出版者

角川書店

巻号頁・発行日

1957

著者

川村和助 著

出版者

川村太洋堂

巻号頁・発行日

1936

出版者

日本文化出版社

巻号頁・発行日

vol.10, 1957

出版者

福井市

巻号頁・発行日

1929

著者

斎藤真一郎 編

出版者

中村書店

巻号頁・発行日

1909

著者

福井市 編

出版者

福井市

巻号頁・発行日

1924

著者

清水友吉 編

出版者

清水友吉

巻号頁・発行日

1915

出版者

安田写真館

巻号頁・発行日

1931

著者

藤田 直

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.122, no.3, pp.203-218, 2002 (Released:2003-02-18)

参考文献数

60

被引用文献数

21 40

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It is well known that biomembranes and subcellular organelles are susceptible to lipid peroxidation. There is a steadily increasing body of evidence indicating that lipid peroxidation is involved in basic deteriorative mechanisms, e.g., membrane damage, enzyme damage, and nucleic acid mutagenicity. The formation of lipid peroxides can be induced by enzymatic or nonenzymatic peroxidation in the presence of oxygen. The mechanisms of formation and removal of reactive oxygen species, lipid peroxides, and free radicals in biological systems are briefly reviewed. In recent years, there has been renewed interest in the role played by lipid peroxidation in many disease states. Xanthine oxidase has been shown to generate reactive oxygen species, superoxide (O2−·), and hydrogen peroxide (H2O2) that are involved in the peroxidative damage to cells that occurs in ischemia-reperfusion injury. During ischemia, this enzyme is induced from xanthine dehydrogenase. We have shown that peroxynitrite (a reactive nitrogen species) has the potential to convert xanthine dehydrogenase to oxidase. The following biological effects of lipid peroxidation were found: a) the lipid peroxidation induced by ascorbic acid and Fe2+ affects the membrane transport in the kidney cortex and the cyclooxygenase activity in the kidney medulla, and b) the hydroperoxy adducts of linoleic acid and eicosapentaenoic acid inhibit the cyclooxygenase activity in platelets. The balance between the formation and removal of lipid peroxides determines the peroxide level in cells. This balance can be disturbed if cellular defenses are decreased or if there is a significant increase in peroxidative reactions. Once lipid peroxidation is initiated, the reactive intermediate formed induces cell damage.

著者

関谷 清景

出版者

日本地質学会

雑誌

地質學雜誌 (ISSN:00167630)

巻号頁・発行日

vol.1, no.2, pp.80-84, 1893-11

著者

橋本万平

出版者

朝日新聞社

雑誌

地震学事始開拓者 関谷清景の生涯

巻号頁・発行日

vol.261, 1983

被引用文献数

2

著者

野口 和子 中村 操 津村 建四朗

出版者

東京大学地震研究所

雑誌

東京大学地震研究所技術研究報告 (ISSN:13426486)

巻号頁・発行日

no.13, pp.147-162, 2007

著者

石井 基博

出版者

Societas Philosophiae Doshisha

雑誌

同志社哲学年報 (ISSN:03871584)

巻号頁・発行日

no.37, pp.135-151, 2014-09

著者

石井 基博 Motohiro Ishii

出版者

Societas Philosophiae Doshisha

雑誌

同志社哲学年報 (ISSN:03871584)

巻号頁・発行日

no.37, pp.135-151, 2014-09

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公募論文

著者

Sachiro Umemoto Takeshi Otsuki

出版者

日本酸化ストレス学会

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.55, no.2, pp.143-146, 2014 (Released:2014-09-01)

参考文献数

25

被引用文献数

2 14

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Chlorella, a unicellular green alga, contains a variety of nutrients including amino acids, carbohydrates, vitamins, and minerals. A previous animal study found that maximal swimming time in mice increased after 14 days on a diet including Chlorella powder compared to no change in swimming performance on a normal diet. However, it is currently unknown whether Chlorella-derived multicomponent supplementation increases aerobic endurance capacity in humans. We investigated the effects of Chlorella-derived supplementation on peak oxygen uptake during incremental maximal cycling in young individuals using a double-blinded, placebo-controlled, crossover study design. Seven men and three women (mean age, 21.3 year) were allocated to placebo or Chlorella tablets (15 tablets × twice per day) for 4 weeks, with at least a 6-week washout period between trials, in a randomized order. Peak oxygen uptake significantly increased after Chlorella supplementation (before vs after, 37.9 ± 1.9 vs 41.4 ± 1.9 ml/kg/min, p = 0.003), but not with placebo (39.4 ± 2.2 vs 40.1 ± 2.1 ml/kg/min, p = 0.38). The change in peak oxygen uptake over the 4-week trial was significantly greater in the Chlorella trial than in the placebo trial (3.5 ± 0.9 vs 0.7 ± 0.8 ml/kg/min, p = 0.03). These results suggest that Chlorella-derived multicomponent supplementation increases aerobic endurance capacity in young individuals.

著者

Takeshi Otsuki Kazuhiro Shimizu Asako Zempo-Miyaki Seiji Maeda

出版者

日本酸化ストレス学会

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

pp.16-3, (Released:2016-05-21)

参考文献数

22

被引用文献数

5

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Decreases in saliva secretion compromise food mastication and swallowing, reduce mucosal immune function, and increase the risk for oral diseases like dental caries. Chlorella is a green alga that contains a variety of nutrients including amino acids, vitamins, and minerals. In our previous study, Chlorella-derived multicomponent supplementation did not affect salivary flow rates in healthy young individuals, but Chlorella-derived supplementation attenuated a decrease in saliva secretion that was observed during a kendo training camp. Hence, we hypothesized that Chlorella-derived supplementation increases saliva secretion in individuals with lower rates of saliva flow. Sixty-four subjects took Chlorella-derived tablets for four weeks. Before and after supplementation, saliva samples were collected by chewing cotton. In the complete study group, there was no difference in saliva production before and after supplementation (1.91 ± 0.11 ml/min before vs 2.01 ± 0.12 ml/min after). Analysis of subgroups based on saliva production before supplementation found an increase in saliva secretion in the lower saliva flow group (1.18 ± 0.06 vs 1.38 ± 0.08 ml/min), but no change in the higher saliva flow group (2.63 ± 0.11 vs 2.64 ± 0.15 ml/min). These results suggest that Chlorella-derived multicomponent supplementation increases saliva production in individuals with lower levels of saliva secretion.

著者

西山 めぐみ 土師 大和 寺澤 孝文

出版者

日本教育心理学会

雑誌

日本教育心理学会総会発表論文集

巻号頁・発行日

no.57, 2015-08-19

著者

Gardner Scott

出版者

岡山大学大学院教育学研究科

雑誌

研究集録 (ISSN:18832423)

巻号頁・発行日

no.145, pp.39-46, 2010

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The linguistic concept of register, while not yet defined to the satisfaction of all, is nevertheless a fairly well used one in describing speakers' shifts in language according to situational nonns or constraints. Inappropriateness of register for context is usually seen as a sociolinguistic or pragmatic error. But in some cases it is done intentionally and creatively, such as in several cases of register-shifting humor in the TV series Monty Python's Flying Circus. This paper gives several examples of humorous register shifting in Monty Python, and analyzes how the shifting has its effect.

著者

板東 俊和 杉山 弘

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.63, no.10, pp.1016-1027, 2005 (Released:2009-11-13)

参考文献数

43

被引用文献数

1 4

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Fifty years after the discovery of the double helical structure of DNA, the complete sequence of the human genome has been determined. All genetic information, which is necessary for life, is written in 30 billion base pairs of DNA. Many diseases, including cancer, hereditary and viral diseases, can be understood at the DNA sequence level. Local DNA conformations are thought to play an important role in biological processes such as gene expression. Therefore, DNA sequences and local DNA conformation are targets of novel drugs that would precisely switch certain genes on or off. Modified bases that perform various functions can also be incorporated into defined DNA sequences. Since DNA can be amplified by PCR and in other organisms, DNA becomes a promising unit for nanotechnology applications. In this review, we focus on the sequence and conformation-specific chemical reactions that occur in DNA, and the prospective uses of the chemical biology of DNA will be discussed.

著者

三浦 修

出版者

東北ジャーナル刊行会

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.30, no.2, pp.196-202, 1936-12-30 (Released:2008-11-28)

参考文献数

2

被引用文献数

1 1

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Clitocybe acromelalga, Ichimura, ein giftiger Pilz, dessen Genuss bei Menschen Vergiftung mit heftigem Schmerz und Nekrose in den Extremitöten verursacht, ruft bei Höhnen eine nekrobiotische Verönderung des Kainmes and der Bartlappen, in denen sick eine hyaline Degeneration mikroskopisch nachweisen lösst, hervor, wöhrend er bei anderen Tierarten, wie Möusen, Ratten, Meerschweinchen und Kaninchen nicht imstande ist, eine solche Verönderung herbeizuführen. Die nekrobiotische Verönderung von Hahnenkömmen wird wie die Sensibilitötsstörung bei Möusen durch zwei verschiedene wasserlosliche Substanzen hervorgerufen, von denen die eine durch Bleiazetat geföllt und durch Kochen zersetzt wird, wöhrend die andere dagegen mit Bleiazetat keinen Niederschlag bildet und kochbestöndig ist. Für die technische Hilfe bei der Ausführung dieser Versuche bin ich Herrn Prof. S. Nasu im Pathologischen Institut zu Dank ver-pflichtet.