著者

Yasuki Nakada Rika Kawakami Shouji Matsushima Tomomi Ide Koshiro Kanaoka Tomoya Ueda Satomi Ishihara Taku Nishida Kenji Onoue Tsunenari Soeda Satoshi Okayama Makoto Watanabe Hiroyuki Okura Miyuki Tsuchihashi-Makaya Hiroyuki Tsutsui Yoshihiko Saito

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.83, no.5, pp.1019-1024, 2019-04-25 (Released:2019-04-25)

参考文献数

22

被引用文献数

8 13

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Background: Prognosis after acute decompensated heart failure (ADHF) is poor. An appropriate risk score that would allow for improved care and treatment of ADHF patients after discharge, however, is lacking. Methods and Results: We used 2 HF cohorts, the NARA-HF study and JCARE-CARD, as derivation and validation cohorts, respectively. The primary endpoint was all-cause death during the 2-year follow-up, excluding in-hospital death. Age, hemoglobin (Hb), and brain natriuretic peptide (BNP) at discharge were identified as independent risk factors. We determined 3 categorizations on the basis of these parameters, termed A2B score: age (<65 years, 0; 65–74 years, 1; ≥75 years, 2), anemia (Hb <10 g/dL, 2; 10–11.9 g/dL, 1; ≥12 g/dL, 0) and BNP (<200 pg/mL, 0; 200–499 pg/mL, 1; ≥500 pg/mL, 2). We divided patients into 4 groups according to A2B score (extremely low, 0; low, 1–2; medium, 3–4; high, 5–6). For the extremely low-risk group, the 2-year survival rate was 97.8%, compared with 84.5%, 66.1%, and 45.2% for the low-, medium-, and high-risk groups, respectively. Using the JCARE-CARD as a validation model, for the extremely low-risk group, the 2-year survival was 95.4%, compared with 90.2%, 75.0%, and 55.6% for the low-, medium-, and high-risk groups, respectively. Conclusions: The user-friendly A2B score is useful for estimating survival rate in ADHF patients at discharge.

著者

Tomotsugu Seki Makoto Murata Kensuke Takabayashi Takashi Yanagisawa Masayuki Ogihara Ritsuko Kurimoto Keisuke Kida Koichi Tamita Xiaoyang Song Neiko Ozasa Ryoji Taniguchi Miho Nishitani-Yokoyama Shinji Koba Ryosuke Murai Yutaka Furukawa Maki Hamasaki Hirokazu Kondo Hironori Hayashi Asako Ootakara-Katsume Kento Tateishi Satoaki Matoba Hitoshi Adachi Hirokazu Shiraishi for the START Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

pp.CR-22-0131, (Released:2023-02-25)

参考文献数

18

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Background: Clinical practice guidelines strongly recommend optimal medical therapy (OMT), including lifestyle modification, pharmacotherapy, and exercise-based cardiac rehabilitation (CR), in patients with stable ischemic heart disease (SIHD). However, the efficacy and safety of CR in patients with SIHD without revascularization remain unclear.Methods and Results: The Prospective Registry of STable Angina RehabiliTation (Pre-START) study is a multicenter, prospective, single-arm, open-label pilot study to evaluate the efficacy and safety of CR on health-related quality of life (HRQL), exercise capacity, and clinical outcomes in Japanese patients with SIHD without revascularization. In this study, all patients will undergo guideline-based OMT and are encouraged to have 36 outpatient CR sessions within 5 months after enrollment. The primary endpoint is the change in the Seattle Angina Questionnaire-7 summary score between baseline and the 6-month visit; an improvement of ≥5 points will be defined as a clinically important change. Secondary endpoints include changes in other HRQL scores and exercise capacity between baseline and the 6-month visit, as well as clinical outcomes between enrollment and the 6-month visit.Conclusions: The Pre-START study will provide valuable evidence to elucidate the efficacy and safety of CR in patients with SIHD and indispensable information for a subsequent randomized controlled trial. The study was registered with the University Hospital Medical Information Network (UMIN) Clinical Trials Registry (ID: UMIN000045415) on April 1, 2022.

著者

Masahiro Kawahara Ken-ichiro Tanaka Midori Kato-Negishi

出版者

Japan Society for Biomedical Research on Trace Elements

雑誌

Metallomics Research (ISSN:24365173)

巻号頁・発行日

vol.1, no.1, pp.rev-47-rev-65, 2021-12-15 (Released:2022-01-29)

参考文献数

176

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Aluminum (Al) is the third most abundant element in the earth’s crust. However, because of its specific chemical properties, Al is not essential for life, and it exerts various adverse effects on plants, animals, and humans. In particular, Al is a widely recognized neurotoxin. The association between Al and neurodegenerative diseases including Alzheimer’s disease, amyotrophic lateral sclerosis and Parkinson’s disease dementia in the Kii Peninsula and Guam has been suspected. However, controversy has persisted for several decades. Based on recent epidemiological, analytical, and toxicological studies, we review the detailed characteristics of Al neurotoxicity and revisit its link to Alzheimer’s disease and other diseases. The daily intake of Al and its bioavailability linked with adverse effects on human health are also described.

著者

Hyung Gon Je Min Ho Ju Chee-Hoon Lee Mi Hee Lim Ji Hye Lee Hye Rim Oh

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.84, no.1, pp.54-60, 2019-12-25 (Released:2019-12-25)

参考文献数

21

被引用文献数

1 1

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Background:Stroke is a major concern in minimally invasive cardiac surgery, so we investigated the incidence and risk factors of cerebral embolism according to the systemic perfusion strategy under thorough imaging assessment.Methods and Results:Between November 2011 and May 2015, 315 cardiac surgery patients who underwent preoperative computed tomography angiography (CTA) as a routine evaluation were enrolled. The incidence and distribution of cerebral embolism were analyzed with routine postoperative brain diffusion-weighted magnetic resonance imaging (DW-MRI) examination. Anterograde perfusion was used in 103 patients (group A), and retrograde perfusion was performed in 212 patients (group R). Operative deaths, incidence of clinical stroke (group A: 0%, group R: 0.5%, P=0.77), and rate of cerebral embolism (group A: 35.9%, group R: 26.4%, P=0.08) were comparable. The median number of new embolic lesions detected by MRI per patient (group A: 2, group R: 2, P=0.16), maximal diameter of the lesion (group A: 6.5 mm, group R: 6.0 mm, P=0.97), and anatomic distribution of the lesion were similar between groups. In the multivariate analysis, hypertension, emergency status, atherosclerosis grade 3 or 4 (intimal thickening >4 mm), and cardiopulmonary bypass time were independent risk factors for postoperative cerebral embolism, but retrograde perfusion was not.Conclusions:According to the results of postoperative DW-MRI, retrograde perfusion itself might not increase the incidence of postoperative cerebral embolism in properly selected cardiac surgery patients undergoing routine preoperative CTA examination.

著者

日本集中治療医学会J-PADガイドライン検討委員会

出版者

一般社団法人 日本集中治療医学会

雑誌

日本集中治療医学会雑誌 (ISSN:13407988)

巻号頁・発行日

vol.27, no.2, pp.150-158, 2020-03-01 (Released:2020-03-01)

参考文献数

5

被引用文献数

1 1

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「日本版・集中治療室における成人重症患者に対する痛み・不穏・せん妄管理のための臨床ガイドライン(2014年)」公表後のわが国の集中治療領域における痛み・不穏・せん妄管理の現状を明らかにすることを目的として,2016年1月に日本集中治療医学会会員を対象にアンケート調査を実施し,今回,2019年3月に2回目の実態調査を実施した。調査の結果,ガイドラインの認知度・活用度は高かったが,同職種内での周知度は低迷していた。ガイドラインの推奨項目については,実施率の増加が確認できたが,さらに周知度や遵守率を高めるため,ガイドラインの周知活動の継続,組織内でガイドラインの教育・普及を推進できる人材への支援活動の充実が今後の課題である。

著者

Robert Jean-Noël

出版者

国文学研究資料館

雑誌

国際日本文学研究集会会議録 = PROCEEDINGS OF INTERNATIONAL CONFERENCE ON JAPANESE LITERATURE (ISSN:03877280)

巻号頁・発行日

no.26, pp.1-15, 2003-03-01

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When it comes to the important question of religion and language in Buddhism, the importance of the Japanese language is wont to be underestimated. By comparison with medieval Chinese or Tibetan, Japanese obviously cannot boast of the same feats in translating the Buddhist Scriptures. Even in the case of Mongolian or Manchu, that former scholars tended to neglect, both these languages produced translations of the Buddhist Canon (albeit a partial one for the latter), which are to be taken, although they are secondary translations, as a landmark in the cultural history of East Asia.Japanese is prima facie different; there was no organized translations of the Canon in that language before modern times, and, in that respect, it would be closer to the situation of Siam or Cambodia. But there was indeed a field in which Japanese monk-scholars engaged in an enterprise that could be deemed akin to the achievements of their Tibetan counterparts, and that was the Japanese poetry (waka) on Buddhist themes, that I will here cover by the general term of “exegetical” poetry or shakkyou kaei.We may for our purpose propose here a broad division of those poems in two, namely those that make use of Chinese Buddhist vocabulary tel quel, and those that endeavor to rely exclusively on ‘pure’ Japanese poetical language.Taking the example of two corpuses of Buddhist waka poems on the theme of the Lotus Sutra by Jien and Sonen, I will consider three points:a) How the scholastic and religious vocabulary of Buddhism has been translated in original Japanese idioms.b) How the poetical expression of the Lotus tenets enhanced and developed the doctrinal interpretation.c) In what way this interpretation or exegesis fits into a precise pattern of religious practice. I hope, through these points, to make a step towards assessing this poetical genre as a full-fledged category of religious literature.

著者

雙林寺文書研究会 The Study Group of Old Documents List on Sorinji-Temple

雑誌

淑徳大学人文学部研究論集 (ISSN:21895791)

巻号頁・発行日

vol.4, pp.147-185, 2019-03-15

著者

Hiroaki Shiraishi Kazuhisa Ikemoto Shin Tada Yasuhiro Udagawa Masatsugu Ohtsuki Chiho Sumi-Ichinose Kazunao Kondo Takahide Nomura

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.18, no.4, pp.312-317, 2011 (Released:2011-04-27)

参考文献数

25

被引用文献数

5 5

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Aims: Cilostazol, a type III phosphodiesterase inhibitor, is utilized for the treatment of intermittent claudication and is considered to have the beneficial effects against the atherogenic process. In the present study, we examined the effects of cilostazol on BH4 biosynthesis in HUVEC treated with a mixture of the pro-inflammatory cytokines IFN-γ and TNF-α.Methods: Isolated HUVECs were grown to confluence and treated with IFN-γ (300 units/mL) and TNF-α (300 units/mL) for 16 h in order to stimulate BH4 biosynthesis. The BH4 levels were mea-sured by HPLC. The mRNA expression of GTP cyclohydrolase I (GTPCH), the rate-limiting enzyme of BH4 biosynthesis, and GTPCH feedback regulatory protein (GFRP) were quantified by real-time PCR. The GTPCH protein expression was assessed by western blot analysis.Results: Cilostazol significantly reduced the BH4 levels in cytokine-stimulated HUVEC. Cilostazol produced a concomitant increase in the cAMP levels in HUVEC. Cilostazol decreased the GTPCH activity as well as the expression of GTPCH mRNA and protein. 8-bromo-cAMP (8Br-cAMP), a cell-permeable cAMP analogue, did not reproduce the effects of cilostazol. Cilostazol did not affect the cytokine-induced inhibition of GFRP mRNA expression.Conclusions: We conclude that cilostazol inhibited cytokine-stimulated BH4 biosynthesis via a cAMP-independent mechanism in HUVEC. Our data indicate that cilostazol reduced GTPCH activity and did so by suppressing the GTPCH protein levels.

著者

Yoshamin Abnoba MORENO-VARGAS Abigailt FLORES-LEDESMA Jacqueline Adelina RODRÍGUEZ-CHAVEZ Irma A. BELÍO-REYES Lauro BUCIO

出版者

The Japanese Society for Dental Materials and Devices

雑誌

Dental Materials Journal (ISSN:02874547)

巻号頁・発行日

pp.2022-091, (Released:2023-01-25)

参考文献数

34

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This article deals with the problem of determining the proportion by weight of radiopacifying material needed to add to a cement clinker of mineral trioxide aggregated (CE) to comply with ISO 6876/2001 and ANSI-ADA 57 regulations for radiopacity. With this aim, CE was synthesized and mixed experimentally with 5, 10, 15, and 20 wt% of ZrO2 as radiopacifying material. Radiographic images were taken so that radiographic density was obtained and related to the mmAl scale by using an aluminum step wedge. From a theoretical point of view, absorbed intensity given by the Lambert-Beer law was calculated using mass attenuation coefficients (NIST database) for each chemical element included in each component of the cement samples. In this way, we predicted that by adding above 10 wt% of ZrO2 to the CE, the requirements stipulated by ISO 6876 for radiopacity were satisfied with discrepancies around 1 mmAl. This theoretical method gives an excellent approximation to determine the amount of radiopacifying material needed to meet the requirements stipulated by ISO.

著者

岩瀬 雅紀 北口 紗織 佐藤 哲也 Li-Chen OU Ronnier LUO

出版者

The Japan Research Association for Textile End-Uses

雑誌

繊維製品消費科学 (ISSN:00372072)

巻号頁・発行日

vol.51, no.6, pp.501-514, 2010-06-20 (Released:2016-09-28)

参考文献数

33

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本研究は,スポーツを観る側の視点から,バレーボールユニフォームの色に対して,どのような印象を受けるのかについて知ることを目的とした.はじめに,観る側のユニフォームの注目度とその印象を形容詞で回答するアンケート調査を行った.そして,静止画像を用いて1つのユニフォームを見た場合と2つのユニフォームを同時に見た場合の色の印象をSD法によって評価した.その結果,黒は‘地味’,‘くすんだ’,‘重い’,‘暗い’,‘かっこいい’,赤は‘あつい’といった印象を与え,因子分析によって,「価値」と「色彩」の因子が抽出された.また,2つのユニフォームを同時に見た場合の印象は,1つのユニフォームを見た場合の印象から予測できることがわかった.さらに,実験結果の一部を4つの色彩感情モデルから予測した結果と比較することで,本研究の結果がいくつかの色彩感情モデルによって予測される色の印象に適応していることが認められた.

著者

岩崎 徹 進藤 賢一 イワサキ トオル シンドウ ケンイチ Toru Iwasaki Ken-ich Shindo

雑誌

経済と経営

巻号頁・発行日

vol.23, no.4, pp.747-774, 1993-03-31

著者

Réginald Garrigou-Lagrange translated by Matthew K. Minerd

出版者

Emmaus Academic

巻号頁・発行日

2020

著者

Yoh-ichi Watanabe Shigeo Yoshinari

出版者

The Society for the Study of the Origin and Evolution of Life Japan

雑誌

Viva Origino (ISSN:09104003)

巻号頁・発行日

vol.41, no.2, pp.12-13, 2013 (Released:2021-12-29)

参考文献数

23

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In Archaea, almost all introns in pre-tRNA, pre-rRNA, and pre-mRNA are spliced through two common steps by protein enzymes: cleavage of the precursor with splicing endonuclease, and ligation of the exons with RNA ligase. We found the first examples of archaeal pre-mRNA splicing and cleavage of the pre-mRNA with a novel subclass of archaeal splicing endonuclease. We further solved the novel tertiary structure of the splicing endonuclease, and revealed that the lineage-specific insertion of amino acid residues in the endonuclease expands the recognition of the substrate precursor RNA. We also discuss the possible involvement of tRNA splicing and its machinery in the origin of the tRNA molecule.

著者

Hiroko Maruki-Uchida Masahiko Sai Kazuhisa Sekimizu

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

Drug Discoveries & Therapeutics (ISSN:18817831)

巻号頁・発行日

pp.2017.01051, (Released:2017-10-30)

参考文献数

15

被引用文献数

1 2

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We evaluated the innate immune-stimulating activity of amazake using a silkworm muscle contraction assay. Sake cake, a raw material used to make amazake, had high innate immunity-stimulating activity, whereas rice malt, another raw material used to make amazake, did not, even after fermentation. These results suggest that the silkworm muscle contraction assay is a useful tool to screen foods with high innate immune-stimulating activity and that amazake made from sake cake has immunomodulatory potential.

著者

SHIGEAKI AOYAGI SATORU TOBINAGA KUMIKO WADA SHIN-ICHI NATA HIROSHI YASUNAGA

出版者

Kurume University School of Medicine

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

pp.MS681002, (Released:2023-02-08)

参考文献数

9

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Summary: Myocardial contusion is the most common cardiac injury from blunt chest trauma (BCT), whereas isolated valve injury is uncommon. We report a case of acute mitral regurgitation (MR) due to isolated valve injury after BCT. A 60-year-old man received an impact on his left chest by a car wheel three weeks prior to visiting our hospital. At the time a diagnosis of contusion of the chest wall without rib and sternal fractures was made. Thereafter, the patient had progressive worsening of heart failure symptoms. Eventually he developed dyspnea on slight exertion but echocardiographic evaluation was not performed at the time of diagnosis or during the three weeks prior to admission. At admission a holosystolic murmur was heard. Transthoracic echocardiography revealed prolapse of the posterior mitral leaflet due to torn chordae tendineae with severe MR and normal left ventricular wall motion. At surgery, torn chordae tendineae and a leaflet tear of the posterior leaflet were detected, and mitral valve repair was achieved without residual MR. Pathological examination of the torn chordae showed no findings of endocarditis or myxomatous degeneration. Echocardiography may play an important role for accurate and prompt diagnosis of cardiac lesions in patients with recent or a history of high-energy BCT.

著者

by George Sphrantzes 1401-1477 translated by Marios Philippides

出版者

University of Massachusetts Press

巻号頁・発行日

1980

著者

丹保 健一 Tanbo Ken-ichi

出版者

三重大学教育学部

雑誌

三重大学教育学部研究紀要. 人文・社会科学 (ISSN:03899241)

巻号頁・発行日

vol.50, pp.1-12, 1999-03-01

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ヨウダが表すとされる「様態」「推量」「伝聞」「婉曲」の意味について考察し、「様態」的なものと「推量」的なものの比重が「時間的空間的心理的」遠近によっていること、「伝聞」に擬似的なものがあること、「婉曲」と呼ばれるものに推量的なものが混在していること等についての指摘をした。

著者

Mayuka Yamada Midori Suzuki Takuya Noguchi Takumi Yokosawa Yuto Sekiguchi Natsumi Mutoh Takashi Toyama Yusuke Hirata Gi-Wook Hwang Atsushi Matsuzawa

出版者

The Pharmaceutical Society of Japan

雑誌

BPB Reports (ISSN:2434432X)

巻号頁・発行日

vol.3, no.1, pp.16-21, 2020 (Released:2020-11-26)

参考文献数

27

被引用文献数

4 7

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Both NF-E2-related factor 2 (Nrf2) and heat shock protein 70 (HSP70) contribute to cellular defense to various stresses, and have emerged as candidates of therapeutic targets to improve or prevent tissue damage. Cefotaxime (CTX), a third-generation cephalosporin antibiotic, is conceived as a safe drug largely free from side effects. CTX exhibits broad-spectrum antimicrobial activity, and thereby, is most commonly prescribed for the treatment of infectious diseases induced by Gram-positive or Gram-negative bacteria. In this study, we unexpectedly found the beneficial properties of CTX that upregulate both Nrf2 and HSP70 to the extent that stress-induced damage is ameliorated. Non-toxic levels of reactive oxygen species (ROS) induced by CTX activated the Nrf2 pathway without cytotoxicity, which in turn upregulated HSP70. Interestingly, the cytotoxicity of Fas/CD95 ligand (FasL), a cytotoxic cytokine that strongly induces apoptosis, was significantly ameliorated by pre-treatment with CTX, most likely because of the upregulation of Nrf2 and HSP70. Our results therefore show novel properties of CTX, which raise the possibility that CTX works as a non-toxic therapeutic agent for preventing and repairing tissue damage.

著者

Daji NOH Hyunjoon SHIN Hyemin NA Sang-Kwon LEE Sooyoung CHOI Kija LEE

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.85, no.2, pp.163-166, 2023 (Released:2023-02-01)

参考文献数

26

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This study aimed to prospectively assess nasopharyngeal luminal changes in brachycephalic dogs without respiratory signs using cervical radiography. Forty brachycephalic dogs without cardiopulmonary diseases were included. The nasopharyngeal luminal change was calculated on inspiratory and expiratory cervical lateral radiographs. The median nasopharyngeal luminal change was 21.6% (range, 0.3–85.6%). In five dogs, a nasopharyngeal luminal change of >50% was identified. There was no correlation between nasopharyngeal luminal changes and age, sex, body weight, or body condition score. These results suggest that brachycephalic dogs without cardiopulmonary diseases may be over-diagnosed with partial pharyngeal collapse. Further studies comparing nasopharyngeal luminal changes between clinically healthy brachycephalic dogs and dogs with respiratory signs are warranted.

著者

Jing ZHANG Dan LI Hong-an LI Xuewen LI Lizhi ZHANG

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE TRANSACTIONS on Information and Systems (ISSN:09168532)

巻号頁・発行日

vol.E106-D, no.2, pp.229-239, 2023-02-01

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In order to solve the low-quality problems such as low brightness, poor contrast, noise interference and color imbalance in night images, a night image enhancement algorithm based on MDIFE-Net curve estimation is presented. This algorithm mainly consists of three parts: Firstly, we design an illumination estimation curve (IEC), which adjusts the pixel level of the low illumination image domain through a non-linear fitting function, maps to the enhanced image domain, and effectively eliminates the effect of illumination loss; Secondly, the DCE-Net is improved, replacing the original Relu activation function with a smoother Mish activation function, so that the parameters can be better updated; Finally, illumination estimation loss function, which combines image attributes with fidelity, is designed to drive the no-reference image enhancement, which preserves more image details while enhancing the night image. The experimental results show that our method can not only effectively improve the image contrast, but also make the details of the target more prominent, improve the visual quality of the image, and make the image achieve a better visual effect. Compared with four existing low illumination image enhancement algorithms, the NIQE and STD evaluation index values are better than other representative algorithms, verify the feasibility and validity of the algorithm, and verify the rationality and necessity of each component design through ablation experiments.