著者

池田 幸弘

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.53, no.5, pp.464-465, 2017 (Released:2017-05-01)

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秋田県横手市の増田町に,中七日町通りという商店街がある.成瀬川と皆瀬川が合流するところに位置し,江戸期以前から商業地として栄えた.東北経済の中心地といってもいいほどの賑わいを見せた頃もあったようであるが,いまでは落ち着いた町並みである.昔の面影を残す多数の商家が,往時の繁栄を静かに物語っている.

著者

横山 晴子 山田 安彦 山村 喜一 中村 均 伊賀 立二

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.121, no.3, pp.233-237, 2001-03-01 (Released:2002-09-27)

参考文献数

7

被引用文献数

13 11

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The effect of mouth wash on the removal of drug residues in both mouth and pharynx after the use of fluticasone propionate dry powder inhaler (FP-DPI) was studied. The concentration of FP in mouth wash after sprinkle and inhalation of Flutide® 50, 100, 200 Rotadisk® was determined by HPLC-UV. The total amount of the removed FP was measured by the sum of the concentration of FP in 5 times of mouth washes. The mouth wash procedures removed totally 79.3±4.4% (50 μg), 68.5±3.6% (100 μg), 69.3±3.4% (200 μg) of sprinkled amount of FP and 29.5±11.1% (50 μg), 35.6±6.6% (100 μg), 31.6±8.3% (200 μg) of inhaled, respectively. It was required for the removal of 90% of the totally recovered FP to do two times of mouth washes in each case. These data suggest that the mouth wash is an effective precaution for candidiasis induced by FP delivered by DPI.

著者

此村 恵子 森井 康博 赤沢 学

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.142, no.4, pp.413-420, 2022-04-01 (Released:2022-04-01)

参考文献数

17

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Pharmacists play a key role in optimizing the safe and effective use of medicines in the super-aged society in Japan. Recently, community pharmacists' role has been transformed and expanded to provide patient-centered care. This study aimed to simulate a change in the demand for community pharmacists resulting from this shift in their role, from 2019 to 2035. The change in demand was estimated by the number of prescriptions obtained from publicly available sources of information. The number of required community pharmacists was calculated separately for full-time and part-time pharmacists and the pharmacists engaged in home medical care. This number was calculated using the estimated demand, the number of prescriptions dispensed per day, and annual working days. We evaluated the effect of changes in the working conditions, which include changes in the dispensing process time, rate of part-time staff and their work time, and number of home medical care per day, on the number of community pharmacists. When the number of prescriptions dispensed per day was set at 19.8, the demand for community pharmacists was estimated as 188,314 in 2035. Furthermore, due to the changes in the working conditions, the demand is expected to change from 153,362 to 266,944. Although the increasing provision of drug information time leads to an increasing number of pharmacists, combining it with work efficiency services could prevent or decrease it. The optimal supply and demand balance of community pharmacists should be determined by both, promoting pharmaceutical care services and improving work efficiency.

著者

佐野 和憲

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.139, no.7, pp.999-1005, 2019-07-01 (Released:2019-07-01)

参考文献数

14

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Pathological α-synuclein (αSyn) has been shown to retain the ability to propagate as prions in humans and animals. However, the molecular basis underlying the prion-like properties of αSyn remains poorly understood. We examined whether brain tissues from cases of dementia with Lewy bodies (DLB), which contain serine 129 (Ser129)-phosphorylated insoluble aggregates of αSyn, exhibit prion-like seeding activity in vitro using the real-time quaking-induced conversion (RT-QuIC) seeding assay. Brain tissues from cases of diffuse neocortical DLB yielded a 50% seeding dose of 107.3-109.8/g brain. The RT-QuIC assay could discriminate between DLB and other neurological and neurodegenerative disorders, suggesting its potential applicability for differential diagnosis. Insoluble aggregates of αSyn>250 kDa detected only in DLB brain tissues by Western blotting analysis were specifically phosphorylated at Ser129. Therefore, we postulated that Ser129-phosphorylated insoluble aggregates of αSyn have prion-like seeding activity. However, insoluble aggregates of recombinant human αSyn (rSyn) with increased β-sheet structures showed little seeding activity in either the phosphorylated or nonphosphorylated state. In contrast, prefibrillar oligomers of rSyn showed seeding activity both with and without phosphorylation. The findings of the present study suggested that soluble oligomeric αSyn, but not the fully fibrillary form, is a seeding species in vitro.

著者

荒田 洋治

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.52, no.9, pp.866_1, 2016 (Released:2016-09-02)

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薬学と関りをもった50年の間,筆者が経験した事柄を,様々な観点から捉え,日本薬学会会員に向けて綴った短いエッセイ集です。

著者

青木 良子 佐井 君江 勝田 由紀子 鈴木 美佳 鈴木 康夫 石井 明子 斎藤 嘉朗

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.142, no.5, pp.547-560, 2022-05-01 (Released:2022-05-01)

参考文献数

19

被引用文献数

1

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Biosimilars are less expensive than their originators, and Japanese government policies call for their development and promotion. However, the adoption and prescription of some biosimilars, especially antibody/its-related ones, have been delayed for use in Japan, possibly due to concerns on the differences in quality attributes such as glycan structures between the originators and their biosimilars, and that clinical efficacy/safety studies are conducted for usually one disease and its results extrapolated to other indications. We conducted a questionnaire survey among physicians in four disease areas (hematology, medical oncology, rheumatoid arthritis, and inflammatory bowel disease), where biosimilars of antibody/its-related drugs have been approved, regarding their thoughts on the adoption and prescription of biosimilars in Japan from January to April 2020. We received totally 1024 responses. When adopting biosimilars and explaining them to patients, physicians requested specific information including the comparative results of phase III clinical trials and quality characteristics between biosimilars and their originators; the results of clinical studies on switching from originators to their biosimilars; and a comparison of the estimated cost on patients in consideration of the high medical cost payment system. Priority differed depending on the studied disease areas. In terms of post-marketing information, physicians requested a variety of information. When explaining biosimilars to the patients, physicians would like to use general material from government describing the comparability between originators and their biosimilars. These results suggest that physicians sought more comparative information on the quality, efficacy, and patients' cost between originators and their biosimilars when adopting or prescribing biosimilars.

著者

高橋 秀依 夏苅 英昭

出版者

公益社団法人 日本薬学会

雑誌

MEDCHEM NEWS (ISSN:24328618)

巻号頁・発行日

vol.30, no.1, pp.47-48, 2020-02-01 (Released:2021-05-01)

著者

金尾 清造

出版者

公益社団法人 日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.1927, no.540, pp.102-120, 1927-02-26 (Released:2010-11-30)

参考文献数

33

被引用文献数

1

著者

倉田 なおみ

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.57, no.6, pp.536-537, 2021 (Released:2021-06-01)

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1976年昭和大学薬学部卒業後、同大学病院に就職、1996年同大学藤が丘リハビリテーション病院に異動、2006年同大学薬学部教員になった。1986年結婚、2016年高速道路で自損事故により危うく天国(地獄?)へ。振り返えると西暦末尾6の年が転換期であった。30年間の臨床薬剤師の後、16年間教員として教育・研究に携わり、現在も客員教授として研究を続ける日々が続いている。忘れてかけている過去を思い出し、思いつくまま最終講義として綴ってみたい。

著者

岡田 浩

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.142, no.3, pp.211-214, 2022-03-01 (Released:2022-03-01)

参考文献数

8

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Evidence-based medicine (EBM) has led to the development of evidence-based guidelines. The quality of guidelines has been improved by measuring their quality with The Appraisal of Guidelines for Research and Evaluation II (AGREE II) and Grading of Recommendations, Assessment, Development and Evaluation (GRADE). However, evidenced by guidelines not implemented in clinical practice or society, the evidence-practice gap has become apparent. The dissemination and implementation research, which studies methods to solve this problem, has attracted the attention of both clinicians and clinical researchers in recent years. In hypertension and diabetes, it is possible to prevent complications by maintaining good blood pressure and blood glucose levels. However, it is difficult for patients to maintain good laboratory values over the long term, and there has been no solution to this problem. Recently, it has been reported that pharmacists in the U.S. and Canada can improve patient outcomes over the long term by using pharmacies to treat these diseases. This review describes the results of the COMPASS study (diabetes) and the COMPASS-BP study (hypertension), which are the first cluster randomized controlled trials conducted in pharmacies in Japan. In addition, it discusses the possibility of implementation in pharmacies in Japan.

著者

松尾 和哉

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.142, no.5, pp.513-519, 2022-05-01 (Released:2022-05-01)

参考文献数

14

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Genetic information is replicated and transmitted from a parent cell to two identical daughter cells through mitotic cell division. To accomplish this dynamic process with high accuracy and precision, various motor proteins work in a concerted manner. Especially in the metaphase, mitotic chromosomes are delivered by the motor protein of centromere-associated protein E (CENP-E) to the cell equatorial plane (metaphase plate) along mitotic spindles. However, the critical functional failure of CENP-E can activate the spindle assembly checkpoint through the misalignment of chromosomes at the metaphase plate. In this symposium review, the reversibly photoswitchable CENP-E inhibitor PCEI-HU (5) is reported. Compound 5 exhibited almost quantitative trans-cis photoisomerization of the arylazopyrazole photoswitch by illuminating light at 365 nm and 510 nm. Depending on the photoisomerization, CENP-E activity was regulated not only in vitro but also in cells. We successfully established a novel technique using 5 to dynamically photocontrol the CENP-E-dependent chromosome movement and mitotic progression in a living cell.

著者

野路 悟 原 義典 三浦 智也 山中 浩 塩﨑 真

出版者

公益社団法人 日本薬学会

雑誌

MEDCHEM NEWS (ISSN:24328618)

巻号頁・発行日

vol.31, no.2, pp.68-74, 2021-05-01 (Released:2021-05-01)

参考文献数

12

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アトピー性皮膚炎は、かゆみを伴う紅斑に象徴される皮膚疾患であり、国内で45万人以上がこの病に苦しむといわれる。治療の第一段階は既存抗炎症薬による炎症鎮静化であるが、皮膚菲薄化等の副作用が報告され、このような副作用のない薬剤の登場が望まれている。Janus kinase(JAK)はサイトカイン産生シグナル上流に存在するリン酸化酵素であり、その阻害薬は自己免疫疾患の新たな治療オプションとして注目を集めていた。筆者らは新規JAK3阻害薬探索の過程で、高活性、高選択的化合物の創出を目指し、分子の三次元性の高さに着目した合成展開を実施した。こうして見出されたdelgocitinibは、臨床試験において期待した効果を示し、JAK阻害薬としては世界初となるアトピー性皮膚炎外用薬(コレクチム®軟膏)として承認されるに至った。

著者

芦澤 一英

出版者

公益社団法人 日本薬学会

雑誌

MEDCHEM NEWS (ISSN:24328618)

巻号頁・発行日

vol.18, no.4, pp.20-23, 2008-11-01 (Released:2020-12-22)

参考文献数

3

著者

栗原 藤三郎 菊地 正雄

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.98, no.4, pp.541-544, 1978-04-25 (Released:2008-05-30)

参考文献数

5

被引用文献数

1 2

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In order to examine fragrant components, the essential oil of the flowers of Paulownia tomentosa STEUDEL was examined and, as the odor substances, hydroquinone dimethyl ether, 1-octen-3-ol, cis-3-hexen-1-ol, l-linalool, benzyl alcohol, phenethyl alcohol, benzaldehyde, anisaldehyde, ethyl palmitate, phenol, cresol (o-, m-, p-), 3, 4-dimethoxyphenol, and 12 kinds of volatile acid were identified. Apigenin, ursolic acid, β-sitosterol, campesterol, stigmasterol, β-sitosterol-β-D-glucoside, caffeic acid, p-hydroxybenzoic acid, p-coumaric acid, 3 kinds of fatty acid, and 17 kinds of normal paraffine were isolated from the steam distillation residue, as odorless components.

著者

水上 進

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.142, no.5, pp.503-511, 2022-05-01 (Released:2022-05-01)

参考文献数

41

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Technologies for the optical control of biomolecular functions have recently attracted considerable attention because they can be combined with advanced laser and microscopic techniques for diverse applications at the cellular and intravital levels. In this account, I review the summary of optical control technologies for biomolecular functions based on organic chemistry or protein science, and then introduce our recent studies on the development of small molecule-based photoregulation techniques. The first is the development of a photoactivatable protein labeling method based on a caged ligand. This method was applied to the photocontrol of intracellular protein dimerization and localization. The second is the development of a reversibly photoswitchable enzyme inhibitor, which was designed from the conformation of the inhibitor in the crystal structure of the enzyme-inhibitor complex. Based on our research strategies and results, I have also outlined the respective advantages and disadvantages of these two technologies: caged compounds and photoswitchable compounds.

著者

大久保 聡子 中畑 則道

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.127, no.1, pp.27-40, 2007-01-01 (Released:2007-01-01)

参考文献数

53

被引用文献数

14 15

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Lipid rafts and caveolae are microdomains in the cell membranes, which contain cholesterol, glycolipids, and sphingomyelin. While caveolae are relatively stable because caveolin, an integral protein, supports the structure, lipid rafts are considered to be unstable, being dynamically produced and degraded. Recent studies have reported that lipid rafts contain many signaling molecules, such as glycosylphosphatidylinositol-anchored proteins, acylated proteins, G-protein-coupled receptors (GPCRs), trimeric and small G-proteins and their effectors, suggesting that the lipid rafts have an important role in receptor-mediated signal transduction. Therefore drugs that modify the composition of lipid rafts might influence the efficacy of cellular signal transduction. In this review, we demonstrate the role of lipid rafts in GPCR-G-protein signaling and also present our recent results showing that the wasp toxin mastoparan modifies Gq/11-mediated phospholipase C activation through the interaction with gangliosides in lipid rafts.

著者

大野 博司

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.53, no.11, pp.1059-1063, 2017 (Released:2017-11-01)

参考文献数

10

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われわれ動物の体内外の境界をなす皮膚や粘膜面には膨大な数の細菌群が常在しており、これらを常在細菌叢(commensal microbiota)と総称する。メタゲノム解析を中心とする最近の研究から、常在細菌叢、特に腸内細菌叢は宿主の生理・病理に多大な影響を与え、消化器疾患のみならず、免疫・アレルギー、メタボリック症候群、さらには脳神経疾患など、多種多様な疾患の要因となることが明らかにされつつある。

著者

塚本 紳一

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.50, no.4, pp.356, 2014 (Released:2016-06-01)

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アステラス製薬の「β3アドレナリン受容体作動薬 ミラベグロンの創製」に対して,平成26年度日本薬学会創薬科学賞が授与された.本業績は,多数の創薬研究者ならびに開発研究者による長年の創意工夫と粘り強い研究の成果である.今回,代表して受賞された丸山龍也,恩田健一,高須俊行,佐藤修一,鵜飼政志の諸氏をはじめ,本プロジェクトに参画された関係者各位に心より祝意を表したい.

著者

松井 康博

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.53, no.5, pp.430-434, 2017 (Released:2017-05-01)

参考文献数

7

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連続生産は2002年頃から始まった医薬品の品質向上のために新技術の採用を促進する取り組みの一環であり、QbD とも深い関係があると考えられる。連続生産ではスケールアップが不要であること、及び、製造工程を常時PATツールによりリアルタイムモニタリングすることからQbDアプローチの適用に適しており、高品質な医薬品の設計に有用であると考えられる。連続生産の実用化に向けては技術上、規制上の課題はあるが、近い将来それらが解決されて高品質な医薬品の迅速な提供に貢献することが期待される。

著者

浅井 禎吾

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.142, no.5, pp.439-446, 2022-05-01 (Released:2022-05-01)

参考文献数

36

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Discovery of natural products that possess novel chemical structures and pharmaceutical activities increases opportunities of drug development. Filamentous fungi have been recognized as an attractive source for pharmaceutically beneficial natural products. Genome sequencing innovation represented by Next-generation sequencer opened fungal genomes one after another, suggesting that one fungal strain has far more biosynthetic gene clusters than that are estimated from the number of previously isolated natural products. In addition, bioinformatics analyses have indicated that most biosynthetic gene clusters are silent under laboratory culture conditions and there are a huge number of natural products hidden in the fungal genome. Therefore, we focused on those silent biosynthetic gene clusters as a potential source for novel natural products and developed methods to activate silent biosynthetic gene clusters by using low molecular weight molecules. In this review, we describe on discovery of novel natural products through activating fungal silent biosynthesis by addition of epigenetic modifiers and plant hormones.