1 0 0 0 OA 伝説

著者
柳田国男 著
出版者
岩波書店
巻号頁・発行日
1940
著者
大木 靖衛 徐 輝竜 渡部 直喜 鈴木 幸治 佐藤 修 河内 一男
出版者
日本第四紀学会
雑誌
第四紀研究 (ISSN:04182642)
巻号頁・発行日
vol.35, no.3, pp.153-163, 1996-07-31 (Released:2009-08-21)
参考文献数
31
被引用文献数
1 2

1995年4月1日,新潟市東方18km付近で新潟県北部の地震M6.0が発生し,全壊家屋55戸,被害総額93億円の被害が出たが,幸いにも死者はなかった.この地震は深さ10kmの浅い地震であったため,被害が大きくなった.90ヵ所の墓地の石塔転倒から水平最大加速度を求め,震度分布図を描いた.震央地区に北北東-南南西方向を長軸とする5.2×1kmの地域が震度6域となり,この地震を発生させた平野深部にある伏在活断層を示唆していた.震央地区では,地球重力加速度以上の上下動があったことを示唆する建物の急激な移動があった.本地震前後に地下水・温泉の異常が観察された.新潟市付近の新潟平野は地震の空白域として指摘されていたところである.本地震は指摘されている空白域の東縁部で発生した地震であり,新潟平野の大地震に対する対策が重要になっていることを示唆している.
著者
Takagaki Kana Satoh Kazuki Honda Shin-ichiro Shibuya Akira
出版者
Elsevier
雑誌
Molecular immunology (ISSN:01615890)
巻号頁・発行日
vol.56, no.1-2, pp.23-27, 2013-11
被引用文献数
4 1

Fcα/μR (CD351) is an Fc receptor for both IgA and IgM and forms an atypical dimer that is resistant to reduction by 2-mercaptoethanol or boiling. We previously demonstrated that the cytoplasmic portion of Fcα/μR is required for dimer formation and for its efficient cell-surface expression. However, the biochemical nature of these phenomena has not been determined. By using a BW5147 mouse cell line expressing deletion mutants of the cytoplasmic region of Fcα/μR, we found that the region spanning amino acids 504–523 was required for efficient cell-surface expression, whereas the region spanning amino acids 481–490 was required for dimmer formation. Immunoblotting analyses of transfectants simultaneously expressing Flag-tagged Fcα/μR and hemagglutinin-tagged Fcα/μR suggested that Fcα/μR does not form homodimers. Instead, our data suggest that Fcα/μR forms heterodimers with an as-yet-unknown molecule with a molecular weight of 60–70 kDa.
著者
Shimizu Tetsu Takaya Naoki Nakamura Akira
出版者
American Society for Biochemistry and Molecular Biology
雑誌
The journal of biological chemistry (ISSN:00219258)
巻号頁・発行日
vol.287, no.48, pp.40448-40456, 2012-11
被引用文献数
36 6

An l-glucose-utilizing bacterium, Paracoccus sp. 43P, was isolated from soil by enrichment cultivation in a minimal medium containing l-glucose as the sole carbon source. In cell-free extracts from this bacterium, NAD+-dependent l-glucose dehydrogenase was detected as having sole activity toward l-glucose. This enzyme, LgdA, was purified, and the lgdA gene was found to be located in a cluster of putative inositol catabolic genes. LgdA showed similar dehydrogenase activity toward scyllo- and myo-inositols. l-Gluconate dehydrogenase activity was also detected in cell-free extracts, which represents the reaction product of LgdA activity toward l-glucose. Enzyme purification and gene cloning revealed that the corresponding gene resides in a nine-gene cluster, the lgn cluster, which may participate in aldonate incorporation and assimilation. Kinetic and reaction product analysis of each gene product in the cluster indicated that they sequentially metabolize l-gluconate to glycolytic intermediates, d-glyceraldehyde-3-phosphate, and pyruvate through reactions of C-5 epimerization by dehydrogenase/reductase, dehydration, phosphorylation, and aldolase reaction, using a pathway similar to l-galactonate catabolism in Escherichia coli. Gene disruption studies indicated that the identified genes are responsible for l-glucose catabolism.
著者
Mukai Saki Hidaka Yoshihiko Hirota-Kawadobora Masako Matsuda Kazuyuki Fujihara Noriko Takezawa Yuka Kubota Seiko Koike Kenichi Honda Takayuki Yamauchi Kazuyoshi
出版者
Elsevier
雑誌
Molecular immunology (ISSN:01615890)
巻号頁・発行日
vol.49, no.1-2, pp.48-55, 2011-10
被引用文献数
8 1

Mutations and polymorphisms of factor H gene (FH1) are known to be closely involved in the developmentof atypical hemolytic uremic syndrome (aHUS). Several groups have identified disease risk mutations andpolymorphisms of FH1 for the development of aHUS, and have investigated frequencies of aHUS in a numberof ethnic groups. However, such studies on Japanese populations are limited. In the present study,we analyzed FH1 in Japanese aHUS patients and healthy volunteers, and examined whether those variantsimpacted on a tendency for the development of aHUS in Japanese populations. Similar to previousstudies, we found that a high frequency of FH1 mutations, located in exon 23 of FH1, encodes short consensusrepeat 20 in C-terminal end of factor H molecule in patients with aHUS (40%), but not in healthyvolunteers. Interestingly, no significant differences in frequency of well-known disease risk polymorphismsfor aHUS were observed between healthy volunteers and aHUS patients. Our results suggestedthat although FH1 mutations relates to the development of Japanese aHUS in accordance with other ethnicstudies, other factor may be required for factor H polymorphism to be a risk factor of Japanese aHUS.
著者
Nakano Takako Tahara-Hanaoka Satoko Nakahashi Chigusa Can Ismail Totsuka Naoya Honda Shin-ichiro Shibuya Kazuko Shibuya Akira
出版者
Elsevier
雑誌
Molecular immunology (ISSN:01615890)
巻号頁・発行日
vol.45, no.1, pp.289-294, 2008-01
被引用文献数
18 19

Neutrophils play a central role in host defenses against infectious microbial pathogens. However, molecular basis for their triggering signals has been incompletely understood. Here, we show molecular and functional characteristics of myeloid-associated immunoglobulin-like receptor (MAIR)-IV. MAIR-IV was preferentially expressed on neutrophils in the peripheral blood, bone marrow, peritoneal cavity and spleen. MAIR-IV physically associates with immunoreceptor tyrosine based activating motif (ITAM)-bearing adaptor FcRγ chain. Cross-linking MAIR-IV with anti-MAIR-IV monoclonal antibody significantly induced secretion of proinflammatory cytokines TNF-α and IL-6 from neutrophils. Thus, MAIR-IV may regulate activation of neutrophils and play an important role for innate immunity.
著者
Kurita Naoki Honda Shin-ichiro Usui Kenta Shimizu Yoshio Miyamoto Akitomo Tahara-Hanaoka Satoko Shibuya Kazuko Shibuya Akira
出版者
Elsevier
雑誌
Molecular immunology (ISSN:01615890)
巻号頁・発行日
vol.46, no.4, pp.749-753, 2009-02
被引用文献数
16 12

Fcα/μR is expressed not only in lymphoid, but also in non-lymphoid organs, including kidney. However, molecular and functional characteristics of Fcα/μR, particularly expressed in non-lymphoid organs, have remained unclear. Here we identified an isoform of Fcα/μR in the murine kidney on the C57BL/6J background. The kidney expressed only the isoform, which was not expressed in other lymphoid and non-lymphoid organs, and this isoform binds both IgA and IgM. Immunohistochemical analyses suggested that the Fcα/μR isoform was expressed in the tubular epithelial cells, but not in the glomeruli. This was confirmed by flow cytometry analysis of isolated tubular epithelial cells and by RT-PCR analyses using the separately excised glomerular and tubular regions by the laser microdissection system. These results suggest that Fcα/μR may not be involved in IgA deposition in glomerular mesangium cells in IgA nephropathy. Rather, it may play an important role in immunity in the renal tubular regions.
著者
國澤 英雄
出版者
朝日大学
雑誌
朝日大学経営論集 (ISSN:09133712)
巻号頁・発行日
vol.21, pp.55-56, 2006-09

日本生産管理学会の第44回全国大会が、日本生産管理学会主催・朝日大学経営学会後援で、2005年9月3日(土)、4日(日)に愛知県中小企業センター(名古屋市中村区名駅)で行われた。統一テーマとして「IT活用型"ものづくり"と生産技術」が掲げられ、基調講演、特別講演、招待講演、研究発表(62件)、支部研究報告(2件)などと時宜にかなったテーマのもと、充実した内容で盛大に行われた。