著者

福島 紀子

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.136, no.7, pp.993-999, 2016 (Released:2016-07-01)

参考文献数

35

被引用文献数

1

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Among private Universities of Pharmacy in Japan, Kyoritsu University of Pharmacy was the first to introduce courses in social pharmacy in 1991. Social pharmacy is a discipline driven by social needs. By studying the relationship between pharmacy and society, particularly through case studies, the impact of drugs and changes in societal expectation of them, as well as through historical background studies and surveys of current trends, this discipline acts to determine the roles of pharmacists and pharmacies expected by society. Social pharmacy requires a basic knowledge of pharmaceutical science, but an understanding from economic viewpoints of the current systems and structures in which healthcare functions is important as well. Once these are understood, the goal is to identify social problems, and to create and apply models for their resolution which connect pharmacy and society. So far, social pharmacy has played an important role in training programs for community-based pharmacists essential for a hyper-aged society, for community pharmacies' health management programs aimed at promoting the health of residents, and educational programs for elementary and middle school children.

著者

山本 哲也 長谷川 香子 小野田 誠 田中 啓一

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.136, no.6, pp.905-911, 2016 (Released:2016-06-01)

参考文献数

13

被引用文献数

1 7

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Iguratimod (IGU), a disease-modifying antirheumatic drug launched in September 2012, has been reported to carry a risk of severe hemorrhages through a suspected interaction with warfarin (WF) in the all-case surveillance and early postmarketing-phase vigilance. To elucidate possible mechanisms of adverse interaction between IGU and WF, we analyzed the effects of IGU on the pharmacodynamics and pharmacokinetics of WF in rats. IGU was orally administered to male Wistar rats once daily for 5 d at 10 or 30 mg/kg in combination with WF at an oral dose of 0.25 mg/kg. Coadministration of IGU 30 mg/kg enhanced the anticoagulant activity of WF; prolonged blood coagulation time (prothrombin time and activated partial thromboplastin time) and decreased levels of vitamin K (VK)-dependent blood coagulation factors (II, VII, IX, and X) were observed. On the other hand, the pharmacokinetic parameters of WF including maximum plasma concentration (Cmax) and area under the plasma concentration-time curve from 0 to 24 h (AUC0-24 h) were not affected by the combination with IGU. IGU alone did not change blood coagulation time at doses up to 100 mg/kg, while VK-dependent blood coagulation factors decreased slightly at 30 and 100 mg/kg. These results suggest that the pharmacodynamic effect of IGU on VK-dependent blood coagulation factors is involved in the mechanism of drug-drug interaction of IGU with WF.

著者

古川 綾 浅田 美子 森 貴幸 井上 岳 厚田 幸一郎

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.136, no.2, pp.251-258, 2016 (Released:2016-02-01)

参考文献数

12

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The Asheville Project® began in 1996 in Asheville, North Carolina, where community pharmacists, in collaboration with physicians, provide health coaching to patients with lifestyle diseases to accomplish their improved self-management of the disease. The project has now widely expanded across the United States. With periodical coaching by pharmacists, according to the reports of these programs, patients have been reported to show improvements in self-management and laboratory data, including the number of doctor visits, medication adherence and the number of foot examinations. Economically, the total medical costs for this disease have decreased 34% over a 5-year period by complying with the Asheville Project. In implementing this model in Japan, various questions, such as the feasibility for busy pharmacists to expend 30-60 min for meeting individually with patients, effective collaboration between pharmacy and physician, patients' acceptance of support by pharmacists to modify their behavior, etc. had to be answered. Thus, we developed a program entitled, “A Health Coaching Program by Community Pharmacists in a Collaborative Practice,” aimed at preventing the aggravation of lifestyle diseases; we evaluated its feasibility for the above mentioned concerns. The content of this coaching program has been prepared with reference to the Asheville Project® and with the support of Kitasato University School of Pharmacy and the Iowa Pharmacy Association, USA. We herein introduce this coaching program, as well as what the pharmacists have learned through this program.

著者

近藤 あゆみ

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.136, no.1, pp.89-94, 2016 (Released:2016-01-01)

参考文献数

18

被引用文献数

1

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The increasing number of law-evading drug users in Japan is becoming a serious social problem. Previous studies have shown that law-evading drug users are younger, more educated, and less antisocial than methamphetamine users. They also tend to have some type of psychiatric disorder before starting drug use; therefore one of the reasons that they start using drugs may be to alleviate certain psychiatric symptoms. Furthermore, if drug users are successful in avoiding arrest, they often lack the motivation to stop, which makes treatment difficult. Therapists are required to be non-confrontational, to keep pace with their patients, and to take their patients' other existing disorders into account. Recently, the Matrix Model has shown promise as a new treatment strategy for drug abusers in Japan. The Matrix Model, which was originally developed in response to the 1980s cocaine epidemic in the USA, is an intensive outpatient treatment approach for drug abuse and dependence. The Matrix Model integrates cognitive-behavioral therapy, contingency management, motivational interviewing, 12-step facilitation, family involvement, and so on, with a directive, non-confrontational approach, and this style of therapy seems to fit with law-evading drug users. A Matrix Model-based treatment program was first established in Japan in 2006. The aim of this report is to introduce and assess the benefits of the TAMA Mental Health and Welfare Center Relapse Prevention Program, a Matrix Model-based treatment program established at the Tama Mental Health and Welfare Center in 2007.

著者

石川 岳志

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.136, no.1, pp.121-130, 2016 (Released:2016-01-01)

参考文献数

42

被引用文献数

1

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Recently, ab initio quantum mechanical calculations have been applied to large molecules, including biomolecular systems. The fragment molecular orbital (FMO) method is one of the most efficient approaches for the quantum mechanical investigation of such molecules. In the FMO method, dividing a target molecule into small fragments reduces computational effort. The clear definition of inter-fragment interaction energy (IFIE) as an expression of total energy is another valuable feature of the FMO method because it provides the ability to analyze interactions in biomolecules. Thus, the FMO method is expected to be useful for drug discovery. This study demonstrates applications of the FMO method related to drug discovery. First, IFIE, according to FMO calculations, was used in the optimization of drug candidates for the development of anti-prion compounds. The second example involved interaction analysis of the human immunodeficiency virus type 1 (HIV-1) protease and a drug compound that used a novel analytical method for dispersion interaction, i.e., fragment interaction analysis based on LMP2 (FILM).

著者

春木 祐人 萩谷 英大 佐久間 晶子 春木 麻衣 岡 泰江 杉山 哲大 川上 恭弘 近藤 祥代

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.135, no.8, pp.987-990, 2015 (Released:2015-08-01)

参考文献数

10

被引用文献数

1

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Intravenous azithromycin (AZM) was approved for use in December 2011 in Japan. In general, intravenous AZM injections are diluted to 1 mg/mL, with a total infusion volume of 500 mL to avoid phlebitis. Patients in intensive care units (ICUs) require small infusion volumes. We retrospectively evaluated the total AZM infusion volume in 65 ICU patients receiving AZM treatment from December 2011 to August 2014. Thirteen patients (20.0%) received a reduced volume [100 mL (5 mg/mL) or 250 mL (2 mg/mL)] using an infusion pump over 2 h. No peripheral phlebitis was observed in any patient. Based on this result, it is assumed that AZM can be safely administered to ICU patients even though the volume of solvent is reduced. AZM is widely recommended for the treatment of community-acquired respiratory infections and is used in patients with severe infections. Further investigation is required in additional patients to understand the effects of AZM volume reduction in greater detail.

著者

大谷 壽一 今岡 鮎子 秋好 健志

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.135, no.3, pp.529-534, 2015 (Released:2015-03-01)

参考文献数

5

被引用文献数

6

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In Japan, it is illegal to sell pharmaceuticals on Internet auction sites, although a considerable number of pharmaceuticals are listed on such sites. We investigated the current situation regarding the illegal trade in pharmaceuticals on Japanese Internet auction sites and the responses of site administrators to such transactions. We searched for pharmaceuticals and “gray” items that were suspected of being pharmaceuticals on Yahoo-oku! (Yahoo! Auctions, Japan) over a 37-day period and then submitted violation reports indicating that selling pharmaceuticals is illegal or that the description of an item was insufficient. The reports were directed to the site administrators and forwarded to the sellers. One hundred and six pharmaceutical products and 34 gray items were identified during the study period. After the submission of the violation reports, only 28 of the pharmaceutical products and one of the gray items were deleted by the administrator, while 18 of the pharmaceutical products and 7 of the gray items were withdrawn by their sellers. However, 41 pharmaceuticals and 20 gray items were sold. Most of the gray items were listed using characteristic terms or abbreviations without photographic images. More than 70% of the identified pharmaceuticals had a contraindication(s) other than hypersensitivity. In conclusion, the illegal trade in pharmaceuticals on Internet auction sites remains a serious problem in Japan, and the responses of site administrators to such transactions are inadequate. The government and pharmaceutical industry may have to take measures such as providing public and administrative guidance to stop the illegal trade in pharmaceuticals on the Internet.

著者

青山 道夫

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.134, no.2, pp.149-154, 2014 (Released:2014-02-01)

参考文献数

17

被引用文献数

1

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Before the Fukushima Nuclear Power Plant 1 (FNPP1) accident, environmental 137Cs was already detectable originating from nuclear weapon tests conducted in the late 1950s and early 1960s. In the western North Pacific Ocean, 90Sr and 137Cs activities in surface water were 10-100 Bqm−3 in the late 1950s and early 1960s, then this parameter decreased gradually; 137Cs activity in surface water subsequently decreased to around a few Bq m−3. After the FNPP1 accident, 137Cs and 134Cs were released into the North Pacific Ocean by two pathways, direct discharge from the Fukushima NPP1 accident site and atmospheric deposition off Honshu Islands of Japan, east and northeast of the site. High-density observations of 137Cs and 134Cs in the surface water were carried out by 17 VOS cruises and several research vessel cruises between April 2011 and March 2012. The main body of radioactive surface plume of which activity exceeded 10 Bqm−3 traveled along 40°N, and reached the International Date Line in March 2012, 1 year after the accident. The radioactive plume was confined along 40°N when the plume reached the International Date Line. Zonal speed of the radioactive plume was estimated to be about 8 cm s−1, which is consistent with zonal speeds derived by Argo floats at the region.

著者

望月 眞弓

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.133, no.12, pp.1315-1318, 2013 (Released:2013-12-01)

参考文献数

4

被引用文献数

1

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Teaching the three health principles and proper use of medicines are the basis of education on medicines. Before seeking prescription drugs, day-to-day health management is important. It is also important to understand that if a minor ailment persists, self-treatment with over-the-counter medications should be attempted. Since medications are double-edged swords, their proper use is the responsibility of patients to minimize the risk and maximize the effectiveness. This awareness should be taught during education on how to use medicines. A better understanding of medicines and fostering awareness through education on medicines will contribute to reductions in healthcare costs and promote the health of patients when they participate in their own care and learn how to self-medicate.

著者

栗本 蕗 堀 里子 佐藤 宏樹 三木 晶子 澤田 康文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.133, no.9, pp.1023-1034, 2013 (Released:2013-09-01)

参考文献数

22

被引用文献数

1

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For drug fostering and evolution, it is important to collect information directly from patients on the efficacy and safety of drugs as well as patient needs. At present, however, information gathered by healthcare professionals, pharmaceutical companies, or governments is not sufficient. There is concern that patients may fail to recognize the importance of providing information voluntarily. The present study was conducted to provide drug information to patients/consumers, to enlighten them on the importance of providing drug information by themselves, and to develop an Internet website, called “Minkusu,” for collecting drug information from patients. This website is based on a registration system (free of charge). It is designed to provide information on proper drug use, and to collect opinions about drugs. As of May 31, 2012, a total of 1149 people had been registered. The male/female ratio of registered members was approximately 1:1, and patients/consumers accounted for 23%. According to the results of a questionnaire survey, several patient/consumer members appreciated the usefulness of the information service, and they took an opportunity to know of the concepts of drug development and evolution (Ikuyaku, in Japanese) through the information services provided by this site. In conclusion, the developed information system would contribute to the proper use of drugs by patients/consumers and to the promotion of drug development and evolution.

著者

平山 匡彦 田中 秀和 鈴木 慎太郎 井上 広平 永富 亜紀 作元 誠司 北原 敏弘 宮﨑 長一郎 吉谷 清光 佐藤 宏樹 堀 里子 三木 晶子 澤田 康文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.133, no.8, pp.913-922, 2013 (Released:2013-08-01)

参考文献数

2

被引用文献数

1

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This study was conducted among 252 inhabitants aged 16 years or older of small remote islands in Gotoh. The survey was conducted in a direct interview format based on a questionnaire. In the interview, the respondents were asked about the statuses of their Internet usage, purchase/use/storage of nonprescription drugs, acquisition of information regarding nonprescription drugs, as well as regulations pertaining to the sale of nonprescription drugs, including the use of postal services. Among the respondents, 7.5% were Internet users, whereas people who had past experiences in purchasing nonprescription drugs through Internet accounted for as few as 0.8% of the total number of respondents; 63.9% of the inhabitants of small remote islands did not use nonprescription drugs, additionally, most inhabitants of small remote islands did not express any need for nonprescription drugs sold through Internet. Further, the findings suggested that a large number of people felt the need for the presence of pharmacists and experts to provide them with explanations and information regarding nonprescription drugs. However, because a large number of these people were unaware of the existence of pharmacists, it is important that in the future, pharmacists should conduct “consultation meetings and briefings regarding medications.” These meeting may be held in a continuous manner in these small remote islands, such that the inhabitants recognize the difference in a pharmacists' profession. It is essential that “family pharmacies/pharmacists” play a central role in promoting the supply, management, and proper use of pharmaceutical products.

著者

笠師 久美子

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.129, no.12, pp.1475-1481, 2009 (Released:2009-12-01)

参考文献数

8

被引用文献数

2 5

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In recent years, appropriate medication and guarantees of safety are being sought not only by medical circles but also by the world of sport. Under normal circumstances, sport should be wholesome in both mind and body, but “doping” by the misuse and abuse of drugs and such is developing into a social issue. This is not just a result of the deliberate behavior of a certain number of people; many cases include use due to a lack of knowledge of drugs and doping, although eventually the sanctions received are the same. Doping tends to be perceived as the problem of just a section of elite athletes, but since the introduction of doping control at the National Athletic Meet 2003, anti-doping measures continue to be a problem close at hand. In 2004, the World Anti-Doping Code came into effect and subsequently not just the world of sport but various national governments became deeply involved with anti-doping. Anti-doping guidelines in Japan were formulated by the Ministry of Education, Culture, Sports, Science and Technology in 2007, stipulating that doctors and pharmacists should be proactive in anti-doping activities. With the aim of eradicating doping, it was deemed that pharmacists can intervene by providing support regarding such issues as drug enlightenment, consultation; the supply of drug information; database production; and therapeutic use exemption. It can be considered that pharmacists can sufficiently use their knowledge and experience gained in these fields, and that such knowledge could lead to more appropriate drug use in sport.

著者

原田 慎一 藤田(濱邊) 和歌子 神谷 浩平 佐武 紀子 徳山 尚吾

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.130, no.5, pp.707-712, 2010-05-01 (Released:2010-05-01)

被引用文献数

2 3

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本総説は、“Biological and Pharmaceutical Bulletin” 誌に掲載された後、取り下げとなった内容と同一か、密接に関連する図表やデータを含んでいることから、編集委員会は本総説を撤回することに決定しました。The Editorial Committee of the Pharmaceutical Society of Japan (February 18, 2020)

著者

月岡 耕太郎 岡崎 朋彦

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.60, no.1, pp.41-45, 2024 (Released:2024-01-01)

参考文献数

25

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自閉スペクトラム症(ASD)は、社会性やコミュニケーションの障害、強いこだわりなどを示す脳機能障害であり、その発症率は近年増加の一途を辿っている。発症原因の約半数は遺伝要因では無く環境要因に起因すると考えられており、特に妊娠中の病原体感染によって引き起こされる母体免疫活性化(MIA)がASD発症のリスクを増加させる可能性が疫学及び動物実験により示されている。本項ではMIAによるASD発症メカニズムについて最近の知見を紹介する。

著者

酒井 弘憲

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.52, no.2, pp.164-165, 2016 (Released:2016-02-23)

参考文献数

1

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生物学や遺伝学の世界に統計学を持ち込んだのは,進化論で著名なチャールズ・ダーウィンの従弟,フランシス・ゴルトンである.ゴルトンは,気象図の等圧線を考案し,気圧という概念を発見したり,指紋による個人の識別をスコットランドヤードに提唱したりするなど,幅広い知識人でもあった.コナン・ドイルも,いち早くその意義を認め,「ノーウッドの建築業者」(作品集:ホームズの帰還)で,ホームズにも指紋による個人鑑別について語らせていることはよくご承知のことであろう.

著者

杉浦 隆之

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.39, no.11, pp.1077-1081, 2003-11-01 (Released:2018-08-26)

参考文献数

13

著者

豊田 勤治

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.1, no.7, pp.273-275, 1965-07-15 (Released:2018-08-26)

著者

石黒 智恵子

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.58, no.8, pp.772-776, 2022 (Released:2022-08-01)

参考文献数

19

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COVID-19ワクチンは、これまでのワクチン開発に比べると非常に短期間で開発・承認され、世界中で接種が開始された。その開発スピードに合わせるかのように、承認後ワクチンの安全性・有効性に関する新しい知見について、既存のデータベースを活用した疫学研究が一流雑誌の紙面を賑わしている。本稿は世界各国のCOVID-19ワクチンの有効性や安全性に関する疫学研究を事例に、最近のワクチン疫学の動向を紹介する。

著者

牧野 利明

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.57, no.2, pp.109-113, 2021 (Released:2021-02-01)

参考文献数

6

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ブシは、トリカブト属植物の根を加熱等により減毒化した生薬であり、鎮痛の効能をもつ。ブシの漢方医学での薬能である散寒止痛から、オキサリプラチンの副作用、冷痛覚過敏に対する作用を検討し、その有効成分としてネオリンを同定した。ブシおよびネオリンは、パクリタキセルまたは坐骨神経結紮によるマウス神経障害性疼痛モデルでも有効であった。ネオリンは加熱により分解せず、減毒化してもブシが鎮痛薬として有用な背景を明らかに出来た。

著者

北島 智也

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.58, no.1, pp.24-28, 2022 (Released:2022-01-01)

参考文献数

16

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卵子の染色体数異常は、卵母細胞の減数分裂における染色体分配エラーによってもたらされ、不妊、流産、ダウン症などの先天性疾患の原因となる。重要なことに、このエラーの頻度は加齢とともに上昇する。本稿では、マウス卵母細胞およびヒト卵母細胞を用いた研究から得られた知見を紹介しながら、染色体分配エラーの原因を細胞生物学的な視点から考察する。