著者
Shin-ichiro Agake Fernanda Plucani do Amaral Tetsuya Yamada Hitoshi Sekimoto Gary Stacey Tadashi Yokoyama Naoko Ohkama-Ohtsu
出版者
Japanese Society of Microbial Ecology / Japanese Society of Soil Microbiology / Taiwan Society of Microbial Ecology / Japanese Society of Plant Microbe Interactions / Japanese Society for Extremophiles
雑誌
Microbes and Environments (ISSN:13426311)
巻号頁・発行日
vol.37, no.1, pp.ME21060, 2022 (Released:2022-01-27)
参考文献数
61
被引用文献数
3

Spores are a stress-resistant form of Bacillus spp., which include species that are plant growth-promoting rhizobacteria (PGPR). Previous studies showed that the inoculation of plants with vegetative cells or spores exerted different plant growth-promoting effects. To elucidate the spore-specific mechanism, we compared the effects of viable vegetative cells, autoclaved dead spores, and viable spores of Bacillus pumilus TUAT1 inoculated at 107 CFU plant–1 on the growth of the C4 model plant, Setaria viridis A10.1. B. pumilus TUAT1 spores exerted stronger growth-promoting effects on Setaria than on control plants 14 days after the inoculation. Viable spores increased shoot weight, root weight, shoot length, root length, and nitrogen uptake efficiency 21 days after the inoculation. These increases involved primary and crown root formation. Additionally, autoclaved dead spores inoculated at 108 or 109 CFU plant–1 had a positive impact on crown root differentiation, which increased total lateral root length, resulting in a greater biomass and more efficient nitrogen uptake. The present results indicate that an inoculation with viable spores of B. pumilus TUAT1 is more effective at enhancing the growth of Setaria than that with vegetative cells. The plant response to dead spores suggests that the spore-specific plant growth-promoting mechanism is at least partly independent of symbiotic colonization.
著者
Jieun Lee Young Ah Lee Seong Yong Lee Choong Ho Shin Jae Hyun Kim
出版者
Tohoku University Medical Press
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.256, no.1, pp.53-62, 2022 (Released:2022-01-27)
参考文献数
50
被引用文献数
8

Triglyceride/high-density lipoprotein (HDL) cholesterol ratio (TG/HDL-C), triglyceride-glucose index (TyG), and non-HDL cholesterol level (non-HDL-C) have been proposed as surrogate markers for predicting metabolic syndrome (MetS). This study investigated whether these lipid-derived surrogate markers can predict MetS in Korean children and adolescents. Data from 1,814 participants were analyzed from the 2013-2016 Korean National Health and Nutrition Examination Survey. MetS was defined using three sets of criteria: Cook et al. (MetS1), de Ferranti et al. (MetS2), and the International Diabetes Federation (MetS3). The prevalence of MetS1, MetS2, and MetS3 was 4.6%, 11.3%, and 2.7%, respectively. In receiver operating characteristic curve analysis of MetS and lipid-derived surrogate markers, TG/HDL-C (0.937 for MetS1, 0.894 for MetS2, and 0.897 for MetS3) had the largest area under the curve (AUC), followed by TyG (0.906 for MetS1, 0.864 for MetS2, and 0.887 for MetS3), and non-HDL-C (0.752 for MetS1, 0.708 for MetS2, and 0.703 for MetS3) (all P < 0.001). The cutoff values for detecting MetS with TG/HDL-C, TyG, and non-HDL-C were 2.64, 8.52, and 111.6 for MetS1; 2.23, 8.47, and 110.7 for MetS2; and 2.64, 8.74, and 110.8 for MetS3, respectively. In conclusion, TG/HDL-C and TyG were similarly predictive of MetS. We propose using TG/HDL-C and TyG as surrogate markers for assessing MetS in Korean children and adolescents.
著者
Shin-ichi Momomura Yoshihiko Saito Yoshio Yasumura Kazuhiro Yamamoto Yasushi Sakata Masao Daimon Koichiro Kinugawa Hiroshi Okamoto Naoki Dohi Issei Komuro
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-17-0532, (Released:2017-08-02)
参考文献数
10
被引用文献数
5 8

Background:TY-0201 (TY) is a transdermal formulation of bisoprolol that is the free base of bisoprolol fumarate (BO), a drug widely used to treat chronic heart failure (CHF). The objectives of this phase II study were to evaluate the efficacy and safety of TY when switching from oral BO to TY in patients with CHF whose drug therapy was optimized, and to determine the dose conversion rate of BO to TY.Methods and Results:The efficacy and safety of once daily TY patch use for 16 weeks was investigated in 40 patients with CHF who were stabilized with an optimized drug treatment, including BO, after switching from BO to TY at the dose conversion rate of 5:8. The pre-switch left ventricular ejection fraction was 50.13±11.09% (mean±SD). The post-switch value was 50.87±10.79% after 16 weeks, which was not significantly different, with similar results for other efficacy and safety parameters. The 16-week study was continued for all patients without changing doses after switching to TY. No cardiovascular deaths, hospitalizations for worsening HF, or significant safety concerns were observed.Conclusions:Efficacy was maintained without significant safety concerns in patients with CHF who were stabilized with BO treatment after switching to TY, suggesting the appropriateness of the dose conversion rate.
著者
Yuuka Shibata Yuhei Shiga Yasunori Suematsu Kohei Tashiro Yuto Kawahira Kai Morita Takashi Kuwano Makoto Sugihara Shin-ichiro Miura
出版者
The Japanese Circulation Society
雑誌
Circulation Reports (ISSN:24340790)
巻号頁・発行日
vol.3, no.11, pp.674-681, 2021-11-10 (Released:2021-11-10)
参考文献数
39
被引用文献数
5

Background:Obesity is a critical cardiovascular risk factor that has been defined in terms of body mass index (BMI), abdominal circumference (AC), and fat area. In this study, we examined which markers of obesity are most closely associated with major adverse cardiovascular events (MACE).Methods and Results:This prospective cohort study enrolled 529 consecutive patients who initially underwent coronary computed tomography angiography for screening of coronary atherosclerosis at Fukuoka University Hospital (FU-CCTA Registry) and either were clinically suspected of having coronary artery disease (CAD) or had at least 1 cardiovascular risk factor with a follow-up of up to 5 years. Measurements of subcutaneous fat area (SFA), visceral fat area (VFA), and AC were quantified using multidetector row computed tomography. The primary endpoint was MACE. SFA and the SFA to VFA ratio (SFA/VFA) were significantly lower in the MACE than non-MACE group. SFA, AC, BMI, and SFA/VFA were each independently associated with MACE. Receiver operating characteristic curve analysis revealed a greater area under the curve for SFA/VFA than for the other parameters. The cut-off level of SFA/VFA with the greatest sensitivity and specificity for the diagnosis of MACE was 1.45 (sensitivity 0.849, specificity 0.472).Conclusions:Our results suggest that SFA/VFA may be a marker for evaluating the presence of MACE.
著者
Arisa Nishihara Katsumi Matsuura Marcus Tank Shawn E. McGlynn Vera Thiel Shin Haruta
出版者
Japanese Society of Microbial Ecology / Japanese Society of Soil Microbiology / Taiwan Society of Microbial Ecology / Japanese Society of Plant Microbe Interactions / Japanese Society for Extremophiles
雑誌
Microbes and Environments (ISSN:13426311)
巻号頁・発行日
vol.33, no.4, pp.394-401, 2018 (Released:2018-12-28)
参考文献数
48
被引用文献数
7 21

The phylum Aquificae comprises chemolithoautotrophic thermophilic to hyperthermophilic bacteria, in which the nitrogenase reductase gene (nifH) has been reported. However, nitrogen-fixing activity has not yet been demonstrated in members of this deeply branching bacterial phylum. We isolated two thermophilic diazotrophic strains from chemosynthetic microbial communities in slightly alkaline hot springs (≥70°C) in Nakabusa, Nagano Prefecture, Japan. A phylogenetic analysis based on 16S rRNA genes identified these strains as members of the genus Hydrogenobacter within Aquificae. Their NifH sequences showed 96.5 and 97.4% amino acid sequence identities to that from Hydrogenobacter thermophilus TK-6. Nitrogenase activity, measured by acetylene reduction, was confirmed in both strains at 70°C. These novel strains grew under semi-aerobic conditions by using CO2 as the sole carbon source and N2 as the sole nitrogen source in media containing hydrogen and/or thiosulfate. To the best of our knowledge, this is the first demonstration of active nitrogen fixation in thermophilic bacteria at 70°C and in the phylum Aquificae.
著者
神山 順 西山 勝彦 Shin'ichi Sato 島田 順一 大賀 興一 岡 隆宏
出版者
The Japanese Association for Chest Surgery
雑誌
日本呼吸器外科学会雑誌 (ISSN:09190945)
巻号頁・発行日
vol.8, no.1, pp.99-102, 1994-01-15 (Released:2009-11-10)
参考文献数
5

欧米では銃器による胸部穿通性外傷の報告が多くみられるが, 日本では, その発生頻度は極めて低い.今回我々は22口径の拳銃による肺損傷の患者を, 緊急開胸術による直接肺縫合で救命し得た.銃器による穿通性胸部外傷の特徴は, ナイフなどによる他の穿通創とは異なり, 弾丸が通過した部分のみの損傷にとどまらない.今回の症例は, 大きな気道の損傷および大血管の損傷はなく縫合閉鎖によって止血できた.しかし, 症例によっては, 肺損傷が著しく肺葉切除や大血管損傷に対する修復が必要な場合もあり, 術前から補助手段なども考慮しておくことが必要である。
著者
Naoshi Hirata Shiro Ohmi Shin'ichi Sakai Kei Katsumata Satoshi Matsumoto Tetsuo Takanami Akira Yamamoto Takashi Iidaka Taku Urabe Mayumi Sekine Tooru Ooida Fumihito Yamazaki Hiroshi Katao Yasuhiro Umeda Masao Nakamura Norihiko Seto Takeshi Matsushima Hiroshi Shimizu Japanese University Group of the Urgent Joint
出版者
The Seismological Society of Japan, The Volcanological Society of Japan, The Geodetic Society of Japan
雑誌
Journal of Physics of the Earth (ISSN:00223743)
巻号頁・発行日
vol.44, no.4, pp.317-328, 1996 (Released:2009-04-30)
参考文献数
21
被引用文献数
41 43

A disastrous earthquake with a magnitude of 7.2 hit the southern part of Hyogo Prefecture on January 17, 1995. The mainshock was located on an active fault of the Arima-Takatsuki-Rokko fault system. Its focal mechanism was consistent with a right-lateral strike-slip fault trending N40°E. Three days after the occurrence of the mainshock, we started to install a highly dense seismic array in and around the fault area of the quake. Two permanent regional seismic networks of more than 30 stations covered the entire area of 200 km × 200 km. The temporarily installed array of 27 stations spanned the fault area of 15 km × 50 km. All data were telemetered to a temporary observation center at Uji. We located about 3, 100 aftershocks in real time for 1 month using an Internet connection between seismic networks. The aftershock area extended 70 km trending northeast to southwest. Hypocenters determined by the network were delivered automatically through the Internet. We found that the aftershock distribution was heterogeneous in space and time: seven clusters of hypocenters were identified and temporary variation in the rate of occurrence of aftershocks had a periodic component with periods of a half of day, 1 day, and 3 days, that are superimposed on decaying of the rate following Omori's law.
著者
Jinju Park Han Joo Kim Sang Hwa Shin Eunjung Park Jin-Kyoung Oh Eun Young Park Min Kyung Lim
出版者
Japan Epidemiological Association
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
pp.JE20200213, (Released:2021-02-06)
参考文献数
23
被引用文献数
10

Background: The popularity of heated tobacco products (HTPs) has been growing globally but, limited information exists on tobacco use behaviors and its impact on tobacco control. This study investigates awareness and perception of HTPs among tobacco users, and whether perceptions of HTPs are associated with HTP use and intention to quit.Methods: 2,000 tobacco users aged 19–65 years with countrywide representation were invited to an online survey in November 2018. Information on general characteristics, tobacco use behaviors, awareness and perception of HTPs, and intention to quit, were gathered. Multinomial logistic regression analysis and ANCOVA were used for estimation of association and comparison.Results: Among all tobacco users, 36.8% were classified as ever users, whereas 28.3% had used HTPs in the past 30 days, which was higher than expected. Users of liquid-based e-cigarettes (OR: 1.578; CI: 1.210–2.056) and poly product (OR: 2.029; CI: 1.121–3.671) showed higher intention to quit within 1 month when compared to users of conventional cigarettes (CCs), whereas HTP users and dual product users did not. HTP users rated HTPs more favorably than CCs in terms of smoke, smell, harm, aid in quitting, design, and price than users of other products did (p-value <0.001).Conclusions: We find that positive perception of HTPs following strategic marketing from tobacco companies could have contributed to an increase in HTP use than expected in Korea. However, HTPs might not be considered substitutes for CCs for quitting tobacco use because a significant proportion of dual product users reported a lower intention to quit.
著者
Makoto Sugihara Kaori Mine Makito Futami Yuta Kato Tadaaki Arimura Masaya Yano Yosuke Takamiya Takashi Kuwano Shin-ichiro Miura
出版者
The Japanese Circulation Society
雑誌
Circulation Reports (ISSN:24340790)
巻号頁・発行日
vol.2, no.11, pp.682-690, 2020-11-10 (Released:2020-11-10)
参考文献数
21
被引用文献数
4

Background:Drug-coated balloon strategies in endovascular therapy often result in severe dissection, so lesion preparation must be improved. We evaluated the efficacy of a gradual inflation method, termed “super slow inflation” (SSI), in preparing lesions to avoid severe dissections.Methods and Results:The association between balloon pressure and the dilatation of a model constricted vessel, as well as the load applied to the balloon surface, were determined using a burst leak detector for a quick inflation (QI; 1 atm/s) protocol and SSI (1 atm/20 s). A retrospective, single-center, non-randomized study evaluated differences in vessel dissection patterns after balloon angioplasty depending on inflation method in 81 consecutive patients (mean [±SD] age 74.6±9.2 years; 54 males) who underwent balloon angioplasty for de novo femoropopliteal lesions between January 2017 and March 2019. In the constricted vessel model, vessel dilatation increased gradually using SSI, with the maximum dilatation load being approximately 100 g lower for the SSI than QI protocol. In patients, the rate of severe vessel dissection was significantly lower in the SSI than non-SSI group (17.6% vs. 55.2%, respectively; P<0.001). Multivariate regression analysis revealed that SSI was an independent factor preventing severe dissection (odds ratio 0.18; 95% confidence interval 0.06–0.53; P=0.002).Conclusions:SSI is a gentle and effective method for the preparation of femoropopliteal lesions to reduce the incidence of severe angiographic dissection when using drug-coated balloons.
著者
Tadashi Nakajima Reika Kawabata-Iwakawa Yoshiaki Kaneko Shin-ichiro Hamano Rie Sano Shuntaro Tamura Hiroshi Hasegawa Takashi Kobari Yoshihiko Kominato Masahiko Nishiyama Masahiko Kurabayashi
出版者
International Heart Journal Association
雑誌
International Heart Journal (ISSN:13492365)
巻号頁・発行日
pp.20-203, (Released:2020-09-12)
参考文献数
19
被引用文献数
7

While a KCND3 V392I mutation uniquely displays a mixed electrophysiological phenotype of Kv4.3, only limited clinical information on the mutation carriers is available. We report two teenage siblings exhibiting both cardiac (early repolarization syndrome and paroxysmal atrial fibrillation) and cerebral phenotypes (epilepsy and intellectual disability), in whom we identified the KCND3 V392I mutation. We propose a link between the KCND3 mutation with a mixed electrophysiological phenotype and cardiocerebral phenotypes, which may be defined as a novel cardiocerebral channelopathy.
著者
Masakatsu Takahashi Hiroko Fukunaga Hiroshi Kaneto Shin-ichi Fukudome Masaaki Yoshikawa
出版者
The Japanese Pharmacological Society
雑誌
The Japanese Journal of Pharmacology (ISSN:00215198)
巻号頁・発行日
vol.84, no.3, pp.259-265, 2000 (Released:2001-05-31)
参考文献数
36
被引用文献数
38 58

Central effects of gluten exorphin A5 (Gly-Tyr-Tyr-Pro-Thr), a fragment from wheat gluten, were studied on the pain-inhibitory system, emotionality and learning/memory processes in mice. Orally administered gluten exorphin A5 produced neither an antinociceptive effect nor an effect on morphine analgesia. Intracerebroventricularly (i.c.v.) administered gluten exorphin A5 produced mild but significant antinociception in a dose-dependent manner, while not affecting the morphine analgesia. On the other hand, oral gluten exorphin A5 suppressed the endogenous pain-inhibitory system, i.e., antinociception induced by socio-psychological- (PSY-) stress (SIA) using a communication box; intraperitoneal gluten exorphin A5 abolished both footshock- (FS-) stress-induced antinociception (SIA) and PSY-SIA; and i.c.v. gluten exorphin A5 suppressed FS-SIA, but rather potentiated PSY-SIA. This peptide given by these routes was withuot effect on forced swim-SIA. In addition, oral gluten exorphin A5 tended to prolong the retention time on open arms in the elevated plus-maze test. Finally, oral gluten exorphin A5 when given during the post-training period of learning/memory processes significantly increased the latency into the dark compartment in the one-trail step-though type passive avoidance test, indicating that the peptide also facilitates the acquire/consolidation process of learning/memory. Thus, gluten exorphin A5 has been found to produce various effects no only in the peripheral nervous systems but also in the central nervous system.
著者
Akiko MIZOTE Mika YAMADA Chiyo YOSHIZANE Norie ARAI Kazuhiko MARUTA Shigeyuki ARAI Shin ENDO Rieko OGAWA Hitoshi MITSUZUMI Toshio ARIYASU Shigeharu FUKUDA
出版者
Center for Academic Publications Japan
雑誌
Journal of Nutritional Science and Vitaminology (ISSN:03014800)
巻号頁・発行日
vol.62, no.6, pp.380-387, 2016 (Released:2017-02-16)
参考文献数
22
被引用文献数
13 33

We previously performed animal studies that suggested that trehalose potentially prevents the development of metabolic syndrome in humans. To evaluate this possibility, we examined whether trehalose suppressed the progression of insulin resistance in a placebo-controlled, double-blind trial in 34 subjects with a body mass index (BMI) ≥23. The subjects were divided into two groups and were assigned to ingest either 10 g/d of trehalose or sucrose with meals for 12 wk. During the study, body composition and blood biochemical parameters were measured at week 0, 8, and 12. These parameters were also measured 4 wk after the end of intake to confirm the washout of test substances. In the trehalose group, blood glucose concentrations after a 2-h oral glucose tolerance test significantly decreased following 12 wk of intake in comparison with baseline values (0 wk). When a stratified analysis was performed in the subjects whose percentage of truncal fat approached the high end of the normal range, the change in body weight, waist circumference, and systolic blood pressure were significantly lower in the trehalose group than in the sucrose group. Our data indicated that a daily intake of 10 g of trehalose improved glucose tolerance and progress to insulin resistance. Furthermore, these results suggested that trehalose can potentially reduce the development of metabolic syndrome and associated lifestyle-related diseases, such as type 2 diabetes.
著者
Aki Tsuji Masaharu Masuda Mitsutoshi Asai Osamu Iida Shin Okamoto Takayuki Ishihara Kiyonori Nanto Takashi Kanda Takuya Tsujimura Yasuhiro Matsuda Shota Okuno Yosuke Hata Toshiaki Mano
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-20-0191, (Released:2020-07-17)
参考文献数
18
被引用文献数
8

Background:The purpose of this study was to elucidate the effect of the temporal relationship between atrial fibrillation (AF) and heart failure (HF) on clinical outcomes after catheter ablation.Methods and Results:We included 129 consecutive patients with AF and HF who underwent catheter ablation in hospital from December 2014 to September 2017. The patients were divided into 2 groups based on the temporal relationship between AF and HF. Group 1 consisted of 42 patients with AF following HF while Group 2 consisted of 87 patients with AF preceding HF or those who developed both of them simultaneously at the timing of first visit to a doctor. The primary endpoint was a composite of death and hospitalization due to HF during a 2-year follow-up. AF recurrence was more common in Group 1 (45% vs. 23%; hazard ratio [HR], 2.49; 95% confidence interval [CI], 1.25–4.94; P=0.009). Death and HF hospitalization were more frequent in Group 1 (19 [45%], 6 [7%] patients, respectively, P<0.0001). After adjustment for several covariates, patients in Group 1 were independently associated with poorer outcomes after AF ablation (HR, 8.66; 95% CI, 2.942–5.5; P<0.0001).Conclusions:Adverse clinical outcomes of death, HF hospitalization and AF recurrence were more frequent in patients with AF following HF than in those with AF preceding HF.
著者
Kazaha Izaki Shin Haruta
出版者
Japanese Society of Microbial Ecology / Japanese Society of Soil Microbiology / Taiwan Society of Microbial Ecology / Japanese Society of Plant Microbe Interactions / Japanese Society for Extremophiles
雑誌
Microbes and Environments (ISSN:13426311)
巻号頁・発行日
vol.35, no.2, pp.ME20015, 2020 (Released:2020-05-15)
参考文献数
55
被引用文献数
4

Filamentous anoxygenic photosynthetic bacteria grow by photosynthesis and aerobic respiration. The present study investigated the effects of light and O2 on bacteriochlorophyll contents and the transcription levels of photosynthesis-related genes in Chloroflexus aurantiacus J-10-fl T. Under aerobic conditions, C. aurantiacus produced marked amounts of bacteriochlorophylls in the presence of light, although their production was strongly suppressed in the dark. The transcription levels of genes related to the synthesis of bacteriochlorophylls, photosystems, and chlorosomes: bchM, bchU, pufL, pufBA, and csmM, were markedly increased by illumination. These results suggest that C. aurantiacus continuously synthesizes ATP by photophosphorylation even in the presence of O2.
著者
肥田 乃梨子 石川 信一 ヒダ ノリコ イシカワ シンイチ Hida Noriko Ishikawa Shin-ichi
出版者
心理臨床科学編集委員会
雑誌
心理臨床科学 = Doshisha Clinical Psychology : therapy and research (ISSN:21864934)
巻号頁・発行日
vol.8, no.1, pp.3-17, 2018-12-15

研究論文精神疾患に対する否定的な態度は,援助を必要とする者の専門家への受診を妨げる重大な問題であると指摘されている。しかしながら,そのような態度を測定できる青年版の尺度は存在しないというのが本邦の現況である。そこで本研究は,パブリックスティグマの一側面に位置づけられる社会的距離の概念に基づいた,青年版社会的距離の近さ尺度(Social Distance of Adolescents Scale : SDAS)の作成および信頼性と妥当性の検討を目的として行われた。中根他(2010)の成人を対象とする社会的距離尺度を参考に,教育現場での活用を考慮した上で,青年期の生徒が理解できる表現に改めた6項目が作成された。研究1では中学生を対象に調査を行い,信頼性と妥当性を検討したところ,十分な信頼性と妥当性が確認された。続いて研究2において,高校生を対象にSDASを測定し尺度の因子構造を再度探索的に検討したところ,中学生と同様の結果が得られた。SDASは不安症の子どもに対する態度を示すパブリックスティグマを測る尺度として有用であることが示唆され,SDASの汎用可能性について議論された。