had long-term symptoms of COVID-19 and 5.63% of those infected with the Omicron strain had such symptoms. The most common symptom was a cough (18.5%), followed by tightness in the chest (6.5%), in patients infected with the original strain. Fatigue (2.4%) and dyspnea (1.7%) were the most commonly reported symptoms in patients infected with the Omicron strain. The respiratory system is the primary target of SARSCoV-2. Supportive treatment is the basis for the treatment of respiratory symptoms in patients with COVID-19. Quality sleep and good nutrition may alleviate fatigue and mental issues. Further knowledge about a long-term syndrome due to Omicron needs to be discussed and assembled so that healthcare and workforce planners can rapidly obtain information to appropriately allocate resources.

著者

Chao ZHAO Kun ZHAO Xiaoyan LIU Yi-fan HUANG Bin LIU

出版者

Japanese Society for Food Science and Technology

雑誌

Food Science and Technology Research (ISSN:13446606)

巻号頁・発行日

vol.19, no.4, pp.661-667, 2013 (Released:2013-09-05)

参考文献数

35

被引用文献数

6 10

---

Orthogonal experiment was used to optimize the extraction conditions of Flammulina velutipes mycelia polysaccharides (FvP). Four independent variables (ratio of water to raw material, initial pH value, extracting temperature, and extracting time) were taken into consideration. A yield of FvP of 2.19% was obtained under an optimized condition (ratio of water to material of 50:1, initial pH value of 6.0, extracting temperature of 85°C, and extracting time of 6 h). Subsequently, antioxidative properties of FvP-2 (crude polysaccharides) and FvP-3 (deproteinized polysaccharides) prepared from F. velutipes mycelia were evaluated by monitoring the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical and hydroxyl radical scavenging activity, together with antitumor activity against the human hepatocellular carcinoma BEL-7402 cells. DPPH scavenging rate of 65.85% and hydroxyl radical scavenging rate of 71.24% were obtained at 200 μg/mL of FvP-3. The inhibition rate of BEL-7402 cells was up to 45% at 640 μg/mL of FvP-2. These results suggested that FvP possesses potent antioxidant and antitumor properties. The polysaccharide may be useful as a functional food additive and an antioxidant and antitumor agent.

著者

Tao Fujiwara Junki Ogiso Sousuke Ishii Kei Togo Narumi Nakato Shunsuke Serizawa Yi-Shan Chao Hyoung-Tak Im Atsushi Ebihara Yasuyuki Watano

出版者

The Japanese Society for Plant Systematics

雑誌

Acta Phytotaxonomica et Geobotanica (ISSN:13467565)

巻号頁・発行日

vol.72, no.3, pp.205-226, 2021-10-31 (Released:2021-11-27)

---

Phegopteris decursivepinnata harbors diploid and tetraploid strains, forming a polyploid species complex together with P. koreana. Hybridization and polyploidization in the complex blur species boundaries, making it challenging to apply the proper taxonomic treatment. Ploidy determinations, phylogenetic analyses, and morphological investigations to elucidate the origins of the polyploid species and improve species classification for the P. decursivepinnata species complex are reported. Ploidy determinations and phylogenetic analyses revealed that diploid members of the complex were separated into two groups, a diploid P. decursivepinnata and a group consisting of Thelypteris itoana and a diploid P. koreana. The tetraploid P. decursivepinnata was shown to be an allotetraploid derived from hybridization between the two diploid groups. The samples of P. koreana revealed to be diploid suggested intraspecific cytotypic variation in P. koreana. The diploid P. koreana was genetically and morphologically indistinguishable from the diploid T. itoana. The diploid members of the complex previously treated as P. decursivepinnata are described as a new species, P. taiwaniana; and T. itoana is placed in synonymy under P. koreana.

著者

Zhihui Liu Pingying Qing Yi Zhao Yi Liu Tony N. Marion

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.255, no.2, pp.143-146, 2021 (Released:2021-10-20)

参考文献数

11

被引用文献数

3

---

Antibody deficiency is a type of primary immunodeficiency that often manifests as primary hypogammaglobulinemia, with or without repeated infections. Although primary immunodeficiency appears to be contrary to autoimmunity, they usually occur simultaneously, and the specific pathogenesis remains unknown. We herein describe an adult patient with autoimmune manifestations and recurrent infections. The case was characterized by a sustained decrease in serum immunoglobulin A, accompanied by decreased T lymphocytes, B lymphocytes, monocytes, and platelets in the peripheral blood and the presence of antinuclear and anti-SSA antibodies. Whole-exome sequencing for the patient revealed two spontaneous mutations in GATA2 (c.1084C>T) and STAT5B (c.1924A>C). This case report provides evidence that mutations in the GATA2 and STAT5B genes may be pathogenic in primary immunodeficiency and provides genetic evidence for the possible pathogenesis of primary immunodeficiency with autoimmune symptoms. However, further studies are needed to confirm the causal relationship.

著者

Takafumi Nakano Yi-Te Lai

出版者

The Japanese Society of Systematic Zoology

雑誌

Species Diversity (ISSN:13421670)

巻号頁・発行日

vol.22, no.2, pp.143-150, 2017-11-25 (Released:2017-12-05)

参考文献数

21

被引用文献数

4

---

A quadrannulate leech species, Orobdella meisai sp. nov., from southern Taiwan is described. This new species is characterized by its camouflage coloration, which is unique among the known Orobdella species. Orobdella meisai is the second species of the genus to be described from Taiwan. Phylogenetic analyses using nuclear 18S rRNA, histone H3, mitochondrial cytochrome c oxidase subunit I, tRNACys, tRNAMet, 12S rRNA, tRNAVal, 16S rRNA, tRNALeu and NADH dehydrogenase subunit 1 markers showed that O. meisai and another Taiwanese species, O. ketagalan Nakano and Lai, 2012, formed a supported clade. According to the results of the morphological examination and the phylogenetic position of O. meisai, morphological-phylogenetic relationships of this species and close congeners are briefly discussed.

著者

阮 毅 Yi RUAN

出版者

創価大学日本語日本文学会

雑誌

日本語日本文学 (ISSN:09171762)

巻号頁・発行日

no.23, pp.29-46, 2013-03

---

周知のように、『西遊記』は「四大奇書」の一つである。江戸時代に、『西遊記』は日本に伝来し、以来日本人に親しまれてきた。『西遊記』は荒唐無稽なだけの作品と思われがちだが、実は極めて論理的な全体構造をもっている。それがゆえに、江戸時代以来、歴代の日本人がそれを翻訳し、研究し、解明に努めてきた。この小論は「四大奇書」のほかの三書と異なる『西遊記』を日本に受け入れた当時の事情から着眼し、論じていく。そして今日まで日本の作者がいかに『西遊記』に影響されてきたかを尾崎紅葉、芥川龍之介、中島敦などの作品を通じて考察する。最後に、できるかぎり日本人における『西遊記』研究の全体像を明らかにするものである。

著者

Yamasaki Chisato Murakami Katsuhiko Fujii Yasuyuki Sato Yoshiharu Harada Erimi Takeda Jun-ichi Taniya Takayuki Satake Ryuichi Kikugawa Shingo Shimada Makoto Tanino Motohiko Halligan Brian Shimoyama Mary Twigger Simon Yura Kei Kimura Kouichi Yasuda Tomohiro Nishikawa Tetsuo Akiyama Yutaka Motono Chie Mukai Yuri Shionyu Masafumi Nagasaki Hideki Suwa Makiko Horton Paul Kikuno Reiko Ohara Osamu Lancet Doron Eveno Eric Graudens Esther Imbeaud Sandrine Debily Marie Anne Jia Libin Hayashizaki Yoshihide Amid Clara Han Michael Osanger Andreas Endo Toshinori Thomas Michael A. Hirakawa Mika Makalowski Wojciech Nakao Mitsuteru Kim Nam-Soon Thierry-Mieg Danielle Yoo Hyang-Sook De Souza Sandro J. Bonaldo Maria de Fatima Niimura Yoshihito Kuryshev Vladimir Schupp Ingo Wiemann Stefan Bellgard Matthew Thierry-Mieg Jean Wagner Lukas Zhang Qinghua Go Mitiko Minoshima Shinsei Ohtsubo Masafumi Hanada Kousuke Koyanagi Kanako O. Tonellato Peter Isogai Takao Zhang Ji Lenhard Boris Kim Sangsoo Chen Zhu Hinz Ursula Estreicher Anne Nakai Kenta Makalowska Izabela Barrero Roberto A. Hide Winston Tiffin Nicola Wilming Laurens Chakraborty Ranajit Soares Marcelo Bento Chiusano Maria Luisa Suzuki Yutaka Auffray Charles Yamaguchi-Kabata Yumi Itoh Takeshi Gough Craig Hishiki Teruyoshi Fukuchi Satoshi Nishikawa Ken Sugano Sumio Nomura Nobuo Tateno Yoshio Imanishi Tadashi Gojobori Takashi Chun Hong-Woo Habara Takuya Hanaoka Hideki Hayakawa Yosuke Hilton Philip B. Kaneko Yayoi Kanno Masako Kawahara Yoshihiro Kawamura Toshiyuki Matsuya Akihiro Nagata Naoki Nishikata Kensaku Ogura Noda Akiko Nurimoto Shin Saichi Naomi Sakai Hiroaki Sanbonmatsu Ryoko Shiba Rie Suzuki Mami Takabayashi Kazuhiko Takahashi Aiko Tamura Takuro Tanaka Masayuki Tanaka Susumu Todokoro Fusano Yamaguchi Kaori Yamamoto Naoyuki Okido Toshihisa Mashima Jun Hashizume Aki Jin Lihua Lee Kyung-Bum Lin Yi-Chueh Nozaki Asami Sakai Katsunaga Tada Masahito Miyazaki Satoru Makino Takashi Ohyanagi Hajime Osato Naoki Tanaka Nobuhiko Suzuki Yoshiyuki Ikeo Kazuho Saitou Naruya Sugawara Hideaki O'Donovan Claire Kulikova Tamara Whitfield Eleanor

出版者

Oxford University Press

雑誌

Nucleic Acids Research (ISSN:03051048)

巻号頁・発行日

vol.36, no.1, pp.D793-D799, 2008-01

被引用文献数

12

---

Here we report the new features and improvements in our latest release of the H-Invitational Database (H-InvDB; http://www.h-invitational.jp/), a comprehensive annotation resource for human genes and transcripts. H-InvDB, originally developed as an integrated database of the human transcriptome based on extensive annotation of large sets of full-length cDNA (FLcDNA) clones, now provides annotation for 120 558 human mRNAs extracted from the International Nucleotide Sequence Databases (INSD), in addition to 54 978 human FLcDNAs, in the latest release H-InvDB_4.6. We mapped those human transcripts onto the human genome sequences (NCBI build 36.1) and determined 34 699 human gene clusters, which could define 34 057 (98.1%) protein-coding and 642 (1.9%) non-protein-coding loci; 858 (2.5%) transcribed loci overlapped with predicted pseudogenes. For all these transcripts and genes, we provide comprehensive annotation including gene structures, gene functions, alternative splicing variants, functional non-protein-coding RNAs, functional domains, predicted sub cellular localizations, metabolic pathways, predictions of protein 3D structure, mapping of SNPs and microsatellite repeat motifs, co-localization with orphan diseases, gene expression profiles, orthologous genes, protein–protein interactions (PPI) and annotation for gene families. The current H-InvDB annotation resources consist of two main views: Transcript view and Locus view and eight sub-databases: the DiseaseInfo Viewer, H-ANGEL, the Clustering Viewer, G-integra, the TOPO Viewer, Evola, the PPI view and the Gene family/group.

著者

Yi-Liang Kuo Yueh-Chu Huang

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.25, no.3, pp.287-291, 2013-03-25 (Released:2013-05-10)

参考文献数

22

被引用文献数

11 28

---

[Purpose] The purposes of this study were to investigate the immediate and delayed effects of two directions of Kinesio taping (KT) on maximal isometric strength of the wrist and finger muscles of healthy adults and compare their differences. [Subjects] Nineteen healthy junior college students participated in this study. [Methods] The inhibition and facilitation KT techniques were separately used to tape on the dominant and non-dominant forearms of the participants, respectively. Maximal isometric strength of wrist extension, middle finger extension, and grip of both hands were measured before taping, immediately after taping, and after 24 h of taping (with the tape in situ). [Results] Compared with the baseline, the average maximal isometric strength of middle finger extensors increased considerably after application of the facilitation technique. No significant time effect was observed for measurement of middle finger extension strength on the dominant side or for wrist extension and grip strength on both sides. Significant differences between both taping techniques were observed for wrist and middle finger extension strength immediately after taping, and for middle finger extension after 24 h of taping. [Conclusion] The results suggest that the application direction of KT may have different effects on isometric muscle strength. Future studies involving a larger sample of subjects and a sham condition are warranted to confirm our findings.

著者

Yi Su Yun Ling Yuyan Ma Lili Tao Qing Miao Qingfeng Shi Jue Pan Hongzhou Lu Bijie Hu

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

BioScience Trends (ISSN:18817815)

巻号頁・発行日

vol.14, no.6, pp.408-414, 2020-12-31 (Released:2021-01-23)

参考文献数

22

被引用文献数

3 4

---

The aim of this study is to assess the efficacy of multiple treatments, especially hydroxychloroquine, used in different disease stages of coronavirus disease 2019 (COVID-19). All consecutive patients with COVID-19 admitted to Shanghai Public Health Clinical Center (Shanghai, China) between January 20, 2020, and April 30, 2020, were enrolled, and their clinical data were retrospectively collected. Binary logistic regression was used to screen the factors associated with disease aggravation, and multivariable analyses with the Cox proportional hazards model were used to estimate the effects of prognostic factors on the improvement time and PCR conversion days in throat swabs and stool swabs. A total of 616 patients, including 50 (8.11%) severe and 18 (2.92%) critical patients, were enrolled in our retrospective cohort study. The early use of hydroxychloroquine was a protective factor associated with disease aggravation (95% CI: 0.040-0.575, p = 0.006). Clinical improvement by 20 days was significantly different between patients with hydroxychloroquine used early and those with hydroxychloroquine not used (p = 0.016, 95% CI: 1.052-1.647). The median time to clinical improvement was 6 days in the hydroxychloroquine used early group, compared with 9 days in the without hydroxychloroquine used group and 8 days in the with hydroxychloroquine not used early group (p < 0.001). Hydroxychloroquine used early was associated with earlier PCR conversion in both throat swabs (HR = 1.558, p = 0.001) and stool swabs (HR = 1.400, p = 0.028). The use of hydroxychloroquine at an early stage is a potential therapeutic strategy for treating patients before irreversible severe respiratory complications occur. The early use of hydroxychloroquine decreased the improvement time and the duration of COVID-19 detection in throat and stool swabs.

著者

Akihito Yokoyama Hiroshi Okazaki Naoyuki Makita Ayako Fukui Yi Piao Yoshifumi Arita Yohji Itoh Naoki Tashiro

出版者

Japanese Society of Allergology

雑誌

Allergology International (ISSN:13238930)

巻号頁・発行日

vol.71, no.1, pp.47-54, 2022 (Released:2022-01-27)

参考文献数

18

被引用文献数

7

---

Background: In Japan, regional differences in asthma mortality have been reported; however, regional differences in asthma exacerbations have not been studied extensively. Therefore, using a health insurance claims database, we investigated the regional differences in the incidence of asthma exacerbations in Japan.Methods: This study used data from Medi-Scope (Japan Medical Information Research Institute Inc., Japan)-a nationwide health insurance claims database. Patients with asthma at the index date (the latest date of an asthma-related prescription with an asthma diagnosis before October 1, 2018) were included in the analysis. The pre-index period was defined as 1 year before the index date, and the follow-up period as 1 year after the index date. The incidence of asthma exacerbation events was analyzed for each region.Results: The primary analysis population comprised 24,883 patients who were continuously prescribed ICS or ICS/LABA at least four times during the pre-index period. The incidence rate of asthma exacerbations with hospitalization was the highest in Chugoku (2.95/100 person-years [95% CI, 1.97-4.43]) and the lowest in Kanto (1.52/100 person-years [95% CI, 1.26-1.83]). The incidence rate of asthma exacerbations for the composite outcome of hospitalization, injectable corticosteroid prescription, and oral corticosteroid burst was the highest in Fukui (105.00/100 person-years [95% CI, 64.53-170.85]) and the lowest in Nagasaki (15.69/100 person-years [95% CI, 10.84-22.72]).Conclusions: Regional differences in the incidence of asthma exacerbations as well as their treatments were observed in Japan.

著者

Da HU Li ZHANG Rong JIANG Cuiting LIAO Juanjuan XU Shifang JIANG Yongqiang YANG Ling LIN Jiayi HUANG Yi SHEN Li TANG Longjiang LI

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.67, no.3, pp.145-152, 2021-06-30 (Released:2021-06-30)

参考文献数

33

被引用文献数

9

---

Acetaminophen (N-acetyl-p-aminophenol, APAP) overdose causes hepatotoxicity, even liver failure, and oxidative stress plays pivotal role in its pathogenesis. Nicotinic acid (NA) is one form of vitamin B3, which has been used to treat a series of diseases in clinic for decades. To date, several studies have evidenced that NA has anti-oxidative property. Therefore, NA may have the hepatoprotective potential against APAP-induced toxicity. Here, our aim was to investigate the beneficial effect of NA against hepatotoxicity induced by APAP and its mechanism in vivo. BALB/c mice were intraperitoneally injected with NA (100 mg/kg) 3 times at 24, 12 and 1 h before APAP (600 mg/kg or 400 mg/kg) challenge. The results showed that pretreatment of NA markedly improved the survival rate, alleviated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and mitigated the histopathological injuries compared to APAP-exposed mice. Furthermore, NA significantly elevated the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) content, while reduced malondialdehyde (MDA) level. Finally, the signaling pathway was probed. The western blot revealed that NA up-regulated Sirtuin1 (Sirt1), nuclear factor erythroid 2-related factor 2 (Nrf2) and NAD(P)H quinone dehydrogenase-1 (NQO-1) expression and down-regulated Kelch-like ECH-associated protein 1 (Keap1) level in liver followed APAP exposure, implying Sirt1/Nrf2 axis exerted an essential role in the protective mechanism of NA on APAP toxicity. In brief, pretreatment of NA effectively protects liver against hepatotoxicity due to overdose of APAP through an antioxidant dependent manner modulated by Sirt1/Nrf2 signaling pathway.

著者

藤本 灯 韓 一 高田 智和 Akari FUJIMOTO Yi HAN Tomokazu TAKADA

出版者

国立国語研究所

雑誌

国立国語研究所論集 = NINJAL Research Papers (ISSN:21861358)

巻号頁・発行日

no.21, pp.85-94, 2021-07

---

京都府立大学韓国国立釜慶大学 大学院生国立国語研究所 研究系 言語変化研究領域古代の日本の辞書には,様々な構造を持つものがあり,各辞書の構成や仕様を理解していなければ解読が困難な面があった。また注文から必要な情報を抽出するためには,隈なく目視で捜索する必要があった。順不同に入り組んだ注文の情報から,効率的に目的の情報に到達するためには,注文に存在する要素の属性が,それぞれ可能な限り定義づけられているべきである。本稿では,平安時代の代表的な漢和辞書である『和名類聚抄』を例として,いかにその構造を記述することが可能か,検討し,『和名類聚抄』の内容に適したタグを設計した。There were many kinds of dictionaries in ancient Japan. Therefore, without highly specialized knowledge, it is quite difficult for users to interpret their contents. Furthermore, users have been compelled to seek the necessary information based on visual observation of the dictionaries. To effectively find the required information within a complex description, a strict definition of the contents is required.This paper thus proposes a model for such a structured description and discloses the tagged data by using Wamyō-Ruijushō, a representative dictionary of the Heian Era in Japan.

著者

Yi ZHANG Hisamine KOBAYASHI Kazunori MAWATARI Juichi SATO Gustavo BAJOTTO Yasuyuki KITAURA Yoshiharu SHIMOMURA

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.57, no.1, pp.114-117, 2011 (Released:2011-04-22)

参考文献数

14

被引用文献数

19 28 8

---

The present study was conducted to examine alterations in the concentrations of plasma free amino acids, glucose, insulin, free fatty acids (FFAs), and urea nitrogen induced by branched-chain amino acid (BCAA) supplementation in young men. Overnight-fasted subjects ingested drinks containing 1 or 5 g of a BCAA mixture (weight ratio of 1 : 2.3 : 1.2 for isoleucine : leucine : valine), and blood was intermittently collected for 3 h after ingestion. Ingestion of the BCAA mixture resulted in significant increases in the plasma concentrations of individual BCAAs, corresponding to the amounts of amino acids ingested. On the other hand, plasma concentrations of methionine and aromatic amino acids tended to decrease in the trial with 5 g BCAAs, suggesting that BCAA ingestion affects the metabolism of these amino acids. The ingestion of BCAAs temporarily increased plasma insulin levels and affected plasma concentrations of FFAs, but had almost no effect on glucose or urea nitrogen.

著者

WANG Chung-Chieh LIN Kuan-Yu DAVIS Christopher A. HUANG Shin-Yi LIU Stefano Chih-Shin TSUBOKI Kazuhisa JOU Ben Jong-Dao

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2020-036, (Released:2020-04-20)

被引用文献数

2

---

In this study, the impacts of Typhoon Morakot (2009)'s vortex structure on the extreme rainfall in Taiwan are investigated through an application of piecewise potential vorticity (PV) inversion. The control (CTL) experiment, starting at 0000 UTC 7 August or 15 h before landfall, reproduces the event realistically and is validated against the observations. By altering the PV perturbation inside 750 km from its center, we conduct sensitivity experiments in which the size and/or circulation strength of Morakot is reduced/weakened in the initial field in several different ways.  In the sensitivity tests, particularly those where the initial PV within the inner core (≤ 250 km) is significantly weakened, the storm makes landfall earlier, stays over land longer, and exits Taiwan later. Such track changes are accompanied by a contraction and spin-up of the inner core at early stages of the integration, caused by convection/latent heating within the inner core under large-scale low-level southwesterly flow. As a result, Taiwan receives an overall rainfall amount either comparable to, or even more than (up to +12 %), CTL in all tests. Thus, a weaker Morakot does not necessarily lead to less total rainfall over Taiwan, and the strong southwesterly flow and its moisture supply were bigger factors than the vortex structure in this event.   On the other hand, the rainfall in the southern Central Mountain Range on 8 August, which were the most-rainy area and period in reality, tended to decrease by up to 40 % with the contraction and a weaker outer circulation. Thus, the rainfall patterns and evolution in the sensitivity tests are considerably different than those in CTL, indicating that the vortex structure plays an important role in the rainfall of this region.

著者

Hyo Jin Kang Young Bin Hong Yong Weon Yi Chi-Heum Cho Antai Wang Insoo Bae

出版者

日本毒性学会

雑誌

The Journal of Toxicological Sciences (ISSN:03881350)

巻号頁・発行日

vol.38, no.3, pp.355-361, 2013-06-01 (Released:2013-05-11)

参考文献数

29

被引用文献数

6 11

---

The risk factors for breast cancer, the most common female malignant cancer, include environmental factors such as radiation, tobacco, a high-fat diet, and xenoestrogens as well as hormones. In addition, BRCA1 and BRCA2 are the most well-known genetic factors that increase risk for breast cancer. Coincidence of those environmental and genetic factors might augment the risk of tumorigenesis of breast. To verify this hypothesis, we briefly evaluated the carcinogenic potency of various environmental factors in the absence or presence of BRCA1 as a genetic factor in a normal mammary epithelial cell line, MCF10A. Many environmental factors tested increased cellular ROS level in the absence of other insult. In addition, TCDD, DMBA, 3MC, and BPA enhanced the BaP-induced ROS production. BRCA1 knockdown (BRCA1-KD) cells by siRNA significantly induced cellular accumulation of ROS compared to control cells. In this setting, the addition of paraquat, TCDD, DMBA, 2OHE2 or 4OHE2 significantly augmented ROS generation in BRCA1-KD MCF10A cells. Measurements of BaP-DNA adduct formation as a marker of DNA damage also revealed that BRCA1 deficiency leads increased DNA damage. In addition, TCDD and DMBA significantly increased BaP-DNA adduct formation in the absence of BRCA1. These results imply that elevated level of ROS is correlated with increase of DNA damage in BRCA1 defective cells. Taken together, our study suggests that several environmental factors might increase the risk of tumorigenesis in BRCA1 defective breast epithelial cells.

著者

Shang-Ju Wu Li-Wei Lo Fa-Po Chung Yenn-Jiang Lin Shih-Lin Chang Yu-Feng Hu Yu-Cheng Hsieh Cheng-Hung Li Ta-Chuan Tuan Tze-Fan Chao Jo-Nan Liao Chin-Yu Lin Ting-Yung Chang Ling Kuo Chih-Min Liu Shin-Huei Liu Cheng-I Wu Chi-Jen Weng Ming-Jen Kuo Guan-Yi Li Yu-Shan Huang Jose Antonio Bautista Yoon-Kee Siow Nguyen Dinh Son Ngoc Shih-Ann Chen

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0364, (Released:2023-10-20)

参考文献数

25

---

Background: Circumferential pulmonary vein isolation (CPVI) has supplanted segmental PVI (SPVI) as standard procedure for atrial fibrillation (AF). However, there is limited evidence examining the efficacy of these strategies in redo ablations. In this study, we investigated the difference in recurrence rates between SPVI and CPVI in redo ablations for PV reconnection.Methods and Results: This study retrospectively enrolled 543 patients who had undergone AF ablation between 2015 and 2017. Among them, 167 patients (30.8%, including 128 male patients and 100 patients with paroxysmal AF) underwent redo ablation for recurrent AF. Excluding 26 patients without PV reconnection, 141 patients [90 patients of SPVI (Group 1) and 51 patients of CPVI (Group 2)] were included. The AF-free survival rates were 53.3% and 56.9% in Group 1 and Group 2, respectively (P=0.700). The atrial flutter (AFL)-free survival rates were 90% and 100% in Group 1 and Group 2, respectively (P=0.036). The ablation time was similar between groups, and there no major complications were observed.Conclusions: For redo AF ablation procedures, SPVI and CPVI showed similar outcomes, except for a higher AFL recurrence rate for SPVI after long-term follow-up (>2 years). This may be due to a higher probability of residual PV gaps causing reentrant AFL.

著者

Liang Fu Yong Feng Tantan Ren Min Yang Qianting Yang Yi Lin Hui Zeng Jiaohong Zhang Lei Liu Qingyun Li Mengqi He Peize Zhang Haibin Chen Guofang Deng

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

BioScience Trends (ISSN:18817815)

巻号頁・発行日

pp.2022.01476, (Released:2023-01-02)

参考文献数

19

被引用文献数

2

---

Mycobacterium tuberculosis (M.tb) infects a quarter of the world's population and may progress to active tuberculosis (ATB). There is no gold standard for diagnosing latent tuberculosis infection (LTBI). Some immunodiagnostic tests are recommended to detect LTBI but can not distinguish ATB from LTBI. The breath test is useful for diagnosing ATB compared to healthy subjects but was never studied for LTBI. This proof-of-concept study (Chinese Clinical Trials Registry number: ChiCTR2200058346) was the first to explore a novel, rapid, and simple LTBI detection method via breath test on high-pressure photon ionization time-of-flight mass spectrometry (HPPI-TOFMS). The case group of LTBI subjects (n = 185) and the control group (n = 250), which included ATB subgroup (n = 121) and healthy control (HC) subgroup (n = 129), were enrolled. The LTBI detection model indicated that a breath test via HPPI-TOFMS could distinguish LTBI from the control with a sensitivity of 80.0% (95% CI: 67.6%, 92.4%) and a specificity of 80.8% (95% CI: 71.8%, 89.9%). Nevertheless, further intensive studies with a larger sample size are required for clinical application.

著者

CHANG Yang-Yi

出版者

The Association of Japanese Geographers

雑誌

Geographical review of Japan series B (ISSN:18834396)

巻号頁・発行日

vol.95, no.1, pp.21-36, 2022-06-30 (Released:2022-07-27)

参考文献数

16

被引用文献数

4

---

This study analyzed the spatial distribution of population and housing in Daejeon Metropolitan City, a regional central city in South Korea, from the perspective of diversity. The diversity index of each administrative Dong is calculated using the population census variables of age, household, and housing type in 2010 and 2015. Variables affecting diversity changes are the increase in the number of people aged 55 or older, the increase in single-person households, and the increase in condominium dwellings. Based on extracted variables, specific population- and housing type- areas of concentration are identified: aged 55 or older, single-person households, detached houses; and age group of 35–44, couples with children, condominium dwellings. The spatial distribution shows that aged 55 or older, single-person households and detached house concentrations are found in the eastern part of the city, mainly the old city area. In contrast, 35–44 years old, couples and children, and condominium concentration districts are found in the western part where the development of condominium complexes occurred. In Daejeon, an elderly population concentration area exists, which is predicted to expand further as the elderly population increases. Since condominium construction serves as a pull factor for 35–44 years old and couples with children, condominium-centered housing construction in old city areas can increase the possibility of preserving age and household diversity.

著者

WU Ying-Jhang LIOU Yu-Chieng LO Yi-Chuan TAI Sheng-Lun CHANG Shao-Fan SUN Juanzhen

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2021-049, (Released:2021-04-20)

被引用文献数

1

---

The evolution of a heavy rainfall event occurred on 19 August 2014 in northern Taiwan is investigated with observed data and analyses from a newly-developed system named IBM_VDRAS, which is based on a four-dimensional Variational Doppler Radar Assimilation System (VDRAS) with the capability to assimilate radar observations and surface station data over a complex terrain by adopting the Immersed Boundary Method (IBM). This event possesses different precipitating processes and track from those frequently observed in that region. From the surface observations and the high spatiotemporal resolution analysis fields generated by IBM_VDRAS, it is found that the rainfall process started with the initiation of two individual convective cells triggered through the interaction between land-sea breeze and terrain in two different cities (Taoyuan and Taipei). The outflow of one of the convective cells developed in Taoyuan City at an earlier time merged with another convective system which grew in Taipei Basin, and provided favorable conditions to intensify the latter. The enhanced major convective cell moved into the Taipei City metropolitan area and produced 80 mm of precipitation within approximately 2.5 h. The kinematic, thermodynamic, and microphysical fields of the convective cells are analyzed in details to explain the mechanisms which helped to maintain the structure of the rainfall system. Sensitivity experiments of quantitative precipitation forecast (QPF) show that the terrains prevent the location of major rainfall from shifting outside of Taipei Basin. By assimilating surface data, the model can better predict the position of the rainfall.