著者
坪口 晋太朗 矢島 隆二 樋口 陽 石川 正典 河内 泉 小山 諭 西澤 正豊
出版者
日本神経学会
雑誌
臨床神経学 (ISSN:0009918X)
巻号頁・発行日
vol.56, no.7, pp.477-480, 2016 (Released:2016-07-28)
参考文献数
14
被引用文献数
3

症例は54歳女性で,緩徐に進行する歩行障害と構音障害を呈した.左乳癌に対して乳房切除術と癌化学療法を受け,神経症候の進行は術後一旦停止していたが,小脳性運動失調が再び増悪した.頭部MRIでの小脳半球の萎縮,血清Yo抗体陽性,乳癌の既往より傍腫瘍性小脳変性症(paraneoplastic cerebellar degeneration; PCD)と診断した.CTで指摘された左腋窩リンパ節の廓清と癌化学療法の変更に加え,免疫グロブリン大量療法を行った結果,神経症候は改善し,独歩可能となった.亜急性の経過と治療反応性の不良が特徴とされるYo抗体陽性PCDにも,緩徐進行性で治療反応性が良好な非典型例があることを報告した.
著者
鈴木 直輝 加藤 昌昭 割田 仁 青木 正志
出版者
日本神経治療学会
雑誌
神経治療学 (ISSN:09168443)
巻号頁・発行日
vol.34, no.5, pp.518-522, 2018 (Released:2018-04-05)
参考文献数
58

Amyotrophic lateral sclerosis (ALS) is the progressive motor neuron disease (MND) in adults, characterized by the selective death of motor neurons in the motor cortex, brainstem and spinal cord. This review provides a general overview of preclinical and clinical advances in 2016 and summarizes the literature regarding emerging therapeutic approaches. The topics include research using next–generation sequencing, progress in the pathomechanism of C9ORF72–mutated ALS, therapeutic strategies on mitochondrial pathology, neuroinflammation, autophagy, growth factor supplementation, axonal pathology in ALS. Clinical trials for ALS targeting on these pathomechanisms are on–going including intrathecal administration of hepatocyte growth factor (HGF).
著者
猪川 和子
雑誌
美術研究 = The bijutsu kenkiu : the journal of art studies
巻号頁・発行日
no.287, pp.1-18, 1973-10-30

The Gokokuin (Kimiidera) in Wakayama City owns some sculptural images from the Late Heian Period. Their principal images are an Elevenheaded Avalokiteśvara, which is the main images of the temple, and a Thousand-armed Avalokiteśvara. Besides, there are two Bodhisattvas, purported to be Brahmā and Indra, and another Eleven-headed Avalokiteśvara. In this paper the author makes a comparative study of these with similar sculptures in adjoining regions, such as eight Avalokiteśvara images of the Kanshinji in Kawachi-Nagano City, Osaka, an Avalokiteśvara image owned by the Ueda District Office in the same city, statues of the Kōonji in Kaizuka City, Osaka, and others. The main image, the Eleven-headed Avalokiteśvara of the Gokokuin is a statue carved out of single block of Japanese Judas-tree wood. The head is proportionally large. The way of carving shows a slightly naive, local character and is close to the Eleven-headed Avalokiteśvara of the Kaijūsenji in Kamo Town, Kyoto, and the Elevenheaded Avalokiteśvara of the Taimadera in Taima Town, Nara. The Thousand-armed Avalokiteśvara of the Gokokuin has forty large arms and nine hundred and sixty smaller arms. The facial expression has something in common with the Bhaiṣajyaguru Triad of the Katsuodera in Mino City, Osaka. The two images purported to be Brahmā and Indra are perhaps Bodhisattvas, judging from their costumes. The one called Indra has a round face with a childish expression and is brightly painted. The drapery is carved skillfully and the entire statue is neatly worked. According to a document dated 1082, written by Myōshō, a priest of the Yakushōji once located near the Gokokuin, Myōshō was engaged in the work of colouring the sculptural images of two important temples in Kyoto, the Enshūji and the Hosshōji. This fact implies a close relationship between this region and Kyoto in the field of the production of Buddhist images and it is easily understood that the image called Brahmā reflects the refined taste of the capital. The statue called Indra is stylistically quite similar, except for the fact, in comparison it shows a more localized taste. There are eight standing statues of Avalokiteśvara in the Kanshinji, Osaka, and some of them show stylistic kinship to these two images of the Gokokuin. The type of crown, the countenances and the colouring effects have some features in common with the two images of the Gokokuin and share their modest and elegant characteristics. The statue of Cuṇḍī owned by the Yakushiji in Nara City (970) and the statue of Avalokiteśvara of the Yūnenji in Ikaruga Town, Nara, (1069) are two dated similar works in adjoining regions. These, however, are rather different in style. Among the contemporaneous Buddhist statues in the Osaka area, the Avalokiteśvara owned by the Ueda District Office of Kwachi-Nagano City is presumed by the author to be a work by a sculptor of Kyoto. It is more in the Kyoto style than the statues of the Gokokuin and the Kanshinji. The author thinks that it is in the same stylistic line as the Thousand-armed Avalokiteśvara of the Hosshōji, Kyoto. The statues in the Kōonji, Osaka, and the one in the Yūnenji still retain to some extent features of the Early Heian Period sculptural style, while also exhibiting local characteristics. The author thus defines the stylistic positions of the statues of the Gokokuin.
著者
杉村 泰
出版者
名古屋大学言語文化研究会
雑誌
ことばの科学 (ISSN:13456156)
巻号頁・発行日
vol.32, pp.5-24, 2018-12-25

本稿は平成27-29年度科学研究費基金(基盤研究(C))「心身の状態を表すオノマトペの習得研究-医療福祉分野への貢献を視野に入れて-」(研究代表者:吉永尚、課題番号15K02670)による研究成果の一部である。
著者
杉村 泰
出版者
名古屋大学言語文化研究会
雑誌
ことばの科学 (ISSN:13456156)
巻号頁・発行日
vol.31, pp.111-130, 2017-12-25

本稿は平成27-29年度科学研究費基金(基盤研究(C))「心身の状態を表すオノマトペの習得研究 : 医療福祉分野への貢献を視野に入れて」(研究代表者:吉永尚、課題番号15K02670)による研究成果の一部である。