著者

野田 正彦 田下 聰 福田 達也 梶島 孝雄

出版者

信州大学理学部

雑誌

信州大学理学部紀要

巻号頁・発行日

vol.19, no.1, pp.89-98, 1984-10-15

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The sex of triploid ginbuna (Carassius auratus langsdorfii) are all females, reproducing gynogenetically. The artificial sex reversal was carried out successfully by the oral treatment of methylteststeron for two months after hatching out. In the sex reversed triploid ginbuna, the processes of spermatogenesis from spermatogonia to the primary spermatocyte was similar with diploid males. But thereafter though in the diploid male two different types of nuclear plate in diameter were observed, in the triploid ginbuna it was observed only the same diameter of nuclear plate. From these observations, it was concluded that the first maturation division might be omitted in these males as in females. Further, the triploid males produced the unequal diameter and DNA contents of sperms. This might be caused by unequal nuclear division during meiosis. Artificial insemination of triploid female with the sperm of sex reversed triploid male, resulted in the all triploid females. The sperm of triploid male might be possess the ability to activate the egg of triploid female gynogenetically.

著者

塩谷 賢

出版者

心の諸問題考究会

雑誌

心の諸問題論叢 (ISSN:13496905)

巻号頁・発行日

vol.1, no.1, pp.23-25, 2004 (Released:2004-09-07)

参考文献数

1

被引用文献数

1

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ロールシャッハ・テストに関する現象学風の解釈可能性を提示したものである。この種の試みはあまり例がなく、とくに「代替可能な視点」を提供する哲学的議論を具体的な臨床現場との接点において導入する試みとしては評価できる。しかし、設定した問題(辻(1997)の批判的解釈)の短い射程内に留まっており、原著作の具体的問題点の提示と解決、論文自身の立っている立場や導入している議論の広範囲への展開可能性についての表明が希薄であり、議論の内在的な発展が望まれる。

著者

竹中 菜苗

出版者

京都大学

巻号頁・発行日

2010-05-24

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新制・課程博士

著者

松本 賢信

出版者

亜細亜大学総合学術文化学会

雑誌

亜細亜大学学術文化紀要 (ISSN:13470248)

巻号頁・発行日

no.2, pp.63-91, 2002

著者

大羽 吉介

出版者

駒澤大学

雑誌

駒澤國文 (ISSN:04523652)

巻号頁・発行日

vol.22, pp.55-65, 1985-02

著者

室鳩巣 著

出版者

扶桑文社

巻号頁・発行日

1910

著者

高埜 利彦

出版者

学習院大学

雑誌

學習院大學經濟論集 (ISSN:00163953)

巻号頁・発行日

vol.42, no.2, pp.153-154, 2005-07

著者

山田義貴

雑誌

皮膚臨床

巻号頁・発行日

vol.35, pp.1020-1021, 1993

被引用文献数

1 3

著者

谷口 彰治

出版者

社団法人日本東洋医学会

雑誌

日本東洋醫學雜誌 (ISSN:02874857)

巻号頁・発行日

vol.50, no.6, 2000-05-23

著者

白上 洋平 後藤 尚絵 西脇 伸二 丹羽 優佳里 久保田 全哉 岩下 雅秀 小野木 啓人 林 隆夫 前田 晃男 齋藤 公志郎

出版者

一般財団法人 日本消化器病学会

雑誌

日本消化器病学会雑誌 (ISSN:04466586)

巻号頁・発行日

vol.104, no.9, pp.1377-1382, 2007 (Released:2007-09-05)

参考文献数

29

被引用文献数

2 5

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症例は33歳男性.心窩部痛を主訴に来院.上部消化管内視鏡検査にて胃および十二指腸粘膜のびらん,浮腫を指摘され入院となった.入院経過中に,胃十二指腸炎の増悪を認めた.血清抗サイトメガロウイルス(以下CMV)抗体価の上昇と,胃粘膜生検組織にて核内封入体を認め,CMV胃十二指腸炎と診断した.健常成人のCMV感染症において,胃のみならず十二指腸まで病変を認める例は極めてまれであると考え報告する.

著者

Dae Young YOO Hee Sun YIM Hyo Young JUNG Sung Min NAM Jong Whi KIM Jung Hoon CHOI Je Kyung SEONG Yeo Sung YOON Dae Won KIM In Koo HWANG

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0589, (Released:2016-02-15)

被引用文献数

1 51

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In the present study, we investigated the effects of type 2 diabetes-induced hyperglycemia on the integrity of the blood–brain barrier and tight junction markers in the rat hippocampus. Forty-week-old diabetic (Zucker diabetic fatty, ZDF) rats and littermate control (Zucker lean control, ZLC) rats were used in this study. We evaluated the integrity of the blood–brain barrier by measuring sodium fluorescein extravasation and blood vessel ultrastructure. In addition, tight junction markers, such as zona occludens-1, occludin and claudin-5, were quantified by western blot analysis. ZDF rats showed significantly increased sodium fluorescein leakage in the hippocampus. Tight junction markers, such as occludin and claudin-5, were significantly decreased in the hippocampi of ZDF rats compared to those of ZLC rats. In addition, ZDF rats showed ultrastructural changes with phagocytic findings in the blood vessels. These results suggest that chronic untreated diabetes impairs the permeability of the hippocampal blood–brain barrier by down-regulating occludin and claudin-5, indicating that chronic untreated diabetes may cause hippocampus-dependent dysfunction.

著者

荒武 達朗

出版者

近現代東北アジア地域史研究会

雑誌

News letter (ISSN:13451596)

巻号頁・発行日

no.27, pp.73-79, 2015-12

著者

石田孫太郎 著

出版者

大日本蚕業学会

巻号頁・発行日

1912

著者

橋本重兵衛 著

出版者

丸山舎

巻号頁・発行日

1902

出版者

統計寮

巻号頁・発行日

1874

著者

本庄 榮治郎

出版者

京都帝國大學經濟學會

雑誌

經濟論叢 (ISSN:00130273)

巻号頁・発行日

vol.51, no.5, pp.16-35, 1940-11

著者

藤本実也 著

出版者

開港と生糸貿易刊行会

巻号頁・発行日

vol.中, 1939

著者

Ji Yin Zhou Shi Wen Zhou Ke Bin Zhang Jian Lin Tang Li Xia Guang Yi Ying Ying Xu Le Zhang Dan Dan Li

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.31, no.6, pp.1169-1176, 2008-06-01 (Released:2008-06-01)

参考文献数

37

被引用文献数

61 114

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Berberine is one of the main alkaloids of Rhizoma coptidis which has been used as a folk medicine to treat diabetes mellitus for more than 1400 years in China. To investigate the chronic effect of berberine on diabetic hyperlipidemic rats, fasted rats were intraperitoneally injected 35 mg/kg streptozotocin. Diabetic rats were admitted after 2 weeks and given a high-carbohydrate/high-fat diet to induce hyperlipidemia. The rats were divided into 7 groups at the end of week 16: normal and diabetic rats received no drug, 5 treatment groups were administered with either 75, 150, 300 mg/kg berberine, 100 mg/kg fenofibrate or 4 mg/kg rosiglitazone per day for 16 weeks, respectively. The blood glucose, hemoglobin A1c, lipid metabolic parameters and hepatic glycogen and triglyceride were measured, and histopathology and peroxisome proliferator-activated receptors (PPARs) α/δ/γ expression of liver were determined by hematoxylin eosin and immunohistochemical staining. Berberine reduced diabetic rats' body weight, liver weight and liver to body weight ratio. Berberine restored the increased blood glucose, hemoglobin A1c, total cholesterol, triglyceride, low density lipoprotein-cholesterol, apolipoprotein B and the decreased high density lipoprotein-cholesterol, apolipoprotein AI levels in diabetic rats to near the control ones. Berberine alleviated the pathological progression of liver and reverted the increased hepatic glycogen and triglyceride to near the control levels. Berberine increased PPARα/δ expression and reduced PPARγ expression in liver of diabetic rat to near the control ones. Berberine improved glucolipid metabolism both in blood and liver in diabetic rats possibly through modulating the metabolic related PPARα/δ/γ protein expression in liver.

著者

Xi Xie Wenyuan Li Tian Lan Weihua Liu Jing Peng Kaipeng Huang Juan Huang Xiaoyan Shen Peiqing Liu Heqing Huang

出版者

(社)日本内分泌学会

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.58, no.9, pp.761-768, 2011 (Released:2011-09-30)

参考文献数

35

被引用文献数

14 40

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Recently, it is implicated that the abnormality of Akt signaling pathway is involved in the diabetic pathology. Previous studies have demonstrated that berberine could decrease blood glucose by elevating liver glycogen synthesis. However, the underlying mechanism is still unclear. In the present study, we investigated the effects of berberine on fasting blood glucose, liver glycogen, Akt, Glycogen synthase kinase-3, glucokinase and insulin receptor substrate (IRS) in alloxan-induced diabetic mice, exploring its possible hypoglycemic mechanism. We found that in alloxan-induced diabetic mice, the high blood glucose was significantly lowered by berberine treatment. Liver glycogen content, the expression and activity of glucokinase and the phosphorylated Akt and IRS were all significantly reduced in diabetic mice whereas berberine blocked these changes. Berberine also depressed the increasing of phosphorylated GSK-3β in diabetic mice. Collectively, Berberine upregulates the activity of Akt possibly via insulin signaling pathway, eventually lowering high blood glucose in alloxan-induced diabetic mice.

著者

前田 正明

出版者

神戸大学大学院人文学研究科地域連携センター

雑誌

Link : 地域・大学・文化 (ISSN:21856265)

巻号頁・発行日

vol.7, pp.142-144, 2015-12