著者
Yi Yen Kuo-Chun Hung Yi-Hsin Chan Victor Chien-Chia Wu Yu-Ting Cheng Chia-Pin Lin Jih-Kai Yeh Pao-Hsien Chu Shao-Wei Chen
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-22-0718, (Released:2023-04-06)
参考文献数
38

Background: Studies of the influence of smaller body type on the severity of prosthesis-patient mismatch (PPM) after small-sized surgical aortic valve replacement (SAVR) are few, but the issue is particularly relevant for Asian patients.Methods and Results: 695 patients who underwent SAVR with bioprosthetic valves had their hemodynamic valve performance analyzed at 3 months, 1 year, 3 years, and 5 years after operation, and clinical outcomes were assessed. The patients were stratified into 3 valve size groups: 19/21, 23, and 25/27 mm. A smaller valve was associated with higher mean pressure gradients at the 4 time points after operation (P trend <0.05). However, the 3 valve size groups demonstrated no significant differences in the risk of clinical events. At none of the time points did patients with projected PPM show increased mean pressure gradients (P>0.05), whereas patients with measured PPM did (P<0.05). Compared with patients with projected PPM, those with measured PPM demonstrated higher rates of infective endocarditis readmission (adjusted hazard ratio [aHR] 3.31, 95% confidence interval [CI] 1.06–10.39) and a higher risk of composite outcomes (aHR 1.45, 95% CI 0.95–2.22, P=0.087).Conclusions: Relative to those receiving larger valves, patients receiving small bioprosthetic valves had poorer hemodynamic performance but did not demonstrate differences in clinical events in long-term follow-up.
著者
Nguyen Thanh Hai NGUYEN Ming Ban HUANG Fa Yong LIU Wei-Ling HUANG Huyen-Trang TRAN Tsai-Wen HSU Chao-Li HUANG Tzen-Yuh CHIANG
出版者
BMFH Press
雑誌
Bioscience of Microbiota, Food and Health (ISSN:21863342)
巻号頁・発行日
vol.42, no.2, pp.104-113, 2023 (Released:2023-04-01)
参考文献数
56
被引用文献数
3

Fermented soy sauce consists of microorganisms that exert beneficial effects. However, the microbial community dynamics during the fermentation course is poorly characterized. Soy sauce production is classified into the stages of mash fermentation with koji (S0), brine addition (S1), microbial transformation (S2), flavor creation (S3), and fermentation completion (S4). In this study, microbial succession was investigated across stages at different temperatures using metagenomics analyses. During mash fermentation, Aspergillus dominated the fungal microbiota in all stages, while the bacterial composition was dominated by Bacillus at room temperature and by a diverse composition of enriched lactic acid bacteria (LAB) at a controlled temperature. Compared with a stable fungal composition, bacterial dynamics were mostly attributable to fluctuations of LAB, which break down carbohydrates into lactic acid. After adding brine, increased levels of Enterococcus and decreased levels of Lactococcus from S1 to S4 may reflect differences in salinity tolerance. Staphylococcus, as a fermentation starter at S0, stayed predominant throughout fermentation and hydrolyzed soybean proteins. Meanwhile, Rhizopus and Penicillium may improve the flavor. The acidification of soy sauce was likely attributable to production of organic acids by Bacillus and LAB under room temperature and controlled temperature conditions, respectively. Metagenomic analysis revealed that microbial succession was associated with the fermentation efficiency and flavor enhancement. Controlled temperature nurture more LAB than uncontrolled temperatures and may ensure the production of lactic acid for the development of soy sauce flavor.
著者
岩澤 昭一郎 Roberto LOPEZ-GULLIVER 河北 真宏 石川 彰夫 奥井 誠人 山本 健詞
出版者
一般社団法人 映像情報メディア学会
雑誌
映像情報メディア学会技術報告 39.36 (ISSN:13426893)
巻号頁・発行日
pp.27-30, 2015-10-08 (Released:2017-09-22)

筆者らのグループでは多視点映像システムの研究開発に取り組んでいる.本稿では,これまで構築してきた撮影・表示装置に伝送装置を加えた統合システムを開発したので報告する.本システムのパフォーマンス評価の予備実験として実施した主観評価実験の結果についても述べる.
著者
Tsuyoshi Shiga Tsuyoshi Suzuki Keisuke Kida Atsushi Suzuki Takashi Kohno Akiko Ushijima Shunsuke Kiuchi Shunsuke Ishii Makoto Murata Takeshi Ijichi Makoto Suzuki Masako Nishikawa on behalf of the EXCILE-HF Trial Investigators
出版者
The Japanese Circulation Society
雑誌
Circulation Reports (ISSN:24340790)
巻号頁・発行日
pp.CR-22-0134, (Released:2023-03-24)
参考文献数
15

Background: A high resting heart rate is an independent risk factor for mortality and morbidity in patients with cardiovascular diseases. Ivabradine selectively inhibits the funny current (If) and decreases heart rate without affecting cardiac conduction, contractility, or blood pressure. The effect of ivabradine on exercise tolerance in patients with heart failure with reduced ejection fraction (HFrEF) on standard drug therapies remains unclear.Methods and Results: This multicenter interventional trial of patients with HFrEF and a resting heart rate ≥75 beats/min in sinus rhythm treated with standard drug therapies will consist of 2 periods: a 12-week open-label, randomized, parallel-group intervention period (standard drug treatment+ivabradine group and standard drug treatment group) to compare changes in exercise tolerance between the 2 groups; and a 12-week open-label ivabradine treatment period for all patients to evaluate the effect of adding ivabradine on exercise tolerance. The primary endpoint will be the change in peak oxygen uptake (V̇O2) during the cardiopulmonary exercise test from Week 0 (baseline) to Week 12. Secondary endpoints will be time-dependent changes in peak V̇O2from Week 0 to Weeks 12 and 24. Adverse events will also be evaluated.Conclusions: The EXCILE-HF trial will provide meaningful information regarding the effects of ivabradine on exercise tolerance in patients with HFrEF receiving standard drug therapies and suggestions for the initiation of ivabradine treatment.
著者
Hiroyuki Ichida Tomohiko Kazama Shin-ichi Arimura Kinya Toriyama
出版者
Japanese Society for Plant Biotechnology
雑誌
Plant Biotechnology (ISSN:13424580)
巻号頁・発行日
vol.40, no.1, pp.109-112, 2023-03-25 (Released:2023-03-25)
参考文献数
11

A highly contiguous mitochondrial and plastid genome sequences of a japonica rice cultivar, Taichung 65, were determined by a hybrid approach with long- and short-read sequences. The assembled mitochondrial genome was 465,453 bases in length with an overall GC content of 43.8%. It was predicted to harbor 62 protein-encoding genes, 16 kinds (33 copies) of transfer RNA, and three kinds (six copies) of ribosomal RNA genes. The mitochondrial genome structure in Taichung 65 is largely the same as that of Nipponbare, but the first ∼9.5 kb sequence in Nipponbare (DQ167400) is replaced with a ∼27 kb sequence duplicated from other parts of the mitochondrial genome. Phylogenetic and sequence polymorphism analysis indicated that Taichung 65 is classified as typical japonica. The assembled plastid genome sequence was 134,551 bases in length and completely identical to the previously reported Nipponbare sequence. These near-complete organelle genome sequences will serve as fundamental resources for investigating alloplasmic cytoplasmic male sterile lines and other organelle-controlled phenomena in rice.
著者
Hayato Tada Hirofumi Okada Akihiro Nomura Satoshi Yashiro Atsushi Nohara Yasushi Ishigaki Masayuki Takamura Masa-aki Kawashiri
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.83, no.9, pp.1917-1924, 2019-08-23 (Released:2019-08-23)
参考文献数
21
被引用文献数
55 55

Background:A substantial proportion of patients clinically diagnosed as having familial hypercholesterolemia (FH) do not manifest causative mutation(s) in the FH genes such asLDLR,APOB, andPCSK9. We aimed to evaluate the effect of rare and deleterious mutation(s) inABCG5/ABCG8on hyper-low-density lipoprotein (LDL) cholesterolemia in individuals who meet the clinical criteria for FH.Methods and Results:We compared the LDL cholesterol (LDL-C) values among 487 subjects with FH; the subjects were grouped according to the presence of mutation(s) in FH andABCG5/ABCG8genes. We identified 276 individuals with a deleterious mutation in 1 FH gene (57%, monogenic FH), but found no causative mutations in 156 individuals (32%, mutation-negative). A total of 37 individuals had deleterious mutations inABCG5orABCG8, but not in FH genes (8%,ABCG5/ABCG8mutation carriers). Among these, 3 individuals had sitosterolemia (0.6%) with double mutations. We also identified 18 individuals with deleterious mutations in an FH gene andABCG5orABCG8(4%,ABCG5/ABCG8-oligogenic FH). Subjects without mutations had significantly higher polygenic scores than those in any other groups. LDL-C levels in oligogenic FH subjects were significantly higher than in the monogenic FH subjects. Moreover, sitosterol/lathosterol levels were significantly affected by those mutations.Conclusions:The results suggested that rare and deleterious mutations inABCG5/ABCG8contribute substantially to mimicking and exacerbation of the FH phenotype.
著者
Alice CC LAU Yongjin QIU Mohamed Abdallah Mohamed MOUSTAFA Ryo NAKAO Michito SHIMOZURU Manabu ONUMA Nobuyoshi NAKAJIMA Mariko SASHIKA Jayasilan MOHD-AZLAN Toshio TSUBOTA
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
vol.84, no.11, pp.1469-1473, 2022 (Released:2022-11-01)
参考文献数
40

In this study, Babesia screening was conducted in 55 rodents and 160 tick samples collected from primary forests and an oil palm plantation in Sarawak, Malaysian Borneo. PCR targeting the 18S ribosomal DNA revealed the presence of Babesia spp. DNA detected in two questing male Haemaphysalis shimoga ticks collected from the oil palm plantation. Sequence analysis revealed that both sequences were identical and had 98.6% identity to a Babesia macropus sequence obtained from Eastern grey kangaroos (Macropus giganteus) in Australia. Phylogenetic tree revealed clustering with marsupial-associated Babesia spp. in the Babesia sensu stricto clade. Whether or not H. shimoga is the competent vector and the importance of the Babesia sp. detected in this study warrants more investigation.
著者
オマ-ル オスマン 奥田 隆明 中村 英樹 林 良嗣
出版者
名古屋大学
雑誌
基盤研究(C)
巻号頁・発行日
1996

本研究では、日本では従来より実施されてきた車検制度が、自動車の大気汚染物質排出を抑制する効果の分析手法を開発するとともに、その効果の事後的分析への適用をはかった。さらにその結果を踏まえ、車検制度を今後の発展途上国での交通公害対策として導入するにあたっての効果および課題について整理を行った。車検制度が自動車の大気汚染物質排出抑制に及ぼす効果には、1)代替促進効果:車検費用の賦課によって、車齢の高い車から新車への買い換えを促進させ、低排出車が早く普及する効果、2)車両整備効果:車両の劣化によって排出レベルが基準を上回るようになった車両に対し、整備によって排出レベルを低下させる効果、の2つがある。以上の効果を推計するために、まず1)については、車保有者の車両存廃選択行動を、集計ロジット型のモデルにより表現した。説明要因として、各車両の車齢に依存する維持・車検費用と、新車購入費用を組み込んだ。また2)については、運輸省が実施した排出ガス実態調査を利用して、車両の加齢による汚染物質排出量変化を車検制度がある場合とない場合に分けて推計るモデルを構築した。以上の計量モデルによる分析例として、日本の全乗用車を対象に車検制度による大気汚染物質削減効果を推計した。その結果、1989年においては、一酸化炭素については23.4%、炭化水素については16.0%、一定の削減効果があることが把握できた。また、両物質ともに、2)車両整備効果による削減が全体の95%以上を占めることも明らかになった。一方、発展途上国の車両整備制度に関する調査を行った結果、日本よりかなり緩やかであることが分かった。したがって、日本と同レベルの車検を実施した場合には、その効果は日本以上に得られることが予想される。
著者
Tzu-Yi Lu Chih-Da Wu Yen-Tsung Huang Yu-Cheng Chen Chien-Jen Chen Hwai-I Yang Wen-Chi Pan
出版者
Japan Epidemiological Association
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
pp.JE20220262, (Released:2023-03-11)
参考文献数
52

Background: Ambient particulate matter is classified as a human Class 1 carcinogen, and recent studies found a positive relationship between fine particulate matter (PM2.5) and liver cancer. Nevertheless, little is known which specific metal constituent contributes to the development of liver cancer.Objective: To evaluate the association of long-term exposure to metal constituents in PM2.5 with the risk of liver cancer using a Taiwanese cohort study.Methods: A total of 13,511 Taiwanese participants were recruited from the REVEAL-HBV in 1991-1992. Participants’ long-term exposure to eight metal constituents (Ba, Cu, Mn, Sb, Zn, Pb, Ni, and Cd) in PM2.5 was based on ambient measurement in 2002-2006 followed by a land-use regression model for spatial interpolation. We ascertained newly developed liver cancer (i.e. hepatocellular carcinoma [HCC]) through data linkage with the Taiwan Cancer Registry and national health death certification in 1991-2014. A Cox proportional hazards model was utilized to assess the association between exposure to PM2.5 metal component and HCC.Results: We identified 322 newly developed HCC with a median follow-up of 23.1 years. Long-term exposure to PM2.5 Cu was positively associated with a risk of liver cancer. The adjusted hazard ratio (HR) was 1.13 (95% confidence interval [CI]: 1.02, 1.25; p-value=0.023) with one unit increment on Cu normalized by PM2.5 mass concentration in the logarithmic scale. The PM2.5 Cu-HCC association remained statistically significant with adjustment for co-exposures to other metal constituents in PM2.5.Conclusions: Our findings suggest PM2.5 containing Cu may attribute to the association of PM2.5 exposure with liver cancer.
著者
Angem Librando-Descallar Zhengyi Ling Takuma Haga Tatsufumi Okino
出版者
THE SESSILE ORGANISMS SOCIETY OF JAPAN
雑誌
Sessile Organisms (ISSN:13424181)
巻号頁・発行日
vol.40, no.1, pp.1-12, 2023-03-14 (Released:2023-03-14)
参考文献数
48

Shipworms of the family Teredinidae were collected from driftwood along the coastal areas of Hokkaido between October 2020 and November 2021. Identification of species recorded a total of five species pervaded wooden debris: Teredo navalis Linnaeus, 1758, Lyrodus pedicellatus (Quatrefages, 1849), Bankia setacea (Tryon, 1863), Bankia bipennata (Turton, 1819), and Bankia carinata (Gray, 1827), the latter two were warm-water elements and considered a new record of species discovered from the temperate zone of Hokkaido waters. This suggests the possibility that ocean currents and suitable environmental conditions caused the settlement of these teredinids in driftwood along the vast coastal stretches of Hokkaido. Also, B. bipennata and B. carinata have been most likely distributed along the Sea of Japan and brought accidentally by typhoons from the Kuroshio region and Tsushima and Tsugaru currents to Hokkaido, respectively. Moreover, biogeographic patterns within Teredinidae from other coastal areas in the country and elsewhere were examined from the available literature.
著者
Toshiyuki Sakai Takeo Kanade Yu-IchiOhta Ken-IchiroYanagi Hideo Hasui
雑誌
Information Processing in Japan
巻号頁・発行日
vol.15, pp.70-74, 1975-01-01

A new conversational picture processing system has been developed. By giving the picture-processing commands via the character CRT the operator can use interactively software and hardware facilities provided by the system: input and output of pictorial data basic picture-processing capabilities such as differentiation enhancement windowing composition of two pictures etc. The remarkable features of the system are:(1) fundamental pictorial data I/O devices and picture-processing routines are both available; (2) by means of the color-TV display multiband photos and color pictures can be processed very conveniently; (3) the editing and correction of the picture-processing commands can be performed in the same fashion as conversational programming; (4) employing a computer complex structure the system can be adapted easily to various classes of picture processing problems
著者
Kei-ichiro Murai Koyumi Yamashita Ginga Kitahara Makoto Tokuda Akira Yoshiasa
出版者
Japan Association of Mineralogical Sciences
雑誌
Journal of Mineralogical and Petrological Sciences (ISSN:13456296)
巻号頁・発行日
pp.220901, (Released:2023-03-11)
被引用文献数
2

Single crystals of CaW1-xMoxO4 scheelite-powellite solid solutions (x= 0.0, 0.03, 0.08, 0.2, 0.3, 0.5, 0.8 and 1.0) were synthesized using a melting method. The light emission spectra of the solid solutions were measured using a JASCO FP-8300 fluorescence spectrometer. The maximum fluorescence peak at 419 nm in the CaWO4 scheelite end-member greatly decreases in intensity and shifts its peak position to 451 nm with only 3% Mo substitution. The change in near-ultraviolet light emission intensity at 292 and 301 nm are more moderate than those in the strong peak at 419 nm. The tendency of change in intensity and wavelength shift due to the Mo substitution differs among these fluorescence peaks. Single crystal X-ray diffraction experiments for the CaW1-xMoxO4 solid solutions (x= 0.0, 0.2, 0.3, 0.5, 0.8 and 1.0) were carried out using a Rigaku Super-Nova Single source at offset/far HyPix3000 diffractometer. The R1 index for CaW1-xMoxO4 solid solutions were convergent to 1.22 -1.71% using anisotropic temperature factors. The expansion of the c-axis and shrinkage of the unit cell volume were induced with an increase in Mo content. The significant increase in the angle ∡Ocloser-Ca-Ocloser was directly related to the expansion of the c-axis. The Debye temperature ΘD for Ca, W and O atoms in CaWO4 were 381, 198 and 534 K, respectively. The obtained ΘD for Ca, Mo and O atoms in CaMoO4 were 363, 257 and 503 K, respectively. The phonon density of states estimated from the lattice dynamics calculations coincided with the observed ΘD values.
著者
Yunfan Li Yukai Gong Jyun-Rong Zhuang Junyan Yang Keisuke Osawa Kei Nakagawa Hee-hyol Lee Louis Yuge Eiichiro Tanaka
出版者
Fuji Technology Press Ltd.
雑誌
Journal of Robotics and Mechatronics (ISSN:09153942)
巻号頁・発行日
vol.34, no.6, pp.1383-1397, 2022-12-20 (Released:2022-12-20)
参考文献数
32
被引用文献数
6

The world’s aging population is increasing. The number of elderly individuals having walking impairments is also increasing. Adequate exercise is becoming necessary for them. Therefore, several walking assistive devices have been developed or are under development. However, elderly individuals may have low motivation for exercising, or they may experience physical damage by excessive fatigue. This study proposed a method to enable elderly individuals to exercise with a positive emotion and prevent damage such as muscle fatigue. We proposed a 3D human condition model to control the walking assistive device. It includes the arousal, pleasure, and fatigue dimensions. With regard to the arousal and pleasure dimensions, we used heartbeat and electromyography (EEG) signals to train a deep neural network (DNN) model to identify human emotions. For fatigue detection, we proposed a method based on near-infrared spectroscopy (NIRS) to detect muscle fatigue. All the sensors are portable. This implies that it can be used for outdoor activities. Then, we proposed a walking strategy based on a 3D human condition model to control the walking assistive device. Finally, we tested the effectiveness of the automatic control system. The wearing of the walking assistive device and implementation of the walking strategy can delay the fatigue time by approximately 24% and increase the walking distance by approximately 16%. In addition, we succeeded in visualizing the distribution of emotion during each walking method variation. It was verified that the walking strategy can improve the mental condition of a user to a certain extent. These results showed the effectiveness of the proposed system. It could help elderlies maintain higher levels of motivation and prevent muscle damage by walking exercise, using the walking assistive device.
著者
Ken-ichi Hiasa Hidetaka Kaku Goro Kawahara Hiroshi Inoue Takeshi Yamashita Masaharu Akao Hirotsugu Atarashi Takanori Ikeda Yukihiro Koretsune Ken Okumura Wataru Shimizu Kazunori Toyoda Atsushi Hirayama Masahiro Yasaka Takenori Yamaguchi Satoshi Teramukai Tetsuya Kimura Jumpei Kaburagi Atsushi Takita Hiroyuki Tsutsui
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.86, no.2, pp.222-232, 2022-01-25 (Released:2022-01-25)
参考文献数
31
被引用文献数
4

Background:Echocardiographic data on the cardiac structure and function in elderly patients with atrial fibrillation (AF) and heart failure (HF) are limited. This subcohort study of the ANAFIE Registry analyzed echocardiographic parameters to identify cardiac structural and functional characteristics.Methods and Results:Of 32,726 subjects in the ANAFIE population, 1,494 (4.6%) were entered as the echocardiography subcohort. Half of the patients, including those with persistent and permanent AF, older age (≥80 years), and CHADS2score ≥2, had left atrial (LA) volume index ≥48 mL/m2, indicating severe LA enlargement. LA enlargement significantly correlated with impaired LA reservoir function, regardless of age and CHADS2score. Types of AF and rhythm were strongly related to LA volume and reservoir function (P<0.0001). Moderate-to-severe mitral and tricuspid regurgitation were significantly more common, and the early diastolic mitral inflow velocity to mitral annulus velocity ratio was significantly higher among patients with than without HF history (all, P<0.0001).Conclusions:In this subcohort, LA enlargement correlated with impaired LA reservoir function. Elderly patients with non-valvular AF and a history of HF had LA enlargement and dysfunction, increased LV mass index, low LV ejection fraction, and high heart rate.
著者
Baohang ZHANG Haichuan YANG Tao ZHENG Rong-Long WANG Shangce GAO
出版者
The Institute of Electronics, Information and Communication Engineers
雑誌
IEICE TRANSACTIONS on Information and Systems (ISSN:09168532)
巻号頁・発行日
vol.E106-D, no.3, pp.365-373, 2023-03-01
被引用文献数
2

The equilibrium optimizer (EO) is a novel physics-based meta-heuristic optimization algorithm that is inspired by estimating dynamics and equilibrium states in controlled volume mass balance models. As a stochastic optimization algorithm, EO inevitably produces duplicated solutions, which is wasteful of valuable evaluation opportunities. In addition, an excessive number of duplicated solutions can increase the risk of the algorithm getting trapped in local optima. In this paper, an improved EO algorithm with a bis-population-based non-revisiting (BNR) mechanism is proposed, namely BEO. It aims to eliminate duplicate solutions generated by the population during iterations, thus avoiding wasted evaluation opportunities. Furthermore, when a revisited solution is detected, the BNR mechanism activates its unique archive population learning mechanism to assist the algorithm in generating a high-quality solution using the excellent genes in the historical information, which not only improves the algorithm's population diversity but also helps the algorithm get out of the local optimum dilemma. Experimental findings with the IEEE CEC2017 benchmark demonstrate that the proposed BEO algorithm outperforms other seven representative meta-heuristic optimization techniques, including the original EO algorithm.
著者
Yoshimasa SASAKI Tsutomu NOZAWA-TAKEDA Kenzo YONEMITSU Tetsuo ASAI Hiroshi ASAKURA Hidetaka NAGAI
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
vol.84, no.7, pp.1029-1033, 2022 (Released:2022-07-25)
参考文献数
31
被引用文献数
1

As free-living crows are a potential source of Campylobacter infections in broilers and cattle, we characterized Campylobacter spp. isolated from crows using multilocus sequence typing and antimicrobial susceptibility testing. We obtained 82 samples from 27 birds captured at seven different times using a trap set in Tochigi prefecture, Japan. Campylobacter jejuni was isolated from 55 (67.1%) of the 82 samples and classified into 29 sequence types, of which 21 were novel. Tetracycline and streptomycin resistance rates were 18.2% and 3.6%, respectively. These results show that most types of C. jejuni infecting crows differ from those isolated from humans, broilers, and cattle. Thus, the importance of free-living crows as reservoirs of Campylobacter infections in broilers and cattle may be limited.