著者

中谷 和彦 齋藤 烈

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.59, no.7, pp.670-679, 2001-07-01 (Released:2010-01-22)

参考文献数

52

被引用文献数

1 1

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In order to gain insight into molecular basis for the sequence selective guanine alkylation by natural products aflatoxin B1 oxide and kapurimycin A3 we have synthesized epoxides with napthopyranone and anthrapyranone rings. Alkylation of guanine in DNA by these models proceeds with sequence selectivity similar to those of natural products. Absolute configuration of the epoxide side chain is significantly effective for the efficiency of guanine alkylation. Guanine alkylation most effectively proceeded at Gs in GG sequence, but G in the GC sequence was the least reactive site for the alkylation. The order of calculated energy levels of highest occupied molecular orbital (HOMO) for dinucleotide base pairs were in a good agreement with the G alkylation susceptibility experimentally obtained by our synthetic models. With these data we concluded that interaction of HOMO of DNA and LUMO of drugs is responsible for the sequence selectivity of guanine alkylation.

著者

橋本 祐一 首藤 紘一

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.43, no.10, pp.908-920, 1985 (Released:2009-11-13)

参考文献数

49

被引用文献数

2

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Bis-intercalators and hemin-intercalators (Hemin-Glu-P-1's) which recognize and/or cleave DNA were designed and synthesized. 2-Aminodipyrido [1, 2-a : 3', 2' -d] imidazoles (Glu-P's) which are potent muta-carcinogens isolated from a pyrolysate of L-glutamic acid were used as intercalator moieties. Bis-intercalators possess extremely high affinity toward double stranded DNA and stabilize the double helix structure of DNA from heat denaturation effectively. Hemin-Glu-P-1's cleaved DNA at G-C and G-T sequences preferentially. Glu-P-1 moiety which recognizes DNA by intercalation and a functional group which can be an intramolecular fifth ligand of the ferrous ion in the hemin moiety are required for strong DNA-cleaving ability. The mode of DNA-cleaving reaction of Hemin-Glu-P-1's is quite similar to that of bleomycin (BLM). In other words, Hemin-Glu-P-1's are functional analogs of BLM. The mechanism of DNA cleavage by Hemin-Glu-P-1's and by BLM is not single. One of the mechanisms involves two bases elimination from the DNA.

著者

小谷 究 清水 貴司 松尾 晋典 KOTANI Kiwamu SHIMIZU Takashi MATSUO Shinsuke コタニ キワム シミズ タカシ マツオ シンスケ

出版者

広島文化学園大学社会情報学部

雑誌

社会情報学研究 : 広島文化学園大学社会情報学部紀要 (ISSN:13418459)

巻号頁・発行日

vol.17, pp.63-75, 2011

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The purpose of this study was to examine statistically the relationship between the shooting position and the place of getting rebounds. For the object, We selected randomly 16 games in the men's top league of university. For the method, We videotaped the games. We divided the court into 5 areas by the angles of the shot and 6 areas by the length of the shot and tally up the data of shooting position and the place of getting rebounds. We analyzed the data by Pearson's correlation analysis, and examined with thepercentage of the rebounds. The results are the following.1)For all the angles of the shot, as the length of the shot gets longer, the distance of the rebound becomes longer.2)For 3 point shots, as the shooting angle gets closer to the left corner, the length of rebound becomes longer.3)For the shot over 3.75 meters, the angle of rebound is same as the angle shot on the help-side.4)As the length of the shot gets longer at the right corner, the angle of the rebound becomes closer to help-side corner. From the above results, it revealed statistically the relationship between the shooting position and the place of getting rebounds. In conclusion, it was suggested that when the team control the place of getting rebounds, it was related to getting more rebounds and the possibility leading to ascendancy in the game.

著者

阿部 光幸 山野 究 松田 晉 アベ ミツユキ ヤマノ キワム マツダ ススム Abe Mitsuyuki Yamano Kiwamu Matsuda Susumu

出版者

日本医学放射線学会

雑誌

日本医学放射線学会雑誌 (ISSN:00480428)

巻号頁・発行日

vol.29, no.12, pp.1488-1493, 1970-03-25

著者

武藤(細谷) 照子

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.27, no.2, pp.75-83, 1987-03-25 (Released:2009-05-25)

参考文献数

61

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The sex of an individual is determined at fertilization by the combination of sex chromosomes, e.g., XX or XY in mammals. Morphological sex differences become evident during the organization of gonadal primordia into ovaries or testes. Consequently, fetal testes produce hormones which are responsible for the development of the male phenotype. The absence of male hormones results in the development of the females phenotype. It has been proposed that a male dominant, histocompatibility-Y (H-Y) antigendetermines testicular differentiation, based on the finding that individuals with testest are H-Y antigen positive regardless of their sex karyotype. Recently, this hypothesis has been challenged bý the finding of several exceptions, e.g., development of ovaries in the presence of H-Y antigen, and testes in its absence.A testis-determining gene (Tdy or TDF) has been thought to occur on the Y chromosome. Over 100 Y-specific DNA fragments have been examined with only one possible candidate for the Tdy gene. In addition to the Tdy gene, at least two autosomal genes (tda-1 and Tas) appear to be involved in testis determination. It has been suggested that gonadal sex determination may also be influenced by environmental factors.Fetal rat and mouse ovaries develop testicular structures (ovotestes) after transplantation into various sites of adult host animals. This finding suggests that XX gonadal primordial cells can differentiate into testicular cells. Electron microscopic examinations have revealed that testicular structures of mouse ovotestes are comparable to those of the genetic male. Furthermore, it has been shown that ovotestes produce hormones and glycoproteins characteristic of normal neontal testes. These results provide strong evidence for sex reversal by transplantation. The study of the factors involved in the induction of ovotestis development should aid better understanding of the mechanism of gonadal sex determination.

出版者

日経BP社

雑誌

日経エレクトロニクス (ISSN:03851680)

巻号頁・発行日

no.802, pp.197-201, 2001-08-13

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「気持ちはよう分かりますが,5月いうんは無茶ちがいますか。あと半年しかないんですよ。ハードウエアの開発に1年はかかるやろうから,いくら急いでも来年末の発売の機種になりますね」「カメラ付き電話はプリクラ」 この時から1カ月前,植松と山下晃司をはじめとするパーソナル通信事業部のスタッフは,IC事業本部がある天理事業所を訪れていた。

著者

中山 祥嗣

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.136, no.6, pp.795-798, 2016 (Released:2016-06-01)

参考文献数

1

被引用文献数

1

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The Japan Ministry of the Environment is conducting a large-scale birth cohort study called the Japan Environment and Children's Study (JECS), which involves 100000 mother-child pairs. Mothers are enrolled during pregnancy, and their children are followed up and studied until they reach the age of 13 years. The JECS started recruiting mothers in January 2011 and completed the registration of more than 103000 mothers in March 2014. The National Institute for Environmental Studies takes the lead in the study programming and implementation in cooperation with the National Centre for Child Health and Development and 15 Regional Centres that reach out to the study participants. In the study, the effects of environmental factors on children's health and development are investigated. The environment in this study is defined not only as air, soil, water, and indoor environments but also as various chemical substances, physical conditions, socioeconomic factors, psychological conditions, lifestyles and community situations. Mothers' and children's exposures to these environmental factors are measured through chemical analyses of biospecimens collected during pregnancy and after birth, questionnaires and computer modelling. The homes of the randomly selected participants (5000) are visited to measure the concentrations of volatile organic compounds, nitrogen and sulphuric oxides and particulate matter. Vacuum dust samples are also collected for chemical analysis. All these data will be combined with the information collected by the dwelling unit observation to assess the exposure of children aged 1.5 and 3 years.

著者

伊藤 健市

出版者

関西大学

雑誌

關西大學商學論集 (ISSN:04513401)

巻号頁・発行日

vol.52, no.4, pp.21-34, 2007-10

著者

飯野 裕 藤巻 拓郎 藤木 慶子 村上 晶

出版者

順天堂大学

雑誌

順天堂医学 (ISSN:00226769)

巻号頁・発行日

vol.54, no.3, 2008-09

著者

須田 亙 宍戸 雅宏

出版者

日本土壌微生物学会

雑誌

土と微生物 (ISSN:09122184)

巻号頁・発行日

vol.63, no.2, pp.93-99, 2009-10-01

被引用文献数

1

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葉に代表される植物体地上部の表面である葉圏には,多種多様な細菌が存在し,植物の健康維持や生態系における物質循環において重要な役割を担っていると考えられる。葉圏細菌に関する研究は,特定の機能を持つ菌を分離・培養し,それらの性質を調べる手法で行われてきた。これまで,細菌群集全体の構造や動態に関する研究は他の環境(根圏や水圏等)と比較すると著しく少なかったが,2001年以降,葉圏においても非培養法による細菌群集全体の構造解析が行われるようになり,知見が蓄積されつつある。本稿では,葉圏細菌群の生存戦略,および注目すべき機能について概説し,さらに,非培養法による細菌群集の解析によって明らかになってきた知見および今後の展望について論考した。

出版者

新日本出版社

巻号頁・発行日

1984

著者

岡部 いさく

出版者

海人社

雑誌

世界の艦船

巻号頁・発行日

no.790, pp.144-149, 2014-01

著者

浜野 裕司 田部 洋

出版者

社団法人 日本写真学会

雑誌

日本写真学会誌 (ISSN:03695662)

巻号頁・発行日

vol.39, no.4, pp.225-231, 1976-07-25 (Released:2011-08-11)

参考文献数

21

著者

疋田 隆康

出版者

京都大学大学院文学研究科

雑誌

西洋古代史研究 = Acta academiae antiquitatis Kiotoensis (ISSN:13468405)

巻号頁・発行日

vol.10, pp.53-62, 2010-12-22

著者

小黒 恵

出版者

東京大学大学院教育学研究科

雑誌

東京大学大学院教育学研究科紀要 (ISSN:13421050)

巻号頁・発行日

vol.53, pp.31-42, 2014-03-28

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The aim of this paper is to consider the new concept of specialty in education, which transcends the dichotomy of general education versus strict specialization, by clarifying the effects and problems of its actual implementation in the vocational course of a general high school. This research reveals that in the case example, three features of the practice ― “ wide and shallow specialization ”, practical training, and presentations―have had various positive effects on students’ learning and career choices. This finding supports the legitimacy of promoting diversification of high schools through the introduction of vocational education to general high schools.

著者

堀井 一摩

出版者

東京大学大学院総合文化研究科言語情報科学専攻

雑誌

言語情報科学 (ISSN:13478931)

巻号頁・発行日

vol.14, pp.225-240, 2016-03-01

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本稿は、泉鏡花の「高野聖」における不気味な他者たちの表象が日清日露戦間期の日本社会においてどのような意味を担っていたのかという問題を考察する。まず「高野聖」に書き込まれた近代性の記号、すなわち地図、徴兵制、衛生学の歴史性を追跡し、それらが近代的国民軍の要請によって整備されたものであることを確認する。そのうえで、宗朝と、富山の薬売り・次郎との分身関係を分析することを通じて、「高野聖」が、不気味な動物的他者が表徴する脱国民的身体への憧憬を保存していたという読解を提示する。最後に、孤家の女が統治する「代がはり」の世界の意味を考察し、壮健な男をもはや戦うことのできない動物に変じる女の魔力が、国民国家にとってサブヴァーシヴな力をもつことを明らかにする。鏡花は、このような異界を仮構することで、対外戦争へと向かっていく近代日本の国民の生きる空間を逆照射し、それに異議を申し立てるようなヘテロトピアを描いている。

著者

村上 克尚

出版者

東京大学大学院総合文化研究科言語情報科学専攻

雑誌

言語情報科学 (ISSN:13478931)

巻号頁・発行日

vol.14, pp.241-257, 2016-03-01

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本稿の目的は、武田泰淳の『富士』を、同時代の精神障害者をめぐる言説を参照しながら検討し、両者の共通性と差異とを分析することである。『富士』は、甘野院長や一条といった登場人物を通じて、患者を「人なみ」になるように「治療」しようとする試みや、患者を神のごとき超越者に高めることで尊厳を回復しようとする試みを批判的に描いている。これは、同時代の「反精神医学」的な言説と響き合う。それに加えて、『富士』の語り手である大島は、序章と終章において、動物をめぐる長大な思索を展開する。これは、健常者/精神障害者の区分が、国家による、人間/動物(=生きるに値する命/生きるに値しない命)の分割に規定されていることを示唆する。最終的に、大島は、患者たちの依存し、寄生する繋がりに、自分の身体を開いていく。ここから読み取られるべきは、依存的(=動物的)な生を否認するのではなく、むしろそれに内在することで、国家が掲げる、自律的な「人間」の理念を解体していくという道筋である。この点にこそ、『富士』というテクストの独自性を指摘できる。

著者

高田 善之

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.80, no.11, pp.1640-1641, 1960-11-25 (Released:2010-02-19)

参考文献数

3

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Application of alkaline hydrogen peroxide to sodium 2-cyanoethanesulfonate, obtained by reaction of acrylonitrile and sodium hydrogensulfite, afforded sodium 2-carbamoylethanesulfonate. Taurine (2-aminoethanesulfonic acid) was obtained in a comparatively good yield of 80-85% by reaction of the foregoing sulfonate and alkaline sodium hypochlorite.

著者

中野 毅

出版者

日本宗教学会

雑誌

宗教研究 (ISSN:03873293)

巻号頁・発行日

vol.82, no.3, pp.742-747, 2008-12

著者

Lanlan BAI Shiaki TAKAGI Tasuke ANDO Hiroshi YONEYAMA Kumiko ITO Hiroyuki MIZUGAI Emiko ISOGAI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.16-0198, (Released:2016-05-28)

被引用文献数

30

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Epigallocatechin gallate (EGCG) is the major polyphenolic compound of green tea. Polyphenolic compounds were extracted from the leaf of Camellia sinensis (Japanese green tea), and the minimum inhibitory concentration against canine oral bacteria was measured. Subsequently, we investigated the inhibitory effects of polyphenolic compounds and EGCG on the growth of canine oral bacteria. EGCG showed antimicrobial activity against a model bacterium, Streptococcus mutans. Our results indicate that EGCG can inhibit the growth and biofilm formation of S. mutans, and that EGCG does not interact with streptococcal lipoteichoic acid (LTA). Furthermore, our findings suggest that EGCG interacts with other component (s) of the bacterial membrane aside from streptococcal LTA to inhibit biofilm formation and damage biofilms.