著者
福本 安甫 田中 睦英 押川 武志
出版者
川崎医療福祉大学
雑誌
川崎医療福祉学会誌 (ISSN:09174605)
巻号頁・発行日
vol.18, no.2, pp.433-438, 2009

高齢者139名を対象に,高齢者意識に関する15項目の質問とQOL評価を行い,高齢者の主観的高齢感とQOLの関係を検討した.日常生活が自立した在宅高齢者の場合は,高齢者であるという意識は少ない傾向にある.高齢感は年齢や性別より「感じ方」の影響が大きく,最大の要因は病気にかかる頻度とそれに対する心配にあるといえ,罹患の頻度が多くなるほど,高齢感が増大する可能性を示唆した.高齢者意識が高いほどQOLが低下する傾向にあり,高齢者自身が高齢者という用語に対して「マイナスイメージ」を持っていることが示唆された.また,高齢感は過去の自分や他者との比較の中から感じ取られる可能性が示唆された.高齢者意識とQOLとの関連において,高齢感が弱い場合は「生活のハリ」「心理的安定感」「積極的外出」などが関連し,高齢感が強い場合は「幸福感」「ゆとり感」「趣味などの楽しみ機会」などに関連することがわかった.これらの関係は,自己受容或いは自己効力感の作用と考えられたが,今後の検討課題となった.これらの結果から,高齢感の変化とQOLの視点をもった予防医学の展開が重要と考えられた.
著者
樋口 博之 田中 睦英 押川 武志 岩本 壮太郎 福本 安甫 ヒグチ ヒロユキ タナカ ムツヒデ オシカワ タケシ イワモト ソウタロウ フクモト ヤスホ Hiroyuki HIGUCHI Mutsuhide TANAKA Takeshi OSHIKAWA Soutarou IWAMOTO Yasuho FUKUMOTO
雑誌
九州保健福祉大学研究紀要 = Journal of Kyushu University of Health and Welfare
巻号頁・発行日
vol.10, pp.141-144, 2009-03

The purpose of this study was to investigate the effect of sports drinks on respiratory quotient (RQ) during moderate exercise, Six young male subjects (aged 20 yr) participated in this study, after the informed consent was obtained from all subjects. Subjects performed a maximal test and four exercises at 50% of maximal oxygen uptake (VO[2]max) using a bicycle ergometer. During exercise tests VO[2], carbon dioxide excretion and RQ were measured by the respiratory gas analyzer. Subjects randomly drunk water or three sports drinks (Pocarisweat, VAAM, Gatorade) (200 ml) before 10 min at the beginning of each exercise, then exercised at 50% VO[2]max for 20min. At rest VO[2] and RQ were 3.6±0.4 ml/kg/min and 0.90±0.09, respectively. VO[2] increased 1.6±3.8 ml/kg/min at 20 min exercise (p<0.001). RQ during exercise was not statistically different from at rest. The differences in VO[2] and RQ among four drinks were not found. These results suggest that VO[2] and RQ during exercise is not extended by the intake of sports drinks.
著者
村井 雄司 青木 裕美 田中 睦 首藤 かい 近藤 有紀 倉重 圭史 疋田 一洋 安彦 善裕 齊藤 正人
出版者
一般財団法人 日本小児歯科学会
雑誌
小児歯科学雑誌 (ISSN:05831199)
巻号頁・発行日
vol.52, no.4, pp.509-517, 2014-11-25 (Released:2015-11-25)
参考文献数
63

生体を覆う上皮は,重層や角化および上皮間の緊密な結合により病原体が生体に侵入することを防ぐ物理的防御機構と,抗菌ペプチドを発現することにより病原体の付着を抑制する化学的防御機構を有している。活性型ビタミンD3 の生理活性は,カルシウム代謝調節による骨リモデリングのみならず,上皮細胞の分化誘導や,免疫調節に関わっていることが明らかになっている。本研究では活性型ビタミンD3 をヒト角化上皮細胞株(HaCaT 細胞)に添加することによる,抗菌ペプチドの発現変化を明らかにすることを目的とした。HaCaT 細胞は,活性型ビタミンD3 添加により抗菌ペプチドであるhBD-1, hBD-2 およびLL-37 mRNA と,それぞれのペプチドの有意な発現上昇を認めた。しかしhBD-3 は変化を認めなかった。本結果から活性型ビタミンD3 は角化上皮の化学的防御機構に寄与し,これを増強すると考えられた。また発現上昇を認めた抗菌ペプチドは,齲蝕原因菌や歯周病菌に対しても抗菌作用を有するため,良好な口腔環境維持するうえで活性型ビタミンD3 の存在が重要である可能性が示唆された。
著者
中島 良和 杉谷 俊明 田中 睦夫 藤井 聰
出版者
社団法人 日本食品科学工学会
雑誌
日本食品工業学会誌 (ISSN:00290394)
巻号頁・発行日
vol.37, no.7, pp.554-558, 1990
被引用文献数
10

シナノキの蜂蜜から,ゲル濾過,イオン交換樹脂クロマトグラフィおよびHPLCを用いてトレハルロース(1-O-α-D-g1ucopyranosyl-D-fructose)を分離し,TLCおよび13C-NMRにより同定した.トレハルロースの存在は日本国内の蜜源植物7種類に由来する蜂蜜試料9点で確認され,その含有率は蜂蜜固形分の0.5から2.5%であった.
著者
紀平 寛 田辺 康児 楠 隆 竹澤 博 安波 博道 田中 睦人 松岡 和巳 原田 佳幸
出版者
公益社団法人 土木学会
雑誌
土木学会論文集 (ISSN:02897806)
巻号頁・発行日
vol.2005, no.780, pp.780_71-780_86, 2005 (Released:2006-04-07)
参考文献数
42
被引用文献数
14 13

耐候性鋼の超長期にわたる腐食減耗予測法について研究を行った. さび安定化概念にもとづく思想を体系的に展開し, 腐食速度パラメータを推定するアルゴリズムや数式モデルの立案, 地域気象情報のデータベース化, 簡易な飛来塩分量および硫黄酸化物量の推定法などを策定した. 複雑な計算過程を容易に操作できるよう, 内桁条件における腐食減耗予測シミュレーションソフトウェアも開発した. 前記の思想展開により, 設計にて考慮すべき予測腐食減耗量を見極めるための工学的指標群を初めて具体的かつ体系的に整理・提案し, 長期耐久性の実現に関わる数多な構成技術要素保障項目の関連性を明確にした. 今後の進化へ向けて検討すべき点を明らかにしつつ, 現在までの進捗内容を詳細に報告する.
著者
鈴木 正彦 荒井 千春 手塚 春樹 中澤 美科 田中 睦子 河野 健治 花輪 剛久 中島 新一郎
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.28, no.6, pp.623-629, 2002-12-10 (Released:2011-03-04)
参考文献数
7

Regarding the management of blood preparations, since September 1995 the Ministry of Heath, Labour and Welfare has had to make and/or to keep documentary records such as the product name, date of dispensing, the patient's name and lot number and so on. At Yamanashi Medical University Hospital, to cope with deleterious accidents caused by blood preparations, we developed a new system for the management of blood preparations. This system consists of a printing system for confirmation labels for blood prescriptions and a computerized management system concerning the medication. In this study, the effect of this new management system on the rational use of blood preparations was evaluated. Compared with the former system, the time required to dispense blood preparations decreased from about 500 to 170 seconds per case. Furthermore, based on a questionnaire to medical doctors and/or nurses, it appeared that this system could reduce the time required to manage blood preparations and improve the rational use of injectable drugs.
著者
田中 睦子 河野 健治 花輪 剛久 鈴木 正彦 中島 新一郎
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.28, no.2, pp.152-156, 2002-04-10 (Released:2011-03-04)
参考文献数
12

Di-2-ethylhexyl Phthalate (DEHP) was reported to dissolve from a polyvinyl chloride (PVC) administration tube during the infusion of an injection fluid containing a solvilizing agent, soybean oil or lecithin, etc. This paper describes the behavior of DEHP dissolution from PVC tubes during enteral tube feeding. The DEHP concentration was determined using HPLC. After the passage the ENSURE LIQUID® (EL) solution through the PVC tube, DEHP was dissolved in the EL solution. The EL solution is one type of enteral nutrition. This dissolution pattern was similar to that of injection fluid containing a solvilizing agent, in which the DEHP concentration in the EL solution increased linearly over time at first and thereafter reached a plateau. 170 μg of the DEHP was dissolved after 200mL of the EL solution had passed through the PVC administration set (the drip conditions were 25°C, 100mL/hr, tube length 115cm and inner diameter 0.3cm). The amount of DEHP which dissolved into the solution depended on the temperature (25-40°C), and no clear difference was observed between the PVC tubes (administration tube, feeding tube). In addition, the amount of DEHP that dissolved into the solution varied depending on the type of enteral nutrition.
著者
河野 彬 菅田 節朗 原 泰寛 田中 睦子 加留部 喜晴 松島 美一
出版者
The Pharmaceutical Society of Japan
雑誌
Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日
vol.31, no.5, pp.1666-1669, 1983-05-25 (Released:2008-03-31)
参考文献数
19
被引用文献数
2

A sensitive method for the assay of pyrimidine nucleoside phosphorylases in preparations of human and animal tissues by determination of pyrimidines is described. Pyrimidines formed enzymatically from thymidine, uridine, 5-fluorouridine, and 5'-deoxy-5-fluorouridine are determined by means of high-performance liquid chromatography with ultraviolet (UV) detection. The pyrimidines, after extraction with ethyl acetate, are separated by reversed-phase chromatography on μ-Bondapak C-18/Porasil. The limits of detection are 2.5, 1.0, and 2.0 pmol for thymine, uracil, and 5-fluorouracil, respectively.
著者
山下 正文 橋本 隆寿 平川 俊彦 福島 武雄 朝長 正道 原 泰寛 河野 彬 田中 睦子
出版者
The Japan Neurosurgical Society
雑誌
Neurologia medico-chirurgica (ISSN:04708105)
巻号頁・発行日
vol.25, no.8, pp.613-619, 1985-08-15 (Released:2006-09-21)
参考文献数
17
被引用文献数
1 2

To evaluate the usefulness of 5'-deoxy-5-fluorouridine (5'-DFUR) therapy for brain tumor, the pharmacokinetics of 5'-DFUR and 5-fluorouracil (5-FU) in the tumor, in the white matter surrounding the tumor and in the serum were investigated, and the thymidine phosphorylase, the main activating enzyme of 5'-DFUR in human tissues, was also studied. Materials were obtained from 24 cases of primary brain tumors and from 4 cases of metastatic carcinoma. During the operation 500 or 1, 000 mg of 5'-DFUR was administrated intravenously, and blood, tumor tissue and white matter were taken mainly within 60 minutes and partly within 180 minutes after intravenous administration of 5'-DFUR. In some cases samplings were performed serially. Concentrations of 5'-DFUR and 5-FU were measured by high performance liquid chromatography, and thymidine phosphorylase activity in tissue extracts was obtained against d-thymidine and/or 5'-DFUR as substrates. The concentrations of 5'-DFUR and 5-FU in serum decreased immediately in an exponential mode after intravenous administration of 1, 000 or 500 mg of 5'-DFUR. High concentrations of 5'-DFUR and 5-FU in the tumor tissues were noticed in malignant tumors, such as glioblastoma, ependymoma and chondrosarcoma, and 5-FU concentrations in the tumor in two cases of glioblastoma and one of ependymoma were higher than that in their sera. An important characteristic of 5'-DFUR was that it was converted to 5-FU in various tissues predominantly in malignant neoplasms. Thymidine phosphorylase activity was more prominent in glioblastoma, metastatic carcinoma and chordoma. Although the 5'-DFUR concentration in white matter was considerable, the 5-FU concentration was negligible suggesting low enzyme activity. An effect of 5'-DFUR therapy on malignant brain tumor should be expected from the high concentration of 5' DFUR and 5-FU in the tumor tissue. However, these high concentrations rapidly decreased, therefore, the appropriate mode of prescription of 5'-DFUR should be considered in clinical practice.
著者
田中 睦英 小浦 誠吾
出版者
九州保健福祉大学
雑誌
九州保健福祉大学研究紀要 (ISSN:13455451)
巻号頁・発行日
vol.13, pp.71-76, 2012-03

Objective:The aim of this study was to evaluate the stress-relieving effect of the aroma of chamomile essential oil by measuring salivary amylase activity and electroencephalogram (EEG) analyses of test subjects. Design:Twenty healthy students performed a calculation task (Uchida-Kraepelin test) for 15 min and then rested for 5 min. During the rest period, 10 students (the aroma group) were exposed to airborne organic chamomile essential oil. After the rest period,all students performed the calculations for further 15 min. Saliva samples were collected at baseline, after the calculation tasks and during the rest period simultaneously with EEG assessment. Results:During the study, no statistically significant changes in levels of salivary amylase activity was detected in either the aroma group or the control group. However, a decrease in frontal beta activity and an increase in slow alpha activity were clearly observed after the rest period among women in the aroma group. The control group and the men in the aroma group showed no such changes. Conclusions:These findings suggest that the aroma of chamomile essential oil has a stress-relieving effect on women.