著者

久保 千恵子

出版者

東北大学教育学部

雑誌

東北大学大学院教育学研究科研究年報 (ISSN:13465740)

巻号頁・発行日

vol.57, no.2, pp.29-47, 2009-06

著者

田口 君代 飯田 澄美子

雑誌

日本看護研究学会雑誌 (ISSN:02859262)

巻号頁・発行日

vol.24, no.3, 2001-06-27

著者

川村 力

雑誌

漢方の臨床 (ISSN:0451307X)

巻号頁・発行日

vol.58, no.2, pp.271-277, 2011-02-25

参考文献数

15

被引用文献数

2

著者

窦水勇编

出版者

綫裝書局

巻号頁・発行日

2004

著者

田口 君彦 松岡 辰郎 香田 忍

出版者

日本ソノケミストリー学会

雑誌

ソノケミストリー討論会講演論文集

巻号頁・発行日

vol.15, pp.63-64, 2006

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The mechanism of ultrasonic degradation is still obscure, but it is well accepted that cavitation bubbles are mainly responsible for the degradation. The intense shear field generated by the collapse of the cavitation bubbles induces chain scission. Most of investigations on ultrasonic degradation have been carried out at low ultrasonic frequency around 20kHz. In this work, the ultrasonic degradation of methyl cellulose in aqueous solution was studied at two frequencies (20kHz and 500kHz) at the constant calorimetric power (20W) and temperature (25℃). The time variation of the average molecular weights and the molecular distribution were determined by Gel Permeation Chromatography (GPC). The mass average molecular weights (M_w) decreases with sonication time. The large lowering of M_w was observed at the frequency 500kHz. The degradation rate was suppressed by the addition of t-BuOH which act as a radical scavenger. The ultrasonic degradation rate coefficient k_d was estimated and compared with the results of other water-soluble polymers. The order of k_d value were PEO > Dextran 〓 Pullulan > MC. We will discuss on the frequency effects on the ultrasonic degradation.

著者

[藤田幽谷] [著]

巻号頁・発行日

vol.[125], 1800

著者

作野 裕司

出版者

一般社団法人 日本リモートセンシング学会

雑誌

日本リモートセンシング学会誌 (ISSN:02897911)

巻号頁・発行日

vol.37, no.3, pp.269-270, 2017-07-21 (Released:2018-01-31)

参考文献数

10

被引用文献数

1

著者

吉田 光二 星 昭夫 榑谷 和男 金井 貞 市野 元信

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.66, no.5, pp.561-564, 1975-10-31 (Released:2008-10-23)

参考文献数

12

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Effect of substitution of 5-position of cyclocytidine with fluorine on its antitumor activity in cultured cells was examined. 5-Fluorocyclocytidine was active against cultured L-5178Y cells similar to cyclocytidine. IC50 of the compound was 0.054μg/ml. This compound inhibited thymidine incorporation into acid-insoluble fraction of the cells. Cell growth inhibition by 5-fluorocyclocytidine was reversed by deoxycytidine but not by thymidine and deoxyuridine. On the other hand, cell growth inhibition by 5-fluorouracil was reversed by thymidine and deoxyuridine. As a result, site of action of 5-fluorocyclocytidine was considered to be similar to that of cyclocytidine and not to 5-fluorouracil.

著者

星 昭夫 飯郷 正明 実吉 峯郎 榑谷 和男

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.21, no.7, pp.1535-1538, 1973-07-25 (Released:2008-03-31)

被引用文献数

4 4

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Deamination of cytidine derivatives especially of cyclocytidine by mouse kidney cytidine deaminase was examined. Cyclocytidine was not deaminated at either pH6.5 or pH7.3 by the enzyme. Furthermore, cyclocytidine did not inhibit the deamination of aracytidine and ([I]/[S])0.5 value for cyclocytidine was over 100. As a result, cyclocytidine is found to be markedly active compound with resistance against cytidine deaminase.

著者

星 昭夫 官沢 文彦 飯郷 正明 榑谷 和男

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.66, no.5, pp.539-546, 1975-10-31 (Released:2008-10-23)

参考文献数

12

被引用文献数

2

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Combination effect of antitumor agents, including cyclocytidine and cytosine arabinoside, was evaluated on the conception of pharmacological synergism and not of therapeutic synergism. Ascites sarcoma-180 and L-1210 leukemia were used as tumor systems. In sarcoma-180 system, combinations of cyclophosphamide plus cyclocytidine or cytosine arabinoside by simultaneous administration and cyclocytidine plus Daunorubicin or Vinblastine by alternate administration provided synergism. In L-1210 system, many compounds in combination with cyclocytidine or cytosine arabinoside in both simultaneous and alternate administrations provided synergism. Combination effect of agents was affected by the schedule of drug administration. It was found that the combination effect of drugs in one tumor system cannot be generalized to that in other tumor systems, even though equally effective doses of agents were administered in both tumor systems. Toxicity of cytosine arabinoside in combination with other drugs was affected by the schedule of administration. Compounds which provided synergism in simultaneous administration provided antagonism in alternate one. As a result, it was found that alternate administration of drugs is advantageous for the activity and diminution of toxicity to the host animal.

著者

平山 八彦 杉原 太助 浜田 福三郎 金井 貞 疋田 重太郎 荒木 靖雄 博谷 和男 星 昭夫

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.65, no.2, pp.153-161, 1974-04-30 (Released:2008-10-23)

参考文献数

23

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The distribution in tissues and excretion of cyclocytidine (2, 2'-anhydro-1-β-D-arabinofuranosylcytosine hydrochloride) and its metabolites in urine and feces of macaca monkeys (Macaca irus, Macaca fuscata, and Macaca mulata) and in beagle dogs were examined by the spectrophotometric assay. Distribution of cyclocytidine in plasma and tissues of rats was also examined.The administered cyclocytidine showed a half-life of 22min in plasma of dogs and monkeys, whereas the half-life of aracytidine (1-β-D-arabinofuranosylcytosine hydrochloride) was 47min in plasma of dogs and less than 5min in plasma of monkeys, because of rapid deamination of the comvound to arauridine (1-β-D-arabinofuranosyluracil) in the latter species. Cyclocytidine exhibited maximum concentration in tissues of rats and monkeys at 20 to 40min after the administration, but its metabolites, aracytidine and arauridine, were not detected in these tissues. Cyclocytidine levels in tissues diminished thereafter but were detected within the next 40 to 80min, Neither cyclocytidine nor its metabolites could be detected in the brain. When cyclocytidine was administered intravenously in dogs and monkeys, 65-85% of it was excreted in urine, almost all as intact cyclocytidine, and small amounts of aracytidine and arauridine were detected. On the other hand, the administered aracytidine was excreted only as arauridine in urine of monkeys, and aracytidine and arauridine in dogs. Cyclocytidine and its metabolites were not detected in feces of both species.It might be suggested that the distribution and elimination rate of cyclocytidine after its intravenous administration is not affected by the presence of cytidine deaminase in plasma and tissues.

著者

森 久美子 小杉 浩美 田口 君代

雑誌

診療録管理 : 日本診療録管理学会会誌 = Medical record administration (ISSN:0916345X)

巻号頁・発行日

vol.9, no.2, pp.92-93, 1997-09-01

参考文献数

1

著者

立川焉馬 著

出版者

丁子屋忠七[ほか5名]

巻号頁・発行日

vol.[5], 1841

著者

足守 直樹 釣田 美奈子 山元 理恵子 武林 悟 峯田 周幸

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.100, no.7, pp.569-574, 2007-07-01 (Released:2011-10-07)

参考文献数

9

被引用文献数

2

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We retrospectively reviewed fine-needle aspiration biopsy diagnosis of malignant lymphoma to evaluate the diagnostic accuracy and pitfalls. Sixty-eight cases of malignant lymphoma and fifty-two cases of non malignant lymphoma evaluated by FNAB were identified between 1997 and 2004. Based on the original diagnosis, 41 (60%) cases had a positive diagnosis of malignant lymphoma, 21 (31%) had a suspicious diagnosis, and 6 (9%) had a false negative diagnosis. On histological examinations DLBCLs yielded a high positive diagnosis, whereas FL and HD had less positive diagnosis and there were also false negative cases. Fourteen (39%) lymphadenitis cases had a suspicious diagnosis and some cases were difficult to differentiate from malignant lymphoma. FNAB is considered a useful and efficient method of estimating malignant lymphoma but we should remain aware of the existence of false negative cases.

著者

星 昭夫 官沢 文彦 榑谷 和男

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.63, no.3, pp.353-360, 1972-06-30 (Released:2008-10-23)

参考文献数

12

被引用文献数

4

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The antitumor activity of cyclocytidine was examined in a variety of tumors. Cyclocytidine was active against adenocarcinoma-755, Nakahara-Fukuoka sarcoma, ascites sarcoma-180, Ehrlich ascites carcinoma, L-1210 leukemia, and C-1498 leukemia. Cures (60-day survivors) were observed at 500mg/kg/day×5 or more of the compound in the L-1210 system and therapeutic ratio was as high as 50, though that of other known antitumor agents tested, including 1-β-D-arabinofuranosylcytosine (Ara-c), was less than 12. Therapeutic index of cyclocytidine in the solid and ascites tumors was always greater than that of Ara-c. Cumulative toxicity of cyclocytidine was surprisingly low and LD10 was 790mg/kg/day×5, whereas that of Ara-c was 82mg/kg/day×5. Cyclocytidine appears therefore to have advantages over Ara-c for clinical use.

著者

星 昭夫 官沢 文彦 榑谷 和男 実吉 峯郎 新井 祥子

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.62, no.2, pp.145-146, 1971-04-30 (Released:2008-10-23)

参考文献数

8

被引用文献数

4

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2, 2'-O-Cyclocytidine was active against L-1210 leukemia. Cures were observed at the optimal dose of the compound, though no cures were obtained at any dose of any of the known antitumor agents. The compound was less toxic than 1-β-D-arabinofuranosyl-cytosine and resistant to cytidine deaminase.

著者

清水 俊宏 長谷川 博

出版者

日経BP社

雑誌

日経ニューメディア (ISSN:02885026)

巻号頁・発行日

no.1615, pp.7-8, 2018-07-02

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フジテレビジョンとその系列局で構成するフジニュースネットワーク(FNN)が新たなオンラインメディア「FNN.jpプライムオンライン」(FNN.jp)を開始してから3カ月が経過した。FNN.jpは、フジテレビが運営する「ホウドウキョク」と、FNN系列局の「FNN-News.com」という…

著者

吉村 良雄

出版者

日本細菌学会

雑誌

日本微生物學會雜誌 (ISSN:18836941)

巻号頁・発行日

vol.1, no.1, pp.440-464, 1915-06-10 (Released:2009-08-24)

著者

村山 祐司 橋本 操 ルウイン ココ

出版者

筑波大学大学院生命環境科学研究科地球環境科学専攻

雑誌

人文地理学研究 (ISSN:18800939)

巻号頁・発行日

vol.34, pp.225-246, 2014

出版者

東京都立大学人文学部考古学研究室

巻号頁・発行日

1998