著者

KUBOTA Shin

出版者

北海道大學

雑誌

北海道大學理學部紀要 (ISSN:03682188)

巻号頁・発行日

vol.22, no.1, pp.122-136, 1979-12

著者

Shiho Toyama Ayuko Takatani Tomohiro Koga Mizuna Eguchi Momoko Okamoto Sosuke Tsuji Yushiro Endo Toshimasa Shimizu Remi Sumiyoshi Takashi Igawa Shin-ya Kawashiri Naoki Iwamoto Kunihiro Ichinose Mami Tamai Hideki Nakamura Tomoki Origuchi Masako Furuyama Maiko Tabuchi Shinichiro Kobayashi Kengo Kanetaka Mikiko Hashisako Kuniko Abe Daisuke Niino Shinya Sato Yasushi Miyazaki Atsushi Kawakami

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.2782-19, (Released:2019-07-22)

参考文献数

20

被引用文献数

1

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A 71-year-old woman being treated with methotrexate (MTX) and tacrolimus (TAC) for rheumatoid arthritis (RA) was admitted to our hospital and underwent surgery for gastric perforation and peritonitis. An endoscopic examination six days post-surgery showed an extensive ulcer in the stomach, and a biopsy revealed diffused large B-cell lymphoma. We diagnosed her with immunodeficiency-associated lymphoproliferative disorder (LPD) and discontinued the MTX and TAC. She underwent gastrectomy due to stenosis approximately two months after the first operation, but the histopathological findings of lymphoma had disappeared. LPD should be considered as a potential cause of gastric perforation during RA treatment.

著者

Yasuaki Takeji Tomohiko Taniguchi Takeshi Morimoto Naritatsu Saito Kenji Ando Shinichi Shirai Genichi Sakaguchi Yoshio Arai Yasushi Fuku Yuichi Kawase Tatsuhiko Komiya Natsuhiko Ehara Takeshi Kitai Tadaaki Koyama Shin Watanabe Hirotoshi Watanabe Hiroki Shiomi Eri Minamino-Muta Shintaro Matsuda Hidenori Yaku Yusuke Yoshikawa Kazuhiro Yamazaki Masahide Kawatou Kazuhisa Sakamoto Toshihiro Tamura Makoto Miyake Hisashi Sakaguchi Koichiro Murata Masanao Nakai Norio Kanamori Chisato Izumi Hirokazu Mitsuoka Masashi Kato Yutaka Hirano Tsukasa Inada Kazuya Nagao Hiroshi Mabuchi Yasuyo Takeuchi Keiichiro Yamane Takashi Tamura Mamoru Toyofuku Mitsuru Ishii Moriaki Inoko Tomoyuki Ikeda Katsuhisa Ishii Kozo Hotta Toshikazu Jinnai Nobuya Higashitani Yoshihiro Kato Yasutaka Inuzuka Yuko Morikami Kenji Minatoya Takeshi Kimura on befalf of the CURRENT AS Registry Investigators and K-TAVI Registry Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-19-0951, (Released:2020-02-01)

参考文献数

35

被引用文献数

12

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Background:There are no data comparing transcatheter aortic valve implantation (TAVI) with surgical aortic valve replacement (SAVR) outcomes in real clinical practice in Japan.Methods and Results:We combined 2 independent registries, the K-TAVI Registry (a 6-center prospective registry of consecutive patients who underwent TAVI) and the CURRENT AS Registry (a large, 27-center registry of 3,815 consecutive patients with severe aortic stenosis [AS]). In the K-TAVI Registry, 338 patients underwent TAVI with SAPIEN XT balloon-expandable valves from October 2013 to January 2016, whereas in the CURRENT AS Registry 237 patients with severe AS underwent SAVR from January 2003 to December 2011. Propensity score matching was conducted, with final cohort comprising 306 patients. The cumulative 2-year incidence of all-cause death and heart failure (HF) hospitalization did not differ significantly between the TAVI and SAVR groups (13.7% vs. 12.4% [P=0.81] and 7.9% vs 3.9% [P=0.13], respectively). After adjusting for residual confounders, there were no significant differences between the TAVI and SAVR groups in the risk for all-cause death (hazard ratio [HR] 0.74; 95% confidence interval [CI] 0.35–1.58; P=0.43) or HF hospitalization (HR 1.27; 95% CI 0.40–4.59; P=0.69).Conclusions:These findings from 2 independent Japanese registries suggest that the 2-year risk of all-cause mortality and HF does not differ significantly between TAVI and SAVR groups in real-world practice in Japan.

著者

Shin OSAKI

出版者

Japan Society of Civil Engineers

雑誌

Journal of JSCE (ISSN:21875103)

巻号頁・発行日

vol.5, no.1, pp.226-245, 2017 (Released:2017-05-20)

参考文献数

44

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This study aims to define site selection characteristics of shrines affected by tsunamis in the coastal areas of the Sanriku region, to understand the differences between the locations of shrines that did or did not survive the disaster through field surveys and historical reviews. First, through the field survey, this research demonstrates that shrines in the area are generally located on ridge of mountains less likely to be affected by tsunamis and the destroyed shrines tend to be located near the low-lying coastline or on flatlands. Second, through the historical reviews, the characteristics of shrine locations have greatly changed since the middle of the 12th century. This research indicated that shrines were mostly positioned along the ridge line during the time of the ancient belief system and became more diverse during the medieval period from the mid-12th century onwards, when the culture of “kanjo,” the ceremonial transfer of a divided tutelary deity to a new location according to the enshrined deity's character, was introduced to the area. In addition to this general site selection characteristics, the experience from earlier tsunamis affects the re-selection of shrine sites. In conclusion, the site selection system for the shrines consists of global and local mechanisms. Finally, the author suggests the possibility of utilizing the shrine's site selection characteristics as a way to hand down the tsunami experience to the next generations.

著者

Hyun-Kyu Cha Hyuk-Shin Cho Jong-Duk Choi

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.26, no.7, pp.981-983, 2014 (Released:2014-07-30)

参考文献数

19

被引用文献数

6 11

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[Purpose] The purpose of the study was to determine the effects of a sciatic nerve mobilization technique on improvement of lower limb function in patient with poststroke hemiparesis. [Subjects] Twenty- two stroke patients participated in this study. [Methods] They were randomly selected based on selection criteria and divided into two groups. In the subject group (n=10), sciatic nerve mobilization with conventional physical therapy was applied to patients. In the control group (n=10), only conventional physical therapy was applied to stroke patients. [Results] There were significant differences between the two groups in pressure, sway, total pressure, angle of the knee joint, and functional reaching test results in the intervention at two weeks and at four weeks. [Conclusion] The present study showed that sciatic nerve mobilization with conventional physical therapy was more effective for lower limb function than conventional physical therapy alone in patient with poststroke hemiparesis.

著者

Hirofumi Tomiyama Masatsune Fujii Kazuki Shiina Shin-ichiro Ueda Yoichi Iwasaki Chisa Matsumoto Taishiro Chikamori

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.1, no.10, pp.438-444, 2019-10-10 (Released:2019-10-10)

参考文献数

31

被引用文献数

2

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Background:This randomized, double-blind, placebo-controlled, cross-over study was conducted to examine the effects of lactotripeptide supplementation on 7-day mean tele-monitored home blood pressure (BP), and also on the markers of vascular function and renal damage in Japanese subjects with prehypertension.Methods and Results:A total of 26 subjects with prehypertension were randomly allocated to receive the active product (lactotripeptide tablet) or a placebo tablet for 8 weeks each in a cross-over manner. Urinary liver-type fatty acid-binding protein-to-creatine ratio (UFABPCR) and vascular function were measured at the end of each intervention. Home systolic and diastolic BP at the end of the lactotripeptide supplementation period was significantly lower than that at the end of the placebo period (P<0.05). On mixed linear model analysis there was a significant difference in the change in home diastolic BP after intervention between the 2 interventions (P=0.04). UFABPCR was significantly lower at the end of the lactotripeptide intervention period than at the end of the placebo period (P<0.05).Conclusions:The beneficial effect of lactotripeptide supplementation on 7-day mean tele-monitored home BP was confirmed in Japanese subjects with prehypertension. In addition, this intervention also seemed to have a protective effect against the progression of renal function decline.

著者

Soon-Seek YOON Jae-Won BYUN Min-Jeong KIM You-Chan BAE Yeun-Kyung SHIN Sorah YOON Garam LEE Jae-Young SONG

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.73, no.2, pp.275-277, 2011 (Released:2011-03-03)

参考文献数

10

被引用文献数

1 7

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Clinical grape poisoning in two dogs (a 1.6-year-old male Shih Tzu and a 5-year-old female Yorkshire Terrier) was described in the present study. Clinical signs included decreased urine output in the Shih Tzu and ataxia in the Yorkshire Terrier after grape ingestion. The Shih Tzu died 5 days post-grape ingestion, while the Yorkshire Terrier died 3 days post-grape ingestion. Erythematous serosae and mucosae, multifocal red small intestinal foci, and blood and grape seeds were identified in the intestinal lumen. Brownish-yellow crystals were bilaterally identified in the renal pelvis. The primary histological findings were acute tubular necrosis of the proximal convoluted tubules, severe necrosis, and mineralization in the renal cortical tubules. Blood urea nitrogen, creatinine, and alanine aminotransferase were increased in the dogs. Many Korean veterinary clinicians have suspected clinical grape poisoning. However, to our knowledge, grape poisoning has not been identified by pathologic and clinicopathologic basis until this writing in Korea. Education and knowledge about the risks of grape poisoning is necessary for the prevention of accidental exposures.

著者

Masahiro KORENAGA Shunroku YAMAMOTO Shunta NODA Shin AOI

出版者

Railway Technical Research Institute

雑誌

Quarterly Report of RTRI (ISSN:00339008)

巻号頁・発行日

vol.60, no.2, pp.134-139, 2019-05-01 (Released:2019-05-26)

参考文献数

9

被引用文献数

4

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This article explains processes for improving the railway earthquake early warning system. These processes were introduced to use data transmitted in real time from recently developed ocean bottom seismic networks. Three mechanisms were designed to be able to exploit this data: 1) an algorithm for servers in OBS system base stations; 2) a procedure to allow transmissions between the servers and railway company receivers; and 3) a system built into the receiver to determine whether running trains need to be stopped or not. Confirmation was obtained that the proposed processes were able to reduce the risks to railways from earthquakes, because they are capable of extending the lead time before the arrival of strong seismic motion.

著者

北村 泰一 福島 紳 小玉 正弘 Taiichi KITAMURA Shin FUKUSHIMA Masahiro KODAMA

雑誌

南極資料 (ISSN:00857289)

巻号頁・発行日

vol.6, pp.301-321, 1959-01

著者

SHINOBU ODA SEIYA NOMURA MANAMI NAKAGAWA KAZUO SHIN-YA NORITAKA KAGAYA TEPPEI KAWAHARA

出版者

The Society for Antibacterial and Antifungal Agents, Japan

雑誌

Biocontrol Science (ISSN:13424815)

巻号頁・発行日

vol.24, no.1, pp.47-56, 2019 (Released:2019-03-18)

参考文献数

33

被引用文献数

1

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A useful tool for the screening of fungi producing biologically active secondary metabolites such as antibiotics and cytotoxic substances has been developed. An agar plate-organic solvent interface cultivation (A/S-IFC) system, which comprised a hydrophobic organic solvent (upper phase) , a fungal mat (middle phase) and an agar plate (lower phase) , was constructed. The metabolite profiles were compared among the A/S-IFC, a traditional submerged cultivation (SmC) and an extractive liquid surface immobilization (Ext-LSI) system consisted of a hydrophobic solvent (upper phase) , a fungal cells–ballooned microspheres (middle phase) and a liquid medium (lower phase) , with high-performance liquid chromatography-photodiode array detector (HPLC-PDA) . In the A/S-IFC, many hydrophobic metabolites vastly different from those in the SmC were accumulated in the organic phase as with the Ext-LSI. For example, a valuable azaphilone, sclerotiorin, was remarkably produced into the organic phase in the A/S-IFC. The A/S-IFC was applied to the screening of antibiotic-producing fungi. As a result of paper disk method, it was found that 321 isolated among 811 strains produced antifungal metabolites (hit rate, 39.6%) . Furthermore, 8, 23, and 30 strains also produced cytotoxic metabolites against SKOV-3 (human ovary adenocarcinoma) , MESO-1 (human malignant pleural mesothelioma) , and Jurkat cells (immortalized human T lymphocyte) .

著者

KAJINO Mizuo DEUSHI Makoto SEKIYAMA Tsuyoshi Thomas OSHIMA Naga YUMIMOTO Keiya TANAKA Taichu Yasumichi CHING Joseph HASHIMOTO Akihiro YAMAMOTO Tetsuya IKEGAMI Masaaki KAMADA Akane MIYASHITA Makoto INOMATA Yayoi SHIMA Shin-ichiro TAKAMI Akinori SHIMIZU Atsushi HATAKEYAMA Shiro SADANAGA Yasuhiro IRIE Hitoshi ADACHI Kouji ZAIZEN Yuji IGARASHI Yasuhito UEDA Hiromasa MAKI Takashi MIKAMI Masao

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2019-020, (Released:2018-12-09)

被引用文献数

36

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Model performance of a regional-scale meteorology – chemistry model (NHM-Chem) has been evaluated for the consistent predictions of the chemical, physical, and optical properties of aerosols. These properties are essentially important for the accurate assessment of air quality and health hazards, contamination of land and ocean ecosystems, and regional climate changes due to aerosol-cloud-radiation interaction processes. Currently, three optional methods are available: the 5-category non-equilibrium, 3-category non-equilibrium, and bulk equilibrium methods. These three methods are suitable for the predictions of regional climate, air quality, and operational forecasts, respectively. In this paper, the simulated aerosol chemical, physical, and optical properties and their consistency were evaluated by using various observation data in East Asia. The simulated mass, size, and deposition of SO42- and NH4+ agreed well with the observations, whereas those of NO3-, sea-salt, and dust needed improvement. The simulated surface mass concentration (PM10 and PM2.5) and spherical extinction coefficient agreed well with the observations. The simulated aerosol optical thickness and dust extinction coefficient were significantly underestimated.

著者

Shin'ichi KUDO Keiko YOSHIMOTO Hiroshige FURUTA Kazumasa INOUE Masahiro FUKUSHI Fumiyoshi KASAGI

出版者

日本保健物理学会

雑誌

保健物理 (ISSN:03676110)

巻号頁・発行日

vol.53, no.3, pp.146-153, 2018 (Released:2018-11-27)

参考文献数

41

被引用文献数

7

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Whether exposure to radiation at low dose and at low dose rate is related to leukemia mortality and morbidity remains controversial. Cohort studies of nuclear workers chronically exposed to radiation at low dose and at low dose rate in their workplaces provide an opportunity to directly evaluate the risks of leukemia in the lower dose ranges. Previous findings have come mostly from Western countries, with few from Asian countries. The present study aimed to examine radiation’s effects on mortality from leukemia, in a cohort of Japanese nuclear workers. The cohort consisted of 204,103 workers, who were followed from 1991 to 2010, with a total of 2.89 million person-years. The mean age and mean cumulative dose at the age at the end of follow-up were 55.6 years and 13.8 mSv. During the study, 209 leukemia deaths were observed. The linear excess relative risk (ERR) for all types of leukemia was negative, but not significant (ERR/Sv = -0.54; 90% confidence interval; -4.04, 2.96). Specific types of leukemia also showed no significant risks. A significant radiation-leukemia association for mortality was not observed in this study of Japanese nuclear workers. The cohort, however, is still young. Further follow-up is needed to obtain more reliable estimates of leukemia risks for Japanese workers exposed to low dose and low-dose rate radiation.

著者

千葉 眞 Shin Chiba

雑誌

国際基督教大学学報. II-B, 社会科学ジャーナル = The Journal of Social Science

巻号頁・発行日

no.54, pp.101-138, 2005-03-30

著者

周 恩来 米原 謙 申 春野 ヨネハラ ケン シン ハルノ Zhou Enlai Yonehara Ken Shin Haruno

出版者

大阪大学大学院国際公共政策研究科

雑誌

国際公共政策研究 (ISSN:13428101)

巻号頁・発行日

vol.5, no.1, pp.355-373, 2000-11

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周, 恩来(著) 米原, 謙/申, 春野(共訳)

著者

周 恩来 米原 謙 申 春野 ヨネハラ ケン シン ハルノ Zhou Enlai Yonehara Ken Shin Haruno

出版者

大阪大学大学院国際公共政策研究科

雑誌

国際公共政策研究 (ISSN:13428101)

巻号頁・発行日

vol.5, no.2, pp.163-178, 2001-04

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周, 恩来(著) 米原, 謙/申, 春野(共訳)

著者

齊藤 伸 Shin Saito 東京工芸大学工学部基礎教育研究センター非常勤講師

雑誌

東京工芸大学工学部紀要. 人文・社会編 = The Academic Reports, the Faculty of Engineering, Tokyo Polytechnic University (ISSN:03876055)

巻号頁・発行日

vol.40, no.2, pp.59-65, 2017-12-25

著者

慎 斗範 Doo-Boem Shin

出版者

国際基督教大学

雑誌

社会科学ジャーナル (ISSN:04542134)

巻号頁・発行日

vol.30, no.1, pp.1-19, 1991-06

著者

Shin-ichi SUZUKI Takeshi MAESAKA Koyuru IWANAMI Shingo SHIMIZU Kaori KIEDA

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

vol.96A, pp.25-33, 2018 (Released:2018-02-19)

参考文献数

20

被引用文献数

4

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X-band dual-polarization (multi-parameter) radars were used to observe a supercell storm that generated an F3 tornado in Ibaraki Prefecture, Japan on 6 May 2012. The observed data collected for this storm clearly exhibited the typical polarimetric features of a supercell storm, such as the ZDR (differential reflectivity) arc, ZDR column, and the KDP (specific differential phase) column, as well as their time evolution. The ZDR arc emerged at 10 to 15 min before the tornadogenesis. The ZDR column appeared approximately 1 h before the formation of the ZDR arc and was intermittent until tornadogenesis. As the ZDR arc appeared, the column became tall and stable and lasted until the dissipation of the tornado. These ZDR signatures of the supercell storm persisted for approximately half an hour.

著者

Arisa Nishihara Shin Haruta Shawn E. McGlynn Vera Thiel Katsumi Matsuura

出版者

日本微生物生態学会・日本土壌微生物学会

雑誌

Microbes and Environments (ISSN:13426311)

巻号頁・発行日

pp.ME17134, (Released:2018-01-24)

被引用文献数

21

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The activity of nitrogen fixation measured by acetylene reduction was examined in chemosynthetic microbial mats at 72–75°C in slightly-alkaline sulfidic hot springs in Nakabusa, Japan. Nitrogenase activity markedly varied from sampling to sampling. Nitrogenase activity did not correlate with methane production, but was detected in samples showing methane production levels less than the maximum amount, indicating a possible redox dependency of nitrogenase activity. Nitrogenase activity was not affected by 2-bromo-ethane sulfonate, an inhibitor of methanogenesis. However, it was inhibited by the addition of molybdate, an inhibitor of sulfate reduction and sulfur disproportionation, suggesting the involvement of sulfate-reducing or sulfur-disproportionating organisms. Nitrogenase activity was affected by different O2 concentrations in the gas phase, again supporting the hypothesis of a redox potential dependency, and was decreased by the dispersion of mats with a homogenizer. The loss of activity that occurred from dispersion was partially recovered by the addition of H2, sulfate, and carbon dioxide. These results suggested that the observed activity of nitrogen fixation was related to chemoautotrophic sulfate reducers, and fixation may be active in a limited range of ambient redox potential. Since thermophilic chemosynthetic communities may resemble ancient microbial communities before the appearance of photosynthesis, the present results may be useful when considering the ancient nitrogen cycle on earth.

著者

Haruki Momma Susumu S. Sawada Robert A. Sloan Yuko Gando Ryoko Kawakami Shin Terada Motohiko Miyachi Chihiro Kinugawa Takashi Okamoto Koji Tsukamoto Cong Huang Ryoichi Nagatomi Steven N. Blair

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20160199, (Released:2017-11-25)

参考文献数

29

被引用文献数

6

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Background: The “Physical Activity Reference for Health Promotion 2013” provides “fit” reference values for cardiorespiratory fitness (CRF) for good health. The importance of achieving a fit CRF level for several years on the subsequent prevention of type 2 diabetes mellitus (T2DM) remains to be clarified.