著者

上釜 兼人

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.101, no.10, pp.857-873, 1981-10-25

被引用文献数

11

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Cyclodextrins are homologous series of cyclic oligosaccharides consisting of glucose units joined by α-1,4 linkages. One of the important characteristics of cyclodextrins is the formation of inclusion complexes with various guest molecules in solid phase and in solution, in which the guest molecules are included in the relatively hydrophobic cavity of cyclodextrins. The present review is mainly concerned with the possible utilities of cyclodextrins in pharmaceutical fields. A number of examples such as improvements of solubility, chemical stability, bioavailability, etc. are presented. These informations will provide a rational basis for design of formulation and a means for improving efficacy of drug activity.

著者

鹿野 美弘 縦 青 小松 健一

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.111, no.1, pp.32-35, 1991-01-25

被引用文献数

1

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A crude drug, Evodia fruit (goshuyu) was processed to detoxicate and reduce the bitter taste. Following the procedure described in Shokanron (傷寒論), Evodia fruit was washed in hot water, and then dried. The alkaloid contents of processed Evodia fruit was analyzed by high performance liquid chromatography. The result shows that the content of hydroxyevodiamine decreased to 0.55 times, while the content of rutaecarpine and evodiamine hardly change in the final processed material. However, evocarpine content increased to 1.3 times comparing with the untreated Evodia fruit. The phenomena was ascribed to the flowing-out of the water-soluble portion, and also the weight of extract and the intense of bitterness in the processed fruit were reduced to about 1/3 times.

著者

小菅 卓夫 横田 正実 長沢 道男

出版者

公益社団法人日本薬学会

雑誌

薬学雑誌 (ISSN:00316903)

巻号頁・発行日

vol.98, no.10, pp.p1370-1375, 1978-10

被引用文献数

3

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Aconite root (Bushi in Japanese) from Aconitum japonicum THUMB. has long been used as one of the most important herbs as a heart stimulant, diuretic agent ; and anodyne in Chinese medichine. Isolation and identification of the cardiac principle predicted by Yakazu are described. In the isolation process, the Yagi-Hartung method using frog heart was found to be useful for pharmacological measurement of cardiac activity of the material. The material was water soluble and was fairly unstable, especilly in a basic medium, and was tightly adsorbed on charcoal, alumina, silica gel, and cellulose powder, indicating that these agents are not useful for the separation. Isolation of the material was finally achieved by the limited combination of gel filtration through Sephadex LH-20 and counter current distribution, and colorless plates, mp 260°, were obtained as HCl salt. This principle stimulates frog heart even 1 : 10^<-9> dilution, and it was designated as Higenamine. Higenamine was identified as dl-demethylcoclaurine (II) from the spectral data and by comparison with synthesized authentic sample.

著者

坂井 進一郎 高山 広光 岡本 敏彦

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.99, no.6, pp.647-656, 1979-06-25

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Reinvestigation of the alkaloidal constituents of Aconitum japonicum THUNB. of Mt. Takao (Tokyo) was made. In addition to the reported constituents, i.e. isohypognavine, delcosine and dehydrodelcosine, two known compounds, isotalatizidine and condelphine, were isolated. Furthermore, five new bases, i.e. 11-acetylisohypognavine, diacetylisohypognavine, 14-acetyltalatizamine, takaosamine and takaonine, were isolated and their structures were elucidated. Takaosamine was proved to be 18-O-demethyldelcosine from the spectroscopic study on the parent material and the acetyl derivatives, and from the chemical correlation with known diterpene alkaloids, gigactonine and delsoline. The structure of takaonine was deduced to be 2,3-dehydro-14-dehydrodelcosine on the basis of ^<13>C-nuclear magnetic resonance spectral evidence and the derivation to the known diterpene alkaloid, delcosine, by catalytic hydrogenation.

著者

植木 昭和

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.103, no.9, pp.909-921, 1983-09-25

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Characteristics of aggressive behavior induced in rats by olfactory bulbectomy, midbrain raphe lesions, nucleus accumbens septi lesions and an administration of Δ^9-tetrahydrocannabinol were compared and the effects of various drugs were investigated in details. Defensive aggression of these rats was readily inhibited by neuroleptics and antianxiety drugs, while muricide (mouse-killing behavior) was selectively suppressed by antidepressants, indicating that muricide of the rat would be a good animal model for depressive illness. It was also clarified that the neural mechanism for inducing muricide and the response to antidepressants differed each other depending upon the method of muricide induction. It is suggested that these various types of muricide are useful in evaluating the mechanisms of action of antidepressants.

著者

Sasaki Hideki Akiyama Hiroshi Yoshida Yoshifumi KONDO Kazunari AMAKURA Yoshiaki KASAHARA Yoshimasa MAITANI Tamio

出版者

公益社団法人日本薬学会

雑誌

Biological & pharmaceutical bulletin (ISSN:09186158)

巻号頁・発行日

vol.29, no.12, pp.2514-2518, 2006-12-01

被引用文献数

4 20

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In autumn 2004, many Japanese patients with renal failure developed cryptogenic encephalopathy by consuming sugihiratake mushroom, a Japanese delicacy. To elucidate the relationship between the cryptogenic cases and this mushroom, we conducted a multivariate analysis of metabolites in 'Probably Toxic' sugihiratake collected from the area of encephalopathy outbreaks, and 'Probably Safe' sugihiratake collected from unaffected areas using UPLC/ToF MS. The results indicate that the presence of milligram quantities of vitamin D-like compounds per 10g of dried sugihiratake from the areas of encephalopathy outbreaks. Two hypotheses to induce the encephalopathy are proposed: the found metabolites are (1) vitamin D agonists, which induce acute and severe hypercalcemia and/or hyperammonemia and/or vitamin D toxicity, or (2) vitamin D antagonists, which induce acute and severe hypocalcemia.

著者

Morito Keiko Hirose Toshiharu Kinjo Junei HIRAKAWA Tomoki OKAWA Masafumi NOHARA Toshihiro OGAWA Sumito INOUE Satoshi MURAMATSU Masami MASAMUNE Yukito

出版者

公益社団法人日本薬学会

雑誌

Biological & pharmaceutical bulletin (ISSN:09186158)

巻号頁・発行日

vol.24, no.4, pp.351-356, 2001-04-01

被引用文献数

26 473

---

The human estrogen receptor(hER) exists as two subtypes, hER α and hER β, that differ in the C-terminal ligand-binding domain and in the N-terminal transactivation domain. In this study, we investigated the estrogenic activities of soy isoflavones after digestion with enteric bacteria in competition binding assays with hER α or hER β protein, and in a gene expression assay using a yeast system. The estrogenic activities of these isoflavones were also investigated by the growth of MCF-7 breast cancer cells. Isoflavone glycoside binds weakly to both receptors and estrogen receptor-dependent transcriptional expression is poor. The aglycones bind more strongly to hER hER β than to hER α. The binding affinities of genistein, dihydrogenistein and equol are comparable to the binding affinity of 17 β-estradiol. Equol induces transcription most strongly with hER α and β. The concentration required for maximal gene expression is much higher than expected from the binding affinities of the compounds, and the maximal activity induced by these compounds is about half activity of 17 β-estradiol. Although genistin binds more weakly to the receptors and induces transcription less than does genistein, it stimulates the growth of MCF-7 cells more strongly than does genistein.

著者

上野

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.142, pp.1201-1207, 1893-12-26

著者

世取山 守 伊藤 功 高島 大典 正山 征洋 西岡 五夫

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.100, no.6, pp.611-614, 1980-06-25

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Cannabinoids (CN) of CBDA stock, Tochishi No. 1 stock and crossed stock were determined on a high-pressure liquid chromatograph equipped with a LiChrosorb RP-18 column (25 cm×4 mm) by elution with a mixture of methanol and 0.02 N sulphuric acid (4 : 1). The CBDA stock was found to contain cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA). Tochishi No. 1 stock was detected to have thtrahydrocannabinolic acid (THCA), CBCA and a small amount of CBDA. F_1 was obtained by crossing CBDA stock (female) and Tochishi No. 1 stock (male). All 79 F_1 specimens were found to contain CBDA, THCA and CBCA. Therefore F_1 was designated the median type. F_2 was then obtained by crossing F_1 and out of 199 F_2 specimens, 58,40 and 101 stocks were designated as CBDA stock type, Tochishi No. 1 stock type and the median type by CN analysis, respectively. F_3 was also gained by crossing CBDA stock type of F_2 and all 166 F_3 specimens were CBDA stock type. F_4,which was obtained by crossing F_3,was also CBDA stock type. In addition, the fibers of F_4 were found to be better than those of the original CBDA stock, and F_4 contained a negligible amount of THCA.

著者

久保 文苗

出版者

公益社団法人日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.14, no.12, 1978-12-01

著者

和久 敬蔵

出版者

公益社団法人日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.25, no.5, pp.470-471, 1989-05-01

著者

永沼 章

出版者

公益社団法人日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.34, no.3, 1998-03-01

著者

今村 主税 金納 明宏 光岡 ちほみ 北島 俊一 井上 秀顕 岩原 正宜 松本 陽子 上岡 龍一

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.116, no.12, pp.942-950, 1996-12-25

被引用文献数

12

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Remarkably high inhibitory effects of the hybrid liposomes composed of L-α-dimyristoyl-phosphatidylcholine (DMPC) and polyoxyethylenealkyl ether (C_<14> (EO)_n, n=6-8 and C_<12> (EO)_n, n=8-12)) on the growth of human lymphoma-human B-lymphocyte hybridoma (HF) cells in vitro were obtained. The hybrid liposomes composed of 90 mol% DMPC/10mol% C_<14> (EO)_n (n=6-8) or C_<12> (EO)_n (n=8-12) were more fluid as compared with 90mol% DMPC/10 mol% C_<14> (EO)_4 or C_<12> (EO)_n (n=4,23) hybrid liposomes on the basis of fluorescence polarization measurements. These results suggest that the inhibitory effects of the hybrid liposomes on the growth of HF cells should be related to the membrane fluidity. No toxicity to normal rats in vivo was observed in the experiment using 90mol% DMPC/10mol% C_<14> (EO)_7 or 90mol% DMPC/10mol% C_<12> (EO)_<12> hybrid liposomes.

著者

黒田 久寅 熊野 明美 岡本 幸子

出版者

公益社団法人日本薬学会

雑誌

衛生化学 (ISSN:0013273X)

巻号頁・発行日

vol.10, no.3, pp.165-168, 1964-09-30

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The present work was undertaken to clarify the physiological mechanism of germination of conidio spore of Cochliobolus miyabeanus. With the spore obtained by wet method, rate of germinaton and regression coefficient of germination curve decreased and the synchronism of spore lowered during storage. But, with the spore obtained by dry method, this phenomena could not be recognized even after 12 weeks'storage. Neither α-picolinic acid nor its analogues were found in the spore. This spore showed a great resistance to such respiration poison as potassium cyanide and sodium azide, therefore, under the condition completely inhibiting the oxygen-uptake (concentration of KCN or NaN_3 was 10^<-3>M/L) or without oxygen the formation of germ tube was observed. Thus, it was supposed that this spore had a metabolic pathway producing energy necessary for germination under an anaerobic condition. The respiration of spore rapidly increased instantly after the beginning of cultivation and the faculty to oxidize external substrate had a tendency to increase after the formation of germ tube.

著者

刈米 達夫 渥美 嶮次郎

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.462, pp.747-758, 1920-08-26

著者

高橋 順太郎

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.109, pp.205-209, 1891-03-26

著者

安本

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.482, 1922-04-26

著者

大塚 恭男

出版者

公益社団法人日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.17, no.12, pp.1159-1163, 1981-12-01

著者

高橋 順太郎

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.52, pp.228-232, 1886-06-26

著者

K. K.

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.122, 1892-04-26