著者
Emiko Okada Shigekazu Ukawa Koshi Nakamura Makoto Hirata Akiko Nagai Koichi Matsuda Toshiharu Ninomiya Yutaka Kiyohara Kaori Muto Yoichiro Kamatani Zentaro Yamagata Michiaki Kubo Yusuke Nakamura BioBank Japan Cooperative Hospital Group Akiko Tamakoshi
出版者
日本疫学会
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
vol.27, no.Supplement_III, pp.S29-S35, 2017 (Released:2017-04-14)
参考文献数
33
被引用文献数
26

Background: Several studies have evaluated associations between the characteristics of patients with esophageal and gastric cancer and survival, but these associations remain unclear. We described the distribution of demographic and lifestyle factors among patients with esophageal and gastric cancer in Japan, and investigated their potential effects on survival.Methods: Between 2003 and 2007, 24- to 95-year-old Japanese patients with esophageal and gastric cancer were enrolled in the BioBank Japan Project. The analysis included 365 patients with esophageal squamous cell carcinoma (ESCC) and 1574 patients with gastric cancer. Hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality were estimated using medical institution-stratified Cox proportional hazards models.Results: During follow-up, 213 patients with ESCC (median follow-up, 4.4 years) and 603 patients with gastric cancer (median follow-up, 6.1 years) died. Among patients with ESCC, the mortality risk was higher in ever drinkers versus never drinkers (multivariable HR = 2.37, 95% CI: 1.24, 4.53). Among patients with gastric cancer, the mortality risk was higher in underweight patients versus patients of normal weight (multivariable HR = 1.66, 95% CI: 1.34, 2.05). Compared to patients with gastric cancer with no physical exercise habit, those who exercised ≥3 times/week had a lower mortality risk (multivariate HR = 0.75, 95% CI = 0.61, 0.93). However, lack of stage in many cases was a limitation.Conclusions: Among patients with ESCC, alcohol drinkers have a poor prognosis. Patients with gastric cancer who are underweight also have a poor prognosis, whereas patients with physical exercise habits have a good prognosis.
著者
Akiko Tamakoshi Koshi Nakamura Shigekazu Ukawa Emiko Okada Makoto Hirata Akiko Nagai Koichi Matsuda Yoichiro Kamatani Kaori Muto Yutaka Kiyohara Zentaro Yamagata Toshiharu Ninomiya Michiaki Kubo Yusuke Nakamura BioBank Japan Cooperative Hospital Group
出版者
日本疫学会
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
vol.27, no.Supplement_III, pp.S36-S42, 2017 (Released:2017-04-14)
参考文献数
16
被引用文献数
33

Background: Colorectal cancer is the third most common cancer worldwide, and in Japan, it is estimated that about 10% of men and 8% of women will be diagnosed with colorectal cancer during their lifetime.Methods: We focused on 5864 participants (3699 men and 2165 women) who had colorectal cancer and were registered with BioBank Japan (BBJ) between April 2003 and March 2008. Characteristics of colon and rectal cancer patients were calculated separately. Among the enrolled patients registered in BBJ within 90 days after diagnosis, we also calculated the 5-year cumulative and relative survival rates, and estimated the effect of lifestyle factors on all-cause mortality.Results: Our participants included younger men than those in the Patient Survey and the Cancer Registry Japan. In more than 95% of cases the histological type was adenocarcinoma both in colon and rectal cancer. Rectal cancer patients tended to eat more meat and less green leafy vegetables compared with colon cancer patients. The 5-year cumulative survival rate was 73.0% (95% CI; 70.1%–75.7%) and the 5-year relative survival rate was 80.6% (77.4%–83.6%), respectively, for colon cancer. For rectal cancer, the rates were 73.3% (69.1%–77.0%) and 80.9% (76.3%–85.0%), in the same order. Lifestyle factors such as consuming less green leafy vegetables, being underweight, smoking, not consuming alcoholic beverages and being physically inactive were found to be related to poor survival.Conclusions: We described lifestyle characteristics of colorectal cancer patients in BBJ and examined the impacts on subsequent all-cause mortality.
著者
Koshi Nakamura Shigekazu Ukawa Emiko Okada Makoto Hirata Akiko Nagai Zentaro Yamagata Toshiharu Ninomiya Kaori Muto Yutaka Kiyohara Koichi Matsuda Yoichiro Kamatani Michiaki Kubo Yusuke Nakamura BioBank Japan Cooperative Hospital Group Akiko Tamakoshi
出版者
日本疫学会
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
vol.27, no.Supplement_III, pp.S49-S57, 2017 (Released:2017-04-14)
参考文献数
20
被引用文献数
15

Background: In Japanese males and females, lung cancer is currently the second and fourth most common type of cancer, and the first and second leading cause of cancer-related deaths, respectively.Methods: Of all Japanese male and female lung cancer patients aged ≥20 years whom the BioBank Japan Project originally enrolled between 2003 and 2008, 764 males and 415 females were registered within 90 days after their diagnosis. We described the lifestyle and clinical characteristics of these patients at study entry. Furthermore, we examined the effect of these characteristics on all-cause mortality.Results: In the lung cancer patients registered within 90 days, the frequencies of occult or stage 0, stage I, II, III and IV were 0.4%, 55.8%, 10.8%, 22.0% and 11.0% for males and 0.3%, 62.4%, 9.9%, 17.1% and 10.2% for females, respectively. The proportions of histological types in males and females were 56.3% and 82.4% for adenocarcinoma, 26.9% and 8.2% for squamous cell carcinoma, 4.5% and 1.5% for large cell carcinoma, 7.7% and 4.1% for small cell carcinoma and 4.6% and 3.8% for others, respectively. Among 1120 participants who registered within 90 days, 572 participants died during 5811 person-years of follow-up. Low body mass index, ever smoker, more advanced stage, squamous cell or small cell carcinoma and high serum carcinoembryonic antigen level at study entry were crudely associated with an increased risk of all-cause mortality after adjustment for age.Conclusions: This study showed the association of several lifestyle and clinical characteristics with all-cause mortality in lung cancer patients.
著者
Nakamura Koshi Okada Emiko Ukawa Shigekazu Hirata Makoto Nagai Akiko Yamagata Zentaro Kiyohara Yutaka Muto Kaori Kamatani Yoichiro Ninomiya Toshiharu Matsuda Koichi Kubo Michiaki Nakamura Yusuke BioBank Japan Cooperative Hospital Group Tamakoshi Akiko
出版者
Elsevier
雑誌
Journal of epidemiology (ISSN:09175040)
巻号頁・発行日
vol.27, no.3, pp.S58-S64, 2017-03
被引用文献数
24

Background: Breast cancer is currently the most common type of cancer in Japanese females. Unlike most other types of cancer, breast cancer develops more frequently in middle-aged females than in elderly females. Methods: Of all Japanese female breast cancer patients aged ≥20 years whom the BioBank Japan Project originally enrolled between 2003 and 2008, 2034 were registered within 90 days after their diagnosis. We described the lifestyle and clinical characteristics of these patients at study entry. Furthermore, we examined the effect of these characteristics on all-cause mortality. Results: In the female patients registered within 90 days after diagnosis, the frequency of stage 0 or unclassified, stage I, II, III and IV were 11.4%, 47.9%, 37.0%, 2.9% and 0.8%, respectively. The proportion of histological types was 12.9% for non-invasive carcinoma (ductal carcinoma and lobular carcinoma), 81.0% for invasive carcinoma (papillotubular carcinoma, solid tubular carcinoma, scirrhous carcinoma and special types), 0.2% for Paget's diseases and 5.8% for others. Those positive for the estrogen and progesterone receptors accounted for 75.8% and 62.1% of all patients, respectively. Among 1860 female participants registered within 90 days, 218 participants died during 144,54 person-years of follow-up. More advanced stage, elevation of serum carcinoembryonic antigen and carbohydrate antigen 15-3 levels and absence of the estrogen receptor at study entry were crudely associated with an increased risk of all-cause mortality after adjustment for age. Conclusions: This study showed the association of several clinical characteristics with all-cause mortality in female breast cancer patients.
著者
Ukawa Shigekazu Nakamura Koshi Okada Emiko Hirata Makoto Nagai Akiko Yamagata Zentaro Muto Kaori Matsuda Koichi Ninomiya Toshiharu Kiyohara Yutaka Kamatani Yoichiro Kubo Michiaki Nakamura Yusuke BioBank Japan Cooperative Hospital Group Tamakoshi Akiko
出版者
Elsevier
雑誌
Journal of epidemiology (ISSN:09175040)
巻号頁・発行日
vol.27, no.3, pp.S65-S70, 2017-03
被引用文献数
7

Background: Prostate cancer is the sixth leading cause of cancer-related deaths in Japan. We aimed to elucidate the clinical and histopathological characteristics of patients with prostate cancer in the BioBank Japan (BBJ) project. Methods: Four thousand, seven hundred and ninety-three patients diagnosed with prostate cancer in the BBJ project were included. Clinical and histopathological data, including causes of death, were analyzed. Relative survival (RS) rates of prostate cancer were calculated. Results: Four thousand, one hundred and seventy-one prostate cancer patients with available histological data had adenocarcinoma. The mean age of the patients was 72.5 years. The proportion of patients who were non-smokers, non-drinkers, had a normal body mass index, did not exercise, had a normal prostate-specific antigen level, and had a family history of prostate cancer were 30.7%, 28.0%, 66.6%, 58.1%, 67.6%, and 6.5%, respectively. The proportion of patients with Stage II, III, and IV disease were 24.4%, 7.3%, and 4.4%, respectively. After limiting to patients with a time from the initial diagnosis of prostate cancer to entry into the study cohort of ≤90 days (n = 869), the 5- and 10-year RS rates were 96.3% and 100.5%, respectively, although we were unable to consider management strategies due to a plenty of data missing. Conclusions: We provide an overview of patients with prostate cancer in the BBJ project. Our findings, coupled with those from various high throughput “omics” technologies, will contribute to the implementation of prevention interventions and medical management of prostate cancer patients.
著者
Jun Hata Akiko Nagai Makoto Hirata Yoichiro Kamatani Akiko Tamakoshi Zentaro Yamagata Kaori Muto Koichi Matsuda Michiaki Kubo Yusuke Nakamura Biobank Japan Cooperative Hospital Group Yutaka Kiyohara Toshiharu Ninomiya
出版者
日本疫学会
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
vol.27, no.Supplement_III, pp.S71-S76, 2017 (Released:2017-04-14)
参考文献数
33
被引用文献数
9

Background: Cardiovascular disease (CVD) is a leading cause of death in Japan. The present study aimed to develop new risk prediction models for long-term risks of all-cause and cardiovascular death in patients with chronic phase CVD.Methods: Among the subjects registered in the BioBank Japan database, 15,058 patients aged ≥40 years with chronic ischemic CVD (ischemic stroke or myocardial infarction) were divided randomly into a derivation cohort (n = 10,039) and validation cohort (n = 5019). These subjects were followed up for 8.55 years in median. Risk prediction models for all-cause and cardiovascular death were developed using the derivation cohort by Cox proportional hazards regression. Their prediction performances for 5-year risk of mortality were evaluated in the validation cohort.Results: During the follow-up, all-cause and cardiovascular death events were observed in 2962 and 962 patients from the derivation cohort and 1536 and 481 from the validation cohort, respectively. Risk prediction models for all-cause and cardiovascular death were developed from the derivation cohort using ten traditional cardiovascular risk factors, namely, age, sex, CVD subtype, hypertension, diabetes, total cholesterol, body mass index, current smoking, current drinking, and physical activity. These models demonstrated modest discrimination (c-statistics, 0.703 for all-cause death; 0.685 for cardiovascular death) and good calibration (Hosmer-Lemeshow χ2-test, P = 0.17 and 0.15, respectively) in the validation cohort.Conclusions: We developed and validated risk prediction models of all-cause and cardiovascular death for patients with chronic ischemic CVD. These models would be useful for estimating the long-term risk of mortality in chronic phase CVD.
著者
Hiroshi Yokomichi Hokuto Noda Akiko Nagai Makoto Hirata Akiko Tamakoshi Yoichiro Kamatani Yutaka Kiyohara Koichi Matsuda Kaori Muto Toshiharu Ninomiya Michiaki Kubo Yusuke Nakamura BioBank Japan Cooperative Hospital Group Zentaro Yamagata
出版者
日本疫学会
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
vol.27, no.Supplement_III, pp.S77-S83, 2017 (Released:2017-04-14)
参考文献数
32
被引用文献数
3

Background: Controlling serum cholesterol is critical to prevent cardiovascular disease in patients with dyslipidaemia. Guidelines emphasise the need to select treatment for dyslipidaemia based on specific patient profiles; however, there is little information about the serum cholesterol levels of patients in each profile in Japan. Therefore, we aimed to describe the serum cholesterol levels and prevalence of uncontrolled cases in Japanese patients with dyslipidaemia.Methods: We included data for patients with dyslipidaemia between 2003 and 2007 from the BioBank Japan Project (66 hospitals). Then, we reported their serum cholesterol levels by age, body mass index, glycaemic control (glycated haemoglobin A1c), blood pressure, smoking, drinking, comorbidity and medication profiles.Results: We included 22,189 male and 21,545 female patients. The mean serum low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG) and non-HDL-C levels in males were 117.4 mg/dL, 51.0 mg/dL, 187.6 mg/dL and 153.6 mg/dL, respectively; the corresponding levels in females were 129.5 mg/dL, 60.5 mg/dL, 144.9 mg/dL and 157.9 mg/dL, respectively. In both males and females, the LDL-C levels were the highest in the following profiles: age 19–44 years, body mass index 18.5–22 kg/m2, glycated haemoglobin A1c <6.0%, never smoker, chronic respiratory disease as a comorbidity and no medication use.Conclusions: These data provide details of serum cholesterol levels by risk-factor profile in patients with dyslipidaemia and could add evidence of treatment decisions.
著者
Hiroshi Yokomichi Akiko Nagai Makoto Hirata Yutaka Kiyohara Kaori Muto Toshiharu Ninomiya Koichi Matsuda Yoichiro Kamatani Akiko Tamakoshi Michiaki Kubo Yusuke Nakamura BioBank Japan Cooperative Hospital Group Zentaro Yamagata
出版者
日本疫学会
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
vol.27, no.Supplement_III, pp.S92-S97, 2017 (Released:2017-04-14)
参考文献数
28
被引用文献数
12

Background: Evidence of characteristics of Japanese patients with diabetes from a large-scale population is necessary. Few studies have compared glycaemic controls, complications and comorbidities between type 1 and 2 diabetic patients. This paper focuses on illustrating a clinical picture of Japanese diabetic patients and comparing glycaemic control and prognoses between type 1 and 2 diabetes using multi-institutional data.Methods: The BioBank Japan Project enrolled adult type 1 and 2 diabetic patients between fiscal years 2003 and 2007. We have presented characteristics, controls of serum glucose, cholesterol and blood pressure, prevalence of complications and comorbidities and survival curves. We have also shown glycaemic controls according to various individual profiles of diabetic patients.Results: A total of 558 type 1 diabetic patients and 30,834 type 2 diabetic patients participated in this study. The mean glycated haemoglobin A1c was higher in type 1 diabetes than in type 2 diabetes. In the type 1 diabetic patients, the glycated haemoglobin A1c had no consistent trend according to age and body mass index. The Kaplan–Meier estimates represented a longer survival time from baseline with type 1 diabetes than with type 2 diabetes. Compared with type 1 diabetic patients, type 2 diabetic patients had double the prevalence of macrovascular complications.Conclusions: This work has revealed detailed plasma glucose levels of type 1 and 2 diabetic patients according to age, body mass index, blood pressure, serum cholesterol levels and smoking and drinking habits. Our data have also shown that the prognosis is worse for type 2 diabetes than for type 1 diabetes in Japan.
著者
Hiroshi Yokomichi Akiko Nagai Makoto Hirata Yutaka Kiyohara Kaori Muto Toshiharu Ninomiya Koichi Matsuda Yoichiro Kamatani Akiko Tamakoshi Michiaki Kubo Yusuke Nakamura BioBank Japan Cooperative Hospital Group Zentaro Yamagata
出版者
日本疫学会
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
vol.27, no.Supplement_III, pp.S98-S106, 2017 (Released:2017-04-14)
参考文献数
39
被引用文献数
17

Background: The number of patients with diabetes is increasing worldwide. Macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking frequently accompany type 2 diabetes. Few data are available related to mortality of Asians with diabetes associated with these serious comorbidities. The present study aimed to quantify the excess mortality risks of type 2 diabetic patients with comorbidities.Methods: We analysed the available records of 30,834 Japanese patients with type 2 diabetes from the BioBank Japan Project between 2003 and 2007. Men and women were followed up for median 8.03 and 8.30 years, respectively. We applied Cox proportional hazard model and Kaplan–Meier estimates for survival curves to evaluate mortality in diabetic patients with or without macrovascular disease, chronic respiratory disease, chronic kidney disease, cancer and smoking.Results: Adjusted hazard ratios (HRs) for mortality were 1.39 (95% CI, 1.09–1.78) for male sex, 2.01 (95% CI, 1.78–2.26) per 10-year increment of age. Adjusted HRs of primary interest were 1.77 (95% CI, 1.42–2.22), macrovascular disease; 1.58 (95% CI, 1.08–2.31), chronic respiratory disease; 2.03 (95% CI, 1.67–2.47), chronic kidney disease; 1.16 (95% CI, 0.86–1.56), cancer; and 1.74 (95% CI, 1.30–2.31), current smoking.Conclusions: Diabetic patients with a past or current history of chronic kidney, macrovascular or respiratory diseases or smoking habit have exhibited the highest risk of mortality. Data were limited to those of survivors of comorbidities but we propose the need to improve comorbidities and terminate cigarette smoking for better prognosis in patients with diabetes.
著者
沼倉 彬雄 加藤 成将 佐藤 和幸 富沢 武弥 三好 扶 明石 卓也 金 天海
雑誌
第77回全国大会講演論文集
巻号頁・発行日
vol.2015, no.1, pp.993-994, 2015-03-17 (Released:2016-06-20)

本稿では,木構造を用いた階層型学習器である力学系学習木を提案する.力学系学習木は力学系の挙動の階層的な関数近似を行う.水面上での船体の運動など,力学的挙動の数式表現が困難な場合には,実機データの関数近似が有効である.力学系学習木は実機データを階層的に整理して学習することで,データ密度に合わせた適応的な汎化(A)を実現できる.また,データのノイズ除去(B)やオンライン学習(C)も同時に実現できる.振り子の運動や船体運動の学習で力学系学習木を評価した結果,機能A,B,Cが確認できた他,船体運動の外乱推定にも応用できることが分かった.力学系学習木は任意の連続力学系に適用できるため,今後は様々な力学系への応用を試みたい.
著者
Fumie Nishikawa Mitsunori Iwasaki Hiroshi Fukamachi Tomoko Endo
出版者
一般社団法人 園芸学会
雑誌
The Horticulture Journal (ISSN:21890102)
巻号頁・発行日
pp.OKD-031, (Released:2016-11-29)
被引用文献数
8

In citrus trees, a technique for predicting the number of flowers is needed to prevent inconsistent fruit production over time. In this study, we investigated whether a flowering-related gene, citrus FLOWERING LOCUS T (CiFT), can be used to predict floral production. We quantified CiFT expression levels in stems of Satsuma mandarin (Citrus unshiu Marc.) trees planted at two remote locations. We collected samples over 3 years, and determined that the CiFT mRNA levels in November were strongly correlated with the number of flowers produced the following spring. The correlation between CiFT expression and floral production exhibited almost no differences among years or between sample collection sites. Thus, the CiFT expression level in November can be used to predict the number of flowers the following spring, and this prediction method can be used at different locations and over several years. To verify the practical utility of this method, Satsuma mandarin shoots were transported in November from eight locations across Japan to our laboratory under cool conditions. Transport times were approximately 4–72 h, and samples were immediately frozen upon arrival. The CiFT expression levels in transported stems correlated with the number of flowers in the following spring. Additionally, those correlations were similar in transported samples and samples that were frozen immediately after collection. Our results suggest that the number of flowers can be predicted even with the CiFT expression levels quantified in transported samples.
著者
三木 盛登 入戸野 宏
出版者
Japanese Society for Physiological Psychology and Psychophysiology
雑誌
生理心理学と精神生理学 (ISSN:02892405)
巻号頁・発行日
2014

視聴者が動画に注意を向けるほど,動画とは無関係なプローブ刺激に対する事象関連電位のP3 (P300) 成分の振幅が減衰する。本研究では,短い動画に対する主観的興味と脳波測度との相関を求めることにより,この知見を追試・拡張した。15名の大学生・大学院生が映画の予告編12本 (<i>M</i> = 143 s) を視聴した。視聴中に,痛みのない電気プローブ刺激 (0.2 ms) を左手中指に5--7 s間隔で提示し,左手親指によるボタン押し反応を求めた。それぞれの予告編について印象評定を行った。6項目 (興味ある,注意を引く,好き,快,目が覚めた,本編が見たい) のヴィジュアルアナログスケールの合成得点を"興味"得点として使用した。ステップワイズ回帰分析により,プローブ誘発P3振幅 (β = -.20) と刺激が提示されない区間の後頭部アルファ帯域パワー (β = -.29) はどちらも興味得点を説明することが分かった。本研究により,単一電気プローブ刺激法が視聴者の興味を客観的に測る実験プロトコルとして有望であることが示された。
著者
中村 豊 佐藤 勉
出版者
Japan Society of Civil Engineers
雑誌
地震工学研究発表会講演論文集 (ISSN:18848435)
巻号頁・発行日
vol.26, pp.225-228, 2001

1999年-2000年にかけて、メキシコシティにおいて地盤や被災程度が異なる地域の地盤および構造物の常時微動を比較的稠密に計測し、卓越振動数や地震動増幅倍率、被災しやすさ等を調査した。メキシコシティは、1985年ミチョアカン地震で大きな被害を受けている。調査の結果、地盤の卓越振動数Fgや地盤の被災しやすさ指標Kg値は、丘陵部、遷移部、堆積部の地盤区分や1985年を含む過去の地震被害状況と調和的な変化を示すことが確認された。また建物に関しては、1985年の地震後の調査結果と比較した。<BR>本研究では、発生が恐れられている地震に備えて的確な耐震診断技術を確立することを目指している。
著者
川本 直美
出版者
日本文化人類学会
雑誌
日本文化人類学会研究大会発表要旨集
巻号頁・発行日
vol.2013, 2013

本発表ではメキシコ西部ミチョアカン州T村にあるカルゴ・システム(自治的、行政的および宗教的な社会組織)が、グローバル化や村内の対立の影響を受けいかに変容しているのかを検討し、現代の文脈で同システムのカルゴを果たすことへの新たな意義及び村内でのカルゴの現在の位置づけを明らかにしたい(ここでいうカルゴとはスペイン語で「(義務的な)仕事」を指す)。

2 0 0 0 OA 新修国文学史

著者
鈴木暢幸 著
出版者
隆文館
巻号頁・発行日
vol.上巻, 1926