著者
Yukihiro Koretsune Takuma Etoh Yousuke Katsuda Tetsuro Suetsugu Kenshi Kumeda Ichiro Sakuma Kenichi Eshima Mitsuhiro Shibuya Shin-ichi Ando Naoto Yokota Shinya Goto Karen S. Pieper Jagan Allu Ajay K. Kakkar for the GARFIELD-AF Investigators
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.83, no.1, pp.67-74, 2018-12-25 (Released:2018-12-25)
参考文献数
20
被引用文献数
11

Background: Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective non-interventional study of stroke prevention in patients with newly diagnosed non-valvular AF (NAVF) that is being conducted in 35 countries. Methods and Results: A total of 52,081 patients with a new diagnosis of NVAF were enrolled prospectively in GARFIELD-AF. Of these, 4859 (9.3%) were recruited in Japan (2010–2016). In cohort 1 (2010–2011), few patients were on non-vitamin K antagonist oral anticoagulants (NOAC) globally. From cohort 2 onwards (2011–2016), however, there was a rapid increase in NOAC use around the globe, especially in Japan. By the last year of enrolment (2015–2016), 67.9% of patients in Japan and 43.1% of patients globally were on NOAC±antiplatelet therapy (AP). In Japan and globally, 17.0% and 12.2% of patients, respectively, did not receive stroke prevention treatment. Few patients in Japan (5.7%) received AP only. Compared with the other countries, the unadjusted rates of all-cause mortality and major bleeding were low, while rates of stroke/systemic embolism were similar after 1 year of follow-up. Conclusions: GARFIELD-AF continues to provide important information on the homogeneity and heterogeneity of baseline characteristics and treatment patterns in patients with newly diagnosed NVAF. This diversity reflects the differences in outcomes in Japan compared with the rest of the world.
著者
Namangala Boniface Hachaambwa Lottie Kajino Kiichi Mweene Aaron S. Hayashida Kyouko Simuunza Martin Simukoko Humphrey Choongo Kennedy Chansa Pamela Lakhi Shabir Moonga Ladslav Chota Amos Ndebe Joseph Nsakashalo-Senkwe Mutale Chizema Elizabeth Kasonka Lackson Sugimoto Chihiro
出版者
BioMed Central
雑誌
Parasites & Vectors (ISSN:17563305)
巻号頁・発行日
vol.5, 2012-12-04
被引用文献数
1 36

Background: Loop-mediated isothermal amplification (LAMP) is a novel strategy which amplifies DNA with high sensitivity and rapidity under isothermal conditions. In the present study, the performance of the repetitive insertion mobile element (RIME)-LAMP and human serum resistance-associated gene (SRA)-LAMP assays were evaluated using clinical specimens obtained from four male patients from Luangwa and Zambezi valleys in Zambia and Zimbabwe, respectively. Findings: The cases reported in this preliminary communication were all first diagnosed by microscopy, through passive surveillance, and confirmed by both RIME-LAMP and SRA-LAMP. A good correlation between microscopy and LAMP was observed and contributed to staging and successful treatment of patient. RIME-LAMP and SRA-LAMP complimented each other well in all the cases. Conclusions: Both RIME-LAMP and SRA-LAMP were able to detect Trypanosoma brucei rhodesiense DNA in patient blood and CSF and hence confirmed HAT in the parasitaemic patients. Our study indicates that the LAMP technique is a potential tool for HAT diagnosis, staging and may be useful for making therapeutic decisions. However, no statistically significant conclusion may be drawn due to the limited sample size used in the present study. It is thus imperative to conduct a detailed study to further evaluate the potential of LAMP as a bedside diagnostic test for HAT.
著者
S. Miki
出版者
The Botanical Society of Japan
雑誌
植物学雑誌 (ISSN:0006808X)
巻号頁・発行日
vol.46, no.552, pp.774-788_1, 1932 (Released:2011-01-26)
参考文献数
4
被引用文献数
8 14
著者
中田 高 堤 浩之 PUNONGBAYAN Raymundo S. RIMANDO Rolly E DALIGDIG Jessie DAAG Arturo
出版者
Tokyo Geographical Society
雑誌
地学雑誌 (ISSN:0022135X)
巻号頁・発行日
vol.99, no.5, pp.515-532, 1990
被引用文献数
5 13

The Philippine Earthquake (Ms=7.8) broke out in July 16, 1990 along the Philippine Fault in Central Luzon. The Philippine Fault is seismically very active and large earthquakes of M 7 class have occurred during this century along this fault. However large earthquakes have not taken place along the active traces of the fault in the Central Luzon during this century, while two large historical earthquakes occurred along its southern trace in 1645 and its northern trace in 1796. Therefore it is considered that the 1990 earthquake was caused by the surface faulting in the seismic (aseismic) gap along the Philippine Fault.<BR>The total length of the surface fault is over 120 km and the fault is divided into two segments by the major bend near Rizal. The surface fault is rather straight and linear and general orientation of the northern segment is N 25 W and the southern segment N40W. Left-lateral displacement is dominant along most of the fault traces and the maximum horizontal displacement is about 6 m in the 60-km-long northern segment and the maximum vertical displacement is 2.0 min the 50-km-long southern section. Sense of vertical displacement changes in places and is consistent with the sense of the displacement along the pre-existing active fault traces. Average displacement along the northern segment is 5-6 m, while 2-3 m along the southern segment.<BR>Along most of the surface fault, ruptures appear exactly along the pre-existing active fault traces. Offsets of roads, foot-pass, streams are common earthquake-induced features. Local extensional and compressional jog forms related to slight change in fault strike creates characteristic features such as depressions, trenches, mole tracks, bulges etc.<BR>The rupture propagated bilaterally northward and southward from hypocenter east of Bongabon near the major bend. The source process of the earthquake deduced from the slip distribution along the surface fault from the epicenter well coincides with that deduced seismologically from the source time function.
著者
藤井 義博 Yoshihiro FUJII 藤女子大学人間生活学部食物栄養学科・藤女子大学大学院人間生活学研究科食物栄養学専攻 Department f Food Science and Human Nutrition Faculty of Human Life Science and Division of Food Science and Human Nutrition Graduate School of Human Life Science Fuji Women's University
出版者
藤女子大学QOL研究所
雑誌
藤女子大学QOL研究所紀要 (ISSN:18816274)
巻号頁・発行日
vol.3, no.1, pp.11-24, 2008-03-01

本論文では、良寛禅師の戒語を分類するに先立って2つの仮説を立てた。一つは、戒語は人々を「調え御する」大乗仏教の托鉢僧の布施行の一環として行なわれたという仮説であった。もう一つは、戒語は道元禅師の愛語の思想に基づいているという仮説であった。これらの仮説に基づいて、良寛禅師の戒語は、道元禅師の愛語を実現するために必要な「慈愛の心」すなわち「もとの心」へ人々をして立ち返えらせるための戒めであると定義した。戒語の項目の分析を行った結果、良寛禅師の一般人に与えた戒語をまず次のように3大分類した。I. 縦社会における戒語、II. 傾聴のための戒語、III. 日常の生活場面における戒語。そしてそれぞれの大分類をさらに分類した。すなわちI. 縦社会における戒語は、1. 上位者、2. 下位者、3. 同類、および4. 子どもに小分類した。II. 傾聴のための戒語は、1. 自慢、2. 情動誘発、3. 無責任、4. まね、5. おだて・おどけ、6. 言い過ぎ、7. へだて、8. とがめ、に小分類した。III. 日常の生活場面における戒語は、1. 生活の仕方、2. 人々の状態、3. その他、に小分類した。小分類の中にはさらに細分類をしたものがある。このように戒語を分類することによって、戒語は現代人にとってよりわかりやすいものになったと思われる。In the present paper, two hypotheses were made to classify Ryokan's Warnings for People about Language; One is that they would have been a part of his giving as a Mahayana mendicant monk, who intended to train and lead people. Another is that they would have been based upon Dogen's idea of kind speech. They were intended to warn people to come to their senses, which, expressed as "the original mind" and "the mind of compassion" by Ryokan and Dogen respectively, were required to realize Dogen's kind speech. The Warnings for People about Language were classified into three main groups: I. Warnings in the hierarchical society; II. Warnings to realize attentive listening; III. Warnings in aspects of the daily life. The three main groups were further divided into subgroups. Group I was subdivided into four subgroups: 1. about people in higher position, 2. about people in lower position, 3. about people in similar position, and 4. about children; Group II into eight subgroups: 1. Pride, 2. Causing negative emotions, 3. Irresponsibility, 4. Mimicry, 5. Flattery & Clowning, 6. Speaking too much, 7. Separation, and 8. Blaming; and Group III into three subgroups: 1. Way of living, 2. Aspects of people, and 3. the others. The classification of the Warnings for People about Language is suggested to have made them more comprehensive for people of today.
著者
SHEKHAWAT G.S. SRIVASTAVA D.N.
出版者
日本植物病理学会
雑誌
日本植物病理学会報 (ISSN:00319473)
巻号頁・発行日
vol.38, no.1, pp.4-6_1, 1972
被引用文献数
4

えい花および種子の生育ステージごとに,穂にイネ条斑細菌病菌を接種したところ,子房,雄ずいおよび胚乳はいずれも褐変もしくは黒変して枯死し,えいは褐変した。成熟した種子では,えいの内側に病原菌が残存しているのを発見した。<br>幼芽は,発芽中にえいの内側で越冬した菌によって汚染される。鞘葉,不完全葉および第1葉は,それぞれ開口した気孔,半開口および正常な気孔を通して,順次感染する。第1葉の伸長によって,病原菌は地上部へと運ばれる。出穂時の種子感染は,止葉上の噴出菌泥によっておこる。
著者
Kimikazu SASAKI Zhiyong MA Tanvir. S. KHATLANI Masaru OKUDA Hisashi INOKUMA Takafumi ONISHI
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
vol.65, no.4, pp.545-548, 2003 (Released:2003-05-02)
参考文献数
25
被引用文献数
25 57

The concentration of feline serum amyloid A (fSAA) was determined by a direct enzyme-linked immunosorbent assay (ELISA) by using fSAA specific monoclonal antibodies, to evaluate the fSAA as an inflammatory marker in cats. The mean concentration ± standard deviation of fSAA was found to be 0.60 ± 1.06 μg/m l and 33.65 ± 67.59 μg/ml in serum samples from normal cats (n=45) and cats (n=312) with various diseases and disorders, respectively. A significant difference (p<0.001) was found between the two groups. It was also found that the concentration of fSAA begins to increase rapidly at approximately 3-6 hr after spay, and increases up to significantly high levels in some disorders, like injury, renal failure, infectious diseases, etc.
著者
Janaina C. O. Sardi Cristiane Duque Flávia S. Mariano Iza T. A. Peixoto José F. Höfling Reginaldo B. Gonçalves
出版者
Nihon University School of Dentistry
雑誌
Journal of Oral Science (ISSN:13434934)
巻号頁・発行日
vol.52, no.2, pp.177-185, 2010 (Released:2010-06-25)
参考文献数
64
被引用文献数
27 53

Although the main reservoir of Candida spp. is believed to be the buccal mucosa, these microorganisms can coaggregate with bacteria in subgingival biofilm and adhere to epithelial cells. Such interactions are associated with the capacity of Candida spp. to invade gingival conjunctive tissue, and may be important in the microbial colonization that contributes to progression of oral alterations caused by diabetes mellitus, some medications, and immunosuppressive diseases such as AIDS. In addition, immune deficiency can result in proliferation of Candida spp. and germination of forms that are more virulent and have a higher capacity to adhere to and penetrate cells in host tissues. The virulence factors of Candida spp. increase host susceptibility to proliferation of these microorganisms and are likely to be important in the study of periodontal disease. Herein, we briefly review the literature pertaining to the role of Candida spp. in periodontal disease, and consider the main virulence factors, the host immune response to these microorganisms, and the effect of concomitant immunosuppressive conditions. (J Oral Sci 52, 177-185, 2010)
著者
YAMADA S
雑誌
Nippon Suisan Gakkaishi
巻号頁・発行日
vol.55, pp.1547-1552, 1989
被引用文献数
1
著者
疋田 努 ダレフスキイ イリヤS.
出版者
日本爬虫両棲類学会
雑誌
爬虫両棲類学雑誌
巻号頁・発行日
vol.12, no.1, pp.10-15, 1987

ベトナム北部のタムダオから,1937年にBourretによって報告されたトカゲ属の1種,<i>Eumeces tamdaoensis</i>は,原記載後なんの報告も採集例もなく,しかも原記載の論文の入手が非常に困難なため,謎につつまれたトカゲとなっていた。このほど,原記載を入手し,さらにベトナム北部から新たに一個体の標本を得たので,本種について再記載を行った。また,従来<i>fasciatus</i>群の一員とされていたこのトカゲが,実際は<i>obsoletus</i>群と近縁であることがわかった。
著者
アーナンディ S
出版者
ジェンダー史学会
雑誌
ジェンダー史学 (ISSN:18804357)
巻号頁・発行日
vol.4, pp.5-16, 2008 (Released:2011-12-20)
参考文献数
15

近代的自己を定義するに際して、インド人男性の手による自伝は、公的な自己を特権化するのみならず、合理的で啓蒙されたものとしてマスキュリンな自己を分節化することによって公的・政治的なるものの境界を画定してきた。マスキュリンな自己とは、欲望、情愛、身体の偶発性を超越するものである。一方、女性の自己は、モダニティの文脈においては特に、私的・ドメスティックな情感的領域に属する、身体化され非-近代的他者とされてきた。他方、女たちの自伝はオルターナティブな近代的自己を想像することによって、対抗的な公的言説を提示する。同言説は、女たちの主体性を、近代的な公共領域における政治的主体として再構成することによって、マスキュリニティとモダニティを同視することに挑戦する。モダニティのジェンダー化された経験を叙述するに際して、女たちの自伝は、「自伝的マニフェスト」として知られる形式を採用してきた。マニフェストという形式は、女たちが抑圧と公共領域からの排除という自らの経験を叙述することを可能とし、新たな政治的集団性への呼びかけを行い、近代的自己への未来の可能性を想像した。本論考は、イギリス植民地期タミルナードゥ(南インド)に生まれたミドル・クラス出身のフェミニスト、S.ムットゥラクシュミ・レッディ(1886-1968)による自伝的マニフェストの分析を試みるものである。ムットゥラクシュミ・レッディは、マドラス管区では女性としては最初の医大卒業生(1912年)であり、英領インドの立法議会における初めての女性議員(1926年)となり、女性運動の活動家・指導者として活躍した。また彼女は、熱心なガンディー主義者でもあり、デーヴァダーシー制度と幼児婚に対して精力的に反対運動を推進し、女性たちに対する多岐にわたる福祉政策を実現させた。本論考は自伝的マニフェストという形式と、ラディカルな政治においてモダニティが内包する限界を批判的に論ずる。
著者
M. Tobise T. Ogawa S. Saito
出版者
The Magnetics Society of Japan
雑誌
Journal of the Magnetics Society of Japan (ISSN:18822924)
巻号頁・発行日
vol.41, no.3, pp.58-62, 2017-05-01 (Released:2017-05-01)
参考文献数
15
被引用文献数
14

Metastable α”-Fe16N2 have attracted much interest as a candidate for rare-earth-free hard magnetic materials. To realize high coercivity, it is necessary to utilize not only the magnetocrystalline anisotropy but also the shape anisotropy of α”-Fe16N2 nanoparticles assemblies. An increase in magnetostatic couplings and intergranular exchange couplings among particles typically reduces the coercivity. Therefore, it is very important to evaluate the anisotropy and magnetic interactions among α”-Fe16N2 nanoparticles. We have examined the changes in morphology, structure and magnetic properties through the synthesis of α”-Fe16N2 nanoparticles from various materials such as α-FeOOH, ɤ-Fe2O3, and Fe3O4. The magnetic interactions were also estimated based on experimental results obtained by analysis of the rotational hysteresis loss of randomly oriented nanoparticles. Hc and Hkptc for the α”-Fe16N2 nanoparticle assemblies for different starting materials ranged from 2.2 to 1.1 kOe, and from 11 to 12 kOe respectively. Experimental results of the normalized coercive force and normalized switching field suggests that the existence of large magnetic interactions among α”-Fe16N2 nanoparticles.