著者

Naoki Ushirooka Kotaro Muratomi Shin Omura Satoru Tanigawa

出版者

Active Aging Research Center

雑誌

Journal of Trainology (ISSN:21865264)

巻号頁・発行日

vol.12, no.2, pp.24-28, 2023-11-09 (Released:2023-11-22)

参考文献数

26

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Objective: This study aimed to examine whether the addition of lower-body aerobic exercise as a warm-up (LGW) improves upper-body resistance training (RT) performance more than a specific warm-up (SW) alone and to investigate whether maximal muscular strength modulates the performance-enhancing effect of LGW. Design: Randomized crossover design. Methods: Fourteen male participants performed 3 sets of 80%1RM bench press under two warm-up conditions. In one con dition, the participants performed only a SW for the bench press exercise. In the other condition (LGW + SW), the participants performed cycling for 20 minutes and the SW for the bench press exercise. Results: There was no statistically significant difference in the total number of repetitions (REPTOTAL) and the mean propulsive velocity (MPV) of the barbell during the concentric phase between the SW and LGW + SW. Also, 1RM did not modu late the relationship between SW and LGW + SW for REPTOTAL and maximum MPV among all sets. Conclusion: This study suggests that the LGW in addition to the SW does not have large additional effects on performance during upper-body RT. In addition, maximal muscular strength does not modulate the performance-enhancing effect of the LGW on upper-body RT performed at 80%1RM.

著者

EUN JIN WOO PRANJALI WAGHMARE YONGJUN KIM NILESH JADHAV GO-UN JUNG WON JOON LEE YOGESH YADAV AVRADEEP MUNSHI MALAVIKA CHATTERJEE AMRITHAVALLI PANYAM JONG HA HONG CHANG SEOK OH DONG HOON SHIN VASANT SHINDE

出版者

The Anthropological Society of Nippon

雑誌

Anthropological Science (ISSN:09187960)

巻号頁・発行日

vol.126, no.2, pp.111-120, 2018 (Released:2018-08-31)

参考文献数

49

被引用文献数

3

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The Rakhigarhi site is the location of the ruins of an ancient megacity of the Harappan civilization and had not previously been investigated thoroughly. We tried to examine the physical and pathological traits of human skeletons (n = 37) from the cemetery at the site. In our study, a cranial index was calculated from one male skull (dolichocranic; index value = 65.78). The mean statures estimated by long bone length were 175.8 cm (male) and 166.1 cm (female). The indices of femoral diaphyseal shape were 79.8 (males) and 90.31 (females) for the platymeric index; and 113.78 (males) and 112.74 (female) for the pilasteric index. The dental health of the subjects appeared to be good as the overall prevalence of oral pathologies (caries and antemortem tooth loss) was generally low. Periosteal reactions were found in tibias and possible evidence of osteomyelitis was also observed in a femur. Some joint parts showed signs of osteoarthritis. Although various pathologies have been identified, we could not find any specific lesions suggestive of leprosy and tuberculosis in these skeletons. Although our study has added invaluable data to the existing information pool on the health and disease status of Harappan society, more accurate conjecture on the structure of Harrappan society based on bioarchaeological evidence will need additional research based on future excavations at Rakhigarhi cemetery.

著者

Masanobu Tanemoto Ryosuke Oda Yuichiro Toyama Hirohiko Shizukawa Kazuki Yokokawa Taro Saito Syuuichirou Suzuki Akihiro Matsumura Shin Hisahara

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.0404-22, (Released:2022-09-13)

参考文献数

15

被引用文献数

3

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A 26-year-old Japanese woman developed a fever, myalgia and gait disturbance one day after receiving the second dose of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. A neurological examination revealed symmetrical weakness and myalgia in proximal lower limbs, and a blood examination showed prominent elevation of creatinine kinase. Magnetic resonance imaging (MRI) revealed a high signal intensity in the thigh muscles on short-tau inversion recovery images, and antibody testing revealed positive findings for anti-signal recognition particle (SRP) antibody. Thus, anti-SRP antibody-positive immune-mediated myopathy was diagnosed. We initiated immunotherapy, and she was ultimately able to walk stably.

著者

辛 在卿 J.K. Shin 京都創成大学

雑誌

京都創成大学紀要 = Kyoto Sosei University review

巻号頁・発行日

no.7, pp.15-28, 2007-01-01

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朝鮮半島が植民地であった当時、鉄道省管轄下の指定航路で、日本と朝鮮半島および満州を結ぶ日本の基幹路線であった、関釜連絡船以外の主要な連絡船としては、済州道と大阪を結ぶ<君が代丸>しかなかった。本論文では、<君が代丸>という船が、どのような船なのか、その歴史的実像を明らかにしたい。

著者

Arisa Nishihara Katsumi Matsuura Marcus Tank Shawn E. McGlynn Vera Thiel Shin Haruta

出版者

Japanese Society of Microbial Ecology · The Japanese Society of Soil Microbiology

雑誌

Microbes and Environments (ISSN:13426311)

巻号頁・発行日

pp.ME18041, (Released:2018-11-23)

被引用文献数

21

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The phylum Aquificae comprises chemolithoautotrophic thermophilic to hyperthermophilic bacteria, in which the nitrogenase reductase gene (nifH) has been reported. However, nitrogen-fixing activity has not yet been demonstrated in members of this deeply branching bacterial phylum. We isolated two thermophilic diazotrophic strains from chemosynthetic microbial communities in slightly alkaline hot springs (≥70°C) in Nakabusa, Nagano Prefecture, Japan. A phylogenetic analysis based on 16S rRNA genes identified these strains as members of the genus Hydrogenobacter within Aquificae. Their NifH sequences showed 96.5 and 97.4% amino acid sequence identities to that from Hydrogenobacter thermophilus TK-6. Nitrogenase activity, measured by acetylene reduction, was confirmed in both strains at 70°C. These novel strains grew under semi-aerobic conditions by using CO2 as the sole carbon source and N2 as the sole nitrogen source in media containing hydrogen and/or thiosulfate. To the best of our knowledge, this is the first demonstration of active nitrogen fixation in thermophilic bacteria at 70°C and in the phylum Aquificae.

著者

Masao Hagihara Yui Imai Tomoyuki Uchida Shin Ohara Morihiro Inoue Tomiyuki Sugi Keiko Mitamura

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.61, no.14, pp.2215-2219, 2022-07-15 (Released:2022-07-15)

参考文献数

28

被引用文献数

4

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A 52-year-old man with mantle cell lymphoma treated with bendamustine and rituximab developed prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Despite elevated titers of anti-spike IgG antibody, protracted pancytopenia persisted for more than six months. Finally, the anti-SARS CoV-2 vaccine, BNT162b2, was administered, which improved his blood cell count and eliminated the virus. The increased anti-spike IgG titer and lymphocyte count after vaccination suggested that both humoral and cellular immunity acted in coordination to eliminate the virus.

著者

Shin Nakao Keiichi Kojima Yuki Sudo

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.44, no.10, pp.1357-1363, 2021-10-01 (Released:2021-10-01)

参考文献数

51

被引用文献数

10

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In life science research, methods to control biological activities with stimuli such as light, heat, pressure and chemicals have been widely utilized to understand their molecular mechanisms. The knowledge obtained by those methods has built a basis for the development of medicinal products. Among those various stimuli, light has the advantage of a high spatiotemporal resolution that allows for the precise control of biological activities. Photoactive membrane protein rhodopsins from microorganisms (called microbial rhodopsins) absorb visible light and that light absorption triggers the trans–cis photoisomerization of the chromophore retinal, leading to various functions such as ion pumps, ion channels, transcriptional regulators and enzymes. In addition to their biological significance, microbial rhodopsins are widely utilized as fundamental molecular tools for optogenetics, a method to control biological activities by light. In this review, we briefly introduce the molecular basis of representative rhodopsin molecules and their applications for optogenetics. Based on those examples, we discuss the high potential of rhodopsin-based optogenetics tools for basic and clinical research in pharmaceutical sciences.

著者

Chan-Won Kim Sungwoo Hong Yoosoo Chang Jung Ah Lee Hocheol Shin Seungho Ryu

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-20-0692, (Released:2020-12-11)

参考文献数

30

被引用文献数

7

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Background:A high level of apolipoprotein B (apoB) is associated with incident coronary artery disease (CAD) when low-density lipoprotein cholesterol (LDL-C) level is discordantly low or concordantly high. However, data on the relationship of apoB with subclinical measure of CAD are limited.Methods and Results:A total of 14,205 men (mean age 41.0 years) who were free of cardiovascular disease at baseline and who underwent a health checkup exam, including measurement of coronary artery calcium (CAC), were studied. Of the study group, 2,773 participants (19.5%) had CAC at baseline, and CAC progression was observed in 2,550 (18.0%). The multivariate-adjusted CAC score ratios (95% confidence interval) comparing discordantly high apoB/low LDL-C and concordantly high apoB/high LDL-C with concordantly low apoB/low LDL-C were 1.51 (0.98–2.32) and 2.70 (2.19–3.33), respectively. The corresponding relative risks for CAC progression were 1.26 (1.02–1.56) and 1.49 (1.34–1.66), respectively. These associations did not change appreciably after adjustment for insulin resistance and subclinical inflammation.Conclusions:Discordant analysis showed that a high apoB level was strongly associated with prevalence and progression of CAC independent of LDL-C in a large cohort of healthy adults. The present study results highlighted the importance of an apoB measure as a potential target for primary prevention of coronary atherosclerosis in healthy adults.

著者

Shin-ichiro Ohmura Yusuke Ohkubo Ryuhei Ishihara Yoshiro Otsuki Toshiaki Miyamoto

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.0293-22, (Released:2022-09-06)

参考文献数

28

被引用文献数

5

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Coronavirus disease 2019 (COVID-19) vaccines have been delivered worldwide to prevent the spread of the disease, and almost all Japanese have received the mRNA vaccines "BNT162b2" (Pfizer-Biotech) or "mRNA-1273" (Moderna). These vaccines have shown efficacy and safety with only minor adverse drug reactions. However, some patients develop severe adverse drug reactions, including autoimmune reactions. In addition, systemic vasculitis, mainly small-vessel vasculitis, following COVID-19 vaccination, has been reported. However, only a few investigators have reported medium-vessel vasculitis following vaccination. We herein report a case of medium-vessel vasculitis presenting with myalgia as the initial clinical manifestation following COVID-19 Moderna vaccination.

著者

Hikaru TAKARA Yoshiki KOHATSU Shota SUZUKI Shuhei SATOH Yoko ABE Shohei MIYAZATO Shin MINAKATA Masamichi MORIYA

出版者

Japanese Society of Physical Therapy

雑誌

Physical Therapy Research (ISSN:21898448)

巻号頁・発行日

pp.E10205, (Released:2022-11-08)

参考文献数

32

被引用文献数

2

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Objective: The study aim was to investigate the association between initiating mobilization within 7 days after onset and symptomatic cerebral vasospasm (SCV) in patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods: This was a retrospective multicenter case-control study in Japan. Patients with a diagnosis of aSAH who underwent physical therapy with/without occupational therapy were included and categorized into 2 groups according to the presence or absence of SCV. Initiating mobilization was defined as sitting on the bed edge (at least once, with/without assist, regardless of duration) within 7 days after aSAH onset. Cox proportional hazards regression analysis was performed to evaluate the association between initiating mobilization within 7 days after onset and SCV. Results: The analysis included 510 patients. Among all included patients, 57 (11.2%) patients had SCV. In the univariate Cox proportional hazards regression analysis, initiating of mobilization was not associated with SCV (hazard ratio [HR] = 0.78; 95% confidence interval [CI] = 0.45–1.32). In the multivariate analysis, only the modified Fisher scale was significantly associated with SCV (HR = 26.23; 95% CI = 1.21–571.0). Conclusion: Initiating mobilization within 7 days after aSAH onset was not associated with SCV in patients with aSAH.

著者

Aya Iwamoto Tomoyo Nakamura Naoki Narisawa Yukimasa Kawasaki Shin Abe Yasuyoshi Torii Hidenobu Senpuku Fumio Takenaga

出版者

Japanese Society for Food Science and Technology

雑誌

Food Science and Technology Research (ISSN:13446606)

巻号頁・発行日

vol.24, no.1, pp.129-137, 2018 (Released:2018-03-24)

参考文献数

33

被引用文献数

3 5

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Our previous study indicated that certain commercially available proteases inhibit biofilm formation by cariogenic streptococci. Natto made from soybeans cultured with Bacillus subtilis natto contains an abundance of proteolytic enzymes. In this study, we investigated the correlation between the protease activity of extracts from 36 commercially available natto products and the inhibition of biofilm formation. The biofilm inhibitory effect was found to correlate with the level of protease activity in the natto extracts, without reducing the viable cell numbers. The natto extract markedly inhibited the production of a water-insoluble glucan by Streptococcus mutans, which is the main agent involved in the formation of biofilm by cariogenic streptococci. The characteristics of the protease present in the extract were similar to those of nattokinase. Our results indicate that the protease activity exhibited by extracts of the Japanese fermented food natto reduces the risk of caries by inhibiting biofilm formation.

著者

Ayumi Fukazawa Takuya Karasawa Yuma Yokota Saki Kondo Toshiaki Aoyama Shin Terada

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.70, no.7, pp.989-993, 2021 (Released:2021-07-01)

参考文献数

19

被引用文献数

2

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We previously reported that consuming a ketogenic diet containing medium-chain triacylglycerols (MCTs) might be a valuable dietary strategy for endurance athletes. However, the long-term safety of the diet has not been established, and there is a concern that a higher intake of MCTs increases the liver triacylglycerol content. In this study, we found that consuming an MCT-containing ketogenic diet for 24 weeks decreased, rather than increased, the liver triacylglycerol concentration and did not aggravate safety-related blood biomarkers in male Wistar rats. Our results may therefore suggest that the long-term intake of a ketogenic diet containing MCTs may have no deleterious effects on physiological functions.

著者

Aya MATSUU Shin-ichi YOKOTA Keiko ITO Tatsunori MASATANI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.79, no.11, pp.1853-1856, 2017 (Released:2017-11-17)

参考文献数

11

被引用文献数

14

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On Amami Oshima Island, free-ranging and feral cats are harmful to wildlife populations. In this study, the seroprevalence of Toxoplasma gondii in these cats was examined using a newly developed Gaussia luciferase immunoprecipitation system assay. Of 1,363 cats, 123 cats (9.0%) was positive for T. gondii. The prevalence was significantly different in different areas; among cats in the rural area, where many wild animals live, including endangered species, T. gondii infection was more prevalent than in the urban area of the island. This finding indicates a possible risk to wildlife of infection from free-ranging and feral cats. Therefore, management of cats is important for wildlife conservation.

著者

Moono SHIN Tomijiro KUBOTA Koji HAMADA Tadayoshi HITOMI Takeshi OTA

出版者

日本水環境学会

雑誌

Journal of Water and Environment Technology (ISSN:13482165)

巻号頁・発行日

vol.13, no.5, pp.383-394, 2015 (Released:2015-10-10)

参考文献数

16

被引用文献数

7

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Radioactive contamination resulting from the Tokyo Electric Power Company Fukushima Daiichi Nuclear Power Station disaster following the Great East Japan earthquake and tsunami on March 11, 2011, has affected large areas of land in Fukushima, Japan. At present, agriculture has been limited to some areas, and there are concerns that radioactive substances carried by rainwater might contaminate water bodies such as ponds and rivers. In order to resume safe agricultural activities, evaluating the dynamics of radioactive substances in agricultural water is essential. In this study, we measured the concentration and analyzed the impact of radioactive cesium in irrigation water on rice in five districts having limited residential population. Further, we analyzed the radioactive cesium balance and soil samples from decontaminated paddy fields. The main findings of the study are (1) radioactive cesium in agricultural water was mainly in suspended form at the experimental locations within the 40 km zone; (2) most of the radioactive cesium in the irrigation water was accumulated in the paddy field, but radioactive cesium in irrigation water had limited impact on brown rice cultivation; and (3) continual monitoring of areas with radiation levels higher than those recorded in this study is recommended.

著者

Yen-Ting Yeh Jung-Chung Hsu Pen-Chih Liao Ai-Hsien Li Yuan-Hung Liu Kuo-Chin Chen Wenpo Chuang Shin-Rong Ke Yu-Wei Chiu Yen-Wen Wu

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.85, no.2, pp.166-174, 2021-01-25 (Released:2021-01-25)

参考文献数

21

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Background:Studies investigating the modulators of mortality benefit conferred by peri-angioplasty glycoprotein IIb/IIIa inhibitors in ST-elevation myocardial infarction (STEMI) are still lacking.Methods and Results:A prospective database (n=1,025) of consecutive cases undergoing primary percutaneous coronary intervention for STEMI was retrospectively analyzed. For patients in Killip class I, II or III, IV, the multivariate-adjusted hazard ratios of 30-day all-cause mortality associated with adjunctive tirofiban were 3.873 (95% CI 0.504–29.745; P=0.193), 0.550 (95% CI 0.188–1.609; P=0.275), and 0.264 (95% CI 0.099–0.704; P=0.008), respectively. The P value for a linear trend was 0.032. Patients who had a body mass index (BMI) within 22.9–25.0 kg/m2had a significant benefit from tirofiban (adjusted HR 0.344; 95% CI 0.145–0.814; P=0.015) compared to other BMI groups. The P value for a quadratic trend was 0.012. A novel Killip−BMI score (KBS = 2.5 × Killip category − | BMI − 24 |) was calculated to select the beneficial population. A KBS ≥2 was associated with significant mortality benefit, whereas a KBS <0 predicted increased 30-day mortality with tirofiban use.Conclusions:Survival benefit from peri-angioplasty tirofiban therapy for STEMI was positively correlated with the Killip class. Tirofiban should be used cautiously in either underweight or overweight patients. The novel KBS used in this study can guide peri-angioplasty use of adjunctive tirofiban in patients with STEMI undergoing primary angioplasty.

著者

Yuxin Chen Arisa Nishihara Shin Haruta

出版者

Japanese Society of Microbial Ecology / Japanese Society of Soil Microbiology / Taiwan Society of Microbial Ecology / Japanese Society of Plant Microbe Interactions / Japanese Society for Extremophiles

雑誌

Microbes and Environments (ISSN:13426311)

巻号頁・発行日

vol.36, no.2, pp.ME21018, 2021 (Released:2021-06-10)

参考文献数

87

被引用文献数

13

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Fermentative nitrogen-fixing bacteria have not yet been examined in detail in thermal environments. In the present study, we isolated the thermophilic fermentative bacterium, strain YA01 from a hot spring. This strain grew at temperatures up to 78°C. A phylogenetic analysis based on its 16S rRNA gene sequence indicated that strain YA01 belonged to the genus Caldicellulosiruptor, which are fermentative bacteria in the phylum Firmicutes, with 97.7–98.0% sequence identity to its closest relatives. Strain YA01 clearly exhibited N2-dependent growth at 70°C. We also confirmed N2-dependent growth in the relatives of strain YA01, Caldicellulosiruptor hydrothermalis 108 and Caldicellulosiruptor kronotskyensis 2002. The nitrogenase activities of these three strains were examined using the acetylene reduction assay. Similar activities were detected for all tested strains, and were slightly suppressed by the addition of ammonium. A genome analysis revealed that strain YA01, as well as other Caldicellulosiruptor, possessed a gene set for nitrogen fixation, but lacked the nifN gene, which encodes a nitrogenase iron-molybdenum cofactor biosynthesis protein that is commonly detected in nitrogen-fixing bacteria. The amino acid sequences of nitrogenase encoded by nifH, nifD, and nifK shared 92–98% similarity in Caldicellulosiruptor. A phylogenetic tree of concatenated NifHDK sequences showed that NifHDK of Caldicellulosiruptor was in the deepest clade. To the best of our knowledge, this is the first study to demonstrate the nitrogen-fixing ability of fermentative bacteria at 70°C. Caldicellulosiruptor may have retained an ancient nitrogen-fixing enzyme system.

著者

堀 新 Shin Hori

雑誌

共立女子大学文芸学部紀要 = The Kyoritsu Journal of Arts and Letters

巻号頁・発行日

vol.65, pp.87-103, 2019-03

著者

福田 盛介 鎌田 弘之 高玉 圭樹 野村 出 滝野 達也 入江 順也 永田 心 原田 智広 臼居 浩太郎 坂井 真一郎 澤井 秀次郎 SLIM WG Fukuda Seisuke Kamata Hiroyuki Takadama Keiki Nomura Izuru Takino Tatsuya Irie Junya Nagata Shin Harada Tomohiro Usui Kotaro Sakai Shin-ichiro Sawai Shujiro SLIM WG

出版者

宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)

雑誌

第15回宇宙科学シンポジウム 講演集 = Proceedings of the 15th Space Science Symposium

巻号頁・発行日

2015-01

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第15回宇宙科学シンポジウム (2015年1月6日-7日. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)相模原キャンパス), 相模原市, 神奈川県

著者

Masayuki Shimamura Takashi Kumaki Shun Hashimoto Kazuhiko Saeki Shin-ichi Ayabe Atsushi Higashitani Tomoyoshi Akashi Shusei Sato Toshio Aoki

出版者

Japanese Society of Microbial Ecology / Japanese Society of Soil Microbiology / Taiwan Society of Microbial Ecology / Japanese Society of Plant Microbe Interactions / Japanese Society for Extremophiles

雑誌

Microbes and Environments (ISSN:13426311)

巻号頁・発行日

vol.37, no.1, pp.ME21094, 2022 (Released:2022-03-12)

参考文献数

50

被引用文献数

9

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In legume–rhizobia symbiosis, partner recognition and the initiation of symbiosis processes require the mutual exchange of chemical signals. Chemicals, generally (iso)flavonoids, in the root exudates of the host plant induce the expression of nod genes in rhizobia, and, thus, are called nod gene inducers. The expression of nod genes leads to the production of lipochitooligosaccharides (LCOs) called Nod factors. Natural nod gene inducer(s) in Lotus japonicus–Mesorhizobium symbiosis remain unknown. Therefore, we developed an LCO detection method based on ultra-high-performance liquid chromatography–tandem-quadrupole mass spectrometry (UPLC-TQMS) to identify these inducers and used it herein to screen 40 phenolic compounds and aldonic acids for their ability to induce LCOs in Mesorhizobium japonicum MAFF303099. We identified five phenolic acids with LCO-inducing activities, including p-coumaric, caffeic, and ferulic acids. The induced LCOs caused root hair deformation, and nodule numbers in L. japonicus inoculated with M. japonicum were increased by these phenolic acids. The three phenolic acids listed above induced the expression of the nodA, nodB, and ttsI genes in a strain harboring a multicopy plasmid encoding NodD1, but not that encoding NodD2. The presence of p-coumaric and ferulic acids in the root exudates of L. japonicus was confirmed by UPLC-TQMS, and the induction of ttsI::lacZ in the strain harboring the nodD1 plasmid was detected in the rhizosphere of L. japonicus. Based on these results, we propose that phenolic acids are a novel type of nod gene inducer in L. japonicus–Mesorhizobium symbiosis.

著者

Akihito Sako Takako Teduka Makito Kawada Shin-ichiro

出版者

National Museum of Nature and Science

雑誌

Bulletin of the National Museum of Nature and Science. Series A, Zoology (ISSN:18819052)

巻号頁・発行日

vol.42, no.3, pp.143-161, 2016-08