著者
大橋 健吾 松岡 知子 篠田 康孝 吉田 真也 新井 かおり 加藤 未紗 森 卓之 吉村 知哲
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.137, no.5, pp.643-650, 2017 (Released:2017-05-01)
参考文献数
19
被引用文献数
6

In recent years, hospitals have routinely implemented antimicrobial stewardship (AS) programs, and it is important that these programs are effective. Consequently, we utilized a customized computer system to support infection management and implemented a pharmacist-driven AS program in our hospital. Using this computer system, a pharmacist monitored the daily usage of carbapenems and agents against anti-methicillin-resistant Staphylococcus aureus and generated a patient database. With the use of this computer system, we found that the patient database entry time significantly decreased from 24 to 12 min (p<0.01). Subsequently, we were also able to monitor tazobactam/piperacillin usage owing to the increased efficiency of our AS program. As a result, the average number of monitored patients significantly increased from 51 to 72 per month (p<0.01) and the number of proposed prescriptions increased from 189 to 238 per year. Additionally, the usage of carbapenems and tazobactam/piperacillin significantly decreased (p<0.01) after implementation of this computer support system. In summary, we recommend that pharmacists utilize computer systems to implement AS programs because they increase the efficiency of interventions and monitoring of patients and promote appropriate antibiotic use.
著者
春日 範樹 小川 祐二 本多 靖 谷口 礼央 酒井 英嗣 今城 健人 日比谷 孝志 米田 正人 桐越 博之 大橋 健一 中島 淳 斉藤 聡
出版者
一般社団法人 日本肝臓学会
雑誌
肝臓 (ISSN:04514203)
巻号頁・発行日
vol.61, no.10, pp.504-512, 2020-10-01 (Released:2020-10-08)
参考文献数
16

症例は45歳女性.急性骨髄性白血病に対して同種骨髄移植が行われ,移植後はタクロリムス,ステロイドによる免疫抑制療法を18カ月継続した.移植前はHBV既往感染の状態であったが,移植から38カ月後に肝機能障害,HBs抗原陽転化,HBV-DNA量上昇を認め,HBV再活性化と診断した.同種骨髄移植前後に赤血球濃厚液の頻回の輸血によりヘモクロマトーシスを合併していた影響もあり,血清フェリチン値は著明高値であった.肝生検では過剰な鉄沈着と急性肝炎の所見を認めた.ラミブジンにより治療を開始し,その後テノホビルアラフェナミドへ切り替えた.HBV再活性化とヘモクロマトーシスの関連性は不明であったが,HBV治療と鉄キレート剤により血清フェリチン値も漸減した.HBV既往感染状態での同種骨髄移植では,長期間にわたりHBV再活性化への注意が必要である.
著者
石内 鉄平 小柳 武和 桑原 祐史 大橋 健一
出版者
Japan Society of Civil Engineers
雑誌
土木学会論文集G(環境) (ISSN:21856648)
巻号頁・発行日
vol.68, no.5, pp.I_111-I_119, 2012
被引用文献数
1

本研究は,茨城県を代表する観光資源である袋田の滝に着目して,気象の変化と滝の凍結度,観光客数,観光客の満足度の関係を分析した.その結果,気温および降水量と滝の凍結度,特に平成17年度以降の観光客数と滝の凍結度の間に相関関係が確認された.加えて,袋田の滝における利用実態調査から,冬期に訪れる観光客の多くが滝の凍結状況に対して高い関心を持っていることが確認された.また,約半数の観光客が滝の凍結情報を得た上で訪れており,活用した情報媒体はテレビとインターネットで9割以上を占める.結論として,今後12~2月の気温上昇により氷瀑する日数および観光客の満足度の減少が予測されるとともに,テレビやインターネットを介した滝の凍結状況に関する更なる情報発信の必要性が確認された.
著者
大橋 健也
出版者
Japan Society of Corrosion Engineering
雑誌
Zairyo-to-Kankyo (ISSN:09170480)
巻号頁・発行日
vol.49, no.11, pp.664-668, 2000-11-15 (Released:2011-12-15)
参考文献数
23

Thin film magnetic heads for high recording density rigid disk drives are composed of ceramics and metal multilayers. These metals take important role for read and write of information storage. It is a vital wound if the thin film metals suffer corrosion attack. Therefore, corrosion of thin film magnetic heads has been studied with surface analysis and electrochemical techniques in several related organizations. The author hopes some data introduced in this paper would helpful for comprehension of corrosion of magnetic heads and for prevention of the corrosion.
著者
大橋 健三郎
出版者
一般財団法人日本英文学会
雑誌
英文學研究 (ISSN:00393649)
巻号頁・発行日
vol.40, no.1, pp.55-76, 1964-02-25

Examining closely some of those modern American novels or stories in which worlds of nature play somewhat dominant parts one way or another, we find that there is a curiously similar attitude more or less common to the authors in their treatments of natural objects or phenomena. There are, it seems, three distinct levels or orders, for example, of which these stories or novels are made, including: first, the world of the actual society in which modern civilization is more or less dominant; second, the natural world where man, who has got out from the actual human society, struggles with some powerful natural object or phenomenon and, in the very struggling, finds some high value or glory which he cannot find in the actual civilized world; and, third, the world of some transcendental order, which is usually suggested by the eternal return of natural phenomena, such as seasons, procreation, celestial movement, or the flowing river, and which seems ultimately to sustain the whole moral of the work of art itself. Take, for example, Hemingway's The Old Man and the Sea, or Faulkner's "The Bear", or even Steinbeck's The Grapes of Wrath. In these novels and stories, the world of the actual society is, almost without exception, something portent, or at least sordid and trivial, from which heroes or heroines get out early or are forced to do so, and they immediately seek something of much higher value and much more glorious (or fertile, in the case of The Grapes of Wrath) in the world of, if we borrow from Faulkner, "the ancient and unremitting contest according to the ancient and immitigable rules which voided all regrets and brooked no quarter." Thus Hemingway's hero fights the 'marlin', Faulkner's Issac seeks to be spiritually equal to Old Ben (these two being nothing but natural objects) and Steinbeck's Joads struggle against injustice, the endless highway and, above all, the dust storm and the flood (natural phenomena). But at the same time, in their struggles, although defeated and vain at the last in physical aspects, they seem to draw their ultimate strength (and embody it in themselves) from some conscious or unconscious cognizance of such transcendental order of nature as is represented by the celestial motion (The Old Man and the Sea, although the old man himself seems scarcely conscious of it), or the "leaf and twig and particle, air and sun and dew and night, acorn oak and leaf and acorn again, ... " ("The Bear"), or the mysterious ever-flow of water and blood and seasons (The Grapes of Wrath). It seems as if these authors, including many more, were trying once more (and, perhaps, once for all) to fall back on the dark power of the transcendental nature, in order to fight back the actual world of the civilization-strained society.

1 0 0 0 病理学

著者
大橋健一著者代表
出版者
医学書院
巻号頁・発行日
2015
著者
稲垣 勉 大橋 健一 白坂 蕃
出版者
立教大学
雑誌
基盤研究(C)
巻号頁・発行日
2011

本研究の目的は、宗主国によって植民地に建設された避暑地・ヒルステーションの現状を、領域横断的なアプローチで明らかにすることである。ヒルステーションはレジャーを通じた国際間の文化接触の先駆けであり、現在でも観光地として機能し続けている。リゾートの祖型のひとつであるヒルステーションの現状分析を通じて、新興国民国家における国内観光の社会的役割を明確化し、さらにグローバル化の下における、気候条件やより良い生活環境を求める「人の移動」を分析することで、ヒルステーションの現代的な意義を明らかにした。