著者

Pungier Marie-Francoise

出版者

大阪府立大学人文学会

雑誌

人文学論集. 平木康平教授退職記念号 (ISSN:02896192)

巻号頁・発行日

no.26, pp.1-50, 2008-03-30

著者

Fernando LÓPEZ-GATIUS Irina GARCIA-ISPIERTO Ronald H.F. HUNTER

出版者

The Society for Reproduction and Development

雑誌

Journal of Reproduction and Development (ISSN:09168818)

巻号頁・発行日

pp.2021-022, (Released:2021-05-30)

被引用文献数

3

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This study sought to establish whether temperature gradients between the cervix, vagina, and rectum at and 7 days post-artificial insemination (AI) were associated with the incidence of pregnancy in lactating dairy cows (Experiment I; n = 90 ovulating cows) and to evaluate temperature gradient dynamics from the time of insemination to 7 days post-AI under heat stress conditions (Experiment II; n = 16 ovulating and 4 non-ovulating cows). In Experiment I, 39 cows (43.3%) became pregnant. The odds ratio for pregnancy was 2.5 for each one-tenth of a degree drop in cervical temperature with reference to the control rectal temperature at the time of AI (P = 0.01), whereas the same decrease in the cervix–rectum temperature differential 7 days post-AI resulted in ana odds ratio of 0.44 (P = 0.02). In Experiment II, 5 of the ovulating cows (31.3%) became pregnant. The mean values of the vagina–rectum, vagina–cervix, and cervix–rectum temperature differentials at AI (day 0), 8 h, 24 h, and 7 days post-AI changed significantly from day 0 to day 7 (within-subject effect; P < 0.02) in ovulating cows but not in non-ovulating cows. Temperature differentials on days 0 and 7 were similar between ovulating cows and cows of Experiment I. Overall, our findings support the notion that a temperature differential between the caudal cervical canal and rectum at AI may be an indicator of the likelihood of pregnancy. Possible prospects of confirming estrus at the herd-level are also suggested.

著者

Akiko Yaguchi-Saito Ken Yamamoto Tami Sengoku Machi Suka Tsugumichi Sato Miwa Hinata Toshiaki Nakamura Takeo Nakayama Michiko Yamamoto

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

Drug Discoveries & Therapeutics (ISSN:18817831)

巻号頁・発行日

pp.2021.01028, (Released:2021-04-30)

参考文献数

20

被引用文献数

2

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Since 2011, pharmaceutical companies in Japan have been required to issue two types of documents regarding severe adverse drug reactions reported post-marketing, namely the Rapid Safety Communication Materials for Patients and the Related Materials. However, the adequacy of these documents has not yet been systematically assessed. The aim of this study was to evaluate the adequacy of these two types of materials. The Rapid Safety Communications for Patients were obtained from the Pharmaceuticals and Medical Devices Agency (PMDA) website. The Related Materials were obtained from pharmaceutical companies or the PMDA website. Three assessors independently scored the Rapid Safety Communication for Patients and the Related Materials using the Centers for Disease Control and Prevention Clear Communication Index (CCI). In addition, the contents and descriptions of the materials were analyzed. In total, 13 materials for seven drugs were assessed. Almost all materials contained the "main message" and "call to action". However, the average CCI scores for the Rapid Safety Communication for Patients and Related Materials for Patients were 68.8 and 74.3 (out of 100), respectively. Further, none of the evaluated materials were scored above the CCI threshold score (i.e., ≥ 90%). Descriptions regarding "language", "state of science", and "risk" were not adequate. In particular, the terminology used in materials seemed difficult for patients to understand. In conclusion, the Japanese Rapid Communication Materials for Patients require improvement. Furthermore, a system for evaluating these materials prior to publication should be established.

著者

Izumi Oh-e Kuniyuki Saitoh Toshiro Kuroda

出版者

CROP SCIENCE SOCIETY OF JAPAN

雑誌

Plant Production Science (ISSN:1343943X)

巻号頁・発行日

vol.10, no.4, pp.412-422, 2007 (Released:2007-10-19)

参考文献数

33

被引用文献数

124

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The effect of high temperatures on growth, yield and dry-matter production of rice growing in the paddy field was examined during the whole growth period in a temperature gradient chamber (TGC) from 2002 to 2006. Experimental plots, TG1 (control), TG2, TG3 and TG4, were arranged along the temperature gradient (from low to high temperature) in TGC. The mean and maximum air-temperatures in TG4 were 2.0-3.6°C and 4.0-7.0°C higher, respectively, than those in TG1. The plant height was taller and the maximum tillering stage was earlier in TG2, TG3 and TG4 than in TG1. Plant dry weight at maturity in TG2 and TG3 was 12.8-16.4% heavier than that in TG1. In TG4, the increase in the panicle dry weight during the ripening period was smallest and plant dry weight at maturity was 11-16% heavier than that in TG1. The increase in plant dry-matter during the ripening period was smallest in TG4. The decrease in the dry weight of stem and leaf during the ripening period, which represents the amount of assimilate translocation to the panicle, was also larger in TG2-4 than in TG1. The increase in the dry weight of stem in TG2-4 at maturity was also larger than that in TG1. The photosynthetic rate in TG2-4 was up to 35.6% lower than that in TG1 because of the acceleration of leaf senescence. Brown rice yield in TG4 was 6.6-39.1% lower than that in TG1. This yield decline was due to the decrease in the percentage of ripened grains and increase in the percentage of sterile spikelets. The relation between brown rice yield and mean air-temperature during 20 days after heading showed that the brown rice yield declined when mean air-temperature exceeded 28°C.

著者

Paul Chacornac présentation par Paul-Redonnel préface de Victor-Emile Michelet

出版者

Editions Tradutionnelles

巻号頁・発行日

1989

著者

竹松 正樹 下 相慶 VOLKOV Y.N. 崔 ぴょん昊 羅 貞烈 金 くー 金 慶烈 蒲生 俊敬 磯田 豊 DANCHENKOV M GONCHAREKO I CREPON M. LI RongーFeng JI ZhougーZhe ZATSEPIN A.G MILLOT C. SU JiーLan 尹 宗煥 OSTROVSKII A 松野 健 柳 哲雄 山形 俊男 野崎 義行 大谷 清隆 小寺山 亘 今脇 資郎 増田 章 YUNG John-fung BYOG S-k. NA J.-y. KIM K.r. CHOI Byong-ho CREPON Michel 崔 秉昊 金 丘 オストロフスキー A.G YURASOV G.I. 金子 新 竹内 謙介 川建 和雄 JIーLAN Su FENG Li Rong FEI Ye Long YARICHIN V.G PONOMAREV V. RYABOV O.A.

出版者

九州大学

雑誌

国際学術研究

巻号頁・発行日

1993

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1.本研究の特色は、研究分担者間の研究連絡・交流を促進し、研究成果の統合を図るに止まらず、研究課題に対する理解を格段に深めるのに必要な新しいデータセットの取得を提案し、実行することにある。実際、前年度の本研究主催の国際研究集会(福岡市)に於いて策定された計画に従い、平成6年7月に、日・韓・露の3国の参加を得て、日本海全域に亘る国際共同観測を実施した。この夏季観測では、海底までの精密CTD、化学計測、ドリフタ-の放流、測流用係留系(3本)の設置・回収と並んで、分担者の開発した特殊な曳航体を用いてクロロフィル、O_2、CO_2及び表層流速の測定が試みられた。特筆すべきは、日本海北部のロシア経済水域内の3点において、11ヶ月に及び長期測流データを取得したことである。これは、日本海誕生以来、初めて、日本海盆の中・深層の流動特性を明らかにしたもので貴重である。なお、現在、3本の係留計(うち1本にはセディメントトラップ付)が海中にあって測流中である。更に、冬期の過冷却による深層水の生成過程を調べる目的で、平成7年3月1日から、ウラジオストック沖において、3国共同観測が実施された。これは、次年度以降に予定されている本格的な冬季観測の準備観測として位置づけられている。2.現地観測による新しいデータセット取得の努力と並んで、室内実験に関する共同研究も活発に実施された。即ち、昨年度の研究集会での打ち合わせに従って、日・韓・露でそれぞれ冷却沈降過程に関する実験を進めるとともに、平成6年10月にはロシア・シルショフ研究所からディカレフ氏(研究協力者)を日本に招き、また、研究代表者が韓国漢陽大学を訪問し研究途中成果の比較検討を行った。この共同研究においては、特に、自由表面を確保する冷却(駆動)方法が試みられ、従来の固体表面を持つ実験と著しい差異があることを見出した。しかし、こうした実験結果を現実の沈降現象と結びつけるには、冬季における集中的現地観測の成果を持たねばならない。3.昨年1月の研究集会での検討・打合わせに従って、日・韓・仏・中・(米)の研究者により、日本海及び東シナ海域に関する数値モデル研究が共同で進められた。その成果として、東韓暖流の挙動(特に離岸現象)を忠実に再現できる新しい日本海数値モデルを開発するとともに、黒潮を含む東シナ海域の季節変動のメカニズムを解明するための数値モデル研究がなされた。4.夏季観測の際に放流したドリフタ-(アルゴスブイ)の挙動は韓国・成均館大学及び海洋研究所で受信され、衛星の熱赤外画像と高度計データは九州大学で連続的に収集された。こうした表層に関する情報を有機的に結合し、検討するため、平成7年1月に成均館大学の崔教授が九州大学を訪問した。5.以上の共同研究活動の全成果を多面的に検討し統合するために、平成6年11月7〜8日の2日間に亘り、韓国ソウル大学に於いて開催された国際研究集会に参加した。この集会には、日本・韓国・ロシアから、一般参加も含めて、約70名の参加者があった。参加者の専門分野が、海洋物理、化学、海洋工学及び生態学と多岐にわたっていることは学際性を標ぼうする本研究の特色を象徴するものである。アメリカからも2名の特別参加があり、本研究が口火を切った日本海及び東シナ海に関する学際的・国際的研究に対するアメリカの並々ならぬ関心が表明された。なお、ここで公表・検討された成果は、逐次、学術誌において印刷公表される予定である。過去2年に亘る本研究成果の総括もなされたが、そこでは、本研究が取得した新しいデータセットは、問題に解答を与えるというよりも、むしろ、新たな問題を提起する性質のものであることが認識された。そのため、最終セッションでは、提起された問題を解明して行くための今後の方策(主に現地観測)が詳細に検討された。

著者

斯波 廣大 Chih-Chieh CHEN 曽我部 完 坂本 克好 山口 浩一 曽我部 東馬

出版者

一般社団法人 人工知能学会

雑誌

人工知能学会全国大会論文集 第34回全国大会(2020)

巻号頁・発行日

pp.4B3GS102, 2020 (Released:2020-06-19)

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ゲート方式の量子コンピュータを用いた最適化問題の解法は、VQEアルゴリズムを用いたものやQAOAアルゴリズムを用いたものが存在し、実社会の最適化問題に対する解法の1つとして、現在注目を集めている。ゲート方式の量子コンピュータを用いた最適化問題の計算手法は、量子アニーリングによる計算手法よりも拡張性が高く、様々な種類の最適化問題に対応できる可能性がある。しかしながら、複数の制約条件を考慮した複雑な最適化問題において、正しい最適解を計算する手法は未だ確立されていない。そこで今回は、制約条件を考慮した、より実問題に近い最適化問題に対する計算手法の1つであるハミルトニアン混合型手法を応用するとともにその有効性を検証する。

著者

Jun Nishihira Mie Nishimura Masanori Kurimoto Hiroyo Kagami-Katsuyama Hiroki Hattori Toshiyuki Nakagawa Takato Muro Masuko Kobori

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

pp.21-17, (Released:2021-05-21)

参考文献数

44

被引用文献数

22

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Quercetin, a type of flavonoid, is believed to reduce age-related cognitive decline. To elucidate its potential function, we carried out a randomized, double-blind, placebo-controlled, parallel-group comparative clinical trial involving 24-week continuous intake of quercetin-rich onion compared to quercetin-free onion as a placebo. Seventy healthy Japanese individuals (aged 60 to 79 years old) were enrolled in this study. We examined the effect of quercetin-rich onion (the active test food) on cognitive function using the Mini-Mental State Examination, Cognitive Assessment for Dementia iPad version, and Neuropsychiatric Inventory Nursing Home version. The Mini-Mental State Examination scores were significantly improved in the active test food group (daily quercetin intake, 50 mg as aglycone equivalent) compared to the placebo food group after 24 weeks. On the Cognitive Assessment for Dementia iPad version for emotional function evaluation, we found that the scores of the active test food group were significantly improved, suggesting that quercetin prevents cognitive decline by improving depressive symptoms and elevating motivation. On the Neuropsychiatric Inventory Nursing Home version, we found significant effects on reducing the burden on study partners. Taking all the data together, we concluded that 24-week continuous intake of quercetin-rich onion reduces age-related cognitive decline, possibly by improving emotional conditions. Clinical trial register and their clinical registration number: This study was registered with UMIN (approval number UMIN000036276, 5 April 2019).

著者

Makoto Sugihara Kaori Mine Makito Futami Yuta Kato Tadaaki Arimura Masaya Yano Yosuke Takamiya Takashi Kuwano Shin-ichiro Miura

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

pp.CR-20-0095, (Released:2020-10-16)

参考文献数

21

被引用文献数

4

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Background:Drug-coated balloon strategies in endovascular therapy often result in severe dissection, so lesion preparation must be improved. We evaluated the efficacy of a gradual inflation method, termed “super slow inflation” (SSI), in preparing lesions to avoid severe dissections.Methods and Results:The association between balloon pressure and the dilatation of a model constricted vessel, as well as the load applied to the balloon surface, were determined using a burst leak detector for a quick inflation (QI; 1 atm/s) protocol and SSI (1 atm/20 s). A retrospective, single-center, non-randomized study evaluated differences in vessel dissection patterns after balloon angioplasty depending on inflation method in 81 consecutive patients (mean [±SD] age 74.6±9.2 years; 54 males) who underwent balloon angioplasty for de novo femoropopliteal lesions between January 2017 and March 2019. In the constricted vessel model, vessel dilatation increased gradually using SSI, with the maximum dilatation load being approximately 100 g lower for the SSI than QI protocol. In patients, the rate of severe vessel dissection was significantly lower in the SSI than non-SSI group (17.6% vs. 55.2%, respectively; P<0.001). Multivariate regression analysis revealed that SSI was an independent factor preventing severe dissection (odds ratio 0.18; 95% confidence interval 0.06–0.53; P=0.002).Conclusions:SSI is a gentle and effective method for the preparation of femoropopliteal lesions to reduce the incidence of severe angiographic dissection when using drug-coated balloons.

著者

Julio C Almanza-Perez Beatriz Mora-Ramiro Wendoline Rosiles-Alanis Francisco J Alarcon-Aguilar Jose L Ventura-Gallegos Luis E Gomez-Quiroz Alejandro Zentlla-Dehesa

出版者

Japanese Pharmacological Society

雑誌

日本薬理学会年会要旨集 (ISSN:24354953)

巻号頁・発行日

pp.PO3-10-20, 2018 (Released:2020-09-10)

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BACKGROUNDThe chronic inflammatory process is a critical characteristic in several diseases. This condition has an important impact on the quality life of patients, as well as on their economic and social state. Patients in this condition use several anti-inflammatory agents, which are classified according to their chemical nature as steroidal (SAIDs) and non-steroidal (NSAIDs). However, It has been reported that its clinical use can generate dangerous adverse effects. For this motive, people use medicinal plants as an alternative of treatment. Several plants have been traditionally used as anti-inflammatory agents worldwide. One example is Psacalium decompositum, which has been reported with anti-inflammatory and antidiabetic effects. In chemical studies, sesquiterpenic compounds have been isolated, being the cacalol the main compound, which is considered the responsible principle of the anti-inflammatory effect of this plant. However, the action mechanisms involved in the anti-inflammatory action of cacalol have not yet been explored.The aim of this investigation was to establish whether the anti-inflammatory action of cacalol involves the Nf-kB pathway, using an in vitro model.METHODSRAW 264.7 macrophages were cultured and pre-stimulated with LPS. Two hours after, the cells were treated with cacalol. The concentration and relative expression of cytokines were quantified by RT-PCR. The cytokines studied were TNF, IL-6, IL-1b and IL-10. The pohosphorylated subunit p65 of Nf-kB and its nuclear translocation were measured by EMSA.RESULTSThe mRNA expression of TNF, IL-6 and IL-1b were significantly decreased in the macrophages due to cacalol. The protein concentrations in the culture of the cytokines also decreased. No changes were detected in the mRNA expression and concentration of IL-10. The cacalol decreased the concentration of the phosphorylated p65 subunit as did the translocation of Nf-kB to the nucleus.CONCLUSIONSCacalol suppressed the concentrations of pro-inflammatory cytokines without affecting the anti-inflammatory cytokines. This could be associated with the inhibition of the Nf-kB pathway, since the levels of the phosphorylated p65 subunit were reduced. It is important to continue with the study of the factors involved in the regulation of said inhibition, as well as of other transcription factors involved in the anti-inflammatory action of cacalol.

著者

Deborah Ribeiro Nascimento Suzana Lopes Bomfim Balaniuc Durval Batista Palhares Adam Underwood Marilene Garcia Palhares Fabiana Alves Francisco Oliveira Vieira Elaine Maria Souza-Fagundes Liane De Rosso Giuliani Paula Cristhina Niz Xavier Helen Lima Del Puerto Robson Augusto Souza Santos Amy Milsted Jose Mauro Brum Iandara Schettert Silva Almir Sousa Martins

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

Intractable & Rare Diseases Research (ISSN:21863644)

巻号頁・発行日

pp.2021.01012, (Released:2021-05-22)

参考文献数

54

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Fibrodysplasia Ossificans Progressiva (FOP) is a rare congenital intractable disease associated with a mutation in ACVR1 gene, characterized by skeleton malformations. Ascorbic acid (AA) and propranolol (PP) in combination is reported to minimize flare-ups in patients. FOP leukocyte phenotype may possibly be modulated by AA and PP treatment. In this study, expression of 22 potential target genes was analyzed by RT-PCR in peripheral blood mononuclear cells culture (PBMC) from FOP patients and controls to determine effectiveness of the combination therapy. PBMC were treated with AA, PP and AA+PP combination. Basal expression of 12 of the 22 genes in FOP PBMC was statistically different from controls. ACVR1, ADCY2, ADCY9 and COL3 were downregulated while COL1 was upregulated. ADRB1, ADRB2, RUNX2, TNF-α and ACTB, were all overexpressed in FOP PBMC. In control, AA upregulated COL1, SVCT1, ACTB, AGTR2 and downregulated ADCY2. In FOP cells, AA upregulated ACVR1, BMP4, COL1, COL3, TNF-α, ADCY2, ADCY9, AGTR2 and MAS, while downregulated ADBR2, RUNX2, ADCY1, SVCT1 and ACTB. PP increased ADBR1 and decreased RUNX2, TNF-α, AGTR1, ACTB and CHRNA7 genes in treated control PBMC compared to untreated. PP upregulated ADBR1, ADBR2 and MAS, and downregulated TNF-α and ACTB in treated FOP PBMC versus untreated. AA+PP augmented ADRB1 and ADRB2 expressions in control PBMC. In FOP PBMC, AA+PP augmented ACVR1, COL1, COL3, ADBR1, AGTR2 and MAS expression and downregulated ADBR2, RUNX2, ACTB and MRGD. These data show distinct gene expression modulation in leukocytes from FOP patients when treated with AA and or PP.

著者

Masayuki Kuroda Hideaki Bujo Koutaro Yokote Takeyoshi Murano Takashi Yamaguchi Masatsune Ogura Katsunori Ikewaki Masahiro Koseki Yasuo Takeuchi Atsuko Nakatsuka Mika Hori Kota Matsuki Takashi Miida Shinji Yokoyama Jun Wada Mariko Harada-Shiba on behalf of the Committee on Primary Dyslipidemia under the Research Program on Rare and Intractable Disease of the Ministry of Health Labour and Welfare of Japan

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.RV17051, (Released:2021-04-18)

参考文献数

68

被引用文献数

7

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Lecithin cholesterol acyltransferase (LCAT) is a lipid-modification enzyme that catalyzes the transfer of the acyl chain from the second position of lecithin to the hydroxyl group of cholesterol (FC) on plasma lipoproteins to form cholesteryl acylester and lysolecithin. Familial LCAT deficiency is an intractable autosomal recessive disorder caused by inherited dysfunction of the LCAT enzyme. The disease appears in two different phenotypes depending on the position of the gene mutation: familial LCAT deficiency (FLD, OMIM 245900) that lacks esterification activity on both HDL and ApoB-containing lipoproteins, and fish-eye disease (FED, OMIM 136120) that lacks activity only on HDL. Impaired metabolism of cholesterol and phospholipids due to LCAT dysfunction results in abnormal concentrations, composition and morphology of plasma lipoproteins and further causes ectopic lipid accumulation and/or abnormal lipid composition in certain tissues/cells, and serious dysfunction and complications in certain organs. Marked reduction of plasma HDL-cholesterol (HDL-C) and corneal opacity are common clinical manifestations of FLD and FED. FLD is also accompanied by anemia, proteinuria and progressive renal failure that eventually requires hemodialysis. Replacement therapy with the LCAT enzyme should prevent progression of serious complications, particularly renal dysfunction and corneal opacity. A clinical research project aiming at gene/cell therapy is currently underway.

著者

BARREYAT Marylis CHAMBON Philippe MAHFOUF Jean-François FAURE Ghislain IKUTA Yasutaka

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2021-050, (Released:2021-04-30)

被引用文献数

3

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The assimilation of cloudy and rainy microwave observations is under investigation at Météo-France with a method called ‘1D-Bay+3D/4D-Var’. This method consists of two steps: (i) a Bayesian inversion of microwave observations and (ii) the assimilation of the retrieved relative humidity profiles in a 3D/4D-Var framework. In this paper, two estimators for the Bayesian inversion are used: either a weighted average (WA) or the maximum likelihood (ML) of a kernel density function. Sensitivity studies over the first step of the method are conducted for different degrees of freedom: the observation error, the channel selection and the scattering properties of frozen hydrometeors in the observation operator. Observations over a two-month period of the Global Precipitation Measurement (GPM) Microwave Imager (GMI) on-board the GPM-Core satellite and forecasts of the convective scale model Application of Research to Operations at Mesoscale (AROME) have been chosen to conduct these studies. Two different meteorological situations are analysed: those predicted cloudy in AROME but clear in the observations and, on the contrary, those predicted clear in AROME but cloudy in the observations.Main conclusions are as follows. First, low observational errors tend to be associated with the profiles with the highest consistency with the observations. Second, the validity of the retrieved profiles varies vertically with the set of channels used. Third, the radiative properties used in the radiative transfer simulations have a strong influence on the retrieved atmospheric profiles. Finally, the ML estimator has the advantage of being independent of the observation error but is less constrained than the WA estimator when few frequencies are considered. While the presented sensitivities have been conducted to incorporate the scheme in a data assimilation system, the results may be generalized for geophysical retrieval purposes.

著者

亀山 敦史 森 啓 小町谷 美帆 小松 佐保 内川 竜太郎 甲田 訓子 奥瀬 稔之 小林 彩 呉 佳瑩 KAMEYAMA ATSUSHI MORI HIROSHI KOMACHIYA MIHO KOMATSU SAHO UCHIKAWA RYUTARO KOHDA KUNIKO OKUSE TOSHIYUKI KOBAYASHI AYA WU CHIA-YING

出版者

松本歯科大学学会

雑誌

松本歯学 = Journal of the Matsumoto Dental University Society (ISSN:21887233)

巻号頁・発行日

vol.46, no.2, pp.88-96, 2021-03-16

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Summary Many attempts to utilize ICT (Information and Communication Technology) tools have been made to promote active and interactive learning between teachers and students. A major area has been the introduction of education using clickers for dental students, and some reports indicated their effects. However, the introduction of mobile devices and software and their maintenance and management very costly. On the other hand, almost allundergraduate students of Matsumoto Dental University have a smartphone, and can connect to the Internet in the lecture room. Therefore, we conducted online exercises to pre- pare for the National Board Dental Examination using students' smartphones and the online real–time voting service"Mentimeter" at the lecture of Operative Dentistry for 6th–year dental students of Matsumoto Dental University, in the school year of 2019. We also conducted some anonymous online questionnaires using Mentimeter. Thirty percent of the participating students answered that they were not good at conservation and restoration studies. Although 97% of students answered that the test questions conducted in the exercise using Mentimeter were difficult, 92% of the students answered that the exercise was effective in deepening their knowledge of Operative Dentistry. The results of the questionnaires suggested the effectiveness of the interactive lecture using Mentimeter in order to deepen and retain knowledge of Operative Dentistry.

著者

崔 勝淏 Seung-Ho Choi

雑誌

立教經濟學研究

巻号頁・発行日

vol.49, no.2, pp.97-110, 1995

著者

edited by Nicolas Detering Clementina Marsico Isabella Walser-Bürgler

出版者

Brill

巻号頁・発行日

2020

著者

Shinji Ouma Jiro Fukae Shinsuke Fujioka Shosaburo Yamamoto Taku Hatano Asako Yoritaka Yasuyuki Okuma Ken-ichi Kashihara Nobutaka Hattori Yoshio Tsuboi

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.56, no.15, pp.1961-1966, 2017-08-01 (Released:2017-08-01)

参考文献数

22

被引用文献数

10 18

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Objective Parkinson's disease (PD) is a common, progressive, neurodegenerative disorder. With progression of PD, the wearing-off phenomenon occurs more frequently as a motor complication, decreasing the patient's quality of life. The aim of this study was to investigate the risk factors for the wearing-off phenomenon in Japanese PD patients. Methods All of the study participants were clinically diagnosed as having PD. Each patient was assessed for the wearing-off phenomenon based on the findings of clinical assessments and interviews that were conducted during a single visit. The risk factors for wearing-off were analyzed by univariate and multivariate logistic regression analyses. Results Wearing-off was observed in 101 of the 180 (56.1%) patients who were enrolled in this study. The multivariate logistic regression analysis revealed that the onset of PD at ≥69 years of age (odds ratio [OR], 0.22; 95% confidence interval [CI], 0.05-0.88; p=0.032), female sex (OR, 6.49; 95% CI, 2.34-17.99; p<0.001), catechol-O-methyltransferase (COMT) inhibitor treatment (OR, 19.59; 95% CI, 3.55-108.11; p<0.001) and a high daily levodopa dosage (≥600 mg/day) (OR, 7.69; 95% CI, 1.41-41.84; p=0.018) were independent predictive factors for wearing-off in Japanese PD patients. Conclusion Age at the symptomatic disease onset, female sex, COMT inhibitor treatment, and a high daily levodopa dose were associated with the occurrence of wearing-off in Japanese PD patients. Physicians need to consider the risk factors and carefully choose medications for PD patients to postpone the occurrence of this phenomenon for as long as possible.

著者

鈴木 浩史1 湊 真一1 Suzuki 1 Hirofumi Shin-ichi Minato

雑誌

SIG-FPAI = SIG-FPAI

巻号頁・発行日

vol.B5, no.01, pp.41-46, 2016-08-01

著者

日経ヘルスケアCOVID-19取材班

出版者

日経BP社

雑誌

日経ヘルスケア = Nikkei healthcare : 医療・介護の経営情報 (ISSN:18815707)

巻号頁・発行日

no.369, pp.24-29, 2020-07

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独立行政法人福祉医療機構が四半期ごとに行っている病院経営動向調査では、2020年6月の実施分で、特別設問として新型コロナウイルス感染症(COVID-19)による経営への影響を尋ねた(回答数311病院、有効回答率は82.9%)。その結果、2020年5月の医業収益(見込み)…

著者

本多ハワード 素子 入吉 礼菜 Motoko HONDA-HOWARD Reina IRIYOSHI

雑誌

昭和女子大学生活心理研究所紀要 = Annual bulletin of Institute of Psychological Studies, Showa Women's University (ISSN:18800548)

巻号頁・発行日

vol.16, pp.11-19, 2014-03-31

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We conducted a scenario experiment to investigate the effects of both of self-presentation style and story-telling style about experiences of past failures, on the evaluations of job applicants. Participants (N = 95) read one of four types of application forms which were constructed by combining one of two stories with or without self-discovery through past failure, and one of two self-presentation styles: self-enhancing or self-effacing. Then, impressions about the applicant, such as intimacy, ability, sincerity, obedience, decency, and attractiveness as an in-group member were evaluated. The results indicated that self-enhancing presentations had a positive effect on evaluations of an applicant's ability, and a negative effect on evaluations of intimacy. Moreover, stories of self-discovery had a positive effect on attractiveness of the applicant as an in-group member. Furthermore, there was an interactive effect between the story-telling and self-presentation styles on evaluation of an applicant's decency. We have discussed the effects of self-effacing presentations on the new graduate job-hunting system in Japan.