著者
Mun Keong KOK James K. CHAMBERS Masaya TSUBOI Ryohei NISHIMURA Hajime TSUJIMOTO Kazuyuki UCHIDA Hiroyuki NAKAYAMA
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.19-0248, (Released:2019-06-28)
被引用文献数
22

Cutaneous tumors are commonly found in dogs. To date, few studies have investigated the epidemiology of canine cutaneous tumors in Asian countries. The present study aims to report the prevalence of canine cutaneous tumors in Japan, and assess the association of breed, age, sex, and anatomical locations with the development of common tumor types. A total of 1,435 cases of cutaneous tumors were examined, of which 813 (56.66%) cases were malignant, and 622 (43.34%) were benign. Soft tissue sarcomas (18.40%), mast cell tumor (16.24%), lipoma (9.69%), hair follicle tumors (9.34%), and benign sebaceous tumors (8.50%) outnumbered the other tumor types. Tumors were commonly found on the head (13.87%), hindlimb (10.52%), forelimb (8.01%), chest (5.78%), and neck (5.57%). The risk of developing cutaneous tumors increased significantly in dogs aged 11-year and above (P<0.001). Mixed-breed dogs (14.63%), Miniature Dachshund (9.90%), and Labrador Retriever (8.01%) were the three most presented breeds; while Boxer, Bernese Mountain Dog, and Golden Retriever had an increased risk of cutaneous tumor development in comparison to mixed-breed dogs (P<0.05). Epidemiological information from the present study will serve as a useful reference for regional veterinarians to establish a preliminary diagnosis of canine cutaneous tumors.
著者
TAJIMA Yuko MAEDA Kaori K. YAMADA Tadasu
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
vol.77, no.1, pp.45-51, 2015
被引用文献数
9

One hundred and twenty stranding events of Stejneger's beaked whales were reported in Japan between 1999 and 2011. The purpose of this study is to introduce pathological data and to discuss probable causes of death for 44 Stejneger's beaked whales among them. The significant pathological findings were the pulmonary edema, parasitic granulomatous nephritis, emaciation, amyloidosis, suppurative bronchopneumonia and so on. The probable causes of death were categorized as noninfectious in 43 of the cases, which included drowning, starvation and secondary amyloidosis. One individual was diagnosed with septicemia, which was the only example of an infectious disease. Because we could not always perform advanced analyses, such as microbiology tests, biotoxin examinations or contaminant analyses, the finality of our findings may be impaired. However, the present study has broad implications on the causes of death of Stejneger's beaked whales of the seas around Japan, which are valuable for the future studies and for the detection of emerging diseases.
著者
A.K.
出版者
公益社団法人日本船舶海洋工学会
雑誌
造船協会雑纂 (ISSN:03861597)
巻号頁・発行日
no.107, pp.25-27, 1931-02
著者
Ohta Ryo Niwa Akira Taniguchi Yukimasa Suzuki Naoya M Toga Junko Yagi Emiko Saiki Norikazu Nishinaka-Arai Yoko Okada Chihiro Watanabe Akira Nakahata Tatsutoshi Sekiguchi Kiyotoshi Saito Megumu K
出版者
Springer Nature
雑誌
Scientific reports (ISSN:20452322)
巻号頁・発行日
vol.6, 2016-11-02
被引用文献数
36

細胞外マトリックスを用いてヒト多能性幹細胞から高効率に血管内皮細胞の誘導に成功. 京都大学プレスリリース. 2016-11-09.
著者
Makiko OZAWA James K. CHAMBERS Kazuyuki UCHIDA Hiroyuki NAKAYAMA
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.15-0624, (Released:2016-02-27)
被引用文献数
35

Canine cognitive dysfunction (CCD) is a syndrome that manifests itself in abnormal behaviors, such as disorientation and wandering. β-amyloid deposition in the brain, including the senile plaque (SP) and cerebral amyloid angiopathy (CAA), has been suggested as a major cause of the syndrome. However, the pathological significance of β-amyloid deposition in CCD dogs remains unclear. The present study was conducted using 16 dogs aged 10 years or older to clarify the relationship between the age-related histopathological lesions, such as β-amyloid deposition, in the brain and the clinical symptoms of CCD as evaluated in a questionnaire previously established in a large survey. In addition, age-related brain lesions were assessed in 37 dogs. The pathological lesions were evaluated by the severity of β-amyloid deposition (SP and CAA), the amount of ubiquitin-positive granules (UBQ), GFAP-positive astrocytes, Iba-1-positive microglia and Nissle stain-positive nerve cells. The results revealed that there was no significant correlation between the severities of canine SP and CCD. The SP increased until 14 years old, but decreased thereafter, although the incidence of CCD is high at these ages. The CAA consistently increased with age, but did not correlate greatly with the CCD score. In contrast, the increases of UBQ, astrocytes and microglia were significantly correlated with CCD. Thus, the impairment in the synapse and/or myelin suggested by increased UBQ and glial activation might be involved in CCD pathogenesis, but β-amyloid deposition, especially SP, is not a direct pathogenic factor of CCD.
著者
ニシオ ハリー・K 竹中 和郎
出版者
日本社会学会
雑誌
社会学評論 (ISSN:00215414)
巻号頁・発行日
vol.20, no.1, pp.73-90,131, 1969-07-30 (Released:2010-05-07)
参考文献数
36

The social sciences, sociology in particular, have aimed to develop an empirically-verifiable body of theory through application of the structural-functional analysis of social action in general. Functional sociologists, whether they be the Grand Theorists or Middle-range Theorists, have therefore concerned themselves with “objective” and “scientific” investigation of phenomena, rejecting metaphysical as well as positivistic interpretations of social reality. While the voluntaristic theory of social action caught the imagination of sociologists articulating the theoretical position of sociology vis-a-vis social idealism, radical utilitarianism and Social Darwinism, a new, though somewhat “off-beat” sociological approach has begun to appear, challenging the theoretical foundation of systematic sociology in general. Ethnomethodology is one of such challenges posed upon against the Orthodox Sociology.Ethnomethodology finds its origin in the work of Alfred Schutz, an Austrian sociologist who wrote a three-volume work titled Collective Papers, in which most of his ideas are contained. His “subjective” approach to social action, tied with his interest in phenomenology, appealed to social scientists in New York and California. Included in this group of ethnomethodologists are Harold Garfinkel, Aron Cicourel, Peter Mcllugh, Marvin Scott and many young sociologists.What these sociologists aim to accomplish may be summarized in the following : 1) in the process of scientific enquiries, a priority should be given to the subjective aspect of social interaction based on mutual understanding and on the accepted “rules of the game”, 2) instead of developing generalized rules arbitarity constructed by scientists, ethnomethodologists, by taking the position of social actors, attempt to understand not only the expressed symbolic interaction but also more subtle, unstated, unpredictable definitions of situations, 3) the ethnomethodologists treat the acting individuals not merely as “actors” but as “theorists” capable of defining the situation, impressing others in ways they desire and to some extent manipulating the given social structure to their advantage, and 4) in this type of observation, it is indispensable for the observer to react with those whom he analyses so as to enable him to identify the processes by which new shared knowledge and group experiences emerge and become sanctioned. In ethnomethodology, however, emphasis is upon culturally unstated social facts, rather than those formally institutionalized or stated. Because of this interest, ethnomethodologists tend to preoccupy themselves with many unusual, off-beat topics such as homosexuality, the social system of gamblers, social interaction in horse racing, etc. They are convinced that orthodox sociology is able to deal with only a very small portion of social reality which appears above the surface while a gigantic mass of unstated social interaction remaining beneath totally untouched. With this approach, E. Goff man attempts to analyse the communication processes which are primarily being “give-off” by the social performers. He uses a dramaturgical approach and cynically examines social interaction in terms of the performance that takes place in front or back of the curtain in relation to the audience. Aron Cicourel, articulating the theory of Harold Garfinkel, attempts to develop the theory-methodology of Ethnomethodology in his recent work by pointing out the theoretical, methodological shortcomings of the conventional survey methods.Ethnomethodology is still theoretically ambiguous and methodologically unclear to many. For one thing, where should we draw a line between ethnomethodology and social interactionist approach?
著者
Ajay K. Sah Chebrolu P. Rao Pauli K. Saarenketo Kari Rissanen
出版者
(社)日本化学会
雑誌
Chemistry Letters (ISSN:03667022)
巻号頁・発行日
vol.30, no.12, pp.1296-1297, 2001 (Released:2003-04-04)
参考文献数
12
被引用文献数
16

In order to understand the binding nature of the glycosylamines possessing imine functionality, a novel tetranuclear Ni(II) complex of N-(2-hydroxybenzylidene)-4,6-O-ethylidene-β-D-glucopyranosylamine having twisted Ni4O4 cubane core was synthesized and structurally characterized.
著者
Song Qilei Cao Shuai Pritchard Robyn H Ghalei Behnam Al-Muhtaseb Shaheen A Terentjev Eugene M Cheetham Anthony K Sivaniah Easan
出版者
Nature Publishing Group
雑誌
Nature communications (ISSN:20411723)
巻号頁・発行日
vol.5, 2014-09-04
被引用文献数
255

排ガスを膜でキャッチ -空気洗浄技術、実用化に期待-. 京都大学プレスリリース. 2014-09-10.
著者
Tonegawa S Kasahara S Fukuda T Sugimoto K Yasuda N Tsuruhara Y Watanabe D Mizukami Y Haga Y Matsuda T D Yamamoto E Onuki Y Ikeda H Matsuda Y Shibauchi T
出版者
Nature Publishing Group
雑誌
Nature communications (ISSN:20411723)
巻号頁・発行日
vol.5, 2014-06-19
被引用文献数
57

直接観測された物質物理学の謎「隠れた秩序」. 京都大学プレスリリース. 2014-06-19.
著者
William K.K. Wu Chi Hin Cho
出版者
(公社)日本薬理学会
雑誌
Journal of Pharmacological Sciences (ISSN:13478613)
巻号頁・発行日
vol.94, no.4, pp.348-358, 2004 (Released:2004-04-20)
参考文献数
105
被引用文献数
22 46

Increasing use of tobacco and its related health problems are a great concern in the world. Recent epidemiological findings have demonstrated the positive association between cigarette smoking and several gastrointestinal (GI) diseases, including peptic ulcer and cancers. Interestingly, smoking also modifies the disease course of ulcerative colitis (UC). Nicotine, a major component of cigarette smoke, seems to mediate some of the actions of cigarette smoking on the pathogenesis of GI disorders. Nicotine worsens the detrimental effects of aggressive factors and attenuates the protective actions of defensive factors in the processes of development and repair of gastric ulceration. Nicotine also takes part in the initiation and promotion of carcinogenesis in the GI tract. In this regard, nicotine and its metabolites are found to be mutagenic and have the ability to modulate cell proliferation, apoptosis, and angiogenesis during tumoriogenesis through specific receptors and signalling pathways. However, to elucidate this complex pathogenic mechanism, further study at the molecular level is warranted. In contrast, findings of clinical trials give promising results on the use of nicotine as an adjuvant therapy for UC. The beneficial effect of nicotine on UC seems to be mediated through multiple mechanisms. More clinical studies are needed to establish the therapeutic value of nicotine in this disease.