著者
吉田寛著
出版者
春秋社
巻号頁・発行日
2019
著者
吉田 正貴 永田 卓士 桝永 浩一 宮本 豊 工藤 惇三
出版者
一般社団法人 日本臨床薬理学会
雑誌
臨床薬理 (ISSN:03881601)
巻号頁・発行日
vol.40, no.5, pp.201-206, 2009 (Released:2009-11-25)
参考文献数
17
被引用文献数
1

Overactive bladder (OAB) syndrome, which is characterized by a complex of storage symptoms (urinary urgency, frequency, nocturia and urgency incontinence) is highly prevalent in the general population; it causes significant distress to patients in terms of their psychosocial and physical functioning. Muscarinic receptors of bladder smooth muscles are involved in both normal and involuntary detrusor contraction (detrusor overactivity). Up-regulation of the muscarinic receptor function may contribute to the pathophysiology of OAB. In addition, several reports have suggested that various stimulations release many substances (ATP, prostaglandins, nitric oxide and acetylcholine) from bladder urothelium, which contribute to the pathophysiology of the increased bladder sensation, OAB symptoms and detrusor overactivity. The bladder urothelium also prossesses the non-neuronal cholinergic system and high density of muscarinic receptors. The roles and functions of the non-neuronal cholinergic system in OAB are currently under evaluation. Furthermore, new action sites of anticholinergic drugs have also been proposed. In this review, in addition to the pathophysiology of detrusor overactivity and OAB, the pharmacotherapy for OAB is discussed.
著者
関口 由紀 畔越 陽子 河路 かおる 長崎 直美 永井 美江 金子 容子 吉田 実 窪田 吉信
出版者
一般社団法人 日本東洋医学会
雑誌
日本東洋医学雑誌 (ISSN:02874857)
巻号頁・発行日
vol.65, no.4, pp.268-272, 2014 (Released:2015-03-30)
参考文献数
4
被引用文献数
1

間質性膀胱炎/慢性骨盤痛症候群の疼痛緩和と自律神経失調症状の治療に漢方薬を西洋薬に併用した症例を4例提示した。1例目は42歳女性で,膀胱部痛・陰部痛にたいして竜胆寫肝湯を投与し,自律神経失調症状の改善と慢性疼痛による血流障害の改善に加味逍遥酸を用いた。2例目は51歳女性で,内臓を温めて下腹部痛を改善する安中散を用いた。3例目は49歳女性で,全身の冷えに対して真武湯合人参湯を用いた。4例目は27歳女性で,下半身の冷えに対して当帰四逆加呉茱萸生姜湯を用いた。間質性膀胱炎/慢性骨盤痛症候群の自律神経症状改善をめざす漢方治療が結果的に患者の気血水のバランスを整えていた。
著者
吉田 翔 金井 秀明
出版者
情報処理学会
雑誌
情報処理学会研究報告 (ISSN:09196072)
巻号頁・発行日
vol.2014-GN-91, no.52, pp.1-8, 2014-03-06

本研究は,食事中のそしゃく癖の改善を目的としたそしゃく状況通知手法に関する研究である.共食の場において周囲に悪影響を及ぼす 「クチャラー」 を対象とし,聴覚遅延フィードバックを用いたそしゃく状態の通知を行った.被験者のそしゃく音を遅延させて再生することで,自分のそしゃく行為が周囲からどのように認識されているかを通知する.構築システムでは通知だけでなく,被験者の顎の動きを検出することで,そしゃく状態を測定することが可能である.このシステムを用いた実験により,遅延時間を大きくした場合,被験者は自らのそしゃく状態を認知でき,そしゃく行為を控えようとする傾向が確認できた. : In this paper, we propose a notification system of a state of mastication in order to improve a habit of mastication during the meals. The system senses user's mastication state, and uses the delayed auditory feedback to notify the user of the state. The system does the feedback of user's mastication sound depending on the mastication state in order to make sense of the state. We carried out user experiments in order to investigate the effects of the system and how to change user's behavior of masticating using the system. From the experiments, we found that the subjects tend to change their masticating action depending on the delayed auditory feedback.
著者
村上 拓彦 吉田 茂二郎 高嶋 敦史
出版者
日本森林学会
雑誌
日本森林学会誌 (ISSN:13498509)
巻号頁・発行日
vol.101, no.4, pp.163-167, 2019-08-01 (Released:2019-10-24)
参考文献数
17

1660年頃作成の屋久島の古い絵図「屋久島古図」が存在する。この絵図は非常に詳細で,島内の集落名,山頂名,河川名,場所名,スギを含む数種の樹木の存在,島中央への歩道等が書き込まれている。そこで本研究では,この地図を現代図と重なるようにGIS上で補正し,当時のヤクスギ分布を推定した。さらに現代図のヤクスギ分布域との比較から,その間の変化を把握しかつその変化要因を分析し,最後にこの地図の今後の利用可能性を検討した。その結果,この地図は現代図と非常に良く重ね合わせることができ,当時のヤクスギ分布域は島東部の安房川流域に偏り,標高200 m付近の低標高域にも存在していたことが判明した。1660年当時にヤクスギが分布していた地域で,その後の伐採でヤクスギが消失した地域は,低標高の地域と川の近くに多かった。以上からこの屋久島の地図は,作成当時の森林状態を詳細に記録した地図として活用できる可能性が示唆された。
著者
小畑 協一 岸本 晃治 西山 明慶 吉田 祥子 野島 鉄人 佐々木 朗
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.61, no.1, pp.20-24, 2015-01-20 (Released:2015-09-08)
参考文献数
25
被引用文献数
2 12

Recently, the occurrence of methotrexate-associated lymphoproliferative disorders (MTX-LPD) in the oral area is reported one after another. We report a case of MTX-LPD of the maxillary gingiva associated with rheumatoid arthritis (RA). A 80-year-old man was referred to our clinic because of severe pain associated with a ulcer on the left side of the maxillary gingiva. On blood tests, soluble interleukin-2 receptor (sIL-2R) was high, and EBV infection was detected. The histopathological diagnosis was EBV-positive diffuse large B cell lymphoma (DLBCL). He had been receiving methotrexate for RA. We therefore requested discontinuation of methotrexate, and the lesion was decreased and symptoms disappeared. Examination after 21 months showed no evidence of recurrence.We reviewed reports documenting 17 cases of oral MTX-LPD in Japan. The age of onset was 40-84 years old, the male-to-female ratio was 4:13, and the methotrexate treatment period was 1-114 months. The affected sites were the maxillary and mandibular gingiva in 14 cases, the tongue in 1 case, and the mouth floor in 1 case. On histopathological classification, 14 cases were non-Hodgkin’s lymphoma, and 1 case was Hodgkin's lymphoma. As for the course of treatment, 11 cases had remission with cessation of methotrexate. Symptoms improved in 1-2 weeks, and lesions disappeared in 1-4 months.
著者
吉田 弥生
出版者
日本公民館学会
雑誌
日本公民館学会年報 (ISSN:1880439X)
巻号頁・発行日
vol.16, pp.34-44, 2019-11-30 (Released:2019-12-29)

The purpose of this study is to consider the role that Kominkan can play when a diversity of residents in mountainous regions move towards cooperative autonomy. In this project, I begin with the perception that traditional autonomy in mountainous regions is based on subservient social relationships that are rooted in feudal customs. I then focus on the process of cooperative autonomy formation, in which people who have been on the periphery as well as those who have traditionally been at the center of community life take part in community development activities, after which I examine the role of Kominkan in this process.The case study taken up was that of the Tobitari Kominkan in Tokamachi, Niigata Prefecture, and the Kominkan activities that supported community organization improvement and increased resident participation. The Tobitari Kominkan has engaged in various efforts to bring together the wide diversity residents in the community in order to come to grips with lingering feudal relationships and to deal with the problems associated with depopulation, the increasing isolation of these areas as well as the divisions between old and new residents. Three main conclusions were reached. First, the process of developing cooperative relationships for autonomous self-government involves the reconstruction of cooperative ties between those on the periphery of the community and their perspectives with long-time residents and their experience in which all parties participate equally to bring on community improvement. Second, the Kominkan plays the role of a trigger in empowering those on the community's periphery and in bringing together all residents into an organization, albeit one that in the past has been prone to splitting apart. Third, it becomes an important factor in developing the cooperative relationships that can mitigate such a split through its educational and cultural activities.
著者
佐野 哲也 吉田 貴紘 井 春夫 大原 誠資
出版者
一般社団法人 日本エネルギー学会
雑誌
バイオマス科学会議発表論文集 第6回バイオマス科学会議 (ISSN:24238333)
巻号頁・発行日
pp.50-51, 2011-01-12 (Released:2017-03-22)

The moisture reduction in fuelwood of Japanese cypress (Chamaecyparis obtusa) and evergreen oak spp. (Quercus glauca) was evaluated under some conditions differentiated in split sizes (one quarter or one eighth), drying area (paved or unpaved, roofed or unroofed), and season (winter or summer). Japanese cypress dried out more rapidly than oak. Splitting enables the acceleration of drying rate and size effect was more enhanced in oak with higher wood density. Any benefits of natural seasoning were realized within the first one or two month. Under natural seasoning with uriroofed condition, there was little benefit in longer drying period of fuelwood in terms of rainfall.