著者

Hironori Uruga Takeshi Fujii Atsuko Kurosaki Shigeo Hanada Hisashi Takaya Atsushi Miyamoto Nasa Morokawa Sakae Homma Kazuma Kishi

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.52, no.12, pp.1317-1323, 2013 (Released:2013-06-15)

参考文献数

25

被引用文献数

23 110

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Objective Pulmonary tumor thrombotic microangiopathy (PTTM) is a unique, rare and fatal form of pulmonary arterial tumor embolism. The aim of this study was to evaluate the clinical characteristics and pathological and immunohistochemical findings of PTTM. Methods Autopsy records dated between January 1983 and May 2008 in our hospital were reviewed, and those of patients who died from pulmonary tumor embolism resulting from malignant neoplasm were retrieved. The relevant tissue slides were reevaluated and examined immunohistochemically to confirm the diagnosis. Results Among 2,215 consecutive autopsy cases of carcinoma, 30 patients (1.4%) were diagnosed with definitive PTTM. The common symptom was progressive dyspnea. A hypercoagulative state was observed in all measured cases (n = 21). The chest computed tomography findings (n = 6) included consolidation, ground-glass opacity, small nodules and a tree-in-bud appearance. Perfusion scans were performed in seven patients, six of whom demonstrated multiple small defects. The median survival time after the initiation of oxygen supplementation was nine days. The most frequent primary site was the stomach (n = 18 ; 60%) , and the most frequent histological type was adenocarcinoma (28/30 ; 93.3%) . The immunohistochemical findings for tumor cells located within the tumor emboli were positive for vascular endothelial growth factor (28/29 ; 96.6%) and tissue factor (29/29 ; 100%). Conclusion Clinicians should suspect PTTM in cancer patients who exhibit acute worsening respiratory insufficiency accompanied by a hypercoagulative state without embolism in major pulmonary arteries. The PTTM patients evaluated in our study had very poor prognoses. Vascular endothelial growth factor and tissue factor may play important roles in PTTM.

著者

Megumi MATSUMOTO Ryo INOUE Takamitsu TSUKAHARA Kazunari USHIDA Hideyuki CHIJI Noritaka MATSUBARA Hiroshi HARA

出版者

(社)日本農芸化学会

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

pp.0801080740-0801080740, (Released:2008-02-07)

参考文献数

20

被引用文献数

258

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The effects of voluntary wheel-running exercise on cecal microbiota and short-chain fatty acid production were investigated in rats. The microbiota composition was notably different between the exercised and sedentary rats. Furthermore, the exercised rats showed a significantly higher n-butyrate concentration than the sedentary rats. This alteration of the cecal microbial environment may contribute to the beneficial effect of exercise on gastrointestinal disorders.

著者

Jyh-Cherng JONG En-Fu CHANG

出版者

Eastern Asia Society for Transportation Studies

雑誌

Journal of the Eastern Asia Society for Transportation Studies (ISSN:18811124)

巻号頁・発行日

vol.6, pp.278-291, 2005 (Released:2008-03-14)

参考文献数

13

被引用文献数

21

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Railway operators are heavy users of electric energy. To implement energy saving programs and to study economical operation strategies, an energy estimating model is required. In this paper, two models for estimating energy consumption of single train operation are presented. To verify the proposed models, a real railway link and an electric train from Taiwan Railway Administration (TRA) are selected for the experiment. The energy consumption estimated from the proposed model is then compared with that estimated by other commercial software. It is found that the difference is only 0.22%, demonstrating that the proposed models are accurate enough in practice for estimating energy consumption. The models can be further extended to develop models and algorithms for estimating power demand of multiple-train operation and minimizing energy consumption through different driving strategies.

著者

小林 厚志 正田 晋一郎

出版者

公益社団法人 高分子学会

雑誌

高分子 (ISSN:04541138)

巻号頁・発行日

vol.55, no.11, pp.892-896, 2006-11-01 (Released:2011-10-14)

参考文献数

35

著者

内藤 昌信

出版者

公益社団法人 高分子学会

雑誌

高分子 (ISSN:04541138)

巻号頁・発行日

vol.55, no.5, pp.357-357, 2006-05-01 (Released:2011-10-14)

参考文献数

3

著者

森 俊明 舟崎 真理子 小林 厚志 岡畑 恵雄

出版者

公益社団法人 高分子学会

雑誌

高分子論文集 (ISSN:03862186)

巻号頁・発行日

vol.58, no.10, pp.564-568, 2001-10-25 (Released:2010-03-15)

参考文献数

20

被引用文献数

1 3

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脂質修飾リパーゼは超臨界フルオロフォルム中に可溶化し, R-1-フェニルエタノールを不斉選択的にエステル化する. 超臨界フルオロフォルムの圧量と温度を変化させると, 系内の誘電率を可逆的に変化でき, それにより反応収率は変化しないが, 反応速度を可逆的に制御できることがわかった.

著者

下木戸 隆司

出版者

公益社団法人 日本心理学会

雑誌

心理学研究 (ISSN:00215236)

巻号頁・発行日

vol.78, no.5, pp.469-477, 2007-12-25 (Released:2010-07-16)

参考文献数

35

被引用文献数

2 2

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This study examined whether semantic satiation effects for a picture exemplar differ from a word exemplar. If massive repetition of the category name leads to an inhibition of conceptual processing, then semantic satiation effects would be found in both the word and picture exemplar conditions. However, if the repetition leads to an inhibition of lexical processing, then effects would be found for the word exemplar but not the picture exemplar. To examine these hypotheses, 48 college students were asked to judge whether a target pair of exemplars belonged to the same named category. The results showed that semantic satiation effects were found equally in both exemplar conditions. Moreover, the picture-superiority effect was intact regardless of the prime repetitions. The possibility was discussed that word and picture exemplars are integrated into an abstract and amodal conceptual unit; hence category judgment was affected by the satiation effect.

著者

柴田 昌彦

出版者

日本外科系連合学会

雑誌

日本外科系連合学会誌 (ISSN:03857883)

巻号頁・発行日

vol.36, no.6, pp.1043-1045, 2011 (Released:2012-12-25)

著者

水林 彪

出版者

法制史学会

雑誌

法制史研究 (ISSN:04412508)

巻号頁・発行日

vol.58, pp.431-448, 2009-03-30 (Released:2014-03-31)

著者

Keisuke Fujita Mitsuhiro Iwaki

出版者

日本生物物理学会

雑誌

BIOPHYSICS (ISSN:13492942)

巻号頁・発行日

vol.10, pp.69-75, 2014 (Released:2014-11-01)

参考文献数

36

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Myosin V is a vesicle transporter that unidirectionally walks along cytoskeletal actin filaments by converting the chemical energy of ATP into mechanical work. Recently, it was found that myosin V force generation is a composition of two processes: a lever-arm swing, which involves a conformational change in the myosin molecule, and a Brownian search-and-catch, which involves a diffusive “search” by the motor domain that is followed by an asymmetric “catch” in the forward actin target such that Brownian motion is rectified. Here we developed a system that combines optical tweezers with DNA nano-material to show that the Brownian search-and-catch mechanism is the energetically dominant process at near stall force, providing 13 kBT of work compared to just 3 kBT by the lever-arm swing. Our result significantly reconsiders the lever-arm swinging model, which assumes the swing dominantly produces work (>10 kBT), and sheds light on the Brownian search-and-catch as a driving process.

著者

Taku Ogawa Masatoshi Sato Shinsuke Yonekawa Chiyo Nakagawa Kenji Uno Kei Kasahara Koichi Maeda Mitsuru Konishi Keiichi Mikasa

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.52, no.10, pp.1131-1135, 2013 (Released:2013-05-15)

参考文献数

21

被引用文献数

5 6

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Aminoglycosides are useful antimicrobial agents for treating infective endocarditis; however, they occasionally cause troublesome side effects, such as nephrotoxicity and ototoxicity. We herein report a case of infective endocarditis caused by Enterococcus faecalis that was treated successfully with continuous infusion of ampicillin without adjunctive aminoglycosides. The serum ampicillin concentrations were higher than the minimal inhibitory concentration for the target strain. Although the use of ampicillin monotherapy is currently avoided because double β-lactam therapy is reportedly more effective, continuous penicillin administration remains an effective therapeutic choice for treating infective endocarditis.

著者

吉岡 敏和 水野 清秀 榊原 信夫

出版者

日本活断層学会

雑誌

活断層研究 (ISSN:09181024)

巻号頁・発行日

vol.1997, no.16, pp.87-94, 1997-08-30 (Released:2012-11-13)

参考文献数

9

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The Senzan fault is an active reverse fault directing N-S to NNE-SSW in the central Awaji Island. During the 1995 Hyogoken-nanbu earthquake, a characteristic surface break appeared along the Nojima fault located at the western side of the Awaji Island, however, no surface break had occurred along the Senzan fault. We excavated an exploratory trench on the Senzan fault to detect the age of the faulting events, and we confirmed a reverse fault making a contact between slope deposits and a granitic rock. The youngest age of the hurried soil deformed by the fault is 1161±67 AD. This means that the last faulting event of the Senzan fault occurred after the 12th Century. This event may correspond to the historical Keicho Fushimi earthquake in 1596 AD.

著者

河野 恵美子 奥野 敏隆 長谷川 寛 京極 高久 高峰 義和 林 雅造

出版者

日本臨床外科学会

雑誌

日本臨床外科学会雑誌 (ISSN:13452843)

巻号頁・発行日

vol.68, no.12, pp.2974-2978, 2007-12-25 (Released:2008-08-08)

参考文献数

11

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乳癌術後13×8cmの皮膚欠損創に対し, ラップ療法で治癒した1例を経験したので報告する. 症例は55歳, 女性. 左乳房に15×25×5cm大のカリフラワー様の腫瘍を認め, 乳癌の診断で左乳房切除術を施行した. 第5肋骨の露出を伴う13×8cm大の皮膚欠損創となったが, 創感染のリスクが高いと判断し, 一期的遊離皮膚移植は行わず, 水道水による洗浄後, ポリ塩化ビニリデン製食品包装用ラップフィルムを用いた開放ドレッシング (ラップ療法) を続けた. 術後8日目に肉芽増生が開始し, 17日目には平坦化した. 上皮化は14日目に縦方向, 37日目に横方向が開始したが, 次第に停滞したため, 57日目よりステロイド外用剤を使用したところ, 翌週には, 潰瘍の辺縁に上皮化を認め, 以後1週間に1cmのスピードで上皮化が進み, 約2カ月でほぼ治癒となった. 以上より, ラップ療法は10cm以上の大きな皮膚欠損創でさえも治癒することができる優れた治療法であると考える.

著者

山田 陽子

出版者

日本社会学会

雑誌

社会学評論 (ISSN:00215414)

巻号頁・発行日

vol.63, no.4, pp.630-631, 2013-03-31 (Released:2014-03-31)

著者

尾高 邦雄

出版者

日本社会学会

雑誌

社会学評論 (ISSN:00215414)

巻号頁・発行日

vol.1, no.2, pp.108-115, 1950-09-20 (Released:2010-02-05)

著者

戸田 裕久

出版者

JAPANESE ASSOCIATION OF INDIAN AND BUDDHIST STUDIES

雑誌

印度學佛教學研究 (ISSN:00194344)

巻号頁・発行日

vol.44, no.1, pp.421-418, 1995-12-20 (Released:2010-03-09)

著者

寺田 一之 水谷 嘉孝

出版者

公益社団法人 砂防学会

雑誌

砂防学会誌 (ISSN:02868385)

巻号頁・発行日

vol.56, no.1, pp.37-44, 2003-05-15 (Released:2010-04-30)

参考文献数

2

著者

Shintaro Akiyama Tsunao Imamura Tetsuo Tamura Yuko Koizumi Rikako Koyama Kazuo Takeuchi Goro Watanabe

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.53, no.21, pp.2489-2492, 2014 (Released:2014-11-01)

参考文献数

9

被引用文献数

2 7

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Ursodeoxycholic acid (UDCA) is often used to treat cholesterol gallstones. UDCA makes cholesterol stones soluble, thereby improving biliary emptying. Conversely, however, UDCA can also form stones via an unknown mechanism, as shown in a few previous reports of cholangitis caused by the formation of UDCA stones in the common bile duct (CBD). We herein report four cases of recurrent cholangitis resulting from UDCA stones. The withdrawal of UDCA administration was highly effective in these patients. The details of these four cases suggest that clinicians must rethink the indications for UDCA treatment in cases in which cholangitis caused by CBD stones frequently recurs over a short period of time.

著者

日野原 重明

出版者

一般社団法人 日本総合健診医学会

雑誌

総合健診 (ISSN:13470086)

巻号頁・発行日

vol.41, no.5, pp.591-599, 2014 (Released:2014-11-01)